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An update on the pharmacotherapy of neovascular age-related macular degeneration

, MD, , MD & , MD
Pages 1017-1028 | Published online: 08 Apr 2013

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Victor M. Villegas, Luis A. Aranguren, Jaclyn L. Kovach, Stephen G. Schwartz & Harry W. Flynn$suffix/text()$suffix/text(). (2017) Current advances in the treatment of neovascular age-related macular degeneration. Expert Opinion on Drug Delivery 14:2, pages 273-282.
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Kevin Lai & Gennady Landa. (2015) Current choice of treatments for neovascular AMD. Expert Review of Clinical Pharmacology 8:1, pages 135-140.
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Sabite Emine Gökce, Ayşenur Çelik & Ceyda Başkan. (2023) The role of blood neutrophil lymphocyte ratio in predicting the initial response to anti-VEGF treatment in neovascular AMD patients. Irish Journal of Medical Science (1971 -).
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Ching-Yao Tsai, Chien-Liang Wu, Cheng-Kuo Cheng, Yun-Dun Shen, Wen-Chuan Wu, Pei-Chang Wu, Arslan Tsai & Jiann-Torng Chen. (2023) Baseline characteristics and treatment response predictive of nAMD outcomes with ranibizumab therapy in treatment-naive patients: the RACER subgroup analysis. BMC Ophthalmology 23:1.
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Giulia Scondotto, Janet Sultana, Maria Vadalà, Teresio Avitabile, Salvatore Cillino, Saveria Serena Foti, Luca Labbate, Antonio Longo, Eliana Mirabelli, Maria Rosalia Puzo, Carlo Rapisarda, Patricia Ibanez Toro, Costantino J. Trombetta, Gianluca Trifirò & Gianni Virgili. (2022) Assessment of intravitreal anti-VEGF drugs and dexamethasone for retinal diseases in real world setting: A multi-centre prospective study from Southern Italy. European Journal of Ophthalmology 32:5, pages 3064-3073.
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Bernhard Kutscher. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry 1 61 .
Yeon-Kyoung Cho, Dae-Hun Park & In-Chul Jeon. (2021) Medication Trends for Age-Related Macular Degeneration. International Journal of Molecular Sciences 22:21, pages 11837.
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Rishi P. Singh, Justin S. Yu, Guruprasad B & Neetu Agashivala. (2021) Anti-VEGF Treatment Patterns in Patients With Wet Age-Related Macular Degeneration in Clinical Practice. Ophthalmic Surgery, Lasers and Imaging Retina 52:5, pages 263-272.
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Saeed T Alshahrani, Uriel Rubin, Vasudha Gupta, Tom Gonder & Sanjay Sharma. (2021) Reflux, Intraocular Pressure Variation and Pain Following Intravitreal Ranibizumab Injections Using 30-Gauge or 32-Gauge Needles for Patients With Retinal Pathologies: A Randomized Clinical Trial. Cureus.
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Faheem Shaik, Gary Cuthbert, Shervanthi Homer-Vanniasinkam, Stephen Muench, Sreenivasan Ponnambalam & Michael Harrison. (2020) Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy. Biomolecules 10:12, pages 1673.
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Nahla Jemni-Damer, Atocha Guedan-Duran, María Fuentes-Andion, Nora Serrano-Bengoechea, Nuria Alfageme-Lopez, Felix Armada-Maresca, Gustavo V. Guinea, José Pérez-Rigueiro, Francisco Rojo, Daniel Gonzalez-Nieto, David L. Kaplan & Fivos Panetsos. (2020) Biotechnology and Biomaterial-Based Therapeutic Strategies for Age-Related Macular Degeneration. Part I: Biomaterials-Based Drug Delivery Devices. Frontiers in Bioengineering and Biotechnology 8.
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Aditya Kelkar, Caroll Webers, Rohit Shetty, Jai Kelkar, Nikhil Labhsetwar, Abhishek Pandit, Madhulika Malode & Sayali Tidke. (2020) Factors affecting compliance to intravitreal anti-vascular endothelial growth factor therapy in Indian patients with retinal vein occlusion, age-related macular degeneration, and diabetic macular edema. Indian Journal of Ophthalmology 68:10, pages 2143.
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Jordi Monés, Rishi P. Singh, Francesco Bandello, Eric Souied, Xin Liu & Richard Gale. (2020) Undertreatment of Neovascular Age-Related Macular Degeneration after 10 Years of Anti-Vascular Endothelial Growth Factor Therapy in the Real World: The Need for A Change of Mindset. Ophthalmologica 243:1, pages 1-8.
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Pravin U. Dugel, Adrian Koh, Yuichiro Ogura, Glenn J. Jaffe, Ursula Schmidt-Erfurth, David M. Brown, Andre V. Gomes, James Warburton, Andreas Weichselberger & Frank G. Holz. (2020) HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration. Ophthalmology 127:1, pages 72-84.
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Simona Sapino, Daniela Chirio, Elena Peira, Elena Abellán Rubio, Valentina Brunella, Sushilkumar A. Jadhav, Giulia Chindamo & Marina Gallarate. (2019) Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach. Nanomaterials 9:6, pages 884.
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Monica Lövestam Adrian, Zdravko P. Vassilev & Inger Westborg. (2019) Baseline visual acuity as a prognostic factor for visual outcomes in patients treated with aflibercept for wet age-related macular degeneration: data from the INSIGHT study using the Swedish Macula Register. Acta Ophthalmologica 97:1, pages 91-98.
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Ryo Kawasaki & Yumiko Kawasaki. 2019. Innovative Approaches in the Delivery of Primary and Secondary Eye Care. Innovative Approaches in the Delivery of Primary and Secondary Eye Care 147 162 .
