288
Views
47
CrossRef citations to date
0
Altmetric
Drug Evaluation

Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma

, , , , , & show all
Pages 1609-1618 | Published online: 02 Jun 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Rita De Sanctis, Andrea Marrari, Silvia Marchetti, Chiara Mussi, Luca Balzarini, Fabio Romano Lutman, Primo Daolio, Stefano Bastoni, Alexia Francesca Bertuzzi, Vittorio Quagliuolo & Armando Santoro. (2015) Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma. Drug Design, Development and Therapy 9, pages 5785-5791.
Read now
Patrick Schöffski. (2012) Pazopanib in the treatment of soft tissue sarcoma. Expert Review of Anticancer Therapy 12:6, pages 711-723.
Read now

Articles from other publishers (45)

Giovanna Romano, Mariana Almeida, Ana Varela Coelho, Adele Cutignano, Luis G Gonçalves, Espen Hansen, Denis Khnykin, Tali Mass, Andreja Ramšak, Miguel S. Rocha, Tiago H. Silva, Michela Sugni, Loriano Ballarin & Anne-Marie Genevière. (2022) Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications. Marine Drugs 20:4, pages 219.
Crossref
Qiongyu Hao, Zhimin Huang, Qun Li, Dingxie Liu, Piwen Wang, Kun Wang, Jieqing Li, Wei Cao, Wenhong Deng, Ke Wu, Rui Su, Zhongmin Liu, Jay Vadgama & Yong Wu. (2022) A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes‐Associated Breast Cancer. Advanced Science 9:6, pages 2102303.
Crossref
Assunta Saide, Chiara Lauritano & Adrianna Ianora. (2021) A Treasure of Bioactive Compounds from the Deep Sea. Biomedicines 9:11, pages 1556.
Crossref
Laura Núñez-Pons, Andrew Shilling, Cinzia Verde, Bill J. Baker & Daniela Giordano. (2020) Marine Terpenoids from Polar Latitudes and Their Potential Applications in Biotechnology. Marine Drugs 18:8, pages 401.
Crossref
Yingbo Shi, Qiaoling Wang & Shuanhu Gao. (2018) Recent advances in the intramolecular Mannich reaction in natural products total synthesis. Organic Chemistry Frontiers 5:6, pages 1049-1066.
Crossref
Daniela Giordano, Maria Costantini, Daniela Coppola, Chiara Lauritano, Laura Núñez Pons, Nadia Ruocco, Guido di Prisco, Adrianna Ianora & Cinzia Verde. 2018. 171 220 .
Alix Blockley, David Elliott, Adam Roberts & Michael Sweet. (2017) Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery. Diversity 9:4, pages 49.
Crossref
G. Romano, M. Costantini, C. Sansone, C. Lauritano, N. Ruocco & A. Ianora. (2017) Marine microorganisms as a promising and sustainable source of bioactive molecules. Marine Environmental Research 128, pages 58-69.
Crossref
Caterina Peraldo Neia, Giuliana Cavalloni, Giovanna Chiorino, Paola Ostano, Massimo Aglietta & Francesco Leone. (2016) Gene and microRNA modulation upon trabectedin treatment in a human intrahepatic cholangiocarcinoma paired patient derived xenograft and cell line. Oncotarget 7:52, pages 86766-86780.
Crossref
Chiara Lauritano & Adrianna Ianora. (2016) Marine Organisms with Anti-Diabetes Properties. Marine Drugs 14:12, pages 220.
Crossref
Marcel Jaspars, Donatella De Pascale, Jeanette H. Andersen, Fernando Reyes, Alexander D. Crawford & Adrianna Ianora. (2016) The marine biodiscovery pipeline and ocean medicines of tomorrow. Journal of the Marine Biological Association of the United Kingdom 96:1, pages 151-158.
Crossref
Joanne L. Blum, Anthony Gonçalves, Noa Efrat, Marc Debled, Pierfranco Conte, Paul D. Richards, Donald Richards, Pilar Lardelli, Antonio Nieto, Martin Cullell-Young & Suzette Delaloge. (2016) A phase II trial of trabectedin in triple-negative and HER2-overexpressing metastatic breast cancer. Breast Cancer Research and Treatment 155:2, pages 295-302.
Crossref
Bradley Petek, Elizabeth Loggers, Seth Pollack & Robin Jones. (2015) Trabectedin in Soft Tissue Sarcomas. Marine Drugs 13:2, pages 974-983.
Crossref
Carmen Avendaño & J. Carlos Menéndez. 2015. Medicinal Chemistry of Anticancer Drugs. Medicinal Chemistry of Anticancer Drugs 243 271 .
