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Drug Evaluations

Sorafenib: activity and clinical application in patients with hepatocellular carcinoma

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Pages 303-313 | Published online: 13 Jan 2011

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Qiuzi Dai, Cunlong Zhang, Zigao Yuan, Qinsheng Sun & Yuyang Jiang. (2020) Current discovery strategies for hepatocellular carcinoma therapeutics. Expert Opinion on Drug Discovery 15:2, pages 243-258.
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Wen Wen Xu, Bin Li & Annie L M Cheung. (2015) The potential of targeted antiangiogenesis therapies in the treatment of esophageal cancer. Gastrointestinal Cancer: Targets and Therapy 5, pages 79-88.
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Articles from other publishers (22)

Anne-Rose W. Schut, Anne L.M. Vriends, Andrea Sacchetti, Milea J.M. Timbergen, Benjamin A. Alman, Mushriq Al-Jazrawe, Dirk J. Grünhagen, Cornelis Verhoef, Stefan Sleijfer & Erik A.C. Wiemer. (2022) In desmoid-type fibromatosis cells sorafenib induces ferroptosis and apoptosis, which are enhanced by autophagy inhibition. European Journal of Surgical Oncology 48:7, pages 1527-1535.
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Kuo-Liang Wei, Guan-Lun Gao, Yu-Ting Chou, Chih-Yi Lin, Shan-Chun Chen, Yi-Ling Chen, Hui Qin Choi, Chi-Chia Cheng & Jyan-Gwo Joseph Su. (2022) Sorafenib is an antagonist of the aryl hydrocarbon receptor. Toxicology 470, pages 153118.
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Simran Kaur, Nupur Angrish, Kajal Gupta, Anil K. Tyagi & Garima Khare. (2021) Inhibition of ABCG2 efflux pumps renders the Mycobacterium tuberculosis hiding in mesenchymal stem cells responsive to antibiotic treatment. Infection, Genetics and Evolution 87, pages 104662.
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Xiaomin Ma, Yumin Qiu, Lihui Zhu, Yunxue Zhao, Yueke Lin, Dapeng Ma, Zhenzhi Qin, Caiyu Sun, Xuecheng Shen, Tao Li & Lihui Han. (2019) NOD1 inhibits proliferation and enhances response to chemotherapy via suppressing SRC-MAPK pathway in hepatocellular carcinoma. Journal of Molecular Medicine 98:2, pages 221-232.
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Laura Mazilu, Dana Stanculeanu, Andreea Gheorghe, Adrian-Paul Suceveanu, Irinel Parepa, Felix Voinea, Doina Catrinoiu & Andra-Iulia Suceveanu. 2019. Metformin [Working Title]. Metformin [Working Title].
Jun Deng, Mei Peng, Zhiren Wang, Sichun Zhou, Di Xiao, Jiating Deng, Xue Yang, Jingyuan Peng & Xiaoping Yang. (2019) Novel application of metformin combined with targeted drugs on anticancer treatment. Cancer Science 110:1, pages 23-30.
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Zhiyong Ma, Xia Liu, Huifen Dong, Dong Xia, Lixia Wang, Yu Chen & Yong Xiong. (2018) Sorafenib and praziquantel synergistically attenuate Schistosoma japonicum-induced liver fibrosis in mice. Parasitology Research 117:9, pages 2831-2839.
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Galina Khemlina, Sadakatsu Ikeda & Razelle Kurzrock. (2017) The biology of Hepatocellular carcinoma: implications for genomic and immune therapies. Molecular Cancer 16:1.
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Nicoletta Potenza, Nicola Mosca, Silvia Zappavigna, Filomena Castiello, Marta Panella, Carmela Ferri, Daniela Vanacore, Antonio Giordano, Paola Stiuso, Michele Caraglia & Aniello Russo. (2017) MicroRNA-125a-5p Is a Downstream Effector of Sorafenib in Its Antiproliferative Activity Toward Human Hepatocellular Carcinoma Cells. Journal of Cellular Physiology 232:7, pages 1907-1913.
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Sufang Yang & Guohua Liu. (2017) Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma. Oncology Letters 13:3, pages 1041-1047.
