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Drug Evaluation

Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771

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Pages 1957-1966 | Published online: 04 Oct 2006

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Charul Lautre, Sanjay Sharma & Jagdish K. Sahu. (2022) Chemistry, Biological Properties and Analytical Methods of Levonadifloxacin: A Review. Critical Reviews in Analytical Chemistry 52:5, pages 1069-1077.
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Sachin S Bhagwat, Manohar Nandanwar, Atul Kansagara, Anusuya Patel, Swapna Takalkar, Rajesh Chavan, Hariharan Periasamy, Ravindra Yeole, Prasad K Deshpande, Satish Bhavsar, Ashima Bhatia, Jaishid Ahdal, Rishi Jain & Mahesh Patel. (2019) Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence. Drug Design, Development and Therapy 13, pages 4351-4365.
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Thrasivoulos Tzellos, Vasiliki Zampeli, Evgenia Makrantonaki & Christos C Zouboulis. (2011) Treating acne with antibiotic-resistant bacterial colonization. Expert Opinion on Pharmacotherapy 12:8, pages 1233-1247.
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Klaus Degitz & Falk Ochsendorf. (2008) Pharmacotherapy of acne. Expert Opinion on Pharmacotherapy 9:6, pages 955-971.
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Articles from other publishers (32)

Abobakr A. Mohamed, Mahmoud A. Omar, Sayed M. Derayea, Mohamed Ahmed Elsayed & Islam M. Mostafa. (2024) Photoluminescence detection of nadifloxacin: Adopts switching off photoinduced electron transfer (PET). Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 305, pages 123451.
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Mark S. Butler, Ian R. Henderson, Robert J. Capon & Mark A. T. Blaskovich. (2023) Antibiotics in the clinical pipeline as of December 2022. The Journal of Antibiotics 76:8, pages 431-473.
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Sanjay Kumar & Tamilisetti Vidya Sagar. (2023) Safety and efficacy of nadifloxacin versus clindamycin observed in a tertiary care teaching hospital of Deccan Plateau. Indian Journal of Pharmacy and Pharmacology 10:1, pages 24-27.
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Kajalben B. Patel & Premlata Kumari. (2022) A review: Structure-activity relationship and antibacterial activities of Quinoline based hybrids. Journal of Molecular Structure 1268, pages 133634.
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Ioana-Andreea Lungu, Octavia-Laura Moldovan, Victoria Biriș & Aura Rusu. (2022) Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance. Pharmaceutics 14:8, pages 1749.
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L. Ruffier d'Epenoux, A. Guillouzouic, P. Bémer, M.‐A. Dagnelie, A. Khammari, B. Dréno & S. Corvec. (2021) Should we consider broad‐spectrum quinolone antibacterial agent as acne treatment in the antimicrobial resistance era?. Journal of the European Academy of Dermatology and Venereology 36:3.
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Claudia Neumeister, Rolf-Hasso Bödeker, Ulrich Schwantes & Claudia Borelli. (2021) Impact of Parallel Topical Treatment with Nadifloxacin and Adapalene on Acne Vulgaris Severity and Quality of Life: A Prospective, Uncontrolled, Multicentric, Noninterventional Study. Biomedicine Hub 6:3, pages 158-172.
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Aura Rusu, Ioana-Andreea Lungu, Octavia-Laura Moldovan, Corneliu Tanase & Gabriel Hancu. (2021) Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation. Pharmaceutics 13:8, pages 1289.
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Debabrata Bandyopadhyay. (2021) Topical antibacterials in dermatology. Indian Journal of Dermatology 66:2, pages 117.
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Mohamed Tarek, Eman S. Elzanfaly, Sawsan M. Amer & Hebatallah A. Wagdy. (2020) Selective analysis of Nadifloxacin in human plasma samples using a molecularly imprinted polymer-based solid-phase extraction proceeded by UPLC-DAD analysis. Microchemical Journal 158, pages 105162.
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Yu Lu, Loïc Deblais, Gireesh Rajashekara, Sally A. Miller, Yorsa A. Helmy, Haijun Zhang, Ping Wu, Yanhong Qiu & Xiulan Xu. (2020) High‐throughput screening reveals small molecule modulators inhibitory to Acidovorax citrulli . Plant Pathology 69:5, pages 818-826.
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Mark S. Butler & David L. Paterson. (2020) Antibiotics in the clinical pipeline in October 2019. The Journal of Antibiotics 73:6, pages 329-364.
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Łukasz Szczupak, Aleksandra Kowalczyk, Damian Trzybiński, Krzysztof Woźniak, Gracia Mendoza, Manuel Arruebo, Dietmar Steverding, Paweł Stączek & Konrad Kowalski. (2020) Organometallic ciprofloxacin conjugates with dual action: synthesis, characterization, and antimicrobial and cytotoxicity studies. Dalton Transactions 49:5, pages 1403-1415.
