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A pan-HER approach for cancer therapy: background, current status and future development

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Pages 97-110 | Published online: 08 Dec 2008

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Jing Yang, Yanfei Yang, Yuquan Wei & Xiawei Wei. (2023) A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma. Frontiers of Medicine 17:2, pages 275-289.
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Amina Majeed Hassan, Adil Muala Dhumad, Rafid Al-Asadi & Ahmed Majeed Jassem. (2020) Synthesis And Molecular Docking Of Some Amic Acid Targeting Breast Cancer. IOP Conference Series: Materials Science and Engineering 928:5, pages 052022.
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Md. Lutful Kabir, Frederick Backler, Andrew H. A. Clayton & Feng Wang. (2020) Deducing the Conformational Properties of a Tyrosine Kinase Inhibitor in Solution by Optical Spectroscopy and Computational Chemistry. Frontiers in Chemistry 8.
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Ye Won Chung, Seongmin Kim, Jin Hwa Hong, Jae Kwan Lee, Nak Woo Lee, Young Seok Lee & Jae Yun Song. (2019) Overexpression of HER2/HER3 and clinical feature of ovarian cancer. Journal of Gynecologic Oncology 30:5.
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Manni Wang, Yuzhu Hu, Ting Yu, Xuelei Ma, Xiawei Wei & Yuquan Wei. (2018) Pan-HER-targeted approach for cancer therapy: Mechanisms, recent advances and clinical prospect. Cancer Letters 439, pages 113-130.
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Shima Moradi-Kalbolandi, Aysooda Hosseinzade, Malihe Salehi, Parnaz Merikhian & Leila Farahmand. (2018) Monoclonal antibody-based therapeutics, targeting the epidermal growth factor receptor family: from herceptin to Pan HER. Journal of Pharmacy and Pharmacology 70:7, pages 841-854.
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Rosalin Mishra, Hima Patel, Samar Alanazi, Long Yuan & Joan T. Garrett. (2018) HER3 signaling and targeted therapy in cancer. Oncology Reviews.
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Maria Rosestedt, Ken G. Andersson, Bogdan Mitran, Sara S. Rinne, Vladimir Tolmachev, John Löfblom, Anna Orlova & Stefan Ståhl. (2017) Evaluation of a radiocobalt-labelled affibody molecule for imaging of human epidermal growth factor receptor 3 expression. International Journal of Oncology 51:6, pages 1765-1774.
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Stefania Napolitano, Giulia Martini, Erika Martinelli, Valentina Belli, Alessia Parascandolo, Mikko O. Laukkanen, Vincenzo Sforza, Floriana Morgillo, Davide Ciardiello, Fortunato Ciardiello & Teresa Troiani. (2017) Therapeutic efficacy of SYM004, a mixture of two anti-EGFR antibodies in human colorectal cancer with acquired resistance to cetuximab and MET activation. Oncotarget 8:40, pages 67592-67604.
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Brigitte Rack, Ewa Zombirt, Elisabeth Trapp, Julia Jückstock, Ulrich Andergassen, Julia Neugebauer, Bernd Kost, Tobias Weissenbacher, Udo Jeschke, Christian Schindlbeck, Wolfgang Janni & Marianna Alunni-Fabbroni. (2016) Comparison of HER2 Expression in Primary Tumor and Disseminated Tumor Cells in the Bone Marrow of Breast Cancer Patients. Oncology 90:4, pages 232-238.
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Ningyan Zhang, Yujun Chang, Adan Rios & Zhiqiang An. (2016) HER3/ErbB3, an emerging cancer therapeutic target. Acta Biochimica et Biophysica Sinica 48:1, pages 39-48.
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Xiaochun Wang, Kathleen M. Batty, Philip J. Crowe, David Goldstein & Jia-Lin Yang. (2015) The Potential of panHER Inhibition in Cancer. Frontiers in Oncology 5.
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Jeong A. Bae, Somy Yoon, So-Yeon Park, Jae Hyuk Lee, Jun-Eul Hwang, Hangun Kim, Young-Woo Seo, Yoon Jin Cha, Sung Pil Hong, Hoguen Kim, Ik Joo Chung & Kyung Keun Kim. (2014) An Unconventional KITENIN/ErbB4-Mediated Downstream Signal of EGF Upregulates c-Jun and the Invasiveness of Colorectal Cancer Cells. Clinical Cancer Research 20:15, pages 4115-4128.
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Shyhmin Huang, Chunrong Li, Eric A. Armstrong, Chimera R. Peet, Jarob Saker, Lukas C. Amler, Mark X. Sliwkowski & Paul M. Harari. (2013) Dual Targeting of EGFR and HER3 with MEHD7945A Overcomes Acquired Resistance to EGFR Inhibitors and Radiation. Cancer Research 73:2, pages 824-833.
