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Expert Opinion on Pharmacotherapy Volume 7, 2006 - Issue 13
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Defining the genetic aetiology of monogenic diabetes can improve treatment

Anna L Gloyn University Research Lecturer, Nuffield Department of Clinical Medicine Prize Fellow, Diabetes UK RD Lawrence Research Fellow, Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK. [email protected]
&
Sian Ellard Professor of Human Genetics, Institute of Biomedical & Clinical Science, Peninsula Medical School, Exeter, UK; Consultant Molecular Geneticist, Department of Molecular Genetics, Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter, EX2 5DW, UK. [email protected]
Pages 1759-1767 | Published online: 23 Aug 2006

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Christina L Aquilante. (2010) Sulfonylurea pharmacogenomics in Type 2 diabetes: the influence of drug target and diabetes risk polymorphisms. Expert Review of Cardiovascular Therapy 8:3, pages 359-372.
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Liu Yang, Chen Huang, Min Zhao, Priscilla M. Y. Lee, Cheng Zhang, Yongfu Yu, Bo Xi & Jiong Li. (2023) Maternal hypertensive disorders during pregnancy and the risk of offspring diabetes mellitus in childhood, adolescence, and early adulthood: a nationwide population-based cohort study. BMC Medicine 21:1.
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Yichen Dai, Rodrigo Pracana & Peter W. H. Holland. (2020) Divergent genes in gerbils: prevalence, relation to GC-biased substitution, and phenotypic relevance. BMC Evolutionary Biology 20:1.
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Pernille Svalastoga, Åsta Sulen, Jarle R. Fehn, Stein M. Aukland, Henrik Irgens, Eivind Sirnes, Silje K.E. Fevang, Eivind Valen, Irene B. Elgen & Pål R. Njølstad. (2020) Intellectual Disability in KATP Channel Neonatal Diabetes. Diabetes Care 43:3, pages 526-533.
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Nina ØyenLars J. DiazElisabeth LeirgulHeather A. BoydJames PriestElisabeth R. MathiesenThomas QuertermousJan WohlfahrtMads Melbye. (2016) Prepregnancy Diabetes and Offspring Risk of Congenital Heart Disease. Circulation 133:23, pages 2243-2253.
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Peter Kovacs & Ewan Pearson. 2016. The Genetics of Type 2 Diabetes and Related Traits. The Genetics of Type 2 Diabetes and Related Traits 483 497 .
Angeli M. van der Zwaag, Stephanie S. Weinreich, Astrid R. Bosma, Tessel Rigter, Monique Losekoot, Lidewij Henneman & Martina C. Cornel. (2015) Current and Best Practices of Genetic Testing for Maturity Onset Diabetes of the Young: Views of Professional Experts. Public Health Genomics 18:1, pages 52-59.
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Anke Tönjes & Peter Kovacs. (2013) SGLT2 : a potential target for the pharmacogenetics of Type 2 diabetes? . Pharmacogenomics 14:7, pages 825-833.
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Christina L. Aquilante & Y.W. Francis Lam. 2013. Pharmacogenomics. Pharmacogenomics 247 271 .
Gaia Chiara Mannino & Giorgio Sesti. (2012) Individualized Therapy for Type 2 Diabetes. Molecular Diagnosis & Therapy 16:5, pages 285-302.
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A. M. Steele, B. M. Shields, M. Shepherd, S. Ellard, A. T. Hattersley & E. R. Pearson. (2010) Increased all‐cause and cardiovascular mortality in monogenic diabetes as a result of mutations in the HNF1A gene. Diabetic Medicine 27:2, pages 157-161.
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Louis H. Philipson, Rinki Murphy, Sian Ellard, Andrew T. Hattersley, Julie Støy, Siri A. Greeley, Graeme I. Bell & Kenneth S. Polonsky. 2010. Genetic Diagnosis of Endocrine Disorders. Genetic Diagnosis of Endocrine Disorders 17 25 .
A. L. Gloyn. (2009) RD Lawrence Lecture 2009 Old genes, new tricks: learning about blood glucose regulation from naturally occurring genetic variation in humans. Diabetic Medicine 26:11, pages 1083-1089.
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Kara K. Osbak, Kevin Colclough, Cecile Saint-Martin, Nicola L. Beer, Christine Bellanné-Chantelot, Sian Ellard & Anna L. Gloyn. (2009) Update on mutations in glucokinase ( GCK ), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia . Human Mutation 30:11, pages 1512-1526.
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Daniela GašperíkováNicolas D. TribbleJuraj StaníkMiroslava HučkováNadežda MišovicováMartijn van de BuntLucia ValentínováBeryl A. BarrowL'ubomir BarákRadoslav DobránskyEva BereczkováJozef MichálekKate WicksKevin ColcloughJulian C. KnightSian EllardIwar KlimešAnna L. Gloyn. (2009) Identification of a Novel β-Cell Glucokinase ( GCK ) Promoter Mutation (−71G>C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans . Diabetes 58:8, pages 1929-1935.
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Thomas Waterfield & Anna L Gloyn. (2008) Monogenic β-cell dysfunction in children: clinical phenotypes, genetic etiology and mutational pathways. Pediatric Health 2:4, pages 517-532.
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A. L. Gloyn & M. I. McCarthy. (2008) Genetics: how the UKPDS contributed to determining the genetic landscape of Type 2 diabetes. Diabetic Medicine 25, pages 35-40.
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Lucimary C. Gurgel & Regina S. Moisés. (2008) Diabetes melito neonatal. Arquivos Brasileiros de Endocrinologia & Metabologia 52:2, pages 181-187.
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Jonathan M. LockeLorna W. Harries. (2008) RNA Processing and mRNA Surveillance in Monogenic Diabetes. Gene Regulation and Systems Biology 2, pages GRSB.S782.
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S. Ellard, K. Thomas, E. L. Edghill, M. Owens, L. Ambye, J. Cropper, J. Little, M. Strachan, A. Stride, B. Ersoy, H. Eiberg, O. Pedersen, M. H. Shepherd, T. Hansen, L. W. Harries & A. T. Hattersley. (2007) Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young. Diabetologia 50:11, pages 2313-2317.
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J. A. L. Minton, M. van de Bunt, C. Boustred, K. Hussain, A. T. Hattersley, S. Ellard & A. L. Gloyn. (2007) Mutations in HHEX are not a common cause of monogenic forms of beta cell dysfunction. Diabetologia 50:9, pages 2019-2022.
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