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Therapies for triple negative breast cancer

, MD (Associate Professor of Medicine) , , &

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Lin-Wei Guo, Lin-Miao Jiang, Yue Gong, Hong-Hua Zhang, Xiao-Guang Li, Min He, Wei-Li Sun, Hong Ling & Xin Hu. (2018) Development and validation of nomograms for predicting overall and breast cancer-specific survival among patients with triple-negative breast cancer. Cancer Management and Research 10, pages 5881-5894.
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Giuliana De Gregoriis, Juliene Antonio Ramos, Priscila Valverde Fernandes, Giselle Maria Vignal, Rafael Canfield Brianese, Dirce Maria Carraro, Alvaro N. Monteiro, Claudio José Struchiner, Guilherme Suarez-Kurtz, Rosane Vianna-Jorge & Marcelo Alex de Carvalho. (2017) DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis. Cancer Biology & Therapy 18:6, pages 439-449.
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Ravi Doddapaneni, Ketan Patel, Ibtisam Hasan Owaid & Mandip Singh. (2016) Tumor neovasculature-targeted cationic PEGylated liposomes of gambogic acid for the treatment of triple-negative breast cancer. Drug Delivery 23:4, pages 1232-1241.
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Articles from other publishers (62)

Abygail G. Chapdelaine & Gongqin Sun. (2023) Challenges and Opportunities in Developing Targeted Therapies for Triple Negative Breast Cancer. Biomolecules 13:8, pages 1207.
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Narasimha M. Beeraka, Jin Zhang, Di Zhao, Junqi Liu, Chinnappa A U, Hemanth Vikram PR, Priyanka Shivaprakash, Namitha Bannimath, Prasath Manogaran, Mikhail Y. Sinelnikov, Gurupadayya Bannimath & Ruitai Fan. (2023) Combinatorial Implications of Nrf2 Inhibitors with FN3K Inhibitor: In vitro Breast Cancer Study. Current Pharmaceutical Design 29:30, pages 2408-2425.
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Onyinyechi Obidiro, Gantumur Battogtokh & Emmanuel O. Akala. (2023) Triple Negative Breast Cancer Treatment Options and Limitations: Future Outlook. Pharmaceutics 15:7, pages 1796.
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Navneet Kaur, Priyanka Sharma, Mimansa, Mahendran Jaganathan, Rafika Munawara, Anjali Aggarwal & Asifkhan Shanavas. (2023) Glycol chitosan stabilized nanomedicine of lapatinib and doxorubicin for the management of metastatic breast tumor. Drug Delivery and Translational Research.
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Lahanya Guha, Ishfaq Ahmad Bhat, Aasiya Bashir, Jawad Ur Rahman & Faheem Hyder Pottoo. (2022) Nanotechnological Approaches for the Treatment of Triple-Negative Breast Cancer: A Comprehensive Review. Current Drug Metabolism 23:10, pages 781-799.
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Hao Sun, Hui Cai, Chang Xu, Hezheng Zhai, François Lux, Yi Xie, Li Feng, Liqing Du, Yang Liu, Xiaohui Sun, Qin Wang, Huijuan Song, Ningning He, Manman Zhang, Kaihua Ji, Jinhan Wang, Yeqing Gu, Géraldine Leduc, Tristan Doussineau, Yan Wang, Qiang Liu & Olivier Tillement. (2022) AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway. Journal of Nanobiotechnology 20:1.
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Geng Chia Ku, Abygail G. Chapdelaine, Marina K. Ayrapetov & Gongqin Sun. (2022) Identification of Lethal Inhibitors and Inhibitor Combinations for Mono-Driver versus Multi-Driver Triple-Negative Breast Cancer Cells. Cancers 14:16, pages 4027.
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Md Khalilur Rahman, Yassir Al-Zubaidi, Kirsi Bourget, Yongjuan Chen, Stanton Tam, Fanfan Zhou & Michael Murray. (2022) Preclinical Evaluation of Ixabepilone in Combination with VEGF Receptor and PARP Inhibitors in Taxane-Sensitive and Taxane-Resistant MDA-MB-231 Breast Cancer Cells. Journal of Pharmaceutical Sciences 111:8, pages 2180-2190.
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Kuo Chen, Jin Zhang, Narasimha M. Beeraka, Chengyun Tang, Yulia V. Babayeva, Mikhail Y. Sinelnikov, Xinliang Zhang, Jiacheng Zhang, Junqi Liu, Igor V. Reshetov, Olga A. Sukocheva, Pengwei Lu & Ruitai Fan. (2022) Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers. Frontiers in Oncology 12.
