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Current and future pharmacological treatments for diarrhea-predominant irritable bowel syndrome

Pages 1151-1160 | Published online: 27 Apr 2013

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Anna Viola, Andrea Fontana, Alessandra Belvedere, Riccardo Scoglio, Giuseppe Costantino, Aldo Sitibondo, Marco Muscianisi, Santi Inferrera, Lucia Maria Bruno, Angela Alibrandi, Gianluca Trifirò & Walter Fries. (2020) Diagnostic accuracy of faecal calprotectin in a symptom-based algorithm for early diagnosis of inflammatory bowel disease adjusting for differential verification bias using a Bayesian approach. Scandinavian Journal of Gastroenterology 55:10, pages 1176-1184.
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Emidio Scarpellini, Lucrezia Laterza, Gianluca Ianiro, Jan Tack, Ludovico Abenavoli & Antonio Gasbarrini. (2016) Eluxadoline for the treatment of diarrhoea-predominant irritable bowel syndrome. Expert Opinion on Pharmacotherapy 17:10, pages 1395-1402.
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Pamela J Hornby. (2015) Drug discovery approaches to irritable bowel syndrome. Expert Opinion on Drug Discovery 10:8, pages 809-824.
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Kosar Namakin, Meysam Hassani Moghaddam, Sara Sadeghzadeh, Maryam Mehranpour, Kimia Vakili, Mobina Fathi, Ahmadreza Golshan, Amir-Hossein Bayat, Amir-Hossein Tajik, Neda Eskandari, Ibrahim Mohammadzadeh, Soheila Zamanlui Benisi, Abbas Aliaghaei & Mohammad-Amin Abdollahifar. (2023) Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome. Metabolic Brain Disease 38:5, pages 1555-1572.
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Zhao-Chun Chi. (2022) Progress in research of low-grade inflammation in irritable bowel syndrome. World Chinese Journal of Digestology 30:24, pages 1051-1065.
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María Jesús Rodríguez-Sojo, Jorge Garcia-Garcia, Antonio Jesús Ruiz-Malagón, Patricia Diez-Echave, Laura Hidalgo-García, José Alberto Molina-Tijeras, Elena González-Lozano, Laura López-Escanez, María Elena Rodríguez-Cabezas, Maria José Rodríguez-Sánchez, Alba Rodríguez-Nogales, Cristina Mediavilla & Julio Galvez. (2022) Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats. Nutrients 15:1, pages 24.
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Sanghyun Kim, Bora Keum, Junhyoung Byun, Byoungjae Kim, Kijeong Lee, Jiwoo Yeon, Jaemin Lee, Hyuksoon Choi, Eunsun Kim, Yoontae Jeen, Hongsik Lee, Hoonjai Chun & Taehoon Kim. (2021) Colonic Mucosal Immune Activation in Mice with Ovalbumin-Induced Allergic Airway Disease: Association between Allergic Airway Disease and Irritable Bowel Syndrome. International Journal of Molecular Sciences 23:1, pages 181.
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Xue Jin, Payam Gharibani, Jieyun Yin & Jiande D. Z. Chen. (2021) Neuro-Immune Modulation Effects of Sacral Nerve Stimulation for Visceral Hypersensitivity in Rats. Frontiers in Neuroscience 15.
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Saranya Vilvanathan. 2021. Introduction to Basics of Pharmacology and Toxicology. Introduction to Basics of Pharmacology and Toxicology 613 620 .
Daniel Hoyer. (2020) Targeting the 5-HT system: Potential side effects. Neuropharmacology 179, pages 108233.
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José Antonio Uranga, Vicente Martínez & Raquel Abalo. (2020) Mast Cell Regulation and Irritable Bowel Syndrome: Effects of Food Components with Potential Nutraceutical Use. Molecules 25:18, pages 4314.
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Yu Zhang, Hua Zhang, Wen Zhang, Yingjuan Zhang, Wei Wang & Lihong Nie. (2020) LncRNA XIST modulates 5-hydroxytrytophan-induced visceral hypersensitivity by epigenetic silencing of the SERT gene in mice with diarrhea-predominant IBS. Cellular Signalling 73, pages 109674.
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Gintautas Grabauskas, Xiaoyin Wu, Jun Gao, Ji-Yao Li, Danielle Kim Turgeon & Chung Owyang. (2020) Prostaglandin E2, Produced by Mast Cells in Colon Tissues From Patients With Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice. Gastroenterology 158:8, pages 2195-2207.e6.
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Steven L. Wright. (2020) Limited Utility for Benzodiazepines in Chronic Pain Management: A Narrative Review. Advances in Therapy 37:6, pages 2604-2619.
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Jinjoo Kim, Kumsun Cho, Joo Sung Kim, Hyun Chae Jung, Bumsik Kim, Myeong Soo Park, Geun Eog Ji, Joo-Youn Cho & Kyoung Sup Hong. (2019) Probiotic treatment induced change of inflammation related metabolites in IBS-D patients/double-blind, randomized, placebo-controlled trial. Food Science and Biotechnology 29:6, pages 837-844.
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Ana Isabel Ferreira, Mónica Garrido & Fernando Castro-Poças. (2020) Irritable Bowel Syndrome: News from an Old Disorder. GE - Portuguese Journal of Gastroenterology 27:4, pages 255-268.
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Fen Wang, Shuxing He, Jian Yan, Lianren Mai & Liangjun Yang. (2020) Effects of herb-partitioned moxibustion for diarrhoea-predominant irritable bowel syndrome. Medicine 99:34, pages e21817.
