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Current pharmacotherapy for cholestatic liver disease

, MD & , MD
Pages 2473-2484 | Published online: 24 Oct 2012

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Benjamin L. Woolbright & Hartmut Jaeschke. (2016) Therapeutic targets for cholestatic liver injury. Expert Opinion on Therapeutic Targets 20:4, pages 463-475.
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Wan Hua, Shiyan Zhang, Qiuxia Lu, Yiran Sun, Shancai Tan, Fang Chen & Lin Tang. (2021) Protective effects of n-Butanol extract and iridoid glycosides of Veronica ciliata Fisch. Against ANIT-induced cholestatic liver injury in mice. Journal of Ethnopharmacology 266, pages 113432.
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Lucy C Chappell, Jennifer L Bell, Anne Smith, Catherine Rounding, Ursula Bowler, Louise Linsell, Edmund Juszczak, Sue Tohill, Amanda Redford, Peter H Dixon, Jenny Chambers, Rachael Hunter, Jon Dorling, Catherine Williamson & Jim G Thornton. (2020) Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT. Efficacy and Mechanism Evaluation 7:9, pages 1-42.
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Arturo J Martí-Carvajal & Cristina Elena Martí-Amarista. (2020) Interventions for treating intrahepatic cholestasis in people with sickle cell disease. Cochrane Database of Systematic Reviews 2020:6.
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Jia-Sheng Wu, Qian Liu, Shan-Hua Fang, Xing Liu, Min Zheng, Tian-Ming Wang, Hua Zhang, Ping Liu, Hu Zhou & Yue-Ming Ma. (2019) Quantitative Proteomics Reveals the Protective Effects of Huangqi Decoction Against Acute Cholestatic Liver Injury by Inhibiting the NF-κB/IL-6/STAT3 Signaling Pathway. Journal of Proteome Research 19:2, pages 677-687.
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René Bartz, Keisuke Fukuchi, Toshiaki Ohtsuka, Tanja Lange, Katrin Gruner, Ichiro Watanabe, Shinko Hayashi, Yoko Oda, Reimi Kawaida, Hironobu Komori, Yoshinori Kashimoto, Peter Wirtz, Jan-Peter A. Mayer, Mauricio Redondo-Müller, Shuntaro Saito, Mizuki Takahashi, Hiroyuki Hanzawa, Emi Imai, Alberto Martinez, Masaharu Hanai, Dieter Häussinger, Roger W. Chapman, Toshinori Agatsuma, Johannes Bange & Reimar Abraham. (2019) Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity. Molecular Cancer Therapeutics 18:10, pages 1832-1843.
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Lucy C Chappell, Jennifer L Bell, Anne Smith, Louise Linsell, Edmund Juszczak, Peter H Dixon, Jenny Chambers, Rachael Hunter, Jon Dorling, Catherine Williamson, Jim G Thornton, Irshad Ahmed, Rita Arya, Virginia Beckett, Amarnath Bhide, Heather Brown, George Bugg, Helen Cameron, Nishigandh Deole, Madhuchanda Dey, James Dwyer, Leila Fahel, Ruta Gada, Joanna Girling, Anna Haestier, Sean Hughes, Radha Indusekhar, Bryony Jones, Rahila Khan, Alison Kirkpatrick, Ellen Knox, Karen Lincoln, Malcolm MacDougall, Franz Majoko, Karen McIntyre, Muna Noori, Wendy Oakley, Jane Preston, Poornima Ranka, Mumtaz Rashid, Marwan Salloum, Manjula Samyraju, Catharina Schram, Seema Sen, Sophia Stone & Bee Tan. (2019) Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. The Lancet 394:10201, pages 849-860.
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Lucy C. Chappell, Jenny Chambers, Peter H. Dixon, Jon Dorling, Rachael Hunter, Jennifer L. Bell, Ursula Bowler, Pollyanna Hardy, Edmund Juszczak, Louise Linsell, Catherine Rounding, Anne Smith, Catherine Williamson & Jim G. Thornton. (2018) Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES). Trials 19:1.
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Zhiqing Yuan, Guiyang Wang, Junwen Qu, Xiaopeng Wang & Kewei Li. (2018) 9-cis-retinoic acid elevates MRP3 expression by inhibiting sumoylation of RXRα to alleviate cholestatic liver injury. Biochemical and Biophysical Research Communications 503:1, pages 188-194.
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Jian-Li Qiu, Ming-Yi Shao, Wen-Fang Xie, Yue Li, Hai-Die Yang, Min-Min Niu & Hua Xu. (2018) Effect of combined ursodeoxycholic acid and glucocorticoid on the outcome of Kasai procedure. Medicine 97:35, pages e12005.
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Vincent Boama, Valerie T. Guinto & Claudio G. Sosa. (2018) Contemporary Issues in Women's Health. International Journal of Gynecology & Obstetrics 141:3, pages 284-286.
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Arturo J Martí-Carvajal & Cristina Elena Martí-Amarista. (2017) Interventions for treating intrahepatic cholestasis in people with sickle cell disease. Cochrane Database of Systematic Reviews.
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Shi-Ying Cai, Xinshou Ouyang, Yonglin Chen, Carol J. Soroka, Juxian Wang, Albert Mennone, Yucheng Wang, Wajahat Z. Mehal, Dhanpat Jain & James L. Boyer. (2017) Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2:5.
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Tanaporn Khamphaya, Piyachat Chansela, Pawinee Piyachaturawat, Apichart Suksamrarn, Michael H. Nathanson & Jittima Weerachayaphorn. (2016) Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats. European Journal of Pharmacology 789, pages 254-264.
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Zhen Tan, Min Luo, Julin Yang, Yuqing Cheng, Jing Huang, Caide Lu, Danjun Song, Meiling Ye, Manyun Dai, Frank J Gonzalez, Aiming Liu & Bin Guo. (2016) Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation. Journal of Pharmacy and Pharmacology 68:9, pages 1203-1213.
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Arturo J Martí-Carvajal & Daniel Simancas-Racines. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
G. Ducarme, J. Bernuau & D. Luton. (2014) Cirrhose biliaire primitive et grossesse. Journal de Gynécologie Obstétrique et Biologie de la Reproduction 43:5, pages 335-341.
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Shi-Ying Cai, Albert Mennone, Carol J. Soroka & James L. Boyer. (2014) All- Trans -Retinoic Acid Improves Cholestasis in α -Naphthylisothiocyanate–Treated Rats and Mdr2 −/− Mice . Journal of Pharmacology and Experimental Therapeutics 349:1, pages 94-98.
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Arturo J Martí-Carvajal & Daniel Simancas-Racines. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Peter Fickert. (2014) Time to say goodbye to the drug or the model? – Why do drugs fail to live up to their promise in bile duct ligated mice?. Journal of Hepatology 60:1, pages 12-15.
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Dennis D. Black. 2014. The Gastrointestinal System. The Gastrointestinal System 295 324 .
Jian Peng, Chunyan Yue, Kai Qiu, Jie Chen, Maria-Angeles Aller, Kwang Suk Ko & Heping Yang. (2013) Protective Effects of Guava Pulp on Cholestatic Liver Injury. ISRN Hepatology 2013, pages 1-11.
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Moreshwar S Desai & Daniel J Penny. (2013) Bile acids induce arrhythmias: old metabolite, new tricks. Heart 99:22, pages 1629-1630.
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Tao Wu, Mu-Jun Chang, Yan-Jiao Xu, Xi-Ping Li, Guang Du & Dong Liu. (2013) Protective Effect of Calculus Bovis Sativus on Intrahepatic Cholestasis in Rats Induced by α-Naphthylisothiocyanate . The American Journal of Chinese Medicine 41:06, pages 1393-1405.
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