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Yu Wu, Zongchen Ma, Xiaoyuan Mai, Xiaoling Liu, Pinglin Li, Xin Qi, Guoqiang Li & Jing Li. (2022) Identification of a Novel Inhibitor of TfR1 from Designed and Synthesized Muriceidine A Derivatives. Antioxidants 11:5, pages 834.
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Susan Fineberg, Xuejun Tian, Della Makower, Malini Harigopal & Yungtai Lo. (2022) EZH2 Protein Expression in Triple-negative Breast Cancer Treated With Neoadjuvant Chemotherapy: An Exploratory Study of Association With Tumor Response and Prognosis. Applied Immunohistochemistry & Molecular Morphology 30:3, pages 157-164.
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Jingnan Zhang, Fan Yang, Xiyu Mei, Rui Yang, Bin Lu, Zhengtao Wang & Lili Ji. (2022) Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy. Chemico-Biological Interactions 351, pages 109739.
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Xiao Luo & Hui Wang. (2021) LINC00514 upregulates CCDC71L to promote cell proliferation, migration and invasion in triple‐negative breast cancer by sponging miR-6504-5p and miR-3139. Cancer Cell International 21:1.
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Fokhrul Hossain, Samarpan Majumder, Justin David & Lucio Miele. (2021) Precision Medicine and Triple-Negative Breast Cancer: Current Landscape and Future Directions. Cancers 13:15, pages 3739.
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Jill J. J. Geenen, Gwen M. H. E. Dackus, Philip C. Schouten, Dick Pluim, Serena Marchetti, Gabe S. Sonke, Katarzyna Jóźwiak, Alwin D. R. Huitema, Jos H. Beijnen, Jan H. M. Schellens & Sabine C. Linn. (2021) A Phase I dose‐escalation study of two cycles carboplatin‐olaparib followed by olaparib monotherapy in patients with advanced cancer. International Journal of Cancer 148:12, pages 3041-3050.
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Rita Moreno, Sourav Banerjee, Angus W. Jackson, Jean Quinn, Gregg Baillie, Jack E. Dixon, Albena T. Dinkova-Kostova, Joanne Edwards & Laureano de la Vega. (2020) The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress. Cell Death & Differentiation 28:5, pages 1563-1578.
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Guang Ma, Cheng Liu, Weiling Lian, Yongping Zhang, Huiyu Yuan, Yingjian Zhang, Shaoli Song & Zhongyi Yang. (2021) 18F-FLT PET/CT imaging for early monitoring response to CDK4/6 inhibitor therapy in triple negative breast cancer. Annals of Nuclear Medicine 35:5, pages 600-607.
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Jeremy Johnson, Zeta Chow, Eun Lee, Heidi L. Weiss, B. Mark Evers & Piotr Rychahou. (2021) Role of AMPK and Akt in triple negative breast cancer lung colonization. Neoplasia 23:4, pages 429-438.
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Farnoosh Attari, Faezeh Keighobadi, Mohammad Abdollahi, Ehsan Arefian, Reza Lotfizadeh, Houri Sepehri & Mahdi Moridi Farimani. (2020) Inhibitory effect of flavonoid xanthomicrol on triple‐negative breast tumor via regulation of cancer‐associated microRNAs. Phytotherapy Research 35:4, pages 1967-1982.
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Fengliang Wang, Sujin Yang, Mingming Lv, Fei Chen, Hong Yin, Sheng Gao, Jinhai Tang & Jing Yu. (2021) Novel Long Noncoding RNA 005620 Induces Epirubicin Resistance in Triple-Negative Breast Cancer by Regulating ITGB1 Expression. Frontiers in Oncology 11.
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Mahsa Keihan Shokooh, Fakhrossadat Emami, Jee-Heon Jeong & Simmyung Yook. (2021) Bio-Inspired and Smart Nanoparticles for Triple Negative Breast Cancer Microenvironment. Pharmaceutics 13:2, pages 287.
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Reza Mehdizadeh, Seyed Peyman Shariatpanahi, Bahram Goliaei, Sanam Peyvandi & Curzio Rüegg. (2021) Dormant Tumor Cell Vaccination: A Mathematical Model of Immunological Dormancy in Triple-Negative Breast Cancer. Cancers 13:2, pages 245.
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Malamati Kourti, Jun Cai, Wen Jiang & Andrew D. Westwell. (2020) Structural Modifications on CORM-3 Lead to Enhanced Anti-angiogenic Properties Against Triple-negative Breast Cancer Cells. Medicinal Chemistry 17:1, pages 40-59.
