1,339
Views
59
CrossRef citations to date
0
Altmetric
Reviews

Treatment of bacterial vaginosis: what we have and what we miss

, MD PhD, , MD & , MD PhD

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Jordi Antoni Vives, María Jesús Cancelo, Miguel Ángel Losada & Alejandro Doménech. (2022) Dequalinium chloride use in adult Spanish women with bacterial vaginosis: an observational study. Journal of Obstetrics and Gynaecology 42:1, pages 103-109.
Read now
Nasrin Baery, Azizeh Ghasemi Nejad, Mohsen Amin, Somaye Mahroozade, Roshanak Mokaberinejad, Soodabeh Bioos, Majid Anushiravani, Jale Aliasl, Malihe Karimi Darmiyan & Gholamreza Amin. (2018) Effect of vaginal suppository on bacterial vaginitis based on Persian medicine (Iranian traditional medicine): a randomised double blind clinical study. Journal of Obstetrics and Gynaecology 38:8, pages 1110-1114.
Read now
JoonHo Lee, Roberto Romero, Sun Min Kim, Piya Chaemsaithong, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun & Bo Hyun Yoon. (2016) A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM. The Journal of Maternal-Fetal & Neonatal Medicine 29:5, pages 707-720.
Read now
Rita Palmeira-de-Oliveira, Paulo Duarte, Ana Palmeira-de-Oliveira, José das Neves, Maria Helena Amaral, Luiza Breitenfeld & José Martinez-de-Oliveira. (2015) Women's experiences, preferences and perceptions regarding vaginal products: Results from a cross-sectional web-based survey in Portugal. The European Journal of Contraception & Reproductive Health Care 20:4, pages 259-271.
Read now

Articles from other publishers (55)

Chunyan Zhong, Xinzheng Li, Yong Teng & Jiyun Tian. (2023) Co-infection with human papillomavirus and sexually transmitted infections among Chinese individuals. Microbial Pathogenesis 185, pages 106395.
Crossref
Alex Farr, Sonja Swidsinski, Daniel Surbek, Brigitte Frey Tirri, Birgit Willinger, Udo Hoyme, Gisela Walter, Inge Reckel-Botzem & Werner Mendling. (2023) Bacterial Vaginosis: Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/028, June 2023). Geburtshilfe und Frauenheilkunde 83:11, pages 1331-1349.
Crossref
Ying Liu, Meng Li, Hongying Yi, Dianrong Song, Ying Lou, Shangrong Fan, Xingsheng Yang, Jing Lu, Lina Hu, Ping Zhou, Ruifang An, Fengjuan Han, Xiping Luo, Shan Gao, Weihua Song, Yongxiu Yang, Fengxia Xue, Zhaojun Yin, Wenying Wang, Bei Zhang, Ping Li, Yuhui Sun, Qiao Qiao, Min Hao, Dai Zhang, Zhaohui Liu, Hongbo Wei, Ting Zou, Jinxiang Ma, Shaobin Wei & Qinping Liao. (2023) Efficacy and safety of Fufang Furong Effervescent Suppository for the treatment of mixed vaginitis: a randomized, multicenter, and non-inferiority study. Pharmacological Research - Modern Chinese Medicine 7, pages 100225.
Crossref
Joo Yun Kim, Eun Chae Moon, Ju-Yeon Kim, Hyeon Ji Kim, Keon Heo, Jae-Jung Shim & Jung-Lyoul Lee. (2022) Lactobacillus helveticus HY7801 ameliorates bacterial vaginosis by inhibiting biofilm formation and epithelial cell adhesion of Gardnerella vaginalis. Food Science and Biotechnology 32:4, pages 507-515.
Crossref
Christine K Mauck, George J Atiee, Jennifer McCulloh, Laurie Reynolds, Nadene Zack & David R Friend. (2023) A Phase 1 pharmacokinetic study of a single-dose bioadhesive clindamycin 2% gel for bacterial vaginosis. Journal of Antimicrobial Chemotherapy 78:1, pages 257-262.
Crossref
Kahkashan Baig, Arshiya Sultana & Khaleequr Rahman. (2022) A randomized comparative study of Kakrasingi (Pistacia integerrima J. L. Stewart ex Brandis) and metronidazole in bacterial vaginosis. Journal of Herbal Medicine 36, pages 100609.
Crossref
Evgenia V. Shikh, Natalia B. Lazareva & Tatyana M. Ponomarenko. (2022) Short courses of antimicrobial therapy for bacterial vaginosis: the possibilities of modern pharmacology: A review. Gynecology 24:4, pages 271-276.
Crossref
Yunxia Li, Yan Jiang, Duncan James Lessing & Weihua Chu. (2022) Exploring of probiotic potential vaginal lactobacillus isolates from healthy women against Gardnerella vaginalis and Caenorhabditis elegans model testing. Journal of Applied Microbiology 133:3, pages 1392-1401.
