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Expert Opinion on Pharmacotherapy Volume 7, 2006 - Issue 11
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Drug Evaluation

Bosentan for the treatment of systemic sclerosis-associated pulmonary arterial hypertension, pulmonary fibrosis and digital ulcers

Manu Jain Division of Pulmonary and Critical Care, Feinberg School of Medicine, Northwestern University, 240 E. Huron Avenue, M-321, IL, USA. [email protected]
&
John Varga Division of Rheumatology, Feinberg School of Medicine, Northwestern University, IL, USA
Pages 1487-1501 | Published online: 21 Jul 2006

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Sabina Antonela Antoniu & Martin RJ Kolb. (2009) Update on models of pulmonary fibrosis therapy for preclinical drug research. Expert Opinion on Drug Discovery 4:9, pages 939-946.
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Sabina A Antoniu. (2008) Targeting the endothelin pathway in the idiopathic pulmonary fibrosis: the role of bosentan. Expert Opinion on Therapeutic Targets 12:9, pages 1077-1084.
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Articles from other publishers (18)

Shuang Li, Yong-li Pan, Wenqiang Xin & Chunhua Yan. (2022) The potential benefit of endothelin receptor antagonists’ therapy in idiopathic pulmonary fibrosis: A meta-analysis of results from randomized controlled trials. Medicine 101:40, pages e29981.
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Jonas Pedersen, Elise R. Hedegaard, Ulf Simonsen, Marcus Krüger, Manfred Infanger & Daniela Grimm. (2018) Current and Future Treatments for Persistent Pulmonary Hypertension in the Newborn. Basic & Clinical Pharmacology & Toxicology 123:4, pages 392-406.
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A De Cata, M Inglese, F Molinaro, S De Cosmo, R Rubino, M Bernal & G Mazzoccoli. (2015) Digital ulcers in scleroderma patients: A retrospective observational study. International Journal of Immunopathology and Pharmacology 29:2, pages 180-187.
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Antonia Valenzuela, Rasidat Adeduntan & Lorinda Chung. 2015. Raynaud’s Phenomenon. Raynaud’s Phenomenon 339 360 .
Kendal Jensen, Damir Nizamutdinov, Micheleine Guerrier, Syeda Afroze, David Dostal & Shannon Glaser. (2012) General mechanisms of nicotine‐induced fibrogenesis. The FASEB Journal 26:12, pages 4778-4787.
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Stephen C. Mathai & Paul M. Hassoun. (2012) Pulmonary Arterial Hypertension in Connective Tissue Diseases. Heart Failure Clinics 8:3, pages 413-425.
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Kait Arefiev, David F. Fiorentino & Lorinda Chung. (2011) Endothelin Receptor Antagonists for the Treatment of Raynaud's Phenomenon and Digital Ulcers in Systemic Sclerosis. International Journal of Rheumatology 2011, pages 1-7.
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Paul M. Hassoun. 2011. Textbook of Pulmonary Vascular Disease. Textbook of Pulmonary Vascular Disease 1011 1022 .
A. Kuhn, M. Haust, V. Ruland, R. Weber, P. Verde, G. Felder, C. Ohmann, K. Gensch & T. Ruzicka. (2010) Effect of bosentan on skin fibrosis in patients with systemic sclerosis: a prospective, open-label, non-comparative trial. Rheumatology 49:7, pages 1336-1345.
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Jérôme Le Pavec, Marc Humbert, Luc Mouthon & Paul M. Hassoun. (2010) Systemic Sclerosis-associated Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine 181:12, pages 1285-1293.
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Fredrick M. Wigley. (2008) Vascular Disease in Scleroderma. Clinical Reviews in Allergy & Immunology 36:2-3, pages 150-175.
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Masanori Funauchi, K. Kishimoto, H. Shimazu, Y. Nagare, S. Hino, T. Yano & K. Kinoshita. (2008) Effects of bosentan on the skin lesions: an observational study from a single center in Japan. Rheumatology International 29:7, pages 769-775.
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Yayoi NAGAI, Akira SHIMIZU & Osamu ISHIKAWA. (2008) Successful treatment with bosentan for refractory digital ulcers in a patient with systemic lupus erythematosus. The Journal of Dermatology 35:7, pages 447-451.
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T. Kisseleva & D. A. Brenner. (2008) Mechanisms of Fibrogenesis. Experimental Biology and Medicine 233:2, pages 109-122.
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John Varga & Fredrick M. Wigley. 2008. Clinical Immunology. Clinical Immunology 813 823 .
J. Cabanea. (2007) Bosentan et sclérodermie. La Revue de Médecine Interne 28, pages S211-S213.
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Lorinda Chung. (2007) Therapeutic Options for Digital Ulcers in Patients with Systemic Sclerosis. JDDG 5:6, pages 460-465.
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I. Rösener & A. Rübben. (2007) Behandlung eines Ulcus cruris mit Bosentan bei einer Patientin mit progressiver systemischer SklerodermieTreatment of a leg ulcer with bosentan in a female patient with progressive systemic scleroderma. Der Hautarzt 58:5, pages 392-393.
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