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Medical management of langerhans cell histiocytosis from diagnosis to treatment

, MD PhD, , MD & , MD PhD
Pages 1309-1322 | Published online: 11 May 2012

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Milen Minkov. (2018) An update on the treatment of pediatric-onset Langerhans cell histiocytosis through pharmacotherapy. Expert Opinion on Pharmacotherapy 19:3, pages 233-242.
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Raquel Ciuvalschi Maia, Lídia Maria Magalhães de Rezende, Marcela Robaina, Alexandre Apa & Claudete Esteves Klumb. (2015) Langerhans cell histiocytosis: Differences and similarities in long-term outcome of paediatric and adult patients at a single institutional centre. Hematology 20:2, pages 83-92.
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Milen Minkov. (2012) Langerhans cell histiocytosis: pragmatic empirism on the road to rational cure. Expert Opinion on Pharmacotherapy 13:12, pages 1671-1673.
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E. Chambenois, F. Chalard, L. Dainese, I. Keller, A. Sergent-Alaoui & C. de Labriolle Vaylet. (2013) Histiocytose langerhansienne : place actuelle de l’imagerie. Médecine Nucléaire 37:7, pages 293-298.
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