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Ali Ashkbar, Fatemeh Rezaei, Farnoosh Attari & Saboura Ashkevarian. (2020) Treatment of breast cancer in vivo by dual photodynamic and photothermal approaches with the aid of curcumin photosensitizer and magnetic nanoparticles. Scientific Reports 10:1.
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Akshay Sharma, Tripti Mishra, Gatha Thacker, Mukul Mishra, Tadigoppula Narender & Arun Kumar Trivedi. (2020) Chebulinic acid inhibits MDA‐MB‐231 breast cancer metastasis and promotes cell death through down regulation of SOD1 and induction of autophagy. Cell Biology International 44:12, pages 2553-2569.
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Mehrnaz Moradi, Hajar Gholipour, Houri Sepehri, Farnoosh Attari, Ladan Delphi, Ehsan Arefian & Mahdi Moridi Farimani. (2020) Flavonoid calycopterin triggers apoptosis in triple-negative and ER-positive human breast cancer cells through activating different patterns of gene expression. Naunyn-Schmiedeberg's Archives of Pharmacology 393:11, pages 2145-2156.
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Gagan K. Gupta, Amber L. Collier, Dasom Lee, Richard A. Hoefer, Vasilena Zheleva, Lauren L. Siewertsz van Reesema, Angela M. Tang-Tan, Mary L. Guye, David Z. Chang, Janet S. Winston, Billur Samli, Rick J. Jansen, Emanuel F. Petricoin, Matthew P. Goetz, Harry D. Bear & Amy H. Tang. (2020) Perspectives on Triple-Negative Breast Cancer: Current Treatment Strategies, Unmet Needs, and Potential Targets for Future Therapies. Cancers 12:9, pages 2392.
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María G. C. Navarrete-Bernal, Mayte G. Cervantes-Badillo, Jose Fabián Martínez-Herrera, César O. Lara-Torres, Raquel Gerson-Cwilich, Alejandro Zentella-Dehesa, María de Jesús Ibarra-Sánchez, José Esparza-López, Juan J. Montesinos, Víctor Adrián Cortés-Morales, Diego Osorio-Pérez, Diana A. Villegas-Osorno, Eduardo Reyes-Sánchez, Pablo Salazar-Sojo, Luis F. Tallabs-Utrilla, Sandra Romero-Córdoba & Leticia Rocha-Zavaleta. (2020) Biological Landscape of Triple Negative Breast Cancers Expressing CTLA-4. Frontiers in Oncology 10.
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Jeremy Johnson, Zeta Chow, Dana Napier, Eun Lee, Heidi L. Weiss, B. Mark Evers & Piotr Rychahou. (2020) Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer. Cells 9:5, pages 1253.
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Yi Luo, Shingo Kishi, Takamitsu Sasaki, Hitoshi Ohmori, Rina Fujiwara‐Tani, Shiori Mori, Kei Goto, Yukiko Nishiguchi, Takuya Mori, Isao Kawahara, Masuo Kondoh & Hiroki Kuniyasu. (2020) Targeting claudin‐4 enhances chemosensitivity in breast cancer. Cancer Science 111:5, pages 1840-1850.
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Elena Alexandrova, Jessica Lamberti, Pasquale Saggese, Giovanni Pecoraro, Domenico Memoli, Valeria Mirici Cappa, Maria Ravo, Roberta Iorio, Roberta Tarallo, Francesca Rizzo, Francesca Collina, Monica Cantile, Maurizio Di Bonito, Gerardo Botti, Giovanni Nassa, Alessandro Weisz & Giorgio Giurato. (2020) Small Non-Coding RNA Profiling Identifies miR-181a-5p as a Mediator of Estrogen Receptor Beta-Induced Inhibition of Cholesterol Biosynthesis in Triple-Negative Breast Cancer. Cells 9:4, pages 874.
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Mingchuan Zhao, Mengmeng Zhang, Zhonghua Tao, Jun Cao, Leiping Wang & Xichun Hu. (2020) miR-331-3p Suppresses Cell Proliferation in TNBC Cells by Downregulating NRP2. Technology in Cancer Research & Treatment 19, pages 153303382090582.
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Yu-Te Liu, Chao-Hsiang Hsiao, Bor-Show Tzang & Tsai-Ching Hsu. (2019) In vitro and in vivo effects of traditional Chinese medicine formula T33 in human breast cancer cells. BMC Complementary and Alternative Medicine 19:1.
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Xiaoqing Guan, Shucheng Gu, Mu Yuan, Xiangxin Zheng & Ji Wu. (2019) MicroRNA‑33a‑5p overexpression sensitizes triple‑negative breast cancer to doxorubicin by inhibiting eIF5A2 and epithelial‑mesenchymal transition. Oncology Letters.
