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Drug Evaluations

Nalfurafine hydrochloride for the treatment of pruritus

, MD PhD
Pages 1507-1513 | Published online: 05 Jun 2012

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Madhulika A. Gupta, Aditya K. Gupta, Branka Vujcic & Meghan Piccinin. (2015) Use of opioid analgesics in skin disorders: Results from a nationally representative US sample. Journal of Dermatological Treatment 26:3, pages 269-274.
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Heike Benecke, Tobias Lotts & Sonja Ständer. (2013) Investigational drugs for pruritus. Expert Opinion on Investigational Drugs 22:9, pages 1167-1179.
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Articles from other publishers (16)

Brian Reed & Surya Dutta. (2023) The Kappa Opioid Receptor: Candidate Pharmacotherapeutic Target for Multiple Sclerosis. Drugs and Drug Candidates 2:4, pages 883-897.
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Ichiei Narita, Yoshiharu Tsubakihara, Naoko Takahashi, Toshiya Ebata, Takuma Uchiyama, Masaya Marumo, Shota Okamura & Fumitake Gejyo. (2023) Difelikefalin for Hemodialysis Patients with Pruritus in Japan. NEJM Evidence 2:11.
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Sally L. Huskinson, Donna M. Platt, C. Austin Zamarripa, Kristen Dunaway, Morgan Brasfield, Thomas E. Prisinzano, Bruce E. Blough & Kevin B. Freeman. (2022) The G-protein biased kappa opioid agonists, triazole 1.1 and nalfurafine, produce non-uniform behavioral effects in male rhesus monkeys. Pharmacology Biochemistry and Behavior 217, pages 173394.
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Raghav Seth, Sumanth S. Kuppalli, Danielle Nadav, Grant Chen & Amitabh Gulati. (2021) Recent Advances in Peripheral Opioid Receptor Therapeutics. Current Pain and Headache Reports 25:7.
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Longfei Wu, Di Wu, Jian Chen, Chunhua Chen, Tianqi Yao, Xiaoduo He, Yanqin Ma, Xinglong Zhi, Renyu Liu & Xunming Ji. (2020) Intranasal salvinorin A improves neurological outcome in rhesus monkey ischemic stroke model using autologous blood clot. Journal of Cerebral Blood Flow & Metabolism 41:4, pages 723-730.
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Yong Zhang & Mary Jeanne Kreek. (2020) Nalfurafine modulates the reinforcing effects of oxycodone in male and female adolescent C57BL/6J mice. Neuropharmacology 176, pages 108244.
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Yasmin Schmid, Alexander Navarini, Zita-Rose Manjaly Thomas, Bettina Pfleiderer, Stephan Krähenbühl & Simon M Mueller. (2019) Sex differences in the pharmacology of itch therapies—a narrative review. Current Opinion in Pharmacology 46, pages 122-142.
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Halina Machelska & Melih Ö. Celik. (2018) Advances in Achieving Opioid Analgesia Without Side Effects. Frontiers in Pharmacology 9.
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Thierry Olivry & Wolfgang Baeumer. 2017. Advances in Veterinary Dermatology. Advances in Veterinary Dermatology 63 70 .
Graham Elliott, Raymond Vanwersch, Michael Soeberdt, Dieter Metze, Tobias Lotts, Sonja Ständer & Christoph Abels. (2016) Topical nalfurafine exhibits anti-inflammatory and anti-pruritic effects in a murine model of AD. Journal of Dermatological Science 84:3, pages 351-354.
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Akihiro Ando, Shinichiro Sasago, Yoshihiro Ohzone & Yohei Miyamoto. (2015) Drug–Drug Interactions of a Novel κ-Opioid Receptor Agonist, Nalfurafine Hydrochloride, Involving the P-Glycoprotein. European Journal of Drug Metabolism and Pharmacokinetics 41:5, pages 549-558.
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Sattar Ostadhadi, Ehsan Azimi, Ethan A. Lerner & Ahmad-Reza Dehpour. (2016) Are itch and scratching the nausea and vomiting of skin?. Experimental Dermatology 25:5, pages 340-343.
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Fabian Galla, Christian Bourgeois, Kirstin Lehmkuhl, Dirk SchepmannMichael Soeberdt, Tobias Lotts, Christoph Abels, Sonja Ständer & Bernhard Wünsch. (2016) Effects of polar κ receptor agonists designed for the periphery on ATP-induced Ca 2+ release from keratinocytes . MedChemComm 7:2, pages 317-326.
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M Salaga, P R Polepally, M Zielinska, M Marynowski, A Fabisiak, N Murawska, K Sobczak, M Sacharczuk, J C Do Rego, B L Roth, J K Zjawiony & J Fichna. (2015) Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice. British Journal of Pharmacology 172:17, pages 4331-4341.
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Pradip K. Sasmal, C. Vamsee Krishna, S. Sudheerkumar Adabala, M. Roshaiah, Khaji Abdul Rawoof, Emima Thadi, K. Pavan Sukumar, Srisailam Cheera, Chandrasekhar Abbineni, K.V.L. Narasimha Rao, A. Prasanthi, Kamal Nijhawan, Mahaboobi Jaleel, Lakshmi Ramachandran Iyer, T. Krishna Chaitanya, Nirbhay Kumar Tiwari, N. Lavanya Krishna, Vijay Potluri, Ish Khanna, Thomas M. Frimurer, Michael Lückmann, Øystein Rist, Lisbeth Elster & Thomas Högberg. (2015) Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists. Bioorganic & Medicinal Chemistry Letters 25:4, pages 887-892.
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Ji Yue, Shoufeng Jiao, Yangfei Xiao, Wei Ren, Tingbao Zhao & Jianzhong Meng. (2014) Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study. International Urology and Nephrology 47:1, pages 161-167.
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