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Expert Opinion on Pharmacotherapy Volume 16, 2015 - Issue 9
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Drug Evaluation

Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia

Anya K HotinskiRoyal Adelaide Hospital, Leukaemia Fellow, SA Pathology, Adelaide, SA 5000, Australia
, BSc (Hons) BMBS,
Ian D LewisRoyal Adelaide Hospital, SA Pathology, Adelaide, SA 5000, Australia;University of Adelaide, School of Medicine, Adelaide, SA 5000, Australia
, MBBS PhD FRACP FRCPA (Associate Professor, Clinical Director of Haematology) &
David M RossUniversity of Adelaide, School of Medicine, Adelaide, SA 5000, Australia;Consultant Haematologist,Royal Adelaide Hospital, SA Pathology, PO Box 14 Rundle Mall, Adelaide, SA 5000, Australia+61 8 8222 3228; [email protected];Flinders University and Medical Centre, Bedford Park, SA 5042, Australia
, MBBS PhD FRACP FRCPA (Consultant Haematologist)
Pages 1395-1402 | Published online: 10 May 2015

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Hadeer K. Swedan, Asmaa E. Kassab, Ehab M. Gedawy & Salwa E. Elmeligie. (2023) Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 118-137.
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Soňa Jantová, Ema Paulovičová, Lucia Paulovičová, Dominika Topoľská, Miroslav Pánik & Viktor Milata. (2017) Assessment of Immunomodulatory Activities and in vitro Toxicity of New Quinolone 7-ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo[3,4-h]quinoline-7-carboxylate. Immunological Investigations 46:4, pages 341-360.
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Kayleigh R. Marx, Hagop Kantarjian & Farhad Ravandi. (2016) Vosaroxin: innovative anticancer quinolone for the treatment of acute myelogenous leukemia. Expert Opinion on Orphan Drugs 4:8, pages 885-892.
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Xavier Thomas & Caroline Le Jeune. (2016) The safety of treatment options for elderly people with acute myeloid leukemia. Expert Opinion on Drug Safety 15:5, pages 635-645.
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Articles from other publishers (9)

Claudia Mugnaini, Filomena Sannio, Antonella Brizzi, Rosita Del Prete, Tiziana Simone, Teresa Ferraro, Filomena De Luca, Federico Corelli & Jean-Denis Docquier. (2020) Screen of Unfocused Libraries Identified Compounds with Direct or Synergistic Antibacterial Activity. ACS Medicinal Chemistry Letters 11:5, pages 899-905.
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Noor Mamdooh, Violet Kasabri, Yusuf Al‐Hiari, Ihab Almasri, Sundus Al‐Alawi & Yasser Bustanji. (2018) Evaluation of selected commercial pharmacotherapeutic drugs as potential pancreatic lipase inhibitors and antiproliferative compounds. Drug Development Research 80:3, pages 310-324.
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Omneya M. Khalil, Ehab M. Gedawy, Afaf A. El-Malah & Mina E. Adly. (2019) Novel nalidixic acid derivatives targeting topoisomerase II enzyme; Design, synthesis, anticancer activity and effect on cell cycle profile. Bioorganic Chemistry 83, pages 262-276.
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Wei Hu, Xu-Sheng Huang, Ji-Feng Wu, Liang Yang, Yong-Tang Zheng, Yue-Mao Shen, Zhi-Yu Li & Xun Li. (2018) Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches. Journal of Medicinal Chemistry 61:20, pages 8947-8980.
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Xian-Li Zhao & Chun-Zhi Yu. (2018) Vosaroxin induces mitochondrial dysfunction and apoptosis in cervical cancer HeLa cells: Involvement of AMPK/Sirt3/HIF-1 pathway. Chemico-Biological Interactions 290, pages 57-63.
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Soňa Jantová, Ema Paulovičová, Lucia Paulovičová, Michaela Janošková, Miroslav Pánik & Viktor Milata. (2018) Immunobiological efficacy and immunotoxicity of novel synthetically prepared fluoroquinolone ethyl 6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate. Immunobiology 223:1, pages 81-93.
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Xavier Poiré, Myriam Labopin, Johan Maertens, Ibrahim Yakoub-Agha, Didier Blaise, Norbert Ifrah, Gérard Socié, Tobias Gedde-Dhal, Nicolaas Schaap, Jan J. Cornelissen, Stéphane Vigouroux, Jaime Sanz, Lucienne Michaux, Jordi Esteve, Mohamad Mohty & Arnon Nagler. (2017) Allogeneic stem cell transplantation in adult patients with acute myeloid leukaemia and 17p abnormalities in first complete remission: a study from the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT). Journal of Hematology & Oncology 10:1.
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Xavier Thomas & Caroline Le Jeune. (2017) Treatment of Elderly Patients With Acute Myeloid Leukemia. Current Treatment Options in Oncology 18:1.
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Marianne Jarfelt, Niels H. Andersen & Henrik Hasle. (2016) Is it possible to cure childhood acute myeloid leukaemia without significant cardiotoxicity?. British Journal of Haematology 175:4, pages 577-587.
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