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Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation

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Pages 831-840 | Published online: 25 May 2009

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Paola Circosta, Angela Rita Elia, Indira Landra, Rodolfo Machiorlatti, Maria Todaro, Sabrina Aliberti, Davide Brusa, Silvia Deaglio, Sabina Chiaretti, Riccardo Bruna, Daniela Gottardi, Massimo Massaia, Filomena Di Giacomo, Anna Rita Guarini, Robin Foà, Peter W. Kyriakides, Rohan Bareja, Olivier Elemento, Gurunadh R. Chichili, Emanuele Monteleone, Paul A. Moore, Syd Johnson, Ezio Bonvini, Alessandro Cignetti & Giorgio Inghirami. (2018) Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms. OncoImmunology 7:4.
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Ludovic Durrieu, Joëlle Gregoire-Gauthier, Mame Massar Dieng, François Fontaine, Françoise le Deist & Elie Haddad. (2012) Human interferon-alpha increases the cytotoxic effect of CD56+cord blood-derived cytokine-induced killer cells on human B-acute lymphoblastic leukemia cell lines. Cytotherapy 14:10, pages 1245-1257.
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Eva Rettinger, Selim KuçI, Ivonne Naumann, Petra Becker, Hermann Kreyenberg, Martina Anzaghe, Andre Willasch, Ulrike Koehl, Gesine Bug, Martin Ruthardt, Thomas Klingebiel, Simone Fulda & Peter Bader. (2012) The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells. Cytotherapy 14:1, pages 91-103.
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Tiffany M. Zúñiga, Forrest L. Baker, Kyle A. Smith, Helena Batatinha, Branden Lau, Michael P. Gustafson, Emmanuel Katsanis & Richard J. Simpson. (2022) Acute exercise mobilizes NKT-like cells with a cytotoxic transcriptomic profile but does not augment the potency of cytokine-induced killer (CIK) cells. Frontiers in Immunology 13.
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Melanie Bremm, Lisa-Marie Pfeffermann, Claudia Cappel, Verena Katzki, Stephanie Erben, Sibille Betz, Andrea Quaiser, Michael Merker, Halvard Bonig, Michael Schmidt, Thomas Klingebiel, Peter Bader, Sabine Huenecke & Eva Rettinger. (2019) Improving Clinical Manufacturing of IL-15 Activated Cytokine-Induced Killer (CIK) Cells. Frontiers in Immunology 10.
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Juan J. Mata-Molanes, Manuel Sureda González, Belén Valenzuela Jiménez, Elena Mª Martínez Navarro & Antonio Brugarolas Masllorens. (2017) Cancer Immunotherapy with Cytokine-Induced Killer Cells. Targeted Oncology 12:3, pages 289-299.
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Fabrizio Carnevale-Schianca, Daniela Caravelli, Susanna Gallo, Valentina Coha, Lorenzo D'Ambrosio, Elena Vassallo, Marco Fizzotti, Francesca Nesi, Luisa Gioeni, Massimo Berger, Alessandra Polo, Loretta Gammaitoni, Paolo Becco, Lidia Giraudo, Monica Mangioni, Dario Sangiolo, Giovanni Grignani, Delia Rota–Scalabrini, Antonino Sottile, Franca Fagioli & Massimo Aglietta. (2017) Post-Transplant Cyclophosphamide and Tacrolimus–Mycophenolate Mofetil Combination Prevents Graft-versus-Host Disease in Allogeneic Peripheral Blood Hematopoietic Cell Transplantation from HLA-Matched Donors. Biology of Blood and Marrow Transplantation