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Expert Opinion on Pharmacotherapy Volume 14, 2013 - Issue 6
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Original Research

Epidermal growth factor receptor gene copy number may predict lapatinib sensitivity in HER2-positive metastatic breast cancer

Alessandra FabiRegina Elena National Cancer Institute, Departments of Oncology A, Via Elio Chianesi, 53, 00144 Rome, Italy+390652665144; +390652665637; [email protected]
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Roberta MerolaRegina Elena National Cancer Institute, Clinical Pathology, Rome, Italy
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Gianluigi FerrettiRegina Elena National Cancer Institute, Departments of Oncology A, Via Elio Chianesi, 53, 00144 Rome, Italy+390652665144; +390652665637; [email protected]
,
Anna Di BenedettoRegina Elena National Cancer Institute, Pathology, Rome, Italy
,
Barbara AntonianiRegina Elena National Cancer Institute, Pathology, Rome, Italy
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Cristiana ErcolaniRegina Elena National Cancer Institute, Pathology, Rome, Italy
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Cecilia NisticòRegina Elena National Cancer Institute, Departments of Oncology A, Via Elio Chianesi, 53, 00144 Rome, Italy+390652665144; +390652665637; [email protected]
,
Paola PapaldoRegina Elena National Cancer Institute, Departments of Oncology A, Via Elio Chianesi, 53, 00144 Rome, Italy+390652665144; +390652665637; [email protected]
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Mariangela CiccareseFazi Hospital, Department of Medical Oncology, Lecce, Italy
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Isabella SperdutiRegina Elena National Cancer Institute, Biostatistics, Rome, Italy
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Patrizia ViciRegina Elena National Cancer Institute, Departments of Oncology A, Via Elio Chianesi, 53, 00144 Rome, Italy+390652665144; +390652665637; [email protected]
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Mirella MarinoRegina Elena National Cancer Institute, Oncology B, Rome, Italy
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Stefania GoriS. Maria della Misericordia Hospital, Department of Medical Oncology, Perugia, Italy
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Claudio BottiRegina Elena National Cancer Institute, Surgery A, Rome, Italy
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Paola MalagutiRegina Elena National Cancer Institute, Departments of Oncology A, Via Elio Chianesi, 53, 00144 Rome, Italy+390652665144; +390652665637; [email protected]
,
Francesco CognettiRegina Elena National Cancer Institute, Departments of Oncology A, Via Elio Chianesi, 53, 00144 Rome, Italy+390652665144; +390652665637; [email protected]
&
Marcella MottoleseRegina Elena National Cancer Institute, Pathology, Rome, Italy
 show all
Pages 699-706 | Published online: 09 Mar 2013

Citations (16)

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Yu Zhang, Cai-feng Wan, Jing Du, Qi Dong, Yuan-yuan Wang, Hong Yang & Feng-hua Li. (2018) The in vitro study of Her-2 targeted gold nanoshell liquid fluorocarbon poly lactic-co-glycolic acid ultrasound microcapsule for ultrasound imaging and breast tumor photothermal therapy. Journal of Biomaterials Science, Polymer Edition 29:1, pages 57-73.
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Neil M Iyengar & Patrick G Morris. (2013) Identifying the challenges of biomarkers that predict response to HER2-directed therapies. Expert Opinion on Pharmacotherapy 14:11, pages 1437-1440.
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Articles from other publishers (14)

