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Drug Evaluation

Meloxicam: a reappraisal of pharmacokinetics, efficacy and safety

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Pages 2117-2140 | Published online: 03 Oct 2005

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Abdelrahman Mahmoud, Mohamed Abuelazm, Ali Ashraf Salah Ahmed, Mahmoud Elshinawy, Toka Ashour, Mohamed Abugdida & Basel Abdelazeem. (2023) Early perioperative versus postoperative meloxicam for pain control in patients undergoing orthopedic surgery: a systematic review and Meta-analysis of randomized controlled trials. Current Medical Research and Opinion 39:1, pages 113-122.
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Juliana Cyrillo Guimarães da Silva, Eliane Dallegrave, Gabriela Zimmermann Prado Rodrigues, Cassiana Bigolin, Taís Morgana Schoffen de Oliveira Neumann, Andriéli Carolina Schuster, Juliana Machado Kayser, Luciane Beatris Mentges Staudt, Melina Floriano Moraes, Débora Graziela Farias, Gabriela Schiling, Juliana Raquel Raasch, Magda Susana Perassolo, Luciano Basso da Silva, Günther Gehlen & Andresa Heemann Betti. (2022) Repeated dose of meloxicam induces genotoxicity and histopathological changes in cardiac tissue of mice. Drug and Chemical Toxicology 45:2, pages 822-833.
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Farzana S. Bandarkar & Pradeep R. Vavia. (2011) An optimized commercially feasible milling technique for molecular encapsulation of meloxicam in β-cyclodextrin. Drug Development and Industrial Pharmacy 37:11, pages 1318-1328.
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Jun-Cheng Chen, Fang Yang, Ming-Hui Duan, Ze-En Li, Yan Dai, Mei Zhang & Fan Yang. (2023) Pharmacokinetics of meloxicam in pigeons after single intravenous, oral, and intramuscular administration. Poultry Science 102:9, pages 102869.
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Hao-Tian Shao, Liang Gao, Hao-tian Li, Mei Zhang, Jun-Cheng Chen, Ming-Hui Duan, Ze-En Li, Yan Dai, Xing-Ping Li & Fan Yang. (2023) Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses. Poultry Science 102:8, pages 102761.
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Devran Coskun, Orhan Corum, Duygu Durna Corum, Gul Cetin, Mehmet Irmak, Hatice Rumeysa Ceyhan & Kamil Uney. (2023) Age‐related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep. Journal of Veterinary Pharmacology and Therapeutics.
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Sydney Song, Lindsey N. Druschel, E. Ricky Chan & Jeffrey R. Capadona. (2023) Differential expression of genes involved in the chronic response to intracortical microelectrodes. Acta Biomaterialia.
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Hadi Valizadeh, Ziba Islambulchilar, Keyhan Eskandarinia & Parvin Zakeri-Milani. (2022) Influence of Oil Phase Surface Properties on the Physicochemical Characteristics of Meloxicam Self-microemulsifying Drug Delivery Systems. Journal of Pharmaceutical Innovation 18:2, pages 381-390.
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Lixue Ma, Zhaohua Li, Jiancheng Fei, Mo Li, Bingyang Liu, Baocheng Tian, Yanhua Liu & Qiang Fu. (2023) In vivo behaviors of meloxicam nanocrystals by intravenous administration are not significantly affected by stabilizers. Journal of Drug Delivery Science and Technology 82, pages 104380.
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Ji‐Hun Jang, Seung‐Hyun Jeong & Yong‐Bok Lee. (2023) Dosage exploration of meloxicam according to CYP2C9 genetic polymorphisms based on a population pharmacokinetic‐pharmacodynamic model . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 43:2, pages 145-157.
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Nannan Ma, Ying Liu, Guixia Ling & Peng Zhang. (2022) Preparation of meloxicam-salicylic acid co-crystal and its application in the treatment of rheumatoid arthritis. Journal of Drug Delivery Science and Technology 74, pages 103542.
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Lingyun Ren, Li Meng, Hong Yan, Wei Sun & Dan Yao. (2020) Preoperative meloxicam versus postoperative meloxicam for pain control, patients’ satisfaction and function recovery in hip osteoarthritis patients who receive total hip arthroplasty: a randomized, controlled study. Inflammopharmacology 28:4, pages 831-838.