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Xiaolong Wang, Tong Chen, Yan Zhang, Ning Zhang, Chen Li, Yaming Li, Ying Liu, Hanwen Zhang, Wenjing Zhao, Bing Chen, Lijuan Wang & Qifeng Yang. (2019) Long noncoding RNA Linc00339 promotes triple‐negative breast cancer progression through miR‐377‐3p/HOXC6 signaling pathway. Journal of Cellular Physiology 234:8, pages 13303-13317.
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M. V. Giuli, E. Giuliani, I. Screpanti, D. Bellavia & S. Checquolo. (2019) Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype. Journal of Oncology 2019, pages 1-15.
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Jeremy Johnson, Piotr Rychahou, Vitaliy M. Sviripa, Heidi L. Weiss, Chunming Liu, David S. Watt & B. Mark Evers. (2019) Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers. PLOS ONE 14:3, pages e0209392.
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Malamati Kourti, Andrew Westwell, Wen Jiang & Jun Cai. (2019) Repurposing old carbon monoxide-releasing molecules towards the anti-angiogenic therapy of triple-negative breast cancer. Oncotarget 10:10, pages 1132-1148.
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Maryam Nakhjavani, Jennifer E Hardingham, Helen M Palethorpe, Tim J Price & Amanda R Townsend. (2019) Druggable Molecular Targets for the Treatment of Triple Negative Breast Cancer. Journal of Breast Cancer 22:3, pages 341.
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Eunae KimHyun Jung KimHa-Na OhAh-Won KwakSu-Nam KimBok Yun KangSeung-Sik ChoJung-Hyun ShimGoo Yoon. (2019) Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells . Natural Product Sciences 25:1, pages 72.
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Adriana-Andreea Jitariu, Marius Raica, Anca Maria Cîmpean & Silviu Cristian Suciu. (2018) The role of PDGF-B/PDGFR-BETA axis in the normal development and carcinogenesis of the breast. Critical Reviews in Oncology/Hematology 131, pages 46-52.
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Guan‐Jun Yang, Wanhe Wang, Simon Wing Fai Mok, Chun Wu, Betty Yuen Kwan Law, Xiang‐Min Miao, Ke‐Jia Wu, Hai‐Jing Zhong, Chun‐Yuen Wong, Vincent Kam Wai Wong, Dik‐Lung Ma & Chung‐Hang Leung. (2018) Selective Inhibition of Lysine‐Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple‐Negative Breast Cancer Therapy. Angewandte Chemie International Edition 57:40, pages 13091-13095.
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Guan‐Jun Yang, Wanhe Wang, Simon Wing Fai Mok, Chun Wu, Betty Yuen Kwan Law, Xiang‐Min Miao, Ke‐Jia Wu, Hai‐Jing Zhong, Chun‐Yuen Wong, Vincent Kam Wai Wong, Dik‐Lung Ma & Chung‐Hang Leung. (2018) Selective Inhibition of Lysine‐Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple‐Negative Breast Cancer Therapy. Angewandte Chemie 130:40, pages 13275-13279.
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Xu Yan, Yu Yu, Lingyu Li, Naifei Chen, Wei Song, Hua He, Jie Dong, Xiangliang Liu & Jiuwei Cui. (2018) Friend leukemia virus integration 1 is a predictor of poor prognosis of breast cancer and promotes metastasis and cancer stem cell properties of breast cancer cells. Cancer Medicine 7:8, pages 3548-3560.
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Jee Young Kim, Thien T. P. Dao, Kwangho Song, Sait Byul Park, Hyeri Jang, Min Kyoung Park, Soo Ueng Gan & Yeong Shik Kim. (2018) Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells . Evidence-Based Complementary and Alternative Medicine 2018, pages 1-10.
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Nicola Ternette, Marloes J. M. Olde Nordkamp, Julius Müller, Amanda P. Anderson, Annalisa Nicastri, Adrian V. S. Hill, Benedikt M. Kessler & Demin Li. (2018) Immunopeptidomic Profiling of HLA-A2-Positive Triple Negative Breast Cancer Identifies Potential Immunotherapy Target Antigens. PROTEOMICS 18:12, pages 1700465.
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Suyeong Nam, Song Yi Lee, Jung-Jin Kim, Wie-Soo Kang, In-Soo Yoon & Hyun-Jong Cho. (2018) Polydopamine-coated nanocomposites of Angelica gigas Nakai extract and their therapeutic potential for triple-negative breast cancer cells. Colloids and Surfaces B: Biointerfaces 165, pages 74-82.
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Jill J. J. Geenen, Sabine C. Linn, Jos H. Beijnen & Jan H. M. Schellens. (2017) PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer. Clinical Pharmacokinetics 57:4, pages 427-437.