Sumayah Al-Mahmood, Justin Sapiezynski, Olga B. Garbuzenko & Tamara Minko. (2018) Metastatic and triple-negative breast cancer: challenges and treatment options. Drug Delivery and Translational Research 8:5, pages 1483-1507.
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Renata Duchnowska, Jeff Sperinde, Bogumiła Czartoryska-Arłukowicz, Paulina Myśliwiec, John Winslow, Barbara Radecka, Christos Petropoulos, Regina Demlova, Marlena Orlikowska, Anna Kowalczyk, Istvan Lang, Barbara Ziółkowska, Sylwia Dębska-Szmich, Monika Merdalska, Aleksandra Grela-Wojewoda, Anton Żawrocki, Wojciech Biernat, Weidong Huang & Jacek Jassem. (2017) Predictive value of quantitative HER2, HER3 and p95HER2 levels in HER2-positive advanced breast cancer patients treated with lapatinib following progression on trastuzumab. Oncotarget 8:61, pages 104149-104159.
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Masahiro Mise, Marika Nio, Shunichi Higaside, Yoshikuni Yonenaga, Yoshihiro Yata, Kenta Horita, Takehisa Harada, Hitoshi Sakamoto, Makoto Wakamiya & Manabu Kurosawa. (2017) Diagnostic Value of Serum Human Epidermal Growth Factor Receptor 2 Extracellular Domain (HER2 ECD) Change in a Patient with Metastatic Recurrent Breast Cancer Resistant to Anti-HER2 Antibody Drugs: A Case Report抗HER2抗体薬耐性に対するHER2-ECDの意義を考えさせられた転移・再発乳癌の１例. Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) 42:6, pages 912-922.
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Stefania Gori, Alessandro Inno, Valentina Rossi, Monica Turazza, Elena Fiorio, Alessandra Fabi, Giancarlo Bisagni, Jennifer Foglietta, Daniele Santini, Ida Pavese, Arianna Pellegrino, Alberto Zambelli, Patrizia Vici, Vita Leonardi, Sandro Barni, Silvana Saracchini, Giuseppe Bogina, Fabiana Marchetti, Simona Duranti, Gianluigi Lunardi & Filippo Montemurro. (2016) Predictive Factors of Lapatinib and Capecitabine Activity in Patients with HER2-Positive, Trastuzumab-Resistant Metastatic Breast Cancer: Results from the Italian Retrospective Multicenter HERLAPAC Study. PLOS ONE 11:5, pages e0156221.
Crossref
Adela Madrid-Paredes, Marisa Cañadas-Garre, Antonio Sánchez-Pozo & Miguel Ángel Calleja-Hernández. (2015) Non-HER2 signaling pathways activated in resistance to anti-HER2 therapy in breast cancer. Breast Cancer Research and Treatment 153:3, pages 493-505.
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Elisabeth J. Diver, Rosemary Foster, Bo R. Rueda & Whitfield B. Growdon. (2015) The Therapeutic Challenge of Targeting HER2 in Endometrial Cancer. The Oncologist 20:9, pages 1058-1068.
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David G. Covell. (2015) Data Mining Approaches for Genomic Biomarker Development: Applications Using Drug Screening Data from the Cancer Genome Project and the Cancer Cell Line Encyclopedia. PLOS ONE 10:7, pages e0127433.
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Jiao Li, Wei Su, Sheng Zhang, Yunhui Hu, Jingjing Liu, Xiaobei Zhang, Jingchao Bai, Weiping Yuan, Linping Hu, Tao Cheng, Anders Zetterberg, Zhenmin Lei & Jin Zhang. (2015) Epidermal growth factor receptor and AKT 1 gene copy numbers by multi‐gene fluorescence in situ hybridization impact on prognosis in breast cancer . Cancer Science 106:5, pages 642-649.
Crossref
H J Lee, A N Seo, E J Kim, M H Jang, Y J Kim, J H Kim, S-W Kim, H S Ryu, I A Park, S-A Im, G Gong, K H Jung, H J Kim & S Y Park. (2014) Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer. British Journal of Cancer 112:1, pages 103-111.
Crossref
Kazuhiro Araki, Ippei Fukada, Rie Horii, Shunji Takahashi, Futoshi Akiyama, Takuji Iwase & Yoshinori Ito. (2014) Lapatinib-associated mucocutaneous toxicities are clinical predictors of improved progression-free survival in patients with human epidermal growth factor receptor (HER2)-positive advanced breast cancer. Breast Cancer Research and Treatment 148:1, pages 197-209.
Crossref
Jennifer J. Wheler, Barbara A. Parker, Jack J. Lee, Johnique T. Atkins, Filip Janku, Apostolia M. Tsimberidou, Ralph Zinner, Vivek Subbiah, Siqing Fu, Richard Schwab, Stacy Moulder, Vicente Valero, Maria Schwaederle, Roman Yelensky, Vincent A. Miller, M Philip J. Stephens, Funda Meric-Bernstam & Razelle Kurzrock. (2014) Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms. Oncotarget 5:9, pages 2349-2354.
Crossref
Hatem A. AzimJrJrDominique Agbor-tarhIan BradburyPhuong DinhJose BaselgaSerena Di CosimoJames G. GregerJrJrIan SmithChristian JackischSung-Bae KimBahriye AktasChiun-Sheng HuangPeter VuylstekeRuey Kuen HsiehLydia DreostiHolger EidtmannMartine PiccartEvandro de Azambuja. (2013) Pattern of Rash, Diarrhea, and Hepatic Toxicities Secondary to Lapatinib and Their Association With Age and Response to Neoadjuvant Therapy: Analysis From the NeoALTTO Trial. Journal of Clinical Oncology 31:36, pages 4504-4511.
Crossref
Brian Godman, Alexander E Finlayson, Parneet K Cheema, Eva Zebedin-Brandl, Inaki Gutiérrez-Ibarluzea, Jan Jones, Rickard E Malmström, Elina Asola, Christoph Baumgärtel, Marion Bennie, Iain Bishop, Anna Bucsics, Stephen Campbell, Eduardo Diogene, Alessandra Ferrario, Jurij Fürst, Kristina Garuoliene, Miguel Gomes, Katharine Harris, Alan Haycox, Harald Herholz, Krystyna Hviding, Saira Jan, Marija Kalaba, Christina Kvalheim, Ott Laius, Sven-Ake Lööv, Kamila Malinowska, Andrew Martin, Laura McCullagh, Fredrik Nilsson, Ken Paterson, Ulrich Schwabe, Gisbert Selke, Catherine Sermet, Steven Simoens, Dominik Tomek, Vera Vlahovic-Palcevski, Luka Voncina, Magdalena Wladysiuk, Menno van Woerkom, Durhane Wong-Rieger, Corrine Zara, Raghib Ali & Lars L Gustafsson. (2013) Personalizing health care: feasibility and future implications. BMC Medicine 11:1.
Crossref
Sara B Giordano & Virginia Kaklamani. (2013) Lapatinib in combination with paclitaxel for the treatment of patients with metastatic breast cancer whose tumors overexpress HER2. Breast Cancer Management 2:6, pages 529-535.
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