215
Views
45
CrossRef citations to date
0
Altmetric
Review

Ras/Raf signalling and emerging pharmacotherapeutic targets

Pages 709-718 | Published online: 25 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Paul Workman. (2002) Cancer genome targets: RAF-ing up tumor cells to overcome oncogene addiction. Expert Review of Anticancer Therapy 2:6, pages 611-614.
Read now
John T Lee Jr & James A McCubrey. (2002) Targeting the Raf kinase cascade in cancer therapy – novel molecular targets and therapeutic strategies. Expert Opinion on Therapeutic Targets 6:6, pages 659-678.
Read now

Articles from other publishers (43)

Mayu Yoshida, Haruna Nagao, Hajime Sugiyama, Masaaki Sawa & Takayoshi Kinoshita. (2022) Identification of a novel target site for ATP-independent ERK2 inhibitors. Biochemical and Biophysical Research Communications 593, pages 73-78.
Crossref
Hongyue Li, Dandan Xi, Yan Niu, Chao Wang, Fengrong Xu, Lei Liang & Ping Xu. (2019) Design, synthesis and biological evaluation of cobalt(II)-Schiff base complexes as ATP-noncompetitive MEK1 inhibitors. Journal of Inorganic Biochemistry 195, pages 174-181.
Crossref
Haet Lim, Seung Baek & Hye Jung. (2019) Bee Venom and Its Peptide Component Melittin Suppress Growth and Migration of Melanoma Cells via Inhibition of PI3K/AKT/mTOR and MAPK Pathways. Molecules 24:5, pages 929.
Crossref
Jingwei Liang, Mingyang Wang, Xinyang Li, Xin He, Chong Cao & Fanhao Meng. (2017) Determination of Structural Requirements of N-Substituted Tetrahydro-β-Carboline Imidazolium Salt Derivatives Using in Silico Approaches for Designing MEK-1 Inhibitors. Molecules 22:6, pages 1020.
Crossref
Sung-Young Shin & Lan K. Nguyen. 2017. ERK Signaling. ERK Signaling 409 432 .
Jialin Shang, Shaoyong Lu, Yongjun Jiang & Jian Zhang. (2016) Allosteric modulators of MEK1: drug design and discovery. Chemical Biology & Drug Design 88:4, pages 485-497.
Crossref
Chao-Feng Lin, Han-Li Huang, Chieh-Yu Peng, Yu-Ching Lee, Hui-Po Wang, Che-Ming Teng & Shiow-Lin Pan. (2016) TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis. Toxicology and Applied Pharmacology 305, pages 194-202.
Crossref
Takayoshi Kinoshita, Hajime Sugiyama, Yurika Mori, Naruhide Takahashi & Atsushi Tomonaga. (2016) Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay. Bioorganic & Medicinal Chemistry Letters 26:3, pages 955-958.
Crossref
Jun-ying Wang, Shu-ping Chen, Yong-hui Gao, Li-na Qiao, Jian-liang Zhang & Jun-ling Liu. (2015) Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-10.
Crossref
Wenjing Zheng, Chengwen Cao, Yanan Liu, Qianqian Yu, Chuping Zheng, Dongdong Sun, Xiaofan Ren & Jie Liu. (2015) Multifunctional polyamidoamine-modified selenium nanoparticles dual-delivering siRNA and cisplatin to A549/DDP cells for reversal multidrug resistance. Acta Biomaterialia 11, pages 368-380.
Crossref
YU-CHIEH SU, CHIH-CHIA YU, FEI-TING HSU, SHU-LING FU, JENG-JONG HWANG, LING-CHIEN HUNG, MOON-SING LEE, WEN-YEN CHIOU, HON-YI LIN & SHIH-KAI HUNG. (2014) Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway. International Journal of Molecular Medicine 34:5, pages 1417-1422.
Crossref
Warangkana Lohcharoenkal, Liying Wang, Todd A. Stueckle, Jino Park, William Tse, Cerasela-Zoica Dinu & Yon Rojanasakul. (2014) Role of H-Ras/ERK signaling in carbon nanotube-induced neoplastic-like transformation of human mesothelial cells. Frontiers in Physiology 5.
Crossref
Lei Zhang, Horace H. Loh & Ping-Yee Law. (2013) A Novel Noncanonical Signaling Pathway for the µ -Opioid Receptor . Molecular Pharmacology 84:6, pages 844-853.
