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Preserving fertility when choosing chemotherapy regimens – the role of gonadotropin-releasing hormone agonists

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Dimitrios Papageorgiou, Michail Diakosavvas, Kyveli Angelou, Nikolaos Kathopoulis, Charalambos Voros, Eleftherios Zachariou, Konstantina Papadatou, Ioannis K. Papapanagiotou & Katerina Papakonstantinou. (2022) Fertility outcomes after treatment with intraperitoneal chemotherapy. Journal of Obstetrics and Gynaecology 42:6, pages 1626-1634.
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Zeev Blumenfeld. (2017) Investigational and experimental GnRH analogs and associated neurotransmitters. Expert Opinion on Investigational Drugs 26:6, pages 661-667.
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M. F. Garrido-Oyarzún & C. Castelo-Branco. (2016) Controversies over the use of GnRH agonists for reduction of chemotherapy-induced gonadotoxicity. Climacteric 19:6, pages 522-525.
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Jenna Kropp, David H Abbott & Elon C. Roti Roti. (2016) The possibility of dexrazoxane to prevent ovarian damage caused by toxicity. Expert Review of Quality of Life in Cancer Care 1:4, pages 269-275.
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Articles from other publishers (32)

Ruxue Han, Ziyi Song, Huiling Li, Chaohua Wang, Leping Zhang & Xin Yang. (2023) Analysis of the benefit of gonadotropin-releasing hormone agonist treatment in premenopausal women undergoing hematopoietic cell transplantation. Scientific Reports 13:1.
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Rossella Attini, Gianfranca Cabiddu, Francesca Ciabatti, Benedetta Montersino, Andrea Roberto Carosso, Giuseppe Gernone, Linda Gammaro, Gabriella Moroni, Massimo Torreggiani, Bianca Masturzo, Domenico Santoro, Alberto Revelli & Giorgina Barbara Piccoli. (2023) Chronic kidney disease, female infertility, and medically assisted reproduction: a best practice position statement by the Kidney and Pregnancy Group of the Italian Society of Nephrology. Journal of Nephrology 36:5, pages 1239-1255.
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Lavinia Casati, Samuele Ciceri, Roberto Maggi & Daniele Bottai. (2023) Physiological and pharmacological overview of the gonadotropin releasing hormone. Biochemical Pharmacology 212, pages 115553.
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William J. GradisharMeena S. MoranJame AbrahamRebecca AftDoreen AgneseKimberly H. AllisonBethany AndersonHarold J. BursteinHelen ChewChau DangAnthony D. EliasSharon H. GiordanoMatthew P. GoetzLori J. GoldsteinSara A. HurvitzSteven J. IsakoffRachel C. JankowitzSara H. JavidJairam KrishnamurthyMarilyn LeitchJanice LyonsJoanne MortimerSameer A. PatelLori J. PierceLaura H. RosenbergerHope S. RugoAmy SitapatiKaren Lisa SmithMary Lou SmithHatem SolimanErica M. Stringer-ReasorMelinda L. TelliJohn H. WardKari B. WisinskiJessica S. Young, Jennifer BurnsRashmi Kumar. (2022) Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network 20:6, pages 691-722.
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A. Santaballa, C. Márquez-Vega, Á. Rodríguez-Lescure, Á. Rovirosa, L. Vázquez, I. Zeberio-Etxetxipia, M. Andrés, L. Bassas, E. Ceballos-Garcia, J. Domingo & D. Manau-Trullas. (2021) Multidisciplinary consensus on the criteria for fertility preservation in cancer patients. Clinical and Translational Oncology 24:2, pages 227-243.
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Jae Hoon Lee & Young Sik Choi. (2021) The role of gonadotropin-releasing hormone agonists in female fertility preservation. Clinical and Experimental Reproductive Medicine 48:1, pages 11-26.
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Hsien-Ming Wu, Hsun-Ming Chang & Peter C.K. Leung. (2021) Gonadotropin-releasing hormone analogs: Mechanisms of action and clinical applications in female reproduction. Frontiers in Neuroendocrinology 60, pages 100876.
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Marie-Madeleine Dolmans, Hugh S. Taylor, Kenny A. Rodriguez-Wallberg, Zeev Blumenfeld, Matteo Lambertini, Michael von Wolff & Jacques Donnez. (2020) Utility of gonadotropin-releasing hormone agonists for fertility preservation in women receiving chemotherapy: pros and cons. Fertility and Sterility 114:4, pages 725-738.
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Dimitrios Papageorgiou, Dimitrios K. Manatakis, Katerina Papakonstantinou & Ioannis D. Kyriazanos. (2020) A comprehensive review of childbearing after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Archives of Gynecology and Obstetrics 302:4, pages 793-799.
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Zeev Blumenfeld. 2020. Textbook of Assisted Reproduction. Textbook of Assisted Reproduction 541 550 .
Javier Domingo & Antonio Pellicer. 2020. Fertility Challenges and Solutions in Women with Cancer. Fertility Challenges and Solutions in Women with Cancer 43 54 .
