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Drug Evaluations

Roflumilast in chronic obstructive pulmonary disease: evidence from large trials

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Pages 441-449 | Published online: 27 Jan 2010

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Paola Rogliani, Luigino Calzetta, Mario Cazzola & Maria Gabriella Matera. (2016) Drug safety evaluation of roflumilast for the treatment of COPD: a meta-analysis. Expert Opinion on Drug Safety 15:8, pages 1133-1146.
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Mario Cazzola, Luigino Calzetta, Paola Rogliani & Maria Gabriella Matera. (2016) The discovery of roflumilast for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Drug Discovery 11:7, pages 733-744.
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Stephen I Rennard, Fernando J Martinez, Klaus F Rabe, Sanjay Sethi, Emilio Pizzichini, Andrew McIvor, Shahid Siddiqui, Antonio Anzueto & Haiyuan Zhu. (2016) Effects of roflumilast in COPD patients receiving inhaled corticosteroid/long-acting β2-agonist fixed-dose combination: RE2SPOND rationale and study design. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 1921-1928.
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Articles from other publishers (16)

Xinjie Zhu, Jun Wei, Chenxian Hu, Qitao Xiao, Lvtao Cai, Hao Wang, Yuanyuan Xie & Rong Sheng. (2022) Difluorocarbene‐Induced Ring Opening of Tetrahydrofuran with TMSCF 2 Br for Difluoromethoxybutylation of N‐Aryl‐N‐hydroxylamines . European Journal of Organic Chemistry 2022:30.
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Guo-Kai Liu, Wen-Bing Qin, Xin Li, Li-Ting Lin & Henry N. C. Wong. (2019) Difluoromethylation of Phenols and Thiophenols with the S -(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study . The Journal of Organic Chemistry 84:24, pages 15948-15957.
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Guo-Kai Liu, Xin Li, Wen-Bing Qin, Wei-Feng Lin, Li-Ting Lin, Jia-Yi Chen & Jian-Jian Liu. (2019) Selective O-difluoromethylation of 1,3-diones using S-(difluoromethyl) sulfonium salt. Chinese Chemical Letters 30:8, pages 1515-1518.
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Guo-Kai Liu, Xin Li, Wen-Bing Qin, Xiao-Shui Peng, Henry N. C. Wong, Linxing Zhang & Xinhao Zhang. (2019) Facile difluoromethylation of aliphatic alcohols with an S -(difluoro-methyl)sulfonium salt: reaction, scope and mechanistic study . Chemical Communications 55:52, pages 7446-7449.
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Mark A. Giembycz & Robert Newton. (2014) How Phosphodiesterase 4 Inhibitors Work in Patients with Chronic Obstructive Pulmonary Disease of the Severe, Bronchitic, Frequent Exacerbator Phenotype. Clinics in Chest Medicine 35:1, pages 203-217.
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Taiji Goto, Akiko Shiina, Takeshi Murata, Masato Tomii, Takanori Yamazaki, Ken-ichi Yoshida, Toshiharu Yoshino, Osamu Suzuki, Yoshitaka Sogawa, Kiyoshi Mizukami, Nana Takagi, Tomomi Yoshitomi, Maki Etori, Hiroshi Tsuchida, Tsuyoshi Mikkaichi, Naoki Nakao, Mizuki Takahashi, Hisashi Takahashi & Shigeki Sasaki. (2014) Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors. Bioorganic & Medicinal Chemistry Letters 24:3, pages 893-899.
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Taiji Goto, Akiko Shiina, Toshiharu Yoshino, Kiyoshi Mizukami, Kazuki Hirahara, Osamu Suzuki, Yoshitaka Sogawa, Tomoko Takahashi, Tsuyoshi Mikkaichi, Naoki Nakao, Mizuki Takahashi, Masashi Hasegawa & Shigeki Sasaki. (2013) Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. Bioorganic & Medicinal Chemistry 21:22, pages 7025-7037.
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Timothy E. Albertson, Michael Schivo, Amir A. Zeki, Samuel Louie, Mark E. Sutter, Mark Avdalovic & Andrew L. Chan. (2013) The Pharmacological Approach to the Elderly COPD Patient. Drugs & Aging 30:7, pages 479-502.
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Taiji Goto, Akiko Shiina, Toshiharu Yoshino, Kiyoshi Mizukami, Kazuki Hirahara, Osamu Suzuki, Yoshitaka Sogawa, Tomoko Takahashi, Tsuyoshi Mikkaichi, Naoki Nakao, Mizuki Takahashi, Masashi Hasegawa & Shigeki Sasaki. (2013) Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters 23:11, pages 3325-3328.
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Neil J. PressRoger J. TaylorJoseph D. Fullerton, Pamela TranterClive McCarthy, Thomas H. Keller, Nicola Arnold, David Beer, Lyndon Brown, Robert Cheung, Julie Christie, Alastair Denholm, Sandra Haberthuer, Julia D. I. HattoMark Keenan, Mark K. Mercer, Helen OakmanHelene Sahri, Andrew R. Tuffnell, Morris Tweed, John W. TylerTrixie Wagner, John R. Fozard & Alexandre Trifilieff. (2012) Solubility-Driven Optimization of Phosphodiesterase-4 Inhibitors Leading to a Clinical Candidate. Journal of Medicinal Chemistry 55:17, pages 7472-7479.
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Mario Cazzola, Clive P. Page, Luigino Calzetta & M. Gabriella Matera. (2012) Pharmacology and Therapeutics of Bronchodilators. Pharmacological Reviews 64:3, pages 450-504.
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Noah P. Zimmerman, Suresh N. Kumar, Jerrold R. Turner & Michael B. Dwinell. (2012) Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA*. Inflammatory Bowel Diseases 18:6, pages 1081-1091.
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Rachael A. Evans, Robert G. Varadi, Kambiz Mirzaei & Roger S. Goldstein. 2012. Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Disease 211 252 .
Nikola Marjanović, Martina Bosnar, Francesca Michielin, David R. Willé, Tatjana Anić-Milić, Ognjen Čulić, Sanja Popović-Grle, Mile Bogdan, Michael J. Parnham & Vesna Eraković Haber. (2011) Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro. Pharmacological Research 63:5, pages 389-397.
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D Peter, R Göggel, F Colbatzky & P Nickolaus. (2010) Inhibition of cyclooxygenase‐2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats. British Journal of Pharmacology 162:2, pages 415-427.
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Mario Cazzola. (2010) The divergent opinions of regulatory authorities on roflumilast are puzzling but we need new drugs for treating chronic obstructive pulmonary disease. Therapeutic Advances in Respiratory Disease 4:4, pages 195-198.
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