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Current pharmacological treatments for tinnitus

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Pages 2495-2509 | Published online: 04 Nov 2012

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Özgül Karaaslan, Yunus Kantekin, Yunus Hacımusalar & Hakan Dağıstan. (2020) Anxiety sensitivities, anxiety and depression levels, and personality traits of patients with chronic subjective tinnitus: a case-control study. International Journal of Psychiatry in Clinical Practice 24:3, pages 264-269.
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Christopher R. Cederroth, Jonas Dyhrfjeld-Johnsen & Berthold Langguth. (2018) An update: emerging drugs for tinnitus. Expert Opinion on Emerging Drugs 23:4, pages 251-260.
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Articles from other publishers (62)

Ourania Manta, Michail Sarafidis, Winfried Schlee, Birgit Mazurek, George K. Matsopoulos & Dimitrios D. Koutsouris. (2023) Development of Machine-Learning Models for Tinnitus-Related Distress Classification Using Wavelet-Transformed Auditory Evoked Potential Signals and Clinical Data. Journal of Clinical Medicine 12:11, pages 3843.
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Madan Ghimire, Rui Cai, Lynne Ling, Kevin A. Brownell, Kurt W. Wisner, Brandon C. Cox, Troy A. Hackett, Thomas J. Brozoski & Donald M. Caspary. (2023) Desensitizing nicotinic agents normalize tinnitus-related inhibitory dysfunction in the auditory cortex and ameliorate behavioral evidence of tinnitus. Frontiers in Neuroscience 17.
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雪 肖. (2023) Current Research Status of Tinnitus Treatment. Advances in Clinical Medicine 13:03, pages 3958-3965.
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Vasiliki Salvari, Daniela Korth, Evangelos Paraskevopoulos, Andreas Wollbrink, Daniela Ivansic, Orlando Guntinas-Lichius, Carsten Klingner, Christo Pantev & Christian Dobel. (2023) Tinnitus-frequency specific activity and connectivity: A MEG study. NeuroImage: Clinical 38, pages 103379.
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Tadeas Mares, Jakub Albrecht, Jozef Buday, Gabriela Podgorna, Thai Hong Le, Eva Magyarova, Katerina Poshor, Jakub Halik, Jan Buna, Vaclav Capek, Lenka Kostylkova, Johana Klasova, Vratislav Fabian & Martin Anders. (2022) Long-term effect of transcranial direct current stimulation in the treatment of chronic tinnitus: A randomized, placebo-controlled trial. Frontiers in Psychiatry 13.
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Wenliang Ji, Yifei Xue, Ping Yu & Lanqun Mao. (2022) Recent studies on dynamics of vitamin C during some pathological injury models. Chinese Science Bulletin 67:20, pages 2318-2332.
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Manuel Czornik, Azim Malekshahi, Wala Mahmoud, Stephan Wolpert & Niels Birbaumer. (2022) Psychophysiological treatment of chronic tinnitus: A review. Clinical Psychology & Psychotherapy 29:4, pages 1236-1253.
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Emir AVŞAR & Meltem ADAİÇİ. (2021) Yaşlı Bireylerde Tinnitus ve Hipertansiyon Arasındaki İlişkiThe Relationship Between Tinnitus and Hypertension in Elderly Individuals. Geriatrik Bilimler Dergisi 4:2, pages 66-71.
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E.V. Shelesko, N.A. Chernikova, L.A. Fomochkina, M.A. Lebedeva, S.D. Nikonova, V.A. Doronina & D.N. Zinkevich. (2021) Principles of diagnosis and treatment of tinnitus. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 121:11, pages 99.
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Patricia Perez-Carpena, Athanasios Bibas, Jose A. Lopez-Escamez, Katerina Vardonikolaki & Dimitris Kikidis. 2021. Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus. Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus 1 21 .
Klaus Kucher, Donald Johns, Frank Wagner, Khalid Abd-Elaziz, Caroline Derne, Oleksandr Sverdlov, Christian U. Pfister & Berthold Langguth. 2021. Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: From Heterogeneity to Personalized Medicine. Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: From Heterogeneity to Personalized Medicine 423 440 .
Daniela Korth, Andreas Wollbrink, Cosima Lukas, Daniela Ivansic, Orlando Guntinas-Lichius, Vasiliki Salvari, Evangelos Paraskevopoulos, Christo Pantev & Christian Dobel. 2021. Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus. Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus 115 137 .
Jinsheng Zhang, Ethan Firestone & Ahmed Elattma. 2021. The Behavioral Neuroscience of Tinnitus. The Behavioral Neuroscience of Tinnitus 83 129 .