Jean-Baptiste Pretalli, Sophie Frontczak Franck, Lionel Pazart, Christophe Roux & Clotilde Amiot. (2019) Development of Ovarian Tissue Autograft to Restore Ovarian Function: Protocol for a French Multicenter Cohort Study. JMIR Research Protocols 8:9, pages e12944.
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Sharon Maynard, Grace Guerrier & Margaret Duffy. (2019) Pregnancy in Women With Systemic Lupus and Lupus Nephritis. Advances in Chronic Kidney Disease 26:5, pages 330-337.
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Zeev Blumenfeld. (2019) Fertility Preservation Using GnRH Agonists: Rationale, Possible Mechanisms, and Explanation of Controversy. Clinical Medicine Insights: Reproductive Health 13, pages 117955811987016.
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Benjamin Fisch & Ronit Abir. (2018) Female fertility preservation: past, present and future. Reproduction 156:1, pages F11-F27.
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Brian D. Friend & Gary J. Schiller. (2018) Closing the gap: Novel therapies in treating acute lymphoblastic leukemia in adolescents and young adults. Blood Reviews 32:2, pages 122-129.
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Patrizia Limonta, Marina Montagnani Marelli, Roberta Moretti, Monica Marzagalli, Fabrizio Fontana & Roberto Maggi. 2018. Ovarian Cycle. Ovarian Cycle 27 66 .
Megan Oberle, Jill L. Brodsky & Adda Grimberg. 2018. Pediatric Endocrinology. Pediatric Endocrinology 231 258 .
Pei-Ying Wu, Ya-Min Cheng, Geok Huey New, Cheng-Yang Chou, Chun-Ting Chiang, Hung-Wen Tsai & Yu-Fang Huang. (2017) Case report: term birth after fertility-sparing treatments for stage IB1 small cell neuroendocrine carcinoma of the cervix. BMC Women's Health 17:1.
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Jennifer Flora Knudtson, Marlen Tellez Santos, Courtney M. Failor, Peter A. Binkley, Jacob P. Venesky, Rajeshwar R. Tekmal, Randal D. Robinson & Robert S. Schenken. (2017) A Combination of a GnRH Antagonist and Agonist for Fertility Preservation in an Adolescent Female Murine Model. Reproductive Sciences 24:9, pages 1280-1283.
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Michael E. Rytting, Elias J. Jabbour, Susan M. O'Brien & Hagop M. Kantarjian. (2017) Acute lymphoblastic leukemia in adolescents and young adults. Cancer 123:13, pages 2398-2403.
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Emily C. Somers & Wendy Marder. (2017) Infertility – Prevention and Management. Rheumatic Disease Clinics of North America 43:2, pages 275-285.
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Giovanni Codacci-Pisanelli, Lino Del Pup, Maria Del Grande & Fedro A. Peccatori. (2017) Mechanisms of chemotherapy-induced ovarian damage in breast cancer patients. Critical Reviews in Oncology/Hematology 113, pages 90-96.
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R Phelan, E Mann, C Napurski, T E DeFor, A Petryk, W P Miller, J E Wagner, M R Verneris & A R Smith. (2016) Ovarian function after hematopoietic cell transplantation: a descriptive study following the use of GnRH agonists for myeloablative conditioning and observation only for reduced-intensity conditioning. Bone Marrow Transplantation 51:10, pages 1369-1375.
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Lisa C. Hickman, Lindsey N. Valentine & Tommaso Falcone. (2016) Preservation of gonadal function in women undergoing chemotherapy: a review of the potential role for gonadotropin-releasing hormone agonists. American Journal of Obstetrics and Gynecology 215:4, pages 415-422.
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Zeev Blumenfeld & Ayelet Evron. (2016) Endocrine prevention of chemotherapy-induced ovarian failure. Current Opinion in Obstetrics & Gynecology 28:4, pages 223-229.
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Zeev Blumenfeld. (2016) Endocrine prevention of chemotherapy-induced ovarian failure. Future Oncology 12:14, pages 1671-1674.
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Lisa J. Green & Ariella Shikanov. (2016) In vitro culture methods of preantral follicles. Theriogenology 86:1, pages 229-238.
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Roberto Maggi, Anna Maria Cariboni, Marina Montagnani Marelli, Roberta Manuela Moretti, Valentina Andrè, Monica Marzagalli & Patrizia Limonta. (2016) GnRH and GnRH receptors in the pathophysiology of the human female reproductive system. Human Reproduction Update 22:3, pages 358-381.
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E. Kniazeva, A. N. Hardy, S. A. Boukaidi, T. K. Woodruff, J. S. Jeruss & L. D. Shea. (2015) Primordial Follicle Transplantation within Designer Biomaterial Grafts Produce Live Births in a Mouse Infertility Model. Scientific Reports 5:1.
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Ahmad Bakr Alwazzan, Shaundra Popowich, Erin Dean, Christine Robinson, Robert Lotocki & Alon D. Altman. (2015) Pure Immature Teratoma of the Ovary in Adults: Thirty-Year Experience of a Single Tertiary Care Center. International Journal of Gynecologic Cancer 25:9, pages 1616-1622.
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Ruth Ronn & Hananel Holzer. (2015) Breast cancer and fertility. Current Opinion in Supportive & Palliative Care 9:3, pages 285-293.
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