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Review

Pharmacological treatment in moderate-to-severe Alzheimer's disease

, MD MHSc FRCPC & , MD FRCPC
Pages 2575-2582 | Published online: 19 Sep 2008

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Cesare Mancuso, Raffaella Siciliano, Eugenio Barone, David Allan Butterfield & Paolo Preziosi. (2011) Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before. Expert Opinion on Investigational Drugs 20:9, pages 1243-1261.
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Antoni Camins, Francesc Xavier Sureda, Felix Junyent, Ester Verdaguer, Jaume Folch, Carlos Beas-Zarate & Merce Pallas. (2010) An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders. Expert Opinion on Investigational Drugs 19:5, pages 587-604.
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Umamon Puangthong & Ging-Yuek Robin Hsiung. (2009) Critical appraisal of the long-term impact of memantine in treatment of moderate to severe Alzheimer’s disease. Neuropsychiatric Disease and Treatment 5, pages 553-561.
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Pei-Pei Guan, Long-Long Cao & Pu Wang. (2021) Elevating the Levels of Calcium Ions Exacerbate Alzheimer’s Disease via Inducing the Production and Aggregation of β-Amyloid Protein and Phosphorylated Tau. International Journal of Molecular Sciences 22:11, pages 5900.
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Carole Parsons, Wei Yin Lim, Clement Loy, Bernadette McGuinness, Peter Passmore, Stephanie A Ward & Carmel Hughes. (2021) Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia. Cochrane Database of Systematic Reviews 2021:2.
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Saeed Samarghandian & Tahereh Farkhondeh. 2020. Saffron. Saffron 103 116 .
John W. Finley & Song Gao. (2017) A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer’s Disease . Journal of Agricultural and Food Chemistry 65:5, pages 1005-1020.
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Stéphane Fourcade, Isidre Ferrer & Aurora Pujol. (2015) Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration. Free Radical Biology and Medicine 88, pages 18-29.
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Nikolaos Pitsikas. (2015) The Effect of Crocus sativus L. and Its Constituents on Memory: Basic Studies and Clinical Applications . Evidence-Based Complementary and Alternative Medicine 2015, pages 1-7.
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Mehdi Farokhnia, Mehdi Shafiee Sabet, Negar Iranpour, Amirhossein Gougol, Habibeh Yekehtaz, Roozbeh Alimardani, Farzaneh Farsad, Maryam Kamalipour & Shahin Akhondzadeh. (2014) Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial . Human Psychopharmacology: Clinical and Experimental 29:4, pages 351-359.
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Alessandra Clodomiro, Pietro Gareri, Gianfranco Puccio, Francesca Frangipane, Roberto Lacava, Alberto Castagna, Valeria Graziella Laura Manfredi, Rosanna Colao & Amalia Cecilia Bruni. (2013) Somatic comorbidities and Alzheimer’s disease treatment. Neurological Sciences 34:9, pages 1581-1589.
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Jorge Alves, Rosana Magalhães, Roger E. Thomas, Óscar F. Gonçalves, Agavni Petrosyan & Adriana Sampaio. (2013) Is There Evidence for Cognitive Intervention in Alzheimer Disease? A Systematic Review of Efficacy, Feasibility, and Cost-Effectiveness. Alzheimer Disease & Associated Disorders 27:3, pages 195-203.
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Claudio Babiloni, Claudio Del Percio, Regis Bordet, Jean-Luis Bourriez, Marina Bentivoglio, Pierre Payoux, Philippe Derambure, Sophie Dix, Francesco Infarinato, Roberta Lizio, Antonio Ivano Triggiani, Jill C. Richardson & Paolo M. Rossini. (2013) Effects of acetylcholinesterase inhibitors and memantine on resting-state electroencephalographic rhythms in Alzheimer’s disease patients. Clinical Neurophysiology 124:5, pages 837-850.
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Carole Parsons, Carmel Hughes, Bernadette McGuinness & Peter Passmore. (2011) Withdrawal or continuation of cholinesterase inhibitors and/or memantine in patients with dementia.. Cochrane Database of Systematic Reviews.
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Samy Babai, Pascal Auriche & Hervé Le-Louët. (2010) Comparison of Adverse Drug Reactions with Donepezil versus Memantine: Analysis of the French Pharmacovigilance Database. Therapies 65:3, pages 255-259.
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Antoni Camins, Felix Junyent, Ester Verdaguer, Carlos Beas-Zarate, Argelia Rojas-Mayorquín, Daniel Ortuño-Sahagún & Mercè Pallàs. (2009) Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases. Pharmaceuticals 2:3, pages 194-205.
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Kim N. Green. (2009) Calcium in the initiation, progression and as an effector of Alzheimer’s disease pathology. Journal of Cellular and Molecular Medicine 13:9a, pages 2787-2799.
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. (2009) Current awareness in geriatric psychiatry. International Journal of Geriatric Psychiatry 24:4.
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