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Expert Opinion on Pharmacotherapy Volume 17, 2016 - Issue 4
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Editorial

Tau aggregation inhibitors: the future of Alzheimer’s pharmacotherapy?

Francesco PanzaNeurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy;Department of Clinical Research in Neurology, University of Bari Aldo Moro, ‘Pia Fondazione Cardinale G. Panico’, Lecce, Italy;Geriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS ‘Casa Sollievo della Sofferenza’, Foggia, ItalyCorrespondence[email protected] [email protected]
,
Davide SeripaGeriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS ‘Casa Sollievo della Sofferenza’, Foggia, Italy
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Vincenzo SolfrizziGeriatric Medicine-Memory Unit and Rare Disease Centre, University of Bari Aldo Moro, Bari, Italy
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Bruno P. ImbimboResearch & Development Department, Chiesi Farmaceutici, Parma, Italy
,
Andrea SantamatoPhysical Medicine and Rehabilitation Section, ‘OORR’ Hospital, University of Foggia, Foggia, Italy
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Madia LozuponeNeurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy
,
Rosa CapozzoNeurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy;Department of Clinical Research in Neurology, University of Bari Aldo Moro, ‘Pia Fondazione Cardinale G. Panico’, Lecce, Italy
,
Camilla PreteDepartment of OrthoGeriatrics, Rehabilitation and Stabilization, Frailty Area, E.O. Galliera NR-HS Hospital, Genova, Italy
,
Alberto PilottoDepartment of OrthoGeriatrics, Rehabilitation and Stabilization, Frailty Area, E.O. Galliera NR-HS Hospital, Genova, Italy
,
Antonio GrecoGeriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS ‘Casa Sollievo della Sofferenza’, Foggia, Italy
&
Giancarlo LogroscinoNeurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy;Department of Clinical Research in Neurology, University of Bari Aldo Moro, ‘Pia Fondazione Cardinale G. Panico’, Lecce, Italy
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Pages 457-461 | Received 22 Oct 2015, Accepted 22 Jan 2016, Published online: 15 Feb 2016

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Simranjeet Singh Narang, Deepti Goyal & Bhupesh Goyal. (2020) Inhibition of Alzheimer’s amyloid-β42 peptide aggregation by a bi-functional bis-tryptoline triazole: key insights from molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 38:6, pages 1598-1611.
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Francisco Salgado, Julio Caballero, Reinaldo Vargas, Alberto Cornejo & Carlos Areche. (2020) Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor. Natural Product Research 34:5, pages 646-650.
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Ali Shoeibi, Nahid Olfati & Irene Litvan. (2018) Preclinical, phase I, and phase II investigational clinical trials for treatment of progressive supranuclear palsy. Expert Opinion on Investigational Drugs 27:4, pages 349-361.
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Articles from other publishers (13)

Shivani Bagga & Manish Kumar. (2023) Current Status of Alzheimer’s Disease and Pathological Mechanisms Investigating the Therapeutic Molecular Targets. Current Molecular Medicine 23:6, pages 492-508.
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Masood Sadiq Butt, Urwa Tariq, Iahtisham‐Ul‐Haq, Ambreen Naz & Muhammad Rizwan. (2021) Neuroprotective effects of oleuropein: Recent developments and contemporary research. Journal of Food Biochemistry 45:12.
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Rajdeep Kaur, Rajneet Kaur Saini, Pritpal Singh & Bhupesh Goyal. (2021) Unveiling the inhibitory mechanism of peptidomimetic inhibitor against Aβ42 aggregation and protofibril disaggregation by molecular dynamics. Journal of Molecular Liquids 335, pages 116474.
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Navid Rabiee, Sepideh Ahmadi, Ronak Afshari, Samira Khalaji, Mohammad Rabiee, Mojtaba Bagherzadeh, Yousef Fatahi, Rassoul Dinarvand, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin & Thomas J. Webster. (2020) Polymeric Nanoparticles for Nasal Drug Delivery to the Brain: Relevance to Alzheimer's Disease. Advanced Therapeutics 4:3, pages 2000076.
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M. Catarina Silva & Stephen J. Haggarty. (2020) Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. International Journal of Molecular Sciences 21:23, pages 8948.
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Kadja L.C. Monteiro, Marcone G. dos S. Alcântara, Thiago M. de Aquino & Edeildo F. da Silva-Júnior. (2020) Tau Protein Aggregation in Alzheimer's Disease: Recent Advances in the Development of Novel Therapeutic Agents. Current Pharmaceutical Design 26:15, pages 1682-1692.
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Matías Silva, Valentina Caro, Camila Guzmán, George Perry, Carlos Areche & Alberto Cornejo. 2020. Bioactive Natural Products. Bioactive Natural Products 1 25 .
Kailash Prasad. (2019) AGE–RAGE stress: a changing landscape in pathology and treatment of Alzheimer’s disease. Molecular and Cellular Biochemistry 459:1-2, pages 95-112.
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Anuradha Venkatramani & Dulal Panda. (2019) Regulation of neuronal microtubule dynamics by tau: Implications for tauopathies. International Journal of Biological Macromolecules 133, pages 473-483.
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Hossein Haghaei, Seyed Rafie Aref Hosseini, Somaieh Soltani, Farzaneh Fathi, Farzad Mokhtari, Saeed Karima & Mohammad-Reza Rashidi. (2019) Kinetic and thermodynamic study of beta-Boswellic acid interaction with Tau protein investigated by surface plasmon resonance and molecular modeling methods. BioImpacts 10:1, pages 17-25.
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Carlos Areche, Francisca Zapata, Mathias González, Esteban Díaz, Rubén Montecinos, Marcos Hernández, Francisco Melo & Alberto Cornejo. (2019) Anthraquinone Derivative Reduces Tau Oligomer Progression by Inhibiting Cysteine‐Cysteine Interaction. ChemistryOpen 8:5, pages 554-559.
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K. Tsafou, P.B. Tiwari, J.D. Forman-Kay, S.J. Metallo & J.A. Toretsky. (2018) Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm. Journal of Molecular Biology 430:16, pages 2321-2341.
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S. Quraishe, C.M. Cowan & A. Mudher. 2017. Neuroprotection in Alzheimer's Disease. Neuroprotection in Alzheimer's Disease 73 96 .

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