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Drug Evaluations

Perampanel, a novel, non-competitive, selective AMPA receptor antagonist as adjunctive therapy for treatment-resistant partial-onset seizures

, MD CSc
Pages 225-235 | Published online: 23 Dec 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Pasquale Striano & Vincenzo Belcastro. (2017) Update on pharmacotherapy of myoclonic seizures. Expert Opinion on Pharmacotherapy 18:2, pages 187-193.
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Andreas Schulze-Bonhage & Mandy Hintz. (2015) Perampanel in the management of partial-onset seizures: a review of safety, efficacy, and patient acceptability. Patient Preference and Adherence 9, pages 1143-1151.
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Anand Iyer & Anthony Marson. (2014) Pharmacotherapy of focal epilepsy. Expert Opinion on Pharmacotherapy 15:11, pages 1543-1551.
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Gaetano Zaccara, Fabio Giovannelli, Massimo Cincotta & Alfonso Iudice. (2013) AMPA receptor inhibitors for the treatment of epilepsy: the role of perampanel. Expert Review of Neurotherapeutics 13:6, pages 647-655.
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Articles from other publishers (33)

Sung Chul Lim, Won Gu Lee, Dong Wook Kim, Kwang Ki Kim, Young-Min Shon, Jihyun Park, Yoona Lee & Dae-Won Seo. (2023) Safety and effectiveness of perampanel monotherapy after adjunctive therapy through retention rate in subjects with focal-onset seizures with or without focal to bilateral tonic-clonic seizures: A multicenter retrospective study in Korea. Epilepsy & Behavior 145, pages 109291.
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Rebecca Bresnahan, Ruaraidh A Hill & Jin Wang. (2023) Perampanel add-on for drug-resistant focal epilepsy. Cochrane Database of Systematic Reviews 2023:4.
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Yangmi Park, Seondeuk Kim, Dae Lim Koo & Hyunwoo Nam. (2022) A Case of Perampanel Overdose Presenting with Respiratory Failure. Journal of Epilepsy Research 12:2, pages 68-70.
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Yangmi Park, Seondeuk Kim, Dae Lim Koo & Hyunwoo Nam. (2022) A Case of Perampanel Overdose Presenting with Respiratory Failure. Journal of Epilepsy Research 12:2, pages 68-70.
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Dong Wook Kim, Ji Hyun Kim, Sang Kun Lee, Sang Ahm Lee, Ji Woong Lee, Min Young Kim & Dae-Won Seo. (2022) Perampanel as First Adjunctive Treatment in Patients with Focal-Onset Seizures in the FAME Study: Post hoc Analyses of Dose-Related Efficacy, Safety and Clinical Factors Associated with Response. Journal of Epilepsy Research 12:1, pages 6-12.
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Wu Yang, Lin Ma, Dong-Mei Hai, Ning Liu, Jia-Mei Yang, Xiao-Bing Lan, Juan Du, Li-Shan Yang, Tao Sun & Jian Qiang Yu. (2022) Hippocampal Proteomic Analysis in Male Mice Following Aggressive Behavior Induced by Long-Term Administration of Perampanel. ACS Omega 7:23, pages 19388-19400.
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Bruno Charlier, Albino Coglianese, Federica De Rosa, Ugo de Grazia, Francesca Felicia Operto, Giangennaro Coppola, Amelia Filippelli, Fabrizio Dal Piaz & Viviana Izzo. (2021) The Effect of Plasma Protein Binding on the Therapeutic Monitoring of Antiseizure Medications. Pharmaceutics 13:8, pages 1208.
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Min Cheol Chang & Donghwi Park. (2021) Effectiveness of perampanel in managing chronic pain caused by the complex regional pain syndrome. Medicine 100:48, pages e27791.
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Xuan Li, Feride Frech, Craig A. Plauschinat & Mugdha Gore. (2021) Real-world hospitalization risk in patients with epilepsy treated with perampanel. Epilepsy & Behavior 114, pages 107270.
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Firdoos Ahmad Sofi & Prasad V. Bharatam. (2020) Synthesis of Drugs and Biorelevant N-heterocycles Employing Recent Advances in C-N Bond Formation. Current Organic Chemistry 24:20, pages 2293-2340.
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Ji Hyun Kim, Dong Wook Kim, Sang Kun Lee, Dae Won Seo, Ji Woong Lee, Hae Joon Park & Sang Ahm Lee. (2019) First add‐on perampanel for focal‐onset seizures: An open‐label, prospective study. Acta Neurologica Scandinavica 141:2, pages 132-140.
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Ondřej Strýček & Ivan Rektor. (2019) Perampanel - what to do with it II?. Neurologie pro praxi 20:5, pages 383-387.
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Puja K. Gangurde, Navya Ajitkumar B.Lalit Kumar. (2018) Lamotrigine Lipid Nanoparticles for Effective Treatment of Epilepsy: a Focus on Brain Targeting via Nasal Route. Journal of Pharmaceutical Innovation 14:2, pages 91-111.
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Naotaka Usui, Naoki Akamatsu, Nobukazu Nakasato, Akihiro Ohnishi, Sunao Kaneko, Hidetaka Hiramatsu, Kazunori Saeki, Hideaki Miyagishi & Yushi Inoue. (2018) Long-term tolerability, safety and efficacy of adjunctive perampanel in the open-label, dose-ascending Study 231 and extension Study 233 in Japanese patients with epilepsy. Seizure 62, pages 26-32.