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Annet Bens, Fotios C. Papadopoulos, Eero Pukkala, Anders Ekbom, Mika Gissler & Lene Mellemkjær. (2017) Worse survival after breast cancer in women with anorexia nervosa. Breast Cancer Research and Treatment 168:2, pages 495-500.
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Jeison Garcia & Fernando Lizcano. (2018) Kdm4c is Recruited to Mitotic Chromosomes and Is Relevant for Chromosomal Stability, Cell Migration and Invasion of Triple Negative Breast Cancer Cells. Breast Cancer: Basic and Clinical Research 12, pages 117822341877307.
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Natasha Borah, Shimara Gunawardana, Haydee Torres, Susan McDonnell & Severine Van Slambrouck. (2017) 5,6,7,3′,4′,5′-Hexamethoxyflavone inhibits growth of triple-negative breast cancer cells via suppression of MAPK and Akt signaling pathways and arresting cell cycle. International Journal of Oncology 51:6, pages 1685-1693.
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Sadiq M.I. Saleh, Nicholas Bertos, Tina Gruosso, Mathieu Gigoux, Margarita Souleimanova, Hong Zhao, Atilla Omeroglu, Michael T. Hallett & Morag Park. (2017) Identification of Interacting Stromal Axes in Triple-Negative Breast Cancer. Cancer Research 77:17, pages 4673-4683.
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Ann P. Lawson, Daniel W. Bak, D. Alexander Shannon, Marcus J.C. Long, Tushara Vijaykumar, Runhan Yu, Farid El Oualid, Eranthie Weerapana & Lizbeth Hedstrom. (2017) Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry. Oncotarget 8:31, pages 51296-51316.
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Concetta Di Mauro, Roberta Rosa, Valentina D'Amato, Paola Ciciola, Alberto Servetto, Roberta Marciano, Roberta Clara Orsini, Luigi Formisano, Sandro De Falco, Valeria Cicatiello, Maurizio Di Bonito, Monica Cantile, Francesca Collina, Angela Chambery, Bianca Maria Veneziani, Sabino De Placido & Roberto Bianco. (2017) Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers. British Journal of Cancer 116:11, pages 1425-1435.
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Yong Jin Oh & Young Ho Seo. (2017) A novel chalcone-based molecule, BDP inhibits MDA-MB-231 triple-negative breast cancer cell growth by suppressing Hsp90 function. Oncology Reports 38:4, pages 2343-2350.
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Megan M. Bernard, Jason R. McConnery & David W. Hoskin. (2017) [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Experimental and Molecular Pathology 102:2, pages 370-376.
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Xiaoran Liu, Huiping Li, Bin Shao, Jianmin Wu, Weiyao Kong, Guohong Song, Hanfang Jiang, Jing Wang & Fengling Wan. (2017) Identification of recurrent BRCA1 mutation and its clinical relevance in Chinese Triple-negative breast cancer cohort. Cancer Medicine 6:3, pages 547-554.
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Matthew L. Smith, Kaylee Murphy, Carolyn D. Doucette, Anna L. Greenshields & David W. Hoskin. (2016) The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells. Journal of Cellular Biochemistry 117:8, pages 1913-1925.
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Pradip De, Jennifer H. Carlson, Hui Wu, Adam Marcus, Brian Leyland-Jones & Nandini Dey. (2016) Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers. Oncotarget 7:28, pages 43124-43149.
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Yong Han, Shenyi Lian, Xingran Cui, Kexin Meng, Balázs Győrffy, Tao Jin & Dongsheng Huang. (2016) Potential options for managing LOX+ ER− breast cancer patients. Oncotarget 7:22, pages 32893-32901.
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Young-Ae Kim, Hee Jin Lee, Sun-Hee Heo, Hye Seon Park, Suk Young Park, WonSeon Bang, In Hye Song, In Ah Park & Gyungyub Gong. (2016) MxA expression is associated with tumor-infiltrating lymphocytes and is a prognostic factor in triple-negative breast cancer. Breast Cancer Research and Treatment 156:3, pages 597-606.
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Anna Wawruszak, Jarogniew J. Luszczki, Aneta Grabarska, Ewelina Gumbarewicz, Magdalena Dmoszynska-Graniczka, Krzysztof Polberg & Andrzej Stepulak. (2015) Assessment of Interactions between Cisplatin and Two Histone Deacetylase Inhibitors in MCF7, T47D and MDA-MB-231 Human Breast Cancer Cell Lines – An Isobolographic Analysis. PLOS ONE 10:11, pages e0143013.
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