Inger Westborg, Elisabet Granstam, Aldana Rosso, Susanne Albrecht, Niklas Karlsson & Monica Lövestam-Adrian. (2017) Treatment for neovascular age-related macular degeneration in Sweden: outcomes at seven years in the Swedish Macula Register. Acta Ophthalmologica 95:8, pages 787-795.
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Xiaolei Wang, Wei Ma, Song Han, Zhaoyang Meng, Lu Zhao, Yi Yin, Yanling Wang & Junfa Li. (2017) TGF-β participates choroid neovascularization through Smad2/3-VEGF/TNF-α signaling in mice with Laser-induced wet age-related macular degeneration. Scientific Reports 7:1.
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Paolo Lanzetta & Anat Loewenstein. (2017) Fundamental principles of an anti-VEGF treatment regimen: optimal application of intravitreal anti–vascular endothelial growth factor therapy of macular diseases. Graefe's Archive for Clinical and Experimental Ophthalmology 255:7, pages 1259-1273.
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Juliana Wons, Magdalena A. Wirth, Nicole Graf, Matthias D. Becker & Stephan Michels. (2017) Comparison of Progression Rate of Retinal Pigment Epithelium Loss in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab and Aflibercept. Journal of Ophthalmology 2017, pages 1-8.
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Peter Adamson, Thomas Wilde, Eric Dobrzynski, Caroline Sychterz, Rodd Polsky, Edit Kurali, Richard Haworth, Chi-Man Tang, Justyna Korczynska, Fiona Cook, Irene Papanicolaou, Lemy Tsikna, Chris Roberts, Zoe Hughes-Thomas, James Walford, Daniel Gibson, John Warrack, Jos Smal, Ruud Verrijk, Paul E. Miller, T. Michael Nork, Jeffery Prusakiewicz, Timothy Streit, Steven Sorden, Craig Struble, Brian Christian & Ian R. Catchpole. (2016) Single ocular injection of a sustained-release anti -VEGF delivers 6 months pharmacokinetics and efficacy in a primate laser CNV model. Journal of Controlled Release 244, pages 1-13.
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G. K. Broadhead, J. R. Grigg, P. McCluskey, M. Korsakova & A. A. Chang. (2016) Bevacizumab for choroidal neovascularisation in enhanced S-cone syndrome. Documenta Ophthalmologica 133:2, pages 139-143.
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Liheng Shi, Andy Jeesu Kim, Richard Cheng-An Chang, Janet Ya-An Chang, Wei Ying, Michael L. Ko, Beiyan Zhou & Gladys Yi-Ping Ko. (2016) Deletion of miR-150 Exacerbates Retinal Vascular Overgrowth in High-Fat-Diet Induced Diabetic Mice. PLOS ONE 11:6, pages e0157543.
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Adam Walker, Chun-Wa Chung, Margarete Neu, Manish Burman, Thil Batuwangala, Gavin Jones, Chi-Man Tang, Michael Steward, Michael Mullin, Nadia Tournier, Alan Lewis, Justyna Korczynska, Vicky Chung & Ian Catchpole. (2016) Novel Interaction Mechanism of a Domain Antibody-based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency than Ranibizumab and Bevacizumab and Improved Capacity over Aflibercept. Journal of Biological Chemistry 291:11, pages 5500-5511.
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Marion Danner, Vera Vennedey, Mickaël Hiligsmann, Sascha Fauser & Stephanie Stock. (2015) Focus Groups in Elderly Ophthalmologic Patients: Setting the Stage for Quantitative Preference Elicitation. The Patient - Patient-Centered Outcomes Research 9:1, pages 47-57.
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Alfredo García-Layana, Marta S. Figueroa, Javier Araiz, José M. Ruiz-Moreno, Francisco Gómez-Ulla, Luis Arias-Barquet & Nicholas Reiter. (2015) Treatment of Exudative Age-related Macular Degeneration: Focus on Aflibercept. Drugs & Aging 32:10, pages 797-807.
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Jennifer I Lim, Marcia Niec & Vernon Wong. (2015) One year results of a phase 1 study of the safety and tolerability of combination therapy using sustained release intravitreal triamcinolone acetonide and ranibizumab for subfoveal neovascular AMD. British Journal of Ophthalmology 99:5, pages 618-623.
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Pablo Hernández-Martínez, Rosa Dolz-Marco, Marta Alonso-Plasencia & Rodrigo Abreu-Gonzalez. (2014) Aflibercept for inflammatory choroidal neovascularization with persistent fluid on intravitreal ranibizumab therapy. Graefe's Archive for Clinical and Experimental Ophthalmology 252:8, pages 1337-1339.
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Tetsuo Kida, Seiko Kozai, Hiroaki Takahashi, Mitsuyoshi Isaka, Hideki Tokushige & Taiji Sakamoto. (2014) Pharmacokinetics and Efficacy of Topically Applied Nonsteroidal Anti-Inflammatory Drugs in Retinochoroidal Tissues in Rabbits. PLoS ONE 9:5, pages e96481.
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K. Bailey Freund, Sarah Mrejen & Roberto Gallego-Pinazo. (2013) Current Strategies for the Management of Treatment-Resistant Neovascular Age-Related Macular Degeneration. Current Ophthalmology Reports 2:1, pages 6-13.
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Menno van Lookeren Campagne, Jennifer LeCouter, Brian L Yaspan & Weilan Ye. (2014) Mechanisms of age-related macular degeneration and therapeutic opportunities. The Journal of Pathology 232:2, pages 151-164.
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Akshay Anand, Neel K. Sharma, Amod Gupta, Sudesh Prabhakar, Suresh K. Sharma & Ramandeep Singh. (2013) Superoxide Dismutase1 Levels in North Indian Population with Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity 2013, pages 1-7.
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