Crossref
Christine Mauck, Sharon L. Hillier, Judy Gendreau, Clint Dart, Steven Chavoustie, Valerie Sorkin-Wells, Clifton Nicholson-Uhl, Brandon Perez, Mark Jacobs, Nadene Zack & David Friend. (2022) Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis. Obstetrics & Gynecology 139:6, pages 1092-1102.
Crossref
Meng Li, Zhen Zeng, Huijun Feng, Yang Cao, Qiongqiong Zhang, Tao Lv, Xingsheng Yang, Dianrong Song, Ping Li, Lina Hu, Shangrong Fan, Ruifang An, Bei Zhang, Lei Zhang & Qinping Liao. (2022) Accurate 16S Absolute Quantification Sequencing Revealed Vaginal Microecological Composition and Dynamics During Mixed Vaginitis Treatment With Fufang FuRong Effervescent Suppository. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Marcos Dibo, María Silvia Ventimiglia, Natalin Valeff, María de los Ángeles Serradell & Federico Jensen. (2022) An overview of the role of probiotics in pregnancy-associated pathologies with a special focus on preterm birth. Journal of Reproductive Immunology 150, pages 103493.
Crossref
Linda Abou Chacra, Florence Fenollar & Khoudia Diop. (2022) Bacterial Vaginosis: What Do We Currently Know?. Frontiers in Cellular and Infection Microbiology 11.
Crossref
O. I. Makedonska, O. S. Voronkova, Yu. S. Voronkova & A. I. Vinnikov. (2022) CORRECTION OF VAGINAL DYSBIOSIS CAUSED BY THE BIOFILM FORMING STRAIN OF STAPHYLOCOCCUS AUREUS, USING PROBIOTIC BASED ON SPORE MICROORGANISMS. World of Medicine and Biology 18:79, pages 209.
Crossref
Arshiya Sultana, Kahkashan Baig, Khaleequr Rahman, Sumbul Mehdi, Md Belal Bin Heyat, Faijan Akhtar & Atif Amin Baig. 2022. Computational Intelligence in Healthcare Applications. Computational Intelligence in Healthcare Applications 33 53 .
Alison Muñoz-Barreno, Fausto Cabezas-Mera, Eduardo Tejera & António Machado. (2021) Comparative Effectiveness of Treatments for Bacterial Vaginosis: A Network Meta-Analysis. Antibiotics 10:8, pages 978.
Crossref
Ahmed Abu‐Zaid, Majed Saeed Alshahrani, Hanadi Bakhsh, Najlaa Talat Miski, Mohammed Abuzaid, Osama Alomar, Emad Jabrah, Mohammed Ziad Jamjoom, Hany Salem, Ismail Abdulrahman Al‐Badawi & Saeed Baradwan. (2021) Astodrimer gel for treatment of bacterial vaginosis: A systematic review and meta‐analysis of randomized controlled trials. International Journal of Clinical Practice 75:7.
Crossref
Michał Smoleński, Bożena Karolewicz, Anna M. Gołkowska, Karol P. Nartowski & Katarzyna Małolepsza-Jarmołowska. (2021) Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels. International Journal of Molecular Sciences 22:12, pages 6455.
Crossref
Zhixiang Qian, Hui Zhu, Dan Zhao, Ping Yang, Fei Gao, Chunyi Lu, Yu Yin, Shidong Kan & Daijie Chen. (2021) Probiotic Lactobacillus sp. Strains Inhibit Growth, Adhesion, Biofilm Formation, and Gene Expression of Bacterial Vaginosis-Inducing Gardnerella vaginalis. Microorganisms 9:4, pages 728.
Crossref
Aleksey A. Khryanin & German Yu. Knorring. (2021) Modern understanding of bacterial vaginosis. Gynecology 23:1, pages 37-42.
Crossref
Carlos Gaspar, Joana Rolo, Nuno Cerca, Rita Palmeira-de-Oliveira, José Martinez-de-Oliveira & Ana Palmeira-de-Oliveira. (2021) Dequalinium Chloride Effectively Disrupts Bacterial Vaginosis (BV) Gardnerella spp. Biofilms. Pathogens 10:3, pages 261.
Crossref
GA Corbett, DA Crosby & FM McAuliffe. (2021) Probiotic therapy in couples with infertility: A systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology 256, pages 95-100.
Crossref
Jiaoning Fang, Lihua Chen, Zhiwei Chen, Xiaoxiang Jiang & Mian Pan. (2020) Association of the vaginal microbiota with pregnancy outcomes in Chinese women after cervical cerclage. Reproductive BioMedicine Online 41:4, pages 698-706.
