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Genetic and non-genetic factors affecting the response to clopidogrel therapy

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Pages 663-683 | Published online: 07 Mar 2012

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Hongyu Xu, Qinglin Yu, Honglin Zhou, Jin Yang, Nan Zheng, Zhifeng Xu & Jia Su. (2021) Polymorphisms in the GCK gene increase the risk of clopidogrel resistance in stable coronary artery disease (SCAD) patients. Hematology 26:1, pages 447-452.
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Gian Marco Rosa, Daniele Bianco, Alberto Valbusa, Laura Massobrio, Francesco Chiarella & Claudio Brunelli. (2016) Pharmacokinetics and pharmacodynamics of ticagrelor in the treatment of cardiac ischemia. Expert Opinion on Drug Metabolism & Toxicology 12:12, pages 1491-1502.
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Aldona Kubica, Karolina Obońska, Tomasz Fabiszak & Jacek Kubica. (2016) Adherence to antiplatelet treatment with P2Y12 receptor inhibitors. Is there anything we can do to improve it? A systematic review of randomized trials. Current Medical Research and Opinion 32:8, pages 1441-1451.
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Annika Lundström, Ann-Charlotte Laska, Magnus Von Arbin, Gun Jörneskog & Håkan Wallén. (2014) Glucose intolerance and insulin resistance as predictors of low platelet response to clopidogrel in patients with minor ischemic stroke or TIA. Platelets 25:2, pages 102-110.
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Jiaqi Shan & Hongbin Sun. (2013) The discovery and development of prasugrel . Expert Opinion on Drug Discovery 8:7, pages 897-905.
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Hong Ting Shi, Yong Yuan Chen, Xiao Ying Li, Jian Hua Luo, Guang Hong Zhong, Jia Jia Hu, Min Zhang & Bo Rong Zhou. (2021) The Dynamic Effect of Non-CYP3A4-Metabolized and CYP3A4-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction. Frontiers in Pharmacology 12.
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Kong-Xiang Zhu, Pei-Yuan Song, He-Li, Mu-Peng Li, Yin-xiao Du, Qi-lin Ma, Li-Ming Peng & Xiao-Ping Chen. (2020) Association of FMO3 rs1736557 polymorphism with clopidogrel response in Chinese patients with coronary artery disease. European Journal of Clinical Pharmacology 77:3, pages 359-368.
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Fatima RodriguezRobert A. Harrington. (2021) Management of Antithrombotic Therapy after Acute Coronary Syndromes. New England Journal of Medicine 384:5, pages 452-460.
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Xiliang Zhao, Quan Li, Chenchen Tu, Yong Zeng & Yicong Ye. (2020) High glycated albumin is an independent predictor of low response to clopidogrel in ACS patients: a cross-sectional study. Cardiovascular Diabetology 19:1.
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Jitender Gairolla, Jasmina Ahluwalia, Madhu Khullar, Rupinder Kler, Kamal Kishore, Bikash Medhi, Manish Modi, Mukesh Kumar, Ashok Kumar & Dheeraj Khurana. (2020) Clopidogrel response in ischemic stroke patients: Is polymorphism or gender more important? Results of the CRISP study. Journal of Clinical Neuroscience 76, pages 81-86.
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Monica Verdoia, Roberta Rolla, Federica Negro, Francesco Tonon, Patrizia Pergolini, Matteo Nardin, Marco Marcolongo & Giuseppe De Luca. (2020) Homocysteine levels and platelet reactivity in coronary artery disease patients treated with ticagrelor. Nutrition, Metabolism and Cardiovascular Diseases 30:2, pages 292-299.
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D. F. Mesitskaya, A. A. Bykova, Ph. Yu. Kopylov & A. L. Syrkin. (2019) The impact of smoking on sensitivity to antiplatelet therapy with clopidogrel. Kardiologiya i serdechno-sosudistaya khirurgiya 12:6, pages 516.
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Jie-Ya Wang, Yan-Jiao Zhang, He Li, Xiao-Lei Hu, Mu-Peng Li, Pei-Yuan Song, Qi-Lin Ma, Li-Ming Peng & Xiao-Ping Chen. (2018) CRISPLD1 rs12115090 polymorphisms alters antiplatelet potency of clopidogrel in coronary artery disease patients in Chinese Han. Gene 678, pages 226-232.
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Shaimaa Fathy, Mohamed H. Shahin, Taimour Langaee, Basma M. Khalil, Ayman Saleh, Nagwa A. Sabry, Mona F. Schaalan, Lamiaa L. El Wakeel & Larisa H. Cavallari. (2018) Pharmacogenetic and clinical predictors of response to clopidogrel plus aspirin after acute coronary syndrome in Egyptians. Pharmacogenetics and Genomics 28:9, pages 207-213.
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Dorota Danielak, Marta Karaźniewicz-Łada, Anna Komosa, Paweł Burchardt, Maciej Lesiak, Łukasz Kruszyna, Agnieszka Graczyk-Szuster & Franciszek Główka. (2017) Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite. European Journal of Clinical Pharmacology 73:12, pages 1623-1632.
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Fei-Yan Xiao, Jian-Quan Luo, Min Liu, Bi-Lian Chen, Shan Cao, Zhao-Qian Liu, Hong-Hao Zhou, Gan Zhou & Wei Zhang. (2017) Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients. Scientific Reports 7:1.