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Michael Boyer, Pasi Antero Jänne, Tony Mok, Kenneth O’Byrne, Luis Paz-Ares, Suresh S Ramalingam, Jane Liang, Ian Taylor, Alicyn Campbell, Joseph O’Connell, Stephen Letrent & Vladan Antic. (2013) Rationale and study design of ARCHER: a randomized, double-blind, Phase III study of dacomitinib versus erlotinib for advanced non-small-cell lung cancer. Clinical Investigation 3:1, pages 29-35.
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Byung-Kwon Choi, Xiumei Cai, Bin Yuan, Zhao Huang, Xuejun Fan, Hui Deng, Ningyan Zhang & Zhiqiang An. (2012) HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways. Protein & Cell 3:10, pages 781-789.
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Van A. Trinh & Wen-Jen Hwu. (2011) Chemoprevention for Brain Metastases. Current Oncology Reports 14:1, pages 63-69.
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Diana CrivellariSimon SpazzapanDavide LombardiLoredana Militello, Elena Torrisi, Alessia E Russo, Roberto SorioRenato Talamini, Gianmaria MioloPaolo CarliAndrea Veronesi. (2018) Lapatinib-Based Therapy in Heavily Pretreated HER2-Positive Metastatic Breast Cancer: A Single Institution Experience. Tumori Journal 98:1, pages 33-38.
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Mariaelena Pierobon, Julie Wulfkuhle, Lance A. Liotta & Emanuel F. PetricoinIIIIII. 2012. Systems Biology in Cancer Research and Drug Discovery. Systems Biology in Cancer Research and Drug Discovery 309 323 .
Andreas D. Hartkopf, Malgorzata Banys & Tanja Fehm. 2012. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer 203 215 .
David M. Goldenberg & Robert M. Sharkey. 2014. Therapeutic Nuclear Medicine. Therapeutic Nuclear Medicine 125 138 .
Ngayu Thairu, Serafim Kiriakidis, Peter Dawson & Ewa Paleolog. (2011) Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience. Angiogenesis 14:3, pages 223-234.
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Karin Haim, Polina Weitzenfeld, Tsipi Meshel & Adit Ben-Baruch. (2011) Epidermal Growth Factor and Estrogen Act by Independent Pathways to Additively Promote the Release of the Angiogenic Chemokine CXCL8 by Breast Tumor Cells. Neoplasia 13:3, pages 230-243.
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Luke L Gompels, Nasser M Malik, Leigh Madden, Pei Jin, Marc Feldmann, H Michael Shepard & Ewa M Paleolog. (2011) Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade. Arthritis Research & Therapy 13:5, pages R161.
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Richard Greil, Simona Borštnar, Katarína Petráková, Yiola Marcou, Joanna Pikiel, Marek Z. Wojtukiewicz, Ivan Koza, Günther G. Steger, Meinolf Linn, Ash Das Gupta & Karel Cwiertka. (2011) Combination Therapy of Lapatinib and Capecitabine forErbB2-Positive Metastatic or Locally Advanced BreastCancer: Results from the Lapatinib Expanded AccessProgram (LEAP) in Central and Eastern Europe. Onkologie 34:5, pages 233-238.
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Mariaelena Pierobon, Claudio Belluco, Lance A. Liotta & Emanuel F. PetricoinIIIIII. 2011. Protein Microarrays. Protein Microarrays 3 12 .
Luisa Paris, Serena Cecchetti, Francesca Spadaro, Laura Abalsamo, Luana Lugini, Maria Elena Pisanu, Egidio Iorio, Pier Giorgio Natali, Carlo Ramoni & Franca Podo. (2010) Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells. Breast Cancer Research 12:3.
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David Lesniak, Yaoxian Xu, Jean Deschenes, Raymond Lai, John Thoms, David Murray, Sunita Gosh, John R. Mackey, Siham Sabri & Bassam Abdulkarim. (2009) β1-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2–Positive Breast Cancer. Cancer Research 69:22, pages 8620-8628.
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Menghong Sun, Carmen Behrens, Lei Feng, Natalie Ozburn, Ximing Tang, Guosheng Yin, Ritsuko Komaki, Marileila Varella-Garcia, Waun Ki Hong, Kenneth D. Aldape & Ignacio I. Wistuba. (2009) HER Family Receptor Abnormalities in Lung Cancer Brain Metastases and Corresponding Primary Tumors. Clinical Cancer Research 15:15, pages 4829-4837.
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