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Expert Opinion on Pharmacotherapy Volume 16, 2015 - Issue 18
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Modulation of sensitivity and resistance to multikinase inhibitors by microenvironmental platelet factors in HCC

Rosalba D’AlessandroLaboratory of Cellular Biology, National Institute for Digestive Diseases, IRCCS “Saverio de Bellis”, Via Turi 27, Castellana Grotte, BA70013, Italy
,
Caterina MessaLaboratory of Cellular Biology, National Institute for Digestive Diseases, IRCCS “Saverio de Bellis”, Via Turi 27, Castellana Grotte, BA70013, Italy
,
Maria Grazia RefoloLaboratory of Cellular Biology, National Institute for Digestive Diseases, IRCCS “Saverio de Bellis”, Via Turi 27, Castellana Grotte, BA70013, Italy
&
Brian I. CarrLaboratory of Cellular Biology, National Institute for Digestive Diseases, IRCCS “Saverio de Bellis”, Via Turi 27, Castellana Grotte, BA70013, Italy;Visiting Professor, Program for Targeted Experimental Therapeutics, Izmir Biomedicine and Genome Center, Dokuz Eylul University, Izmir, TurkeyCorrespondence[email protected]
Pages 2773-2780 | Published online: 19 Oct 2015

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Qi-Rui Li, Hua-Zhen Xu, Rong-Cheng Xiao, Yan Liu, Jun-Ming Tang, Jian Li, Ting-Ting Yu, Bin Liu, Liu-Gen Li, Mei-Fang Wang, Ning Han, Yong-Hong Xu, Chao Wang, Naoki Komatsu, Li Zhao, Xing-Chun Peng, Tong-Fei Li & Xiao Chen. (2022) Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery. Drug Delivery 29:1, pages 937-949.
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Giovanni Marasco, Francesco Poggioli, Antonio Colecchia, Giuseppe Cabibbo, Filippo Pelizzaro, Edoardo Giannini, Sara Marinelli, Gian Rapaccini, Eugenio Caturelli, Mariella Di Marco, Elisabetta Biasini, Fabio Marra, Filomena Morisco, Francesco Foschi, Marco Zoli, Antonio Gasbarrini, Gianluca Svegliati Baroni, Alberto Masotto, Rodolfo Sacco, Giovanni Raimondo, Francesco Azzaroli, Andrea Mega, Gianpaolo Vidili, Maurizia Brunetto, Gerardo Nardone, Luigina Alemanni, Elton Dajti, Federico Ravaioli, Davide Festi & Franco Trevisani. (2021) A Nomogram-Based Prognostic Model for Advanced Hepatocellular Carcinoma Patients Treated with Sorafenib: A Multicenter Study. Cancers 13:11, pages 2677.
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Yanghong Ni, Xiaoting Zhou, Jia Yang, Houhui Shi, Hongyi Li, Xia Zhao & Xuelei Ma. (2021) The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment. Frontiers in Cell and Developmental Biology 9.
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Gundula Streubel, Sabine Schrepfer, Hannah Kallus, Ulrike Parnitzke, Tanja Wulff, Frank Hermann, Matthias Borgmann & Svetlana Hamm. (2021) Histone deacetylase inhibitor resminostat in combination with sorafenib counteracts platelet-mediated pro-tumoral effects in hepatocellular carcinoma. Scientific Reports 11:1.
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Yangyang Guo, Hengyue Zhu, Min Weng, Bicheng Chen, Cheng Wang & Linxiao Sun. (2020) Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration. Biomedicine & Pharmacotherapy 128, pages 110366.
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Maria Grazia Refolo, Caterina Messa, Vito Guerra, Brian Irving Carr & Rosalba D’Alessandro. (2020) Inflammatory Mechanisms of HCC Development. Cancers 12:3, pages 641.
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Peter Dietrich, Anne Gaza, Laura Wormser, Valerie Fritz, Claus Hellerbrand & Anja Katrin Bosserhoff. (2019) Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Is a Novel Prognostic Marker and Contributes to Sorafenib Resistance in Hepatocellular Carcinoma. Neoplasia 21:3, pages 257-268.
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Peter Dietrich, Andreas Koch, Valerie Fritz, Arndt Hartmann, Anja Katrin Bosserhoff & Claus Hellerbrand. (2018) Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance. Gut 67:7, pages 1328-1341.
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Rosalba D’Alessandro, Maria Grazia Refolo, Catia Lippolis, Nicola Carella, Caterina Messa, Aldo Cavallini & Brian Irving Carr. (2018) Strong enhancement by IGF1-R antagonists of hepatocellular carcinoma cell migration inhibition by Sorafenib and/or vitamin K1. Cellular Oncology 41:3, pages 283-296.
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Maria Grazia Refolo, Rosalba D’Alessandro, Catia Lippolis, Nicola Carella, Aldo Cavallini, Caterina Messa & Brian Irving Carr. (2017) IGF-1R tyrosine kinase inhibitors and Vitamin K1 enhance the antitumor effects of Regorafenib in HCC cell lines. Oncotarget 8:61, pages 103465-103476.
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Liye Cao, Quan Zhang, Shujie Cheng, Zhi Chen, Zhijuan Hua, Jihong Yang, Dan Liu & Na Cui. (2016) Long non-coding RNAs and genes contributing to the generation of cancer stem cells in hepatocellular carcinoma identified by RNA sequencing analysis. Oncology Reports.
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Brian I. Carr. 2016. Hepatocellular Carcinoma. Hepatocellular Carcinoma 579 584 .

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