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New therapeutic landscape of NNRTIs for treatment of HIV: a look at recent data

, MD MRCOG FACP & , DO
Pages 2601-2612 | Published online: 24 Nov 2012

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Chan-Loi Yong, Joseph C. Gathe, Gabriele Knecht, Catherine Orrell, Josep Mallolas, Daniel Podzamczer, Benoit Trottier, Wei Zhang, John P. Sabo, Richard Vinisko, Murray Drulak & Anne-Marie Quinson. (2017) Pharmacokinetic analysis of nevirapine extended release 400 mg once daily vs nevirapine immediate release 200 mg twice daily formulation in treatment-naïve patients with HIV-1 infection. HIV Clinical Trials 18:5-6, pages 189-195.
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Xiao Li, Ping Gao, Peng Zhan & Xinyong Liu. (2016) Substituted indoles as HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent evaluation (WO2015044928). Expert Opinion on Therapeutic Patents 26:5, pages 629-635.
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Qing Meng, Na Liu, Boshi Huang, Peng Zhan & Xinyong Liu. (2015) Novel fluorine-containing DAPY derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2014072419. Expert Opinion on Therapeutic Patents 25:12, pages 1477-1486.
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Xiao Li, Lingzi Zhang, Ye Tian, Yu’ning Song, Peng Zhan & Xinyong Liu. (2014) Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011 – 2014). Expert Opinion on Therapeutic Patents 24:11, pages 1199-1227.
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Jiangzhou You, Hongren Wang, Xiaojun Huang, Zhen Qin, Zhaomin Deng, Jun Luo, Baoning Wang & Mingyuan Li. (2016) Therapy-Emergent Drug Resistance to Integrase Strand Transfer Inhibitors in HIV-1 Patients: A Subgroup Meta-Analysis of Clinical Trials. PLOS ONE 11:8, pages e0160087.
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Meizhen Feng, Deping Wang, Jay A. Grobler, Daria J. Hazuda, Michael D. Miller & Ming-Tain Lai. (2015) In Vitro Resistance Selection with Doravirine (MK-1439), a Novel Nonnucleoside Reverse Transcriptase Inhibitor with Distinct Mutation Development Pathways . Antimicrobial Agents and Chemotherapy 59:1, pages 590-598.
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Minghui Dong & Yujie Ren. (2015) Molecular modeling studies of dihydro-alkyloxy-benzyl-oxopyrimidines (DABOs) as non-nucleoside inhibitors of HIV-1 reverse transcriptase using 3D-QSAR, Topomer CoMFA and molecular docking simulations. RSC Advances 5:18, pages 13754-13761.
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Dante Rotili, Domenico Tarantino, Maxim B. Nawrozkij, Alexandre S. Babushkin, Giorgia Botta, Biagina Marrocco, Roberto Cirilli, Sergio Menta, Roger Badia, Emmanuele Crespan, Flavio Ballante, Rino Ragno, José A. Esté, Giovanni Maga & Antonello Mai. (2014) Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3 H )-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes . Journal of Medicinal Chemistry 57:12, pages 5212-5225.
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Michael J. Dapp, Laurent Bonnac, Steven E. Patterson & Louis M. Mansky. (2014) Discovery of Novel Ribonucleoside Analogs with Activity against Human Immunodeficiency Virus Type 1. Journal of Virology 88:1, pages 354-363.
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Guoyi Wu, Bo Liu, Yingjun Zhang, Jing Li, Alla Arzumanyan, Marcia M. Clayton, Raymond F. Schinazi, Zhaohe Wang, Siegfried Goldmann, Qingyun Ren, Faxhou Zhang & Mark A. Feitelson. (2013) Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly. Antimicrobial Agents and Chemotherapy 57:11, pages 5344-5354.
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Devinder Sharma, Aik Jiang Lau, Matthew A. Sherman & Thomas K.H. Chang. (2013) Agonism of human pregnane X receptor by rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse transcriptase inhibitors. Biochemical Pharmacology 85:11, pages 1700-1711.
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Yu’ning Song, Peng Zhan, Dongwei Kang, Xiao Li, Ye Tian, Zhenyu Li, Xuwang Chen, Wenmin Chen, Christophe Pannecouque, Erik De Clercq & Xinyong Liu. (2013) Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach. MedChemComm 4:5, pages 810.
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