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Expert Opinion on Pharmacotherapy Volume 8, 2007 - Issue 12
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Review

Pharmacogenetics and paediatric drug development: issues and consequences to labelling and dosing recommendations

Elke HJ Krekels Teddy Network of Excellence Leiden/Amsterdam Center for Drug Research, University of Leiden, The Netherlands
, MSc,
John N van den Anker Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, USA
, MD, PhD,
Paola Baiardi Consorzio per Valutazioni Biologichee Farmacologiche, S. Maugeri Foundation & University of Pavia, Italy
, D Math Sc, PhD,
Massimo Cella Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, University of Leiden, The Netherlands
, MSc,
Katharine Y Cheng Medicines Development Centre, GlaxoSmithKline R&D, Greenford, United Kingdom
, MB ChB, MRCPI MD,
Diana M Gibb MRC Clinical Trials Unit, London, United Kingdom
, MD,
Hannah Green MRC Clinical Trials Unit, London, United Kingdom
, MSc,
Achille Iolascon Department of Biochemistry and Medical Biotechnologies, University Federico II of Naples, CEINGE- Advanced Biotechnologies Naples, Italy
, MD, PhD,
Evelyne M Jacqz-Aigrain Department of Paediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, Paris, France
, MD, PhD,
Catherijne AJ Knibbe St. Antonius Hospital, Department of Clinical Pharmacy, Nieuwegein, The Netherlands
, Pharm D, PhD,
Gijs WE Santen Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, University of Leiden, The Netherlands
, MSc,
Ron HN van Schaik Department of Clinical Chemistry, Erasmus Medical Center, University of Rotterdam, The Netherlands
, PhD,
Dick Tibboel Department of Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands
, MD, PhD &
Oscar E Della Pasqua Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, University of Leiden, The Netherlands; Clinical Pharmacology & Discovery Medicine, GlaxoSmithKline R&D, Greenford, Middlesex UB6 0HE, United Kingdom [email protected]
, MD, PhD show all
Pages 1787-1799 | Published online: 14 Aug 2007

Citations (14)

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Read on this site (2)

Chiara Piana, Natalicia de Jesus Antunes & Oscar Della Pasqua. (2014) Implications of pharmacogenetics for the therapeutic use of antiepileptic drugs. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 341-358.
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Karel Allegaert, Maissa Rayyan, Sophie Vanhaesebrouck & Gunnar Naulaers. (2008) Developmental pharmacokinetics in neonates. Expert Review of Clinical Pharmacology 1:3, pages 415-428.
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Articles from other publishers (12)

John N. van den Anker & Dick Tibboel. 2018. Rickham's Neonatal Surgery. Rickham's Neonatal Surgery 169 183 .
Pathma D. Joseph, Jonathan C. Craig & Patrina H.Y. Caldwell. (2015) Clinical trials in children. British Journal of Clinical Pharmacology 79:3, pages 357-369.
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Anna‐Karin Hamberg, Mia Wadelius, Lena E. Friberg, Tina T. Biss, Farhad Kamali & E. Niclas Jonsson. (2014) Characterizing variability in warfarin dose requirements in children using modelling and simulation. British Journal of Clinical Pharmacology 78:1, pages 158-169.
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Chiara Piana, Linda Surh, Sabine Furst‐Recktenwald, Achille Iolascon, Evelyne M. Jacqz‐Aigrain, Ineke Jonker, Roberta Russo, Ron H.N. van Schaik, Judith Wessels & Oscar E. Della Pasqua. (2013) Integration of Pharmacogenetics and Pharmacogenomics in Drug Development: Implications for Regulatory and Medical Decision Making in Pediatric Diseases. The Journal of Clinical Pharmacology 52:5, pages 704-716.
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Catherijne A.J. Knibbe & Meindert Danhof. (2011) Individualized dosing regimens in children based on population PKPD modelling: Are we ready for it?. International Journal of Pharmaceutics 415:1-2, pages 9-14.
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Francesco Bellanti, Bertil Kågedal & Oscar Della Pasqua. (2011) Do pharmacokinetic polymorphisms explain treatment failure in high-risk patients with neuroblastoma?. European Journal of Clinical Pharmacology 67:S1, pages 87-107.
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Roberta Russo, Mario Capasso, Paolo Paolucci & Achille Iolascon. (2010) Pediatric pharmacogenetic and pharmacogenomic studies: the current state and future perspectives. European Journal of Clinical Pharmacology 67:S1, pages 17-27.
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Roosmarijn F. W. De Cock, Chiara Piana, Elke H. J. Krekels, Meindert Danhof, Karel Allegaert & Catherijne A. J. Knibbe. (2010) The role of population PK–PD modelling in paediatric clinical research. European Journal of Clinical Pharmacology 67:S1, pages 5-16.
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Johannes N. van den Anker, Matthias Schwab & Gregory L. Kearns. 2011. Pediatric Clinical Pharmacology. Pediatric Clinical Pharmacology 51 75 .
Johannes N. van den Anker. (2010) Developmental pharmacology. Developmental Disabilities Research Reviews 16:3, pages 233-238.
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Ibrahim Ince, Saskia N. de Wildt, Dick Tibboel, Meindert Danhof & Catherijne A.J. Knibbe. (2009) Tailor-made drug treatment for children. Drug Discovery Today 14:5-6, pages 316-320.
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K. Allegaert & J.N. van den Anker. (2012) How to use drugs for pain management: from pharmacokinetics to pharmacogenomics. European Journal of Pain Supplements 2:S1, pages 25-30.
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