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I.A.M. van Thiel, S. Botschuijver, W.J. de Jonge & J. Seppen. (2020) Painful interactions: Microbial compounds and visceral pain. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866:1, pages 165534.
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Satoshi Endo, Tomoe Matsuoka, Tsubasa Nishiyama, Yuki Arai, Hirohito Kashiwagi, Naohito Abe, Masayoshi Oyama, Toshiyuki Matsunaga & Akira Ikari. (2019) Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells. Nutrition Research 72, pages 92-104.
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Roxana Cojocariu, Alin Ciobica, Ioana-Miruna Balmus, Samson Guenne, Anca Trifan, Carol Stanciu, Luminita Hrițcu & Radu Lefter. (2019) Antioxidant Capacity and Behavioral Relevance of a Polyphenolic Extract of Chrysanthellum americanum in a Rat Model of Irritable Bowel Syndrome . Oxidative Medicine and Cellular Longevity 2019, pages 1-13.
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Hans Törnblom, Richard Goosey, Gwen Wiseman, Stephen Baker & Anton Emmanuel. (2018) Understanding symptom burden and attitudes to irritable bowel syndrome with diarrhoea: Results from patient and healthcare professional surveys. United European Gastroenterology Journal 6:9, pages 1417-1427.
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Maria C. Urdaci, Marie Lefevre, Guylene Lafforgue, Christel Cartier, Bertrand Rodriguez & Jean Fioramonti. (2018) Antidiarrheal Action of Bacillus subtilis CU1 CNCM I-2745 and Lactobacillus plantarum CNCM I-4547 in Mice. Frontiers in Microbiology 9.
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S. Fukudo, K. Matsueda, K. Haruma, M. Ida, H. Hayase, H. Akiho, Y. Nakashima & M. Hongo. (2017) Optimal dose of ramosetron in female patients with irritable bowel syndrome with diarrhea: A randomized, placebo-controlled phase II study. Neurogastroenterology & Motility 29:6, pages e13023.
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Jessie Pettit & Richard Glickman-Simon. (2016) Osteopathic Manipulative Therapy for Preterm Infants, Acupuncture for Menopausal Symptoms, Mindfulness-Based Stress Reduction for Chronic Low Back Pain, Chocolate for Ischemic Heart Disease, Berberine for Irritable Bowel Syndrome. EXPLORE 12:5, pages 388-392.
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N. Cenac, M. Castro, C. Desormeaux, P. Colin, M. Sie, M. Ranger & N. Vergnolle. (2016) A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice. European Journal of Pain 20:5, pages 723-730.
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Lei Zhang, Jun Song & Xiaohua Hou. (2016) Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside. Journal of Neurogastroenterology and Motility 22:2, pages 181-192.
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Chunqiu Chen, Chunhua Tao, Zhongchen Liu, Meiling Lu, Qiuhui Pan, Lijun Zheng, Qing Li, Zhenshun Song & Jakub Fichna. (2015) A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome. Phytotherapy Research 29:11, pages 1822-1827.
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M. Corsetti, F. Akyuz & J. Tack. (2015) Targeting tachykinin receptors for the treatment of functional gastrointestinal disorders with a focus on irritable bowel syndrome. Neurogastroenterology & Motility 27:10, pages 1354-1370.
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C M Keenan, M A Storr, G A Thakur, J T Wood, J Wager-Miller, A Straiker, M R Eno, S P Nikas, M Bashashati, H Hu, K Mackie, A Makriyannis & K A Sharkey. (2015) AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner. British Journal of Pharmacology 172:9, pages 2406-2418.
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Daniel Hoyer. 2015. Antitargets and Drug Safety. Antitargets and Drug Safety 57 80 .
Tina Didari. (2015) Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World Journal of Gastroenterology 21:10, pages 3072.
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Tomohisa Mori, Sachiko Komiya, Jumpei Ohya, Naoki Uzawa, Koichi Sugiyama, Yusuke Saitoh, Masahiro Shibasaki & Tsutomu Suzuki. (2014) Involvement of 5-HT2 receptors in the expression of withdrawal diarrhea in morphine-dependent mice. European Journal of Pharmacology 740, pages 160-167.
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Paolo Caraceni, Francesca Borrelli, Ferdinando A. Giannone & Angelo A. Izzo. 2014. Cannabinoids. Cannabinoids 219 260 .
Madhusudan Grover & Michael Camilleri. (2014) Ramosetron in Irritable Bowel Syndrome With Diarrhea: New Hope or the Same Old Story?. Clinical Gastroenterology and Hepatology 12:6, pages 960-962.
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H. L. DuPont. (2014) Review article: evidence for the role of gut microbiota in irritable bowel syndrome and its potential influence on therapeutic targets. Alimentary Pharmacology & Therapeutics 39:10, pages 1033-1042.
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A. C. Ford, P. Bercik, D. G. Morgan, C. Bolino, M. I. Pintos‐Sanchez & P. Moayyedi. (2013) Characteristics of functional bowel disorder patients: a cross‐sectional survey using the Rome III criteria. Alimentary Pharmacology & Therapeutics 39:3, pages 312-321.
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A Young Seo, Nayoung Kim & Dong Hyun Oh. (2013) Abdominal Bloating: Pathophysiology and Treatment. Journal of Neurogastroenterology and Motility 19:4, pages 433-453.
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Michael Camilleri. (2013) Pharmacological agents currently in clinical trials for disorders in neurogastroenterology. Journal of Clinical Investigation 123:10, pages 4111-4120.
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