Edwin L. Cooper & Ralph Albert. 2015. Handbook of Anticancer Drugs from Marine Origin. Handbook of Anticancer Drugs from Marine Origin 383 395 .
Elisa Zanardi, Marco Maruzzo, Maria C. Montesco, Anna Roma, Marco Rastrelli & Umberto Basso. (2014) Response to trabectedin in a patient with advanced synovial sarcoma with lung metastases. Anti-Cancer Drugs 25:10, pages 1227-1230.
Crossref
Rima Beesoo, Vidushi Neergheen-Bhujun, Ranjeet Bhagooli & Theeshan Bahorun. (2014) Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 768, pages 84-97.
Crossref
S. Delaloge, R. Wolp-Diniz, T. Byrski, J.L. Blum, A. Gonçalves, M. Campone, P. Lardelli, C. Kahatt, A. Nieto, M. Cullell-Young & J. Lubinski. (2014) Activity of trabectedin in germline BRCA1/2-mutated metastatic breast cancer: results of an international first-in-class phase II study. Annals of Oncology 25:6, pages 1152-1158.
Crossref
Patrick Schöffski, Jasmien Cornillie, Agnieszka Wozniak, Haifu Li & Daphne Hompes. (2014) Soft Tissue Sarcoma: An Update on Systemic Treatment Options for Patients with Advanced Disease. Oncology Research and Treatment 37:6, pages 355-362.
Crossref
Satyajit Patra & Meenakshi Sundaram Muthuraman. (2013) Gracilaria edulis extract induces apoptosis and inhibits tumor in Ehrlich Ascites tumor cells in vivo. BMC Complementary and Alternative Medicine 13:1.
Crossref
Rawad Farhat, Roy Raad, Nabil J. Khoury, Julien Feghaly, Toufic Eid, Samar Muwakkit, Miguel Abboud, Hassan El-Solh & Raya Saab. (2013) Cyclophosphamide and Topotecan as First-line Salvage Therapy in Patients With Relapsed Ewing Sarcoma at a Single Institution. Journal of Pediatric Hematology/Oncology 35:5, pages 356-360.
Crossref
Karin von Schwarzenberg & Angelika M. Vollmar. (2013) Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy. Cancer Letters 332:2, pages 295-303.
Crossref
Bartomeu Massuti, Manuel Cobo, Carlos Camps, Manuel Dómine, Mariano Provencio, Vicente Alberola, Nuria Viñolas, Rafael Rosell, Miguel Tarón, Vanesa Gutiérrez-Calderón, Pilar Lardelli, Vicente Alfaro, Antonio Nieto & Dolores Isla. (2012) Trabectedin in patients with advanced non-small-cell lung cancer (NSCLC) with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum. Lung Cancer 76:3, pages 354-361.
Crossref
Edwin L. Cooper & David Yao. (2012) Diving for drugs: tunicate anticancer compounds. Drug Discovery Today 17:11-12, pages 636-648.
Crossref
A. Gronchi, B.N. Bui, S. Bonvalot, S. Pilotti, S. Ferrari, P. Hohenberger, R.J. Hohl, G.D. Demetri, A. Le Cesne, P. Lardelli, I. Pérez, A. Nieto, J.C. Tercero, V. Alfaro, E. Tamborini & J.Y. Blay. (2012) Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma. Annals of Oncology 23:3, pages 771-776.
Crossref
Patrick Schöffski, Linda Cerbone, Pascal Wolter, Ivo De Wever, Ignace Samson, Herlinde Dumez, Paul Clement, Hans Wildiers & Marguerite Stas. (2012) Administration of 24-h Intravenous Infusions of Trabectedin in Ambulatory Patients with Mesenchymal Tumors via Disposable Elastomeric Pumps: An Effective and Patient-Friendly Palliative Treatment Option. Onkologie 35:1-2, pages 14-17.
Crossref
Scott Okuno, Howard Bailey, Michelle R. Mahoney, Douglas Adkins, William Maples, Tom Fitch, David Ettinger, Charles Erlichman & Jann N. Sarkaria. (2011) A phase 2 study of temsirolimus (CCI‐779) in patients with soft tissue sarcomas. Cancer 117:15, pages 3468-3475.
Crossref
Kevin B. Jones, Malay Haldar, Joshua D. Schiffman, Lisa Cannon-AlbrightStephen L. Lessnick, Sunil Sharma, Mario R. Capecchi & R. Lor Randall. (2011) Of Mice and Men: Opportunities to Use Genetically Engineered Mouse Models of Synovial Sarcoma for Preclinical Cancer Therapeutic Evaluation. Cancer Control 18:3, pages 196-203.
