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Expert Opinion on Pharmacotherapy Volume 14, 2013 - Issue 1
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Original Research

Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study

Joel MorganrotheResearch Technology, Inc., Philadelphia, PA, USA
,
Daniel D GretlerPortola Pharmaceuticals, Inc., 270 E. Grand Avenue, South San Francisco, CA 94080, USA+1 650 246 7560; +1 650 246 7776; [email protected]
,
Stanley J HollenbachPortola Pharmaceuticals, Inc., 270 E. Grand Avenue, South San Francisco, CA 94080, USA+1 650 246 7560; +1 650 246 7776; [email protected]
,
Joseph L LambingPortola Pharmaceuticals, Inc., 270 E. Grand Avenue, South San Francisco, CA 94080, USA+1 650 246 7560; +1 650 246 7776; [email protected]
&
Uma SinhaPortola Pharmaceuticals, Inc., 270 E. Grand Avenue, South San Francisco, CA 94080, USA+1 650 246 7560; +1 650 246 7776; [email protected]
, PhD
Pages 5-13 | Published online: 10 Dec 2012

Citations (12)

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Daniele Scarpa, Gentian Denas, Luciano Babuin & Vittorio Pengo. (2019) The benefit of betrixaban for the extended thromboprophylaxis in acutely ill medical patients. Expert Opinion on Pharmacotherapy 20:3, pages 261-268.
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Martin Thoenes, Joan Minguet, Karin Bramlage, Peter Bramlage & Carmen Ferrero. (2016) Betrixaban – the next direct factor Xa inhibitor?. Expert Review of Hematology 9:12, pages 1111-1117.
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Noel C Chan, Vinai Bhagirath & John W Eikelboom. (2015) Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vascular Health and Risk Management 11, pages 343-351.
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Michael Palladino, Geno Merli & Lynda Thomson. (2013) Evaluation of the oral direct factor Xa inhibitor – betrixaban . Expert Opinion on Investigational Drugs 22:11, pages 1465-1472.
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Articles from other publishers (8)

Claire Dunois. (2021) Laboratory Monitoring of Direct Oral Anticoagulants (DOACs). Biomedicines 9:5, pages 445.
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Katelyn W Sylvester & Jean M Connors. (2018) Betrixaban in the prevention of venous thromboembolism in medically ill patients. Future Cardiology 14:6, pages 455-470.
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Paolo Gelosa, Laura Castiglioni, Marco Tenconi, Ludovico Baldessin, Giorgio Racagni, Alberto Corsini & Stefano Bellosta. (2018) Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs). Pharmacological Research 135, pages 60-79.
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Menno V Huisman & Frederikus A Klok. (2018) Pharmacological properties of betrixaban. European Heart Journal Supplements 20:suppl_E, pages E12-E15.
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Karin Meiser, Pierre Jordaan, Sasha Latypova & Borje Darpo. (2016) Comparing QT interval variability of semiautomated and high‐precision ECG methodologies in seven thorough QT studies—implications for the power of studies intended for definitive evaluation of a drug's QT effect . Annals of Noninvasive Electrocardiology 22:1.
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Zofia Tylutki, Sebastian Polak & Barbara Wiśniowska. (2016) Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations. Current Pharmacology Reports 2:4, pages 171-177.
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Borje Darpo. 2015. Principles of Safety Pharmacology. Principles of Safety Pharmacology 435 468 .
Noel C ChanJack Hirsh, Jeffrey S Ginsberg & John W Eikelboom. (2014) Betrixaban (PRT054021): pharmacology, dose selection and clinical studies. Future Cardiology 10:1, pages 43-52.
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