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A. Montesinos, M. Ardiaca, J. A. Gilabert, C. Bonvehí, J. Oros & T. Encinas. (2017) Pharmacokinetics of meloxicam after intravenous, intramuscular and oral administration of a single dose to African grey parrots ( Psittacus erithacus ) . Journal of Veterinary Pharmacology and Therapeutics 40:3, pages 279-284.
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Damien Hazelard, Pierre-Antoine Nocquet & Philippe Compain. (2017) Catalytic C–H amination at its limits: challenges and solutions. Organic Chemistry Frontiers 4:12, pages 2500-2521.
Crossref
A E Karateev & E N Nasonov. (2016) Meloxicam in Russia: 20 years together. Terapevticheskii arkhiv 88:12, pages 149-158.
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Prajakta S. Badri, Jennifer R. King, Akshanth R. Polepally, Barbara H. McGovern, Sandeep Dutta & Rajeev M. Menon. (2015) Dosing Recommendations for Concomitant Medications During 3D Anti-HCV Therapy. Clinical Pharmacokinetics 55:3, pages 275-295.
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Memy H. Hassan, Mohamed Ghobara & Gamil M. Abd-Allah. (2014) Modulator Effects of Meloxicam against Doxorubicin-Induced Nephrotoxicity in Mice. Journal of Biochemical and Molecular Toxicology 28:8, pages 337-346.
Crossref
Gabriella Tamasi & Renzo Cini. 2009. PATAI'S Chemistry of Functional Groups. PATAI'S Chemistry of Functional Groups 1 58 .
B. Kimble, K.M. Li, P. Valtchev, D.P. Higgins, M.B. Krockenberger & M. Govendir. (2014) In vitro hepatic microsomal metabolism of meloxicam in koalas (Phascolarctos cinereus), brushtail possums (Trichosurus vulpecula), ringtail possums (Pseudocheirus peregrinus), rats (Rattus norvegicus) and dogs (Canis lupus familiaris). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 161, pages 7-14.
Crossref
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Shipra Bhardwaj & K. L. Ameta. 2014. Green Chemistry: Synthesis of Bioactive Heterocycles. Green Chemistry: Synthesis of Bioactive Heterocycles 329 366 .
B. Kimble, L. A. Black, K. M. Li, P. Valtchev, S. Gilchrist, A. Gillett, D. P. Higgins, M. B. Krockenberger & M. Govendir. (2013) Pharmacokinetics of meloxicam in koalas ( Phascolarctos cinereus ) after intravenous, subcutaneous and oral administration . Journal of Veterinary Pharmacology and Therapeutics 36:5, pages 486-493.
Crossref
Daniel V. Fredholm, James W. Carpenter, Butch KuKanich & Micah Kohles. (2013) Pharmacokinetics of meloxicam in rabbits after oral administration of single and multiple doses. American Journal of Veterinary Research 74:4, pages 636-641.
Crossref
Benjamin KimbleKong Ming LiMerran Govendir. (2013) Quantitation of meloxicam in the plasma of koalas ( Phascolarctos cinereus ) by improved high performance liquid chromatography . Journal of Veterinary Science 14:1, pages 7.
Crossref
Clemens Lamberth & Jürgen Dinges. 2012. Bioactive Heterocyclic Compound Classes. Bioactive Heterocyclic Compound Classes 1 20 .
Clemens Lamberth & Jürgen Dinges. 2012. Bioactive Heterocyclic Compound Classes. Bioactive Heterocyclic Compound Classes 1 20 .
Howard S. Smith & Marco Pappagallo. 2012. Essential Pain Pharmacology. Essential Pain Pharmacology 283 285 .
Mario I. Ortiz, Gilberto Castañeda-Hernández, Jeannett A. Izquierdo-Vega, Manuel Sánchez-Gutiérrez, Héctor A. Ponce-Monter & Vinicio Granados-Soto. (2012) Role of ATP-sensitive K+ channels in the antinociception induced by non-steroidal anti-inflammatory drugs in streptozotocin-diabetic and non-diabetic rats. Pharmacology Biochemistry and Behavior 102:1, pages 163-169.
