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Is passive immunization for Alzheimer's disease ‘alive and well’ or ‘dead and buried’?

, MD PhD
Pages 481-491 | Published online: 03 Apr 2009

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Paul J. Derry, Muralidhar L. Hegde, George R. Jackson, Rakez Kayed, James M. Tour, Ah-Lim Tsai & Thomas A. Kent. (2020) Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective. Progress in Neurobiology 184, pages 101716.
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Arne Ittner, Josefine Bertz, Lisa S. Suh, Claire H. Stevens, Jürgen Götz & Lars M. Ittner. (2015) Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. Journal of Neurochemistry 132:1, pages 135-145.
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Rajesh S. Omtri, Michael W. Davidson, Balasubramaniam Arumugam, Joseph F. Poduslo & Karunya K. Kandimalla. (2012) Differences in the Cellular Uptake and Intracellular Itineraries of Amyloid Beta Proteins 40 and 42: Ramifications for the Alzheimer’s Drug Discovery. Molecular Pharmaceutics 9:7, pages 1887-1897.
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Francesco PanzaVincenza Frisardi, Bruno P Imbimbo, Giancarlo Logroscino, Davide Seripa, Alberto Pilotto & Vincenzo Solfrizzi. (2012) Amyloid-related imaging abnormalities associated with immunotherapy in Alzheimer’s disease patients. Future Neurology 7:4, pages 395-401.
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Rob J. A. Nabuurs, Kim S. Rutgers, Mick M. Welling, Athanasios Metaxas, Maaike E. de Backer, Maarten Rotman, Brian J. Bacskai, Mark A. van Buchem, Silvère M. van der Maarel & Louise van der Weerd. (2012) In Vivo Detection of Amyloid-β Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease. PLoS ONE 7:6, pages e38284.
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Jennifer D. Lanning & Stephen C. Meredith. 2012. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases 433 560 .
Pavan K. Krishnamurthy & Einar M. Sigurdsson. (2011) Therapeutic applications of antibodies in non-infectious neurodegenerative diseases. New Biotechnology 28:5, pages 511-517.
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Yulia Vugmeyster, Pam Szklut, David Wensel, John Ross, Xin Xu, Michel Awwad, Davinder Gill, Lioudmila Tchistiakov & Garvin Warner. (2011) Complex Pharmacokinetics of a Humanized Antibody Against Human Amyloid Beta Peptide, Anti-Abeta Ab2, in Nonclinical Species. Pharmaceutical Research 28:7, pages 1696-1706.
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Francesco Panza, Vincenza Frisardi, Bruno P Imbimbo, Grazia D’Onofrio, Giuseppe Pietrarossa, Davide Seripa, Alberto Pilotto & Vincenzo Solfrizzi. (2010) Bapineuzumab: anti-β-amyloid monoclonal antibodies for the treatment of Alzheimer’s disease. Immunotherapy 2:6, pages 767-782.
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Ravindra Kodali, Angela D. Williams, Saketh Chemuru & Ronald Wetzel. (2010) Aβ(1–40) Forms Five Distinct Amyloid Structures whose β-Sheet Contents and Fibril Stabilities Are Correlated. Journal of Molecular Biology 401:3, pages 503-517.
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M. Buttmann & H. Wiendl. (2010) Therapeutische monoklonale Antikörper in der NeurologieTherapeutic monoclonal antibodies in clinical neurology. Der Nervenarzt 81:6, pages 753-766.
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Manuela Bartolini & Vincenza Andrisano. (2010) Strategies for the Inhibition of Protein Aggregation in Human Diseases. ChemBioChem 11:8, pages 1018-1035.
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Ruben J. Boado, Jeff Zhiqiang Lu, Eric Ka‐Wai Hui & William M. Pardridge. (2009) IgG‐single chain Fv fusion protein therapeutic for alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey. Biotechnology and Bioengineering 105:3, pages 627-635.
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Alan M. Palmer. (2010) The role of the blood–CNS barrier in CNS disorders and their treatment. Neurobiology of Disease 37:1, pages 3-12.
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. (2009) Current awareness in geriatric psychiatry. International Journal of Geriatric Psychiatry 24:11.
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Jason Pitt, William Roth, Pascale Lacor, Amos B. SmithIIIIII, Matthew Blankenship, Pauline Velasco, Fernanda De Felice, Paul Breslin & William L. Klein. (2009) Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicology and Applied Pharmacology 240:2, pages 189-197.
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