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Ivan Haralampiev, Holger A. Scheidt, Tobias Abel, Madlen Luckner, Andreas Herrmann, Daniel Huster & Peter Müller. (2016) The interaction of sorafenib and regorafenib with membranes is modulated by their lipid composition. Biochimica et Biophysica Acta (BBA) - Biomembranes 1858:11, pages 2871-2881.
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Nestor Prieto-Domínguez, Raquel Ordóñez, Anna Fernández, Andres García-Palomo, Jordi Muntané, Javier González-Gallego & José L. Mauriz. (2016) Modulation of Autophagy by Sorafenib: Effects on Treatment Response. Frontiers in Pharmacology 7.
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Constantinos Alifieris & Dimitrios T. Trafalis. (2015) Glioblastoma multiforme: Pathogenesis and treatment. Pharmacology & Therapeutics 152, pages 63-82.
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Li Xu, Hengjun Gao, Junting Huang, Haoyuan Wang, Zhongguo Zhou, Yaojun Zhang, Shaohua Li & Minshan Chen. (2015) Antiviral therapy in the improvement of survival of patients with hepatitis B virus-related hepatocellular carcinoma treated with sorafenib. Journal of Gastroenterology and Hepatology 30:6, pages 1032-1039.
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Djoeke de Wit, Henk-Jan Guchelaar, Jan den Hartigh, Hans Gelderblom & Nielka P. van Erp. (2015) Individualized dosing of tyrosine kinase inhibitors: are we there yet?. Drug Discovery Today 20:1, pages 18-36.
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Carmen Fucile, Simona Marenco, Marco Bazzica, Maria Laura Zuccoli, Francesca Lantieri, Luigi Robbiano, Valeria Marini, Paola Di Gion, Giulia Pieri, Paola Stura, Antonietta Martelli, Vincenzo Savarino, Francesca Mattioli & Antonino Picciotto. (2014) Measurement of sorafenib plasma concentration by high-performance liquid chromatography in patients with advanced hepatocellular carcinoma: is it useful the application in clinical practice? A pilot study. Medical Oncology 32:1.
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A. Kornberg. (2014) Liver Transplantation for Hepatocellular Carcinoma beyond Milan Criteria: Multidisciplinary Approach to Improve Outcome. ISRN Hepatology 2014, pages 1-25.
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Chieh-Lin Teng, Wen-Li Hwang, Yi-Ju Chen, Kuang-Hsi Chang & Shao-Bin Cheng. (2012) Sorafenib for hepatocellular carcinoma patients beyond Milan criteria after orthotopic liver transplantation: a case control study. World Journal of Surgical Oncology 10:1.
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Anastasios J. Karayiannakis, Stylianos Kakolyris, Alexandra Giatromanolaki, Nikos Courcoutsakis, Helen Bolanaki, Leonidas Chelis, Efthimios Sivridis & Constantinos Simopoulos. (2011) Hepatoid Adenocarcinoma of the Gallbladder. Journal of Gastrointestinal Cancer 43:S1, pages 139-144.
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HIROKI UEDA, HIROKO FUKUCHI & CHIGUSA TANAKA. (2012) Toxicity and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma (Review). Oncology Letters 3:2, pages 259-263.
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Yafei Zhang, Bicheng Zhang, Anran Zhang, Yong Zhao, Jie Zhao, Jian Liu, Jianfei Gao, Dianchun Fang & Zhiguo Rao. (2012) Synergistic growth inhibition by sorafenib and vitamin K2 in human hepatocellular carcinoma cells. Clinics 67:9, pages 1093-1099.
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Adrian Lupescu, Nazneen Shaik, Kashif Jilani, Christine Zelenak, Elisabeth Lang, Venkanna Pasham, Mohanad Zbidah, Ansgar Plate, Michael Bitzer, Michael Föller, Syed M. Qadri & Florian Lang. (2012) Enhanced Erythrocyte Membrane Exposure of Phosphatidylserine Following Sorafenib Treatment: An in vivo and in vitro Study . Cellular Physiology and Biochemistry 30:4, pages 876-888.
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