Crossref
H.N. Basavaprabhu, K.S. Sonu & R. Prabha. (2020) Mechanistic insights into the action of probiotics against bacterial vaginosis and its mediated preterm birth: An overview. Microbial Pathogenesis 141, pages 104029.
Crossref
Steven E. Chavoustie, Belvia A. Carter, Arthur S. Waldbaum, Gilbert G.G. Donders, Klaus H. Peters, Jane R. Schwebke, Jeremy R.A. Paull, Clare F. Price, Alex Castellarnau, Philip McCloud & George R. Kinghorn. (2020) Two phase 3, double-blind, placebo-controlled studies of the efficacy and safety of Astodrimer 1% Gel for the treatment of bacterial vaginosis. European Journal of Obstetrics & Gynecology and Reproductive Biology 245, pages 13-18.
Crossref
Fernando Vazquez, Ana Fernández-Blázquez & Beatriz García. (2019) Vaginosis. Vaginal microbiota. Enfermedades infecciosas y microbiologia clinica (English ed.) 37:9, pages 592-601.
Crossref
Fernando Vazquez, Ana Fernández-Blázquez & Beatriz García. (2019) Vaginosis. Microbiota vaginal. Enfermedades Infecciosas y Microbiología Clínica 37:9, pages 592-601.
Crossref
Da-Eun KimJeon-Kyung KimSang-Kap HanSe-Eun JangMyung Joo HanDong-Hyun Kim. (2019) Lactobacillus plantarum NK3 and Bifidobacterium longum NK49 Alleviate Bacterial Vaginosis and Osteoporosis in Mice by Suppressing NF- κ B-Linked TNF- α Expression . Journal of Medicinal Food 22:10, pages 1022-1031.
Crossref
A. L. Tikhomirov & S. I. Sarsania. (2019) Compliance in the treatment of vaginal dysbiosis. Medical Council:12, pages 146-152.
Crossref
Xiuzhen Ma, Junfeng Deng, Xinmu Cui, Qi Chen & Weihua Wang. (2019) Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis. Experimental and Therapeutic Medicine.
Crossref
Shrouk M. Elghazaly, Khaled M. Hamam, Marwa M. Badawy, Nadim Aiman Yakoub Agha, Ahmed Samy & Ahmed M. Abbas. (2019) Efficacy and safety of single dose of oral secnidazole 2 g in treatment of bacterial vaginosis: A systematic review and meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology 238, pages 125-131.
Crossref
Werner Mendling, Ana Palmeira-de-Oliveira, Stephan Biber & Valdas Prasauskas. (2019) An update on the role of Atopobium vaginae in bacterial vaginosis: what to consider when choosing a treatment? A mini review. Archives of Gynecology and Obstetrics 300:1, pages 1-6.
Crossref
Víctor M. Muñoz-Pérez, Mario I. Ortiz, Raquel Cariño-Cortés, Eduardo Fernández-Martínez, Leticia Rocha-Zavaleta & Mirandeli Bautista-Ávila. (2019) Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention. Current Pharmaceutical Biotechnology 20:5, pages 354-365.
Crossref
I. O. MalovaI. G. Afanasyeva. (2019) Bacterial Vaginosis: Is there an alternative to traditional drugs?. Medical Council:7, pages 93-103.
Crossref
Liza Ouarabi, Yasmina Ait Chait, Hamza Ait Seddik, Djamel Drider & Farida Bendali. (2017) Newly Isolated Lactobacilli strains from Algerian Human Vaginal Microbiota: Lactobacillus fermentum Strains Relevant Probiotic’s Candidates. Probiotics and Antimicrobial Proteins 11:1, pages 43-54.
Crossref
Pedro Vieira-Baptista & Jacob Bornstein. 2019. Vulvar Disease. Vulvar Disease 167 205 .
A. Maleb, M. Frikh, Y. Ben Lahlou, B. Belefquih, A. Lemnouer & M. Elouennass. (2018) Écoulements vaginaux d’origine infectieuse chez la femme adulte à l’hôpital militaire d’instruction Mohammed V de Rabat (Maroc) : étude de 412 cas. La Revue Sage-Femme 17:3, pages 122-126.
Crossref
Helen S. Pentikis & Nikki Adetoro. (2018) Two Phase 1, Open-Label, Single-Dose, Randomized, Crossover Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Orally Administered Granules of Secnidazole (2 g) in Healthy Female Volunteers Under Different Administration Conditions. Clinical Pharmacology in Drug Development 7:5, pages 543-553.
Crossref
María Teresa Sánchez, María Adolfina Ruiz, Herminia Castán & María Encarnación Morales. (2018) A novel double-layer mucoadhesive tablet containing probiotic strain for vaginal administration: Design, development and technological evaluation. European Journal of Pharmaceutical Sciences 112, pages 63-70.