Crossref
P. Schöffski, M. Taron, J. Jimeno, F. Grosso, R. Sanfilipio, P.G. Casali, A. Le Cesne, R.L. Jones, J.-Y. Blay, A. Poveda, R.G. Maki, A. Nieto, J.C. Tercero & R. Rosell. (2011) Predictive impact of DNA repair functionality on clinical outcome of advanced sarcoma patients treated with trabectedin: A retrospective multicentric study. European Journal of Cancer 47:7, pages 1006-1012.
Crossref
Ansgar Brüning & Ioannis Mylonas. (2010) New emerging drugs targeting the genomic integrity and replication machinery in ovarian cancer. Archives of Gynecology and Obstetrics 283:5, pages 1087-1096.
Crossref
Patrick J. Grohar, Laurie B. Griffin, Choh Yeung, Qing-Rong Chen, Yves Pommier, Chand Khanna, Javed Khan & Lee J. Helman. (2011) Ecteinascidin 743 Interferes with the Activity of EWS-FLI1 in Ewing Sarcoma Cells. Neoplasia 13:2, pages 145-IN10.
Crossref
Trinh L. Doan, Michael Pollastri, Michael A. Walters & Gunda I. Georg. 2011. 385 401 .
Elisa Stroppa, Alexia Bertuzzi, Gabriele Di Comite, Chiara Mussi, Romano Fabio Lutman, Alfredo Barbato & Armando Santoro. (2009) Phase I study of non-pegylated liposomal doxorubicin in combination with ifosfamide in adult patients with metastatic soft tissue sarcomas. Investigational New Drugs 28:6, pages 834-838.
Crossref
Javier Martinez-Trufero, Jorge Alfaro, Francesc Felipo, Maria Alvarez, Julia Madani & Ana Cebollero. (2010) Response to trabectedin treatment in a highly pretreated patient with an advanced meningeal hemangiopericytoma. Anti-Cancer Drugs 21:8, pages 795-798.
Crossref
Paolo G Casali, Roberta Sanfilippo & Maurizio D'Incalci. (2010) Trabectedin therapy for sarcomas. Current Opinion in Oncology 22:4, pages 342-346.
Crossref
Susanne C. Miller, Ruili Huang, Srilatha Sakamuru, Sunita J. Shukla, Matias S. Attene-Ramos, Paul Shinn, Danielle Van Leer, William Leister, Christopher P. Austin & Menghang Xia. (2010) Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action. Biochemical Pharmacology 79:9, pages 1272-1280.
Crossref
Li-yang Tao, Jian-ye Zhang, Yong-ju Liang, Li-ming Chen, Li-sheng Zheng, Fang Wang, Yan-jun Mi, Zhi-gang She, Kenneth Kin Wah To, Yong-cheng Lin & Li-wu Fu. (2010) Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea. Marine Drugs 8:4, pages 1094-1105.
Crossref
Natalie J. Carter & Susan J. Keam. (2010) Trabectedin. Drugs 70:3, pages 335-376.
Crossref
John W. Blunt, Brent R. Copp, Murray H. G. Munro, Peter T. Northcote & Michèle R. Prinsep. (2010) Marine natural products. Natural Product Reports 27:2, pages 165.
Crossref
Keith B. Glaser & Alejandro M.S. Mayer. (2009) A renaissance in marine pharmacology: From preclinical curiosity to clinical reality. Biochemical Pharmacology 78:5, pages 440-448.
Crossref
Josée Guirouilh-Barbat, Yong-Wei Zhang & Yves Pommier. (2009) Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin. Molecular Cancer Therapeutics 8:7, pages 1985-1994.
Crossref
. (2009) Current World Literature. Current Opinion in Oncology 21:4, pages 386-392.
Crossref
Bahram Forouzesh, Manuel Hidalgo, Quincy Chu, Alain Mita, Monica Mita, Garry Schwartz, José Jimeno, Javier Gómez, Vicente Alfaro, Claudia Lebedinsky, Patrik Zintl & Eric K. Rowinsky. (2009) Phase I and Pharmacokinetic Study of Trabectedin as a 1- or 3-hour Infusion Weekly in Patients with Advanced Solid Malignancies. Clinical Cancer Research 15:10, pages 3591-3599.
Crossref
Kenji Watanabe, Hiroki Oguri & Hideaki Oikawa. (2009) Enzymatic Synthesis of Molecular Skeletons of Complex Antitumor Antibiotics with Non-ribosomal Peptide Synthetases. Journal of Synthetic Organic Chemistry, Japan 67:11, pages 1152-1160.
Crossref
José Luis Ordóñez, Ana Sofia Martins, Daniel Osuna, Juan Madoz–Gúrpide & Enrique de Alava. (2008) Targeting sarcomas: therapeutic targets and their rational. Seminars in Diagnostic Pathology 25:4, pages 304-316.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.