Crossref
Mohamed Edfawy, Memy H. Hassan, Ahmed Mansour, Abdel-Aziz Hamed & Hebat Allah A. Amin. (2012) Meloxicam Modulates Oxidative Stress Status, Inhibits Prostaglandin E2, and Abrogates Apoptosis in Carbon Tetrachloride–Induced Rat Hepatic Injury. International Journal of Toxicology 31:3, pages 276-286.
Crossref
Larry J. Minter, Elsburgh O. Clarke3rd3rd, Jenessa L. Gjeltema, Kate E. Archibald, Lysa P. Posner & Gregory A. Lewbart. (2011) Effects of Intramuscular Meloxicam Administration on Prostaglandin E2 Synthesis in the North American Bullfrog ( Rana catesbeiana ) . Journal of Zoo and Wildlife Medicine 42:4, pages 680-685.
Crossref
S. Montori, S. DosAnjos, M. A. Ríos-Granja, C. C. Pérez-García, A. Fernández-López & B. Martínez-Villayandre. (2010) AMPA receptor downregulation induced by ischaemia/reperfusion is attenuated by age and blocked by meloxicam. Neuropathology and Applied Neurobiology 36:5, pages 436-447.
Crossref
Yogeshwar Bachhav & Vandana Patravale. (2010) Formulation of meloxicam gel for topical application: In vitro and in vivo evaluation. Acta Pharmaceutica 60:2, pages 153-163.
Crossref
C. Jesam, A. M. Salvatierra, J. L. Schwartz & H. B. Croxatto. (2009) Suppression of follicular rupture with meloxicam, a cyclooxygenase-2 inhibitor: potential for emergency contraception. Human Reproduction 25:2, pages 368-373.
Crossref
James W. Carpenter, Christal G. Pollock, David E. Koch & Robert P. Hunter. (2009) Single and Multiple-Dose Pharmacokinetics of Meloxicam After Oral Administration to the Rabbit (Oryctolagus cuniculus). Journal of Zoo and Wildlife Medicine 40:4, pages 601-606.
Crossref
R Andrew Moore, Sheena Derry & Henry J McQuay. (2009) Single dose oral meloxicam for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2019:5.
Crossref
Thorsten Lehr, Alexander Staab, Christiane Tillmann, Dirk Trommeshauser, Hans-Guenter Schaefer & Charlotte Kloft. (2009) A Quantitative Enterohepatic Circulation Model. Clinical Pharmacokinetics 48:8, pages 529-542.
Crossref
V. V. Hynninen, K. T. Olkkola, L. Bertilsson, K. J. Kurkinen, T. Korhonen, P. J. Neuvonen & K. Laine. (2009) Voriconazole Increases while Itraconazole Decreases Plasma Meloxicam Concentrations. Antimicrobial Agents and Chemotherapy 53:2, pages 587-592.
Crossref
R Andrew Moore, Sheena Derry & Henry J McQuay. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Asokumar Buvanendran & Scott S. Reuben. 2008. Raj's Practical Management of Pain. Raj's Practical Management of Pain 671 692 .
Dianne Little, S. Aubrey Brown, Nigel B. Campbell, Adam J. Moeser, Jennifer L. Davis & Anthony T. Blikslager. (2007) Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum. American Journal of Veterinary Research 68:6, pages 614-624.
Crossref
Hossam M.M. Arafa, Mohamed H. Abdel-Wahab, Mohamed F. El-Shafeey, Osama A. Badary & Farid M.A. Hamada. (2007) Anti-fibrotic effect of meloxicam in a murine lung fibrosis model. European Journal of Pharmacology 564:1-3, pages 181-189.
Crossref
Manoj Shukla, Gurpreet Singh, B.G. Sindhura, A.G. Telang, G.S. Rao & J.K. Malik. (2007) Comparative plasma pharmacokinetics of meloxicam in sheep and goats following intravenous administration. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 145:4, pages 528-532.
Crossref
D. Williams, M. Singh & C. Hind. (2006) The effect of the withdrawal of rofecoxib on prescribing patterns of COX-2 inhibitors in Scotland. British Journal of Clinical Pharmacology 62:3, pages 366-368.
Crossref
. (2006) Current awareness: Pharmacoepidemiology and drug safety. Pharmacoepidemiology and Drug Safety 15:4.
Crossref

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