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Expert Opinion on Pharmacotherapy Volume 13, 2012 - Issue 9
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Treatment Evaluation

Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus

Elisa GuarinoUniversity of Siena, Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, Diabetes Unit, Policlinico ‘Le Scotte', 3° Lotto – 5S, Viale Bracci 18, 53100 Siena, Italy+39 0577 586269; +39 0577 586186; [email protected]
, MD,
Laura NigiUniversity of Siena, Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, Diabetes Unit, Policlinico ‘Le Scotte', 3° Lotto – 5S, Viale Bracci 18, 53100 Siena, Italy+39 0577 586269; +39 0577 586186; [email protected]
, MD,
Aurora PattiUniversity of Siena, Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, Diabetes Unit, Policlinico ‘Le Scotte', 3° Lotto – 5S, Viale Bracci 18, 53100 Siena, Italy+39 0577 586269; +39 0577 586186; [email protected];Fondazione Umberto Di Mario ONLUS, c/o Toscana Life Science Park, Siena, Italy
, MD,
Cecilia FondelliUniversity of Siena, Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, Diabetes Unit, Policlinico ‘Le Scotte', 3° Lotto – 5S, Viale Bracci 18, 53100 Siena, Italy+39 0577 586269; +39 0577 586186; [email protected]
, MD &
Francesco DottaUniversity of Siena, Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, Diabetes Unit, Policlinico ‘Le Scotte', 3° Lotto – 5S, Viale Bracci 18, 53100 Siena, Italy+39 0577 586269; +39 0577 586186; [email protected];Fondazione Umberto Di Mario ONLUS, c/o Toscana Life Science Park, Siena, Italy
, MD
Pages 1377-1384 | Published online: 07 Mar 2012

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Zhongke Sun, Xuejiao Sun, Juan Li, Zhaoyang Li, Qingwei Hu, Lili Li, Xinqi Hao, Maoping Song & Chengwei Li. (2020) Using probiotics for type 2 diabetes mellitus intervention: Advances, questions, and potential. Critical Reviews in Food Science and Nutrition 60:4, pages 670-683.
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André J Scheen. (2015) Pharmacokinetics and clinical evaluation of the alogliptin plus pioglitazone combination for type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 11:6, pages 1005-1020.
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Thomas Forst & Peter Bramlage. (2014) Vildagliptin, a DPP-4 inhibitor for the twice-daily treatment of type 2 diabetes mellitus with or without metformin. Expert Opinion on Pharmacotherapy 15:9, pages 1299-1313.
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Eleonora Russo, Giuseppe Penno & Stefano Del Prato. (2013) Managing diabetic patients with moderate or severe renal impairment using DPP-4 inhibitors: focus on vildagliptin. Diabetes, Metabolic Syndrome and Obesity 6, pages 161-170.
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Niki Katsiki, Vasilios G. Athyros & Asterios Karagiannis. (2013) Single-pill combinations: a therapeutic option or necessity for vascular risk treatment?. Journal of Drug Assessment 2:1, pages 67-71.
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André J Scheen. (2013) Linagliptin plus metformin: a pharmacokinetic and pharmacodynamic evaluation. Expert Opinion on Drug Metabolism & Toxicology 9:3, pages 363-377.
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André J Scheen. (2013) Efficacy and safety of Jentadueto® (linagliptin plus metformin). Expert Opinion on Drug Safety 12:2, pages 275-289.
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Articles from other publishers (6)

Vikas Rathod, Pankaj Saini, Ramandeep Kaur, Srinivasa Marimganti & Kamlesh J. Ranbhan. (2023) A Critical Account of Synthetic Approaches toward Vildagliptin, an Antidiabetic Drug. Organic Process Research & Development 27:11, pages 1880-1899.
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Kumar Gautam, Ratikanta Tripathy, Dayanidhi Meher & Jyoti Prakash Sahoo. (2023) Dapagliflozin Versus Vildagliptin as an Adjuvant to Metformin in Patients With Type 2 Diabetes Mellitus: A Randomized, Open-label Study. Cureus.
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Romeu Mendes, Nelson Sousa, José Luís Themudo-Barata & Victor Machado Reis. (2019) High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in Middle-Aged and Older Patients with Type 2 Diabetes: A Randomized Controlled Crossover Trial of the Acute Effects of Treadmill Walking on Glycemic Control. International Journal of Environmental Research and Public Health 16:21, pages 4163.
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Lingli Zhou, Xiaoling Cai, Yingying Luo, Fang Zhang & Linong Ji. (2019) Baseline Triglyceride Level Affected the Efficacy of Vildagliptin in Treating Type 2 Diabetes: A Post Hoc Analysis of the VISION Study. Journal of Diabetes Research 2019, pages 1-5.
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L.-N. Ji, C.-Y. Pan, J.-M. Lu, H. Li, D.-L. Zhu, Q. Li, Q.-F. Li, Y.-D. Peng, H.-M. Tian, C. Yao, Z.-G. Zhao, L. Wang & B.-H. Wang. (2016) Efficacy and safety of combination therapy with vildagliptin and metformin versus metformin uptitration in Chinese patients with type 2 diabetes inadequately controlled with metformin monotherapy: a randomized, open-label, prospective study (VISION). Diabetes, Obesity and Metabolism 18:8, pages 775-782.
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Helena Pelantová, Martina Bugáňová, Martina Holubová, Blanka Šedivá, Jana Zemenová, David Sýkora, Petra Kaválková, Martin Haluzík, Blanka Železná, Lenka Maletínská, Jaroslav Kuneš & Marek Kuzma. (2016) Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination. Molecular and Cellular Endocrinology 431, pages 88-100.
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