Crossref
Carolina Sanitá Tafner Ferreira, Gilbert Gerard Donders, Cristina Maria Garcia de Lima Parada, Andrea da Rocha Tristão, Thaiz Fernandes, Márcia Guimarães da Silva & Camila Marconi. (2017) Treatment failure of bacterial vaginosis is not associated with higher loads of Atopobium vaginae and Gardnerella vaginalis. Journal of Medical Microbiology 66:8, pages 1217-1224.
Crossref
Dai Zhang, Ting Li, Lei Chen, Xiaosong Zhang, Gengli Zhao & Zhaohui Liu. (2017) Epidemiological investigation of the relationship between common lower genital tract infections and high-risk human papillomavirus infections among women in Beijing, China. PLOS ONE 12:5, pages e0178033.
Crossref
G. Donders, G. Bellen, F. Donders, J. Pinget, I. Vandevelde, T. Michiels & J. Byamughisa. (2016) Improvement of abnormal vaginal flora in Ugandan women by self-testing and short use of intravaginal antimicrobials. European Journal of Clinical Microbiology & Infectious Diseases 36:4, pages 731-738.
Crossref
Fiona Lewis, Fabrizio Bogliatto & Marc van Beurden. 2017. A Practical Guide to Vulval Disease. A Practical Guide to Vulval Disease 155 166 .
Z. A. Murtazina, A. G. Yashchuk, R. R. Galimov, L. A. Dautova & A. V. Tsvetkova. (2017) Office diagnosis of bacterial vaginosis by hardware topographic pH-metry. Rossiiskii vestnik akushera-ginekologa 17:4, pages 54.
Crossref
Jeff A Keelan & John P Newnham. (2017) Recent advances in the prevention of preterm birth. F1000Research 6, pages 1139.
Crossref
B. Vitali, A. Abruzzo & P. Mastromarino. 2017. The Microbiota in Gastrointestinal Pathophysiology. The Microbiota in Gastrointestinal Pathophysiology 399 407 .
L. Párducz, I. Eszik, G. Wagner, K. Burián, V. Endrész & D.P. Virok. (2016) Impact of antiseptics on Chlamydia trachomatis growth . Letters in Applied Microbiology 63:4, pages 260-267.
Crossref
Kanchan V. Mogha & Jashbhai B. Prajapati. (2016) Probiotics for treating bacterial vaginosis. Reviews in Medical Microbiology 27:3, pages 87-94.
Crossref
Werner Mendling, Ernst Rainer Weissenbacher, Stefan Gerber, Valdas Prasauskas & Philipp Grob. (2015) Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review. Archives of Gynecology and Obstetrics 293:3, pages 469-484.
Crossref
P. Njomnang Soh, F. Vidal, E. Huyghe, P. Gourdy, J.M. Halimi & B. Bouhanick. (2016) Urinary and genital infections in patients with diabetes: How to diagnose and how to treat. Diabetes & Metabolism 42:1, pages 16-24.
Crossref
Sevi Giakoumelou, Nick Wheelhouse, Kate Cuschieri, Gary Entrican, Sarah E.M. Howie & Andrew W. Horne. (2016) The role of infection in miscarriage. Human Reproduction Update 22:1, pages 116-133.
Crossref
Melinda Zeron Mullins & Konia M. Trouton. (2015) BASIC study: is intravaginal boric acid non-inferior to metronidazole in symptomatic bacterial vaginosis? Study protocol for a randomized controlled trial. Trials 16:1.
Crossref
Davide De Alberti, Rosario Russo, Fabio Terruzzi, Vincenzo Nobile & Arthur C. Ouwehand. (2015) Lactobacilli vaginal colonisation after oral consumption of Respecta® complex: a randomised controlled pilot study. Archives of Gynecology and Obstetrics 292:4, pages 861-867.
Crossref
Rita Palmeira-de-Oliveira, Ana Palmeira-de-Oliveira & José Martinez-de-Oliveira. (2015) New strategies for local treatment of vaginal infections. Advanced Drug Delivery Reviews 92, pages 105-122.
Crossref
Vinay K. Singh, Arfat Anis, Indranil Banerjee, Krishna Pramanik, Mrinal K. Bhattacharya & Kunal Pal. (2014) Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis. Materials Science and Engineering: C 44, pages 151-158.
Crossref
Javier Haya, Africa García, Carlos López-Manzanara, Maher Balawi & Lara Haya. (2014) Importance of Lactic Acid in Maintaining Vaginal Health: A Review of Vaginitis and Vaginosis Etiopathogenic Bases and a Proposal for a New Treatment. Open Journal of Obstetrics and Gynecology 04:13, pages 787-799.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.