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Nanxue Zhang, Ruoyue Yuan, Kevin Z. Xin, Zhong Lu & Ying Ma. (2019) Antimicrobial Susceptibility, Biotypes and Phylotypes of Clinical Cutibacterium (Formerly Propionibacterium) acnes Strains Isolated from Acne Patients: An Observational Study. Dermatology and Therapy 9:4, pages 735-746.
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Ramkrushna Ashok Salunke, Manjulika Shukla, Grace Kaul, Baldev Raj Bansal, Sidharth Chopra & Manmohan Chhibber. (2019) New fluoroquinolone compounds with endo ‐nortropine derivatives at C‐7 position show antibacterial activity against fluoroquinolone‐resistant strains of Staphylococcus aureus . Chemical Biology & Drug Design 94:3, pages 1626-1633.
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Sumana Ghosh, Mau Sinha, Anamika Bhattacharyya, Suresh Sadhasivam, Jayasundarnaidu Megha, Sreedhar Reddy, Swamini Saini, Himanshi Singh, Deepak Kumar, Simar Preet Kaur, Mallika Mishra, Dandamudi Usharani, Shamik Ghosh & Shiladitya Sengupta. (2018) A Rationally Designed Multifunctional Antibiotic for the Treatment of Drug-Resistant Acne. Journal of Investigative Dermatology 138:6, pages 1400-1408.
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Keith A. Rodvold, Mark H. Gotfried, Rakesh Chugh, Mugdha Gupta, Ravindra Yeole, Anasuya Patel & Ashima Bhatia. (2018) Intrapulmonary Pharmacokinetics of Levonadifloxacin following Oral Administration of Alalevonadifloxacin to Healthy Adult Subjects. Antimicrobial Agents and Chemotherapy 62:3.
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Wafaa S. Hamama, Mona E. Ibrahim, Ayaa A. Gooda & Hanafi H. Zoorob. (2018) Recent advances in the chemistry of 2-chloroquinoline-3-carbaldehyde and related analogs. RSC Advances 8:16, pages 8484-8515.
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Karen Bush & Malcolm G. P. Page. (2017) What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles. Journal of Pharmacokinetics and Pharmacodynamics 44:2, pages 113-132.
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Mark S Butler, Mark AT Blaskovich & Matthew A Cooper. (2016) Antibiotics in the clinical pipeline at the end of 2015. The Journal of Antibiotics 70:1, pages 3-24.
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Yukun Fan, Fei Hao, Weizhen Wang, Yonghong Lu, Li He, Gang Wang & Wenchieh Chen. (2015) Multicenter cross‐sectional observational study of antibiotic resistance and the genotypes of Propionibacterium acnes isolated from Chinese patients with acne vulgaris . The Journal of Dermatology 43:4, pages 406-413.
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Varsha Narayanan, Salman Motlekar, Ganesh Kadhe & Seema Bhagat. (2014) Efficacy and Safety of Nadifloxacin for Bacterial Skin Infections: Results from Clinical and Post-Marketing Studies. Dermatology and Therapy 4:2, pages 233-248.
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Brigitte Dréno. 2014. Pathogenesis and Treatment of Acne and Rosacea. Pathogenesis and Treatment of Acne and Rosacea 415 418 .
Mark S Butler, Mark A Blaskovich & Matthew A Cooper. (2013) Antibiotics in the clinical pipeline in 2013. The Journal of Antibiotics 66:10, pages 571-591.
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Masahiro Takigawa, Yoshiki Tokura, Shinji Shimada, Fukumi Furukawa, Norihisa Noguchi & Taisuke Ito. (2013) Clinical and bacteriological evaluation of adapalene 0.1% gel plus nadifloxacin 1% cream versus adapalene 0.1% gel in patients with acne vulgaris. The Journal of Dermatology 40:8, pages 620-625.
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K. Kumar & S. Chopra. (2013) New drugs for methicillin-resistant Staphylococcus aureus: an update. Journal of Antimicrobial Chemotherapy 68:7, pages 1465-1470.
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Rosaleen J. Anderson, Paul W. Groundwater, Adam Todd & Alan J. Worsley. 2012. Antibacterial Agents. Antibacterial Agents 35 61 .
Peter C. Appelbaum & André Bryskier. 2010. Antibiotic and Chemotherapy. Antibiotic and Chemotherapy 306 325 .
Dirk M. Elston. (2009) Topical Antibiotics in Dermatology: Emerging Patterns of Resistance. Dermatologic Clinics 27:1, pages 25-31.
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Carlo Gelmetti. (2008) Local antibiotics in dermatology. Dermatologic Therapy 21:3, pages 187-195.
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R. Loughlin, B.F. Gilmore, P.A. McCarron & M.M. Tunney. (2008) Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells. Letters in Applied Microbiology 46:4, pages 428-433.
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Michael R Jacobs. (2007) Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children. Future Microbiology 2:6, pages 591-600.
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