Crossref
Christopher F. Harrison, Sébastien Kicka, Valentin Trofimov, Kathrin Berschl, Hajer Ouertatani-Sakouhi, Nikolaus Ackermann, Christian Hedberg, Pierre Cosson, Thierry Soldati & Hubert Hilbi. (2013) Exploring Anti-Bacterial Compounds against Intracellular Legionella. PLoS ONE 8:9, pages e74813.
Crossref
Lei An, Wei Jia, Yang Yu, Ning Zou, Li Liang, Yanling Zhao, Yihui Fan, Jin Cheng, Zhongcheng Shi, Gufeng Xu, Grace Li, Jianhua Yang & Hong Zhang. (2013) Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling. Scientific Reports 3:1.
Crossref
Zhenli Hu, Ruohua Chen, Zhijian Cai, Lei Yu, Yang Fei, Lixia Weng, Jinghan Wang, Xiahui Ge, Tianyi Zhu, Jianli Wang & Chong Bai. (2012) Salmeterol attenuates the inflammatory response in asthma and decreases the pro-inflammatory cytokine secretion of dendritic cells. Cellular & Molecular Immunology 9:3, pages 267-275.
Crossref
O. L. Polanovski, E. N. Lebedenko & S. M. Deyev. (2012) ERBB oncogene proteins as targets for monoclonal antibodies. Biochemistry (Moscow) 77:3, pages 227-245.
Crossref
Alessia E. Russo, Ylenia Bevelacqua, Andrea Marconi, Andrea Veronesi & Massimo Libra. 2012. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma 265 279 .
CJ Hu, L Zhou, J Zhang, C Huang & GM Zhang. (2011) Immunohistochemical Detection of Raf Kinase Inhibitor Protein in Normal Cervical Tissue and Cervical Cancer Tissue. Journal of International Medical Research 39:1, pages 229-237.
Crossref
R. Dutt & A. K. Madan. (2010) Models for Prediction of V600EBRAF and Melanoma Cells Growth Inhibitory Activities of Pyridoimidazolones. Archiv der Pharmazie 343:11-12, pages 664-679.
Crossref
Reinhard Laubenbacher, Valerie Hower, Abdul Jarrah, Suzy V. Torti, Vladimir Shulaev, Pedro Mendes, Frank M. Torti & Steven Akman. (2009) A systems biology view of cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1796:2, pages 129-139.
Crossref
Tobias Sinnberg, Konstantinos Lasithiotakis, Heike Niessner, Birgit Schittek, Keith T. Flaherty, Dagmar Kulms, Evelyn Maczey, Minia Campos, Jeannette Gogel, Claus Garbe & Friedegund Meier. (2009) Inhibition of PI3K-AKT-mTOR Signaling Sensitizes Melanoma Cells to Cisplatin and Temozolomide. Journal of Investigative Dermatology 129:6, pages 1500-1515.
Crossref
Sung-Young Shin, Oliver Rath, Sang-Mok Choo, Frances Fee, Brian McFerran, Walter Kolch & Kwang-Hyun Cho. (2009) Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway. Journal of Cell Science 122:3, pages 425-435.
Crossref
Marian Case, Elizabeth Matheson, Lynne Minto, Rosline Hassan, Christine J. Harrison, Nick Bown, Simon Bailey, Josef Vormoor, Andrew G. Hall & Julie A.E. Irving. (2008) Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia. Cancer Research 68:16, pages 6803-6809.
Crossref
Jürgen Borlak & Hans Stephan Jenke. (2008) Cross-talk between Aryl Hydrocarbon Receptor and Mitogen-Activated Protein Kinase Signaling Pathway in Liver Cancer through c-raf Transcriptional Regulation. Molecular Cancer Research 6:8, pages 1326-1336.
Crossref
Hong Zhao Li, Yue Wang, Yan Gao, Jie Shao, Xiu Lan Zhao, Wei Min Deng, Yi Xin Liu, Jie Yang & Zhi Yao. (2008) Effects of Raf Kinase Inhibitor Protein Expression on Metastasis and Progression of Human Epithelial Ovarian Cancer. Molecular Cancer Research 6:6, pages 917-928.
Crossref
Mariana Varela, Matthew Golder, Fabienne Archer, Marcelo de las Heras, Caroline Leroux & Massimo Palmarini. (2008) A large animal model to evaluate the effects of Hsp90 inhibitors for the treatment of lung adenocarcinoma. Virology 371:1, pages 206-215.
Crossref
Joseph A. Sparano. 2008. Molecular Targeting in Oncology. Molecular Targeting in Oncology 55 73 .