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André Ducati Luchessi, Marta Concheiro, Juliana de Freitas Germano, Vivian Nogueira Silbiger, Raul Hernandes Bortolin, Angelines Cruz, Oscar Quintela, Maria Brion, Angel Carracedo, Andres Iñiguez, Marisol Bravo, Manuel López-Rivadulla, Rosario Dominguez Crespo Hirata, Amanda Guerra Moraes Rego Sousa & Mario Hiroyuki Hirata. (2017) ABCC3 Polymorphisms and mRNA Expression Influence the Concentration of a Carboxylic Acid Metabolite in Patients on Clopidogrel and Aspirin Therapy . Basic & Clinical Pharmacology & Toxicology 120:5, pages 466-474.
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Dorota Danielak, Marta Karaźniewicz-Łada, Karolina Wiśniewska, Piotr Bergus, Paweł Burchardt, Anna Komosa & Franciszek Główka. (2016) Impact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel. European Journal of Drug Metabolism and Pharmacokinetics 42:1, pages 99-107.
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Fatima Rodriguez & Kenneth W. Mahaffey. (2016) Management of Patients With NSTE-ACS. Journal of the American College of Cardiology 68:3, pages 313-321.
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V. Arya, P. Mahajan, A. Saraf, A. Mohanty, J. P. S. Sawhney & M. Bhargava. (2015) Association of CYP2C19, CYP3A5 and GPIIb/IIIa gene polymorphisms with Aspirin and Clopidogrel Resistance in a cohort of Indian patients with Coronary Artery Disease. International Journal of Laboratory Hematology 37:6, pages 809-818.
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Annika Lundström, Håkan Wallén, Magnus von Arbin, Gun Jörneskog, Bruna Gigante, Karin Höeg Dembrower, Evaldas Laurencikas & Ann Charlotte Laska. (2015) Clopidogrel Resistance after Minor Ischemic Stroke or Transient Ischemic Attack is Associated with Radiological Cerebral Small-Vessel Disease. Journal of Stroke and Cerebrovascular Diseases 24:10, pages 2348-2357.
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Monica Verdoia, Alon Schaffer, Patrizia Pergolini, Roberta Rolla, Lucia Barbieri, Giorgio Bellomo, Fabiola Sinigaglia, Paolo Marino, Harry Suryapranata & Giuseppe De Luca. (2015) Homocysteine Levels Influence Platelet Reactivity in Coronary Artery Disease Patients Treated With Acetylsalicylic Acid. Journal of Cardiovascular Pharmacology 66:1, pages 35-40.
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Guillaume Cayla, Johanne Silvain, Jean-Philippe Collet & Gilles Montalescot. (2015) Updates and Current Recommendations for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes: What It Means for Clinical Practice. The American Journal of Cardiology 115:5, pages 10A-22A.
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Aldona Kubica, Michał Kasprzak, Jolanta Siller-Matula, Marek Koziński, Eliano Pio Navarese, Karolina Obońska, Anna Andruszkiewicz, Beata Sztuba, Tomasz Fabiszak, Iwona Świątkiewicz, Przemysław Paciorek & Jacek Kubica. (2014) Time-related changes in determinants of antiplatelet effect of clopidogrel in patients after myocardial infarction. European Journal of Pharmacology 742, pages 47-54.
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Paul P. Dobesh & Julie H. Oestreich. (2014) Ticagrelor: Pharmacokinetics, Pharmacodynamics, Clinical Efficacy, and Safety. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 34:10, pages 1077-1090.
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Marta Karaźniewicz-Łada, Dorota Danielak, Błażej Rubiś, Paweł Burchardt, Grzegorz Oszkinis & Franciszek Główka. (2014) The influence of genetic polymorphism of Cyp2c19 isoenzyme on the pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases. The Journal of Clinical Pharmacology 54:8, pages 874-880.
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Andrzej Budaj. 2014. Antiplatelet Therapy in Cardiovascular Disease. Antiplatelet Therapy in Cardiovascular Disease 160 165 .
Marta Karaźniewicz-Łada, Dorota Danielak, Paweł Burchardt, Łukasz Kruszyna, Anna Komosa, Maciej Lesiak & Franciszek Główka. (2013) Clinical Pharmacokinetics of Clopidogrel and Its Metabolites in Patients with Cardiovascular Diseases. Clinical Pharmacokinetics 53:2, pages 155-164.
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Jia Su, Xiaojing Li, Qinglin Yu, Yahui Liu, Yaqing Wang, Haojun Song, Hanbin Cui, Weiping Du, Xiaohong Fei, Junsong Liu, Shaoyi Lin, Jian Wang, Wenyuan Zheng, Jinyan Zhong, Lulu Zhang, Maoqing Tong, Jin Xu & Xiaomin Chen. (2014) Association of P2Y12 Gene Promoter DNA Methylation with the Risk of Clopidogrel Resistance in Coronary Artery Disease Patients . BioMed Research International 2014, pages 1-8.
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Ingvild Birschmann, Marcus Dittrich, Thomas Eller, Bettina Wiegmann, Armin J. Reininger, Ulrich Budde & Martin Strüber. (2014) Ambient hemolysis and activation of coagulation is different between HeartMate II and HeartWare left ventricular assist devices. The Journal of Heart and Lung Transplantation 33:1, pages 80-87.
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Hao-Jie Zhu, Xinwen Wang, Brian E. Gawronski, Bryan J. Brinda, Dominick J. Angiolillo & John S. Markowitz. (2013) Carboxylesterase 1 as a Determinant of Clopidogrel Metabolism and Activation. Journal of Pharmacology and Experimental Therapeutics 344:3, pages 665-672.
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Adriana Dana Oprea & Wanda M. Popescu. (2013) Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon?. Cardiology Research and Practice 2013, pages 1-15.
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Marta Karaźniewicz-Łada, Dorota Danielak, Artur Teżyk, Czesław Żaba, Gilles Tuffal & Franciszek Główka. (2012) HPLC–MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples. Journal of Chromatography B 911, pages 105-112.
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