Miro Schleicher, Vishnu Unnikrishnan, Patrick Neff, Jorge Simoes, Thomas Probst, Rüdiger Pryss, Winfried Schlee & Myra Spiliopoulou. (2020) Understanding adherence to the recording of ecological momentary assessments in the example of tinnitus monitoring. Scientific Reports 10:1.
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Mohammad Farhadi, Mohammad Mahdi Salem, Alimohamad Asghari, Ahmad Daneshi, Marjan Mirsalehi & Saeid Mahmoudian. (2020) Impact of Acamprosate on Chronic Tinnitus: A Randomized-Controlled Trial. Annals of Otology, Rhinology & Laryngology 129:11, pages 1110-1119.
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Tang-Chuan Wang, Ta-Yuan Chang, Richard Tyler, Ying-Ju Lin, Wen-Miin Liang, Yio-Wha Shau, Wei-Yong Lin, Yi-Wen Chen, Chia-Der Lin & Ming-Hsui Tsai. (2020) Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention. Brain Sciences 10:10, pages 732.
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Maryam Karimi Boroujeni, Saeid Mahmoudian & Farnoush Jarollahi. (2020) The investigation of semantic memory deficit in chronic tinnitus: a behavioral report. Brazilian Journal of Otorhinolaryngology 86:2, pages 185-190.
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Yeong Cheol Kim, Heejin Kim, Young Seon Kim, Seo Kyung Jung, Il Yong Park, Yun-Hoon Choung & Jeong Hun Jang. (2020) Objective Verification of Acute Tinnitus and Validation of Efficacy of Systemic Steroids in Rats. Journal of Korean Medical Science 35:13.
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Jihane Melloui, Jamila Bakkoury & Omar Bouattane. (2020) Study of the Effect of Abnormalities in the External Ear Inducing Hearing Problems. Advances in Science, Technology and Engineering Systems Journal 5:4, pages 477-487.
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Rilana F F Cima, Dimitris Kikidis, Birgit Mazurek, Haúla Haider, Chistopher R Cederroth, Arnaud Norena, Alec Lapira, Athanasios Bibas & Derek J Hoare. (2020) Tinnitus healthcare: a survey revealing extensive variation in opinion and practices across Europe. BMJ Open 10:1, pages e029346.
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Kadar N. Prasad & Stephen C. Bondy. (2020) Increased oxidative stress, inflammation, and glutamate: Potential preventive and therapeutic targets for hearing disorders. Mechanisms of Ageing and Development 185, pages 111191.
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Yiwen Zheng, Jessica McTavish & Paul F. Smith. 2021. The Behavioral Neuroscience of Tinnitus. The Behavioral Neuroscience of Tinnitus 51 82 .
Jinsheng Zhang. (2019) Blast-induced tinnitus: Animal models. The Journal of the Acoustical Society of America 146:5, pages 3811-3831.
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Tamer A. Abo El Ezz, Fathy N. Fattoh & Tahany Rabie. (2019) Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus. The Egyptian Journal of Otolaryngology 35:3, pages 300-306.
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Minke J C van den Berge, Marc J M C van Dijk, Jan D M Metzemaekers, Bert Maat, Rolien H Free & Pim van Dijk. (2019) An auditory brainstem implant for treatment of unilateral tinnitus: protocol for an interventional pilot study. BMJ Open 9:6, pages e026185.
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R. F. F. Cima, B. Mazurek, H. Haider, D. Kikidis, A. Lapira, A. Noreña & D. J. Hoare. (2019) A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatmentMultidisziplinäre europäische Leitlinie für Tinnitus: Diagnostik, Einschätzung und Behandlung. HNO 67:S1, pages 10-42.
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Dongmei Tang, Huawei Li & Lin Chen. 2019. Hearing Loss: Mechanisms, Prevention and Cure. Hearing Loss: Mechanisms, Prevention and Cure 109 128 .
Hidehiko Okamoto. (2018) Manipulation of Auditory Inputs as Rehabilitation Therapy for Maladaptive Auditory Cortical Reorganization. Neural Plasticity 2018, pages 1-9.
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Tang-Chuan Wang, Richard S. Tyler, Ta-Yuan Chang, Jui-Cheng Chen, Chia-Der Lin, Hsiung-Kwang Chung & Yung-An Tsou. (2017) Effect of Transcranial Direct Current Stimulation in Patients With Tinnitus: A Meta-Analysis and Systematic Review. Annals of Otology, Rhinology & Laryngology 127:2, pages 79-88.
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Thomas Probst, Rüdiger C. Pryss, Berthold Langguth, Josef P. Rauschecker, Johannes Schobel, Manfred Reichert, Myra Spiliopoulou, Winfried Schlee & Johannes Zimmermann. (2017) Does Tinnitus Depend on Time-of-Day? An Ecological Momentary Assessment Study with the “TrackYourTinnitus” Application. Frontiers in Aging Neuroscience 9.
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Diaa El Din M. El Hennawi, Mohamed R. Ahmed, Wael Abdelkafy, Ahmed Geneid & Ibrahim H. Ibrahim. (2017) Intratympanic methylprednisolone acetate versus intratympanic lidocaine in the treatment of idiopathic subjective unilateral tinnitus of less than 1-year duration: a randomized, double-blind, clinical trial. The Egyptian Journal of Otolaryngology 33:3, pages 564-568.
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Jun He, Yejin Zhu, Jiye Aa, Paul F. Smith, Dirk De Ridder, Guangji Wang & Yiwen Zheng. (2017) Brain Metabolic Changes in Rats following Acoustic Trauma. Frontiers in Neuroscience 11.
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Kenichi Sekiya, Mariko Takahashi, Shingo Murakami, Ryusuke Kakigi & Hidehiko Okamoto. (2017) Broadened population-level frequency tuning in the auditory cortex of tinnitus patients. Journal of Neurophysiology 117:3, pages 1379-1384.
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Thomas E. Fuller, Haula F. Haider, Dimitris Kikidis, Alec Lapira, Birgit Mazurek, Arnaud Norena, Sarah Rabau, Rachelle Lardinois, Christopher R. Cederroth, Niklas K. Edvall, Petra G. Brueggemann, Susanne N. Rosing, Anestis Kapandais, Dorte Lungaard, Derek J. Hoare & Rilana F. F Cima. (2017) Different Teams, Same Conclusions? A Systematic Review of Existing Clinical Guidelines for the Assessment and Treatment of Tinnitus in Adults. Frontiers in Psychology 8.
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Winfried Schlee, Rüdiger C. Pryss, Thomas Probst, Johannes Schobel, Alexander Bachmeier, Manfred Reichert & Berthold Langguth. (2016) Measuring the Moment-to-Moment Variability of Tinnitus: The TrackYourTinnitus Smart Phone App. Frontiers in Aging Neuroscience 8.
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Susan E. Shore, Larry E. Roberts & Berthold Langguth. (2016) Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment. Nature Reviews Neurology 12:3, pages 150-160.
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D. Malinvaud, A. Londero, R. Niarra, Ph Peignard, O. Warusfel, I. Viaud-Delmon, G. Chatellier & P. Bonfils. (2016) Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus: Results of a randomized controlled trial. Hearing Research 333, pages 127-135.
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T. Pattyn, F. Van Den Eede, S. Vanneste, L. Cassiers, D.J. Veltman, P. Van De Heyning & B.C.G. Sabbe. (2016) Tinnitus and anxiety disorders: A review. Hearing Research 333, pages 255-265.
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Hyun Joon Shim. (2016) Intratympanic Steroid Injection in Tinnitus Management. Hanyang Medical Reviews 36:2, pages 125.
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So Young Park. (2016) Pharmacological Treatments for Tinnitus. Hanyang Medical Reviews 36:2, pages 113.
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Brian L. Allman, Ashley L. Schormans, Marei Typlt & Edward Lobarinas. 2016. Translational Research in Audiology, Neurotology, and the Hearing Sciences. Translational Research in Audiology, Neurotology, and the Hearing Sciences 165 195 .
Colleen G. Le Prell. 2016. Translational Research in Audiology, Neurotology, and the Hearing Sciences. Translational Research in Audiology, Neurotology, and the Hearing Sciences 19 50 .
Tian-Tian Li, Zhao-Jun Wang, Song-Bai Yang, Jun-Hong Zhu, Shi-Zhong Zhang, San-Jin Cai, Wen-Han Ma, Ding-Qi Zhang & Zhi-Gang Mei. (2015) Transcutaneous electrical stimulation at auricular acupoints innervated by auricular branch of vagus nerve pairing tone for tinnitus: study protocol for a randomized controlled clinical trial. Trials 16:1.
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Berthold Langguth. (2015) Treatment of tinnitus. Current Opinion in Otolaryngology & Head and Neck Surgery 23:5, pages 361-368.
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Giancarlo Cianfrone, Filippo Mazzei, Massimo Salviati, Rosaria Turchetta, Maria Patrizia Orlando, Valeria Testugini, Laura Carchiolo, Francesca Cianfrone & Giancarlo Altissimi. (2015) Tinnitus Holistic Simplified Classification (THoSC). Annals of Otology, Rhinology & Laryngology 124:7, pages 550-560.
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Xiao-Peng Liu & Lin Chen. (2015) Forward acoustic masking enhances the auditory brainstem response in a diotic, but not dichotic, paradigm in salicylate-induced tinnitus. Hearing Research 323, pages 51-60.
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Chia-Hui Lin, Chun-En Kuo, Hao-Chang Yu, Yu-Kai Lai, Yu-Chuen Huang & Ming-Yen Tsai. (2015) Efficacy of adjuvant Chinese herbal formula treatment for chronic tinnitus: A retrospective observational study. Complementary Therapies in Medicine 23:2, pages 226-232.
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Mohamed N. Thabit, Naglaa Fouad, Badawy Shahat & Mostafa Youssif. (2014) Combined Central and Peripheral Stimulation for Treatment of Chronic Tinnitus. Neurorehabilitation and Neural Repair 29:3, pages 224-233.
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Hyo-Sang KimJae Hyun LimSeung Hoon HanMin-Young LeeMoo Kyun ParkJun Ho LeeSeung Ha OhMyung-Whan Suh. (2015) Correlation between Tinnitus Induced Distress and Sleep Quality. Korean Journal of Otorhinolaryngology-Head and Neck Surgery 58:11, pages 754.
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Hinrich Staecker, Kenneth S. Maxwell, John R. Morris, Paul van de Heyning, Krzysztof Morawski, Frank Reintjes & Thomas Meyer. (2015) Selecting Appropriate Dose Regimens for AM-101 in the Intratympanic Treatment of Acute Inner Ear Tinnitus. Audiology and Neurotology 20:3, pages 172-182.
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Yong-Hwi An, Kwang-Kyu Yu, Min Young Kwak, Sang Won Yoon & Hyun Joon Shim. (2014) Prognostic Factors for the Outcomes of Intratympanic Dexamethasone in the Treatment of Acute Subjective Tinnitus. Otology & Neurotology 35:8, pages 1330-1337.
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Peter M. Kreuzer, Michael Landgrebe, Veronika Vielsmeier, Tobias Kleinjung, Dirk De Ridder & Berthold Langguth. (2014) Trauma-Associated Tinnitus. Journal of Head Trauma Rehabilitation 29:5, pages 432-442.
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G. Mahmood, Z. Mei, H. Hojjat, E. Pace, S. Kallakuri & J.S. Zhang. (2014) Therapeutic effect of sildenafil on blast-induced tinnitus and auditory impairment. Neuroscience 269, pages 367-382.
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Zhang Chao, Wang Qiuju & Sun Wei. (2014) Animal Behavioral Models of Tinnitus. Journal of Otology 9:2, pages 58-63.
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Marzena Mielczarek & Jurek Olszewski. (2013) Direct current stimulation of the ear in tinnitus treatment: a double-blind placebo-controlled study. European Archives of Oto-Rhino-Laryngology 271:6, pages 1815-1822.
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Paul van de Heyning, Guido Muehlmeier, Tony Cox, Grazyna Lisowska, Heinz Maier, Krzysztof Morawski & Thomas Meyer. (2014) Efficacy and Safety of AM-101 in the Treatment of Acute Inner Ear Tinnitus—A Double-Blind, Randomized, Placebo-Controlled Phase II Study. Otology & Neurotology 35:4, pages 589-597.
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Y. Zheng, K. McPherson & P.F. Smith. (2014) Effects of early and late treatment with l-baclofen on the development and maintenance of tinnitus caused by acoustic trauma in rats. Neuroscience 258, pages 410-421.
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Christopher R Cederroth, Barbara Canlon & Berthold Langguth. (2013) Hearing loss and tinnitus—are funders and industry listening?. Nature Biotechnology 31:11, pages 972-974.
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Berthold Langguth, Peter M Kreuzer, Tobias Kleinjung & Dirk De Ridder. (2013) Tinnitus: causes and clinical management. The Lancet Neurology 12:9, pages 920-930.
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Maria Kleinstäuber, Berthold Langguth & Peter M. Kreuzer. (2013) Aktuelle therapeutische Ansätze bei subjektivem Tinnitus. DNP - Der Neurologe und Psychiater 14:6, pages 68-74.
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