Jana Wolf, Serge Dronov, Frank Tobin & Igor Goryanin. (2007) The impact of the regulatory design on the response of epidermal growth factor receptor‐mediated signal transduction towards oncogenic mutations. The FEBS Journal 274:21, pages 5505-5517.
Crossref
Jian Shi, Darryl K. Miles, Benjamin A. Orr, Stephen M. Massa & Steven G. Kernie. (2007) Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels. European Journal of Neuroscience 25:12, pages 3499-3512.
Crossref
Natalia Skobeleva, Sanjay Menon, Lutz Weber, Erica A. Golemis & Vladimir Khazak. (2007) In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway– and microtubule-targeting inhibitors . Molecular Cancer Therapeutics 6:3, pages 898-906.
Crossref
Takayoshi Kinoshita, Masaichi Warizaya, Makoto Ohori, Kentaro Sato, Masahiro Neya & Takashi Fujii. (2006) Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative. Bioorganic & Medicinal Chemistry Letters 16:1, pages 55-58.
Crossref
Lila Adnane, Pamela A. Trail, Ian Taylor & Scott M. Wilhelm. 2006. Regulators and Effectors of Small GTPases: Ras Family. Regulators and Effectors of Small GTPases: Ras Family 597 612 .
Suzanne Hagan, Fahd Al-Mulla, Elizabeth Mallon, Karin Oien, Rhona Ferrier, Barry Gusterson, Jorge J. Curto García & Walter Kolch. (2005) Reduction of Raf-1 Kinase Inhibitor Protein Expression Correlates with Breast Cancer Metastasis. Clinical Cancer Research 11:20, pages 7392-7397.
Crossref
Jun Zhu, Vitaly Balan, Agnieszka Bronisz, Karina Balan, Hengrui Sun, Deborah T. Leicht, Zhijun Luo, Jun Qin, Joseph Avruch & Guri Tzivion. (2005) Identification of Raf-1 S471 as a Novel Phosphorylation Site Critical for Raf-1 and B-Raf Kinase Activities and for MEK Binding. Molecular Biology of the Cell 16:10, pages 4733-4744.
Crossref
Junji Tsurutani, Kip A. West, Jacqueline Sayyah, Joell J. Gills & Phillip A. Dennis. (2005) Inhibition of the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway but not the MEK/ERK Pathway Attenuates Laminin-Mediated Small Cell Lung Cancer Cellular Survival and Resistance to Imatinib Mesylate or Chemotherapy. Cancer Research 65:18, pages 8423-8432.
Crossref
G Bocci, A Fioravanti, P Orlandi, N Bernardini, P Collecchi, M Del Tacca & R Danesi. (2005) Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. British Journal of Cancer 93:3, pages 319-330.
Crossref
Jing Yuan Fang & Bruce C Richardson. (2005) The MAPK signalling pathways and colorectal cancer. The Lancet Oncology 6:5, pages 322-327.
Crossref
Jeffrey F Ohren, Huifen Chen, Alexander Pavlovsky, Christopher Whitehead, Erli Zhang, Peter Kuffa, Chunhong Yan, Patrick McConnell, Cindy Spessard, Craig Banotai, W Thomas Mueller, Amy Delaney, Charles Omer, Judith Sebolt-Leopold, David T Dudley, Iris K Leung, Cathlin Flamme, Joseph Warmus, Michael Kaufman, Stephen Barrett, Haile Tecle & Charles A Hasemann. (2004) Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nature Structural & Molecular Biology 11:12, pages 1192-1197.
Crossref
Vladimir V. Lunin, Christine Munger, John Wagner, Zheng Ye, Miroslaw Cygler & Michael Sacher. (2004) The Structure of the MAPK Scaffold, MP1, Bound to Its Partner, p14. Journal of Biological Chemistry 279:22, pages 23422-23430.
Crossref
Nathan R Treff, Derek Pouchnik, Gregory A Dement, Rachel L Britt & Raymond Reeves. (2004) High-mobility group A1a protein regulates Ras/ERK signaling in MCF-7 human breast cancer cells. Oncogene 23:3, pages 777-785.
Crossref
Kathryn E. Mercer & Catrin A. Pritchard. (2003) Raf proteins and cancer: B-Raf is identified as a mutational target. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1653:1, pages 25-40.
Crossref
Tianhong Li & Joseph A. Sparano. (2003) Inhibiting Ras Signaling in the Therapy of Breast Cancer. Clinical Breast Cancer 3:6, pages 405-416.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.