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Gonçalo Campos, Ana Fortuna, Amílcar Falcão & Gilberto Alves. (2018) In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy. Epilepsy Research 146, pages 63-86.
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Ivan Rektor & Ondřej Strýček. (2017) Perampanel - what to do with it?. Neurologie pro praxi 18:3, pages 208-211.
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Gabriel Tremblay, Victoria Barghout, Vardhaman Patel, Wan Tsong & Zhixiao Wang. (2017) Budget impact of perampanel as adjunctive treatment of uncontrolled partial-onset and primary generalized tonic?clonic seizures in the United States. Epilepsy & Behavior 68, pages 196-202.
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Cai Zhong & Yousheng Xiao. (2016) Perampanel monotherapy for epilepsy. Cochrane Database of Systematic Reviews.
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N. Talma, W.F. Kok, C.F. de Veij Mestdagh, N.C. Shanbhag, H.R. Bouma & R.H. Henning. (2016) Neuroprotective hypothermia – Why keep your head cool during ischemia and reperfusion. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:11, pages 2521-2528.
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Eduardo E. Benarroch. (2016) AMPA receptors. Neurology 87:12, pages 1281-1288.
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Pishan Chang, Katrin Augustin, Kim Boddum, Sophie Williams, Min Sun, John A. Terschak, J?rg D. Hardege, Philip E. Chen, Matthew C. Walker & Robin S. B. Williams. (2016) Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain 139:2, pages 431-443.
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Tracy Glauser, Antonio Laurenza, Haichen Yang, Betsy Williams, Tony Ma & Randi Fain. (2016) Efficacy and tolerability of adjunct perampanel based on number of antiepileptic drugs at baseline and baseline predictors of efficacy: A phase III post-hoc analysis. Epilepsy Research 119, pages 34-40.
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Georgia Montouris, Haichen Yang, Betsy Williams, Sharon Zhou, Antonio Laurenza & Randi Fain. (2015) Efficacy and safety of perampanel in patients with drug-resistant partial seizures after conversion from double-blind placebo to open-label perampanel. Epilepsy Research 114, pages 131-140.
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Antonio Laurenza, Haichen Yang, Betsy Williams, Sharon Zhou & Jim Ferry. (2015) Absence of Liver Toxicity in Perampanel-Treated Subjects: Pooled results from partial seizure phase III perampanel clinical studies. Epilepsy Research 113, pages 76-85.
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William Rosenfeld, Joan Conry, Lieven Lagae, Guntis Rozentals, Haichen Yang, Randi Fain, Betsy Williams, Dinesh Kumar, Jin Zhu & Antonio Laurenza. (2015) Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study. European Journal of Paediatric Neurology 19:4, pages 435-445.
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Barry E. GidalAntonio LaurenzaZiad HusseinHaichen YangRandi FainJacob EdelsteinDinesh KumarJim Ferry. (2015) Perampanel efficacy and tolerability with enzyme-inducing AEDs in patients with epilepsy. Neurology 84:19, pages 1972-1980.
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Antonio Laurenza, Jim Ferry, Haichen Yang, Shigeki Hibi, Takahisa Hanada & Andrew Satlin. 2015. Blood-Brain Barrier in Drug Discovery. Blood-Brain Barrier in Drug Discovery 483 504 .
R. Zwart, E. Sher, X. Ping, X. Jin, J. R. SimsJr.Jr., A. S. Chappell, S. D. Gleason, P. J. Hahn, K. Gardinier, D. L. Gernert, J. Hobbs, J. L. Smith, S. N. Valli & J. M. Witkin. (2014) Perampanel, an Antagonist of α -Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors, for the Treatment of Epilepsy: Studies in Human Epileptic Brain and Nonepileptic Brain and in Rodent Models . Journal of Pharmacology and Experimental Therapeutics 351:1, pages 124-133.
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Wenya Huang, Fan Jian, Wenli Lai, Wen Li, Declan T Millett, Grant T McIntyre, Zhihe Zhao, Yan Wang, Zongdao Shi, Taixiang Wu, Guan J Liu, Joy Hickman & Amit Arora. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Barry E. Gidal, Oneeb Majid, Jim Ferry, Ziad Hussein, Haichen Yang, Jin Zhu, Randi Fain & Antonio Laurenza. (2014) The practical impact of altered dosing on perampanel plasma concentrations: Pharmacokinetic modeling from clinical studies. Epilepsy & Behavior 35, pages 6-12.
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Hong X. Ding, Carolyn A. Leverett, Robert E. KyneJr.Jr., Kevin K.-C. Liu, Subas M. Sakya, Andrew C. Flick & Christopher J. O’Donnell. (2014) Synthetic approaches to the 2012 new drugs. Bioorganic & Medicinal Chemistry 22:7, pages 2005-2032.
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Jianyi Huang, Yousheng Xiao, Man Luo, Hongye Luo & Jin Wang. (2014) Perampanel add-on for drug-resistant partial epilepsy. Cochrane Database of Systematic Reviews.
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Barry E. Gidal, Jim Ferry, Oneeb Majid & Ziad Hussein. (2013) Concentration-effect relationships with perampanel in patients with pharmacoresistant partial-onset seizures. Epilepsia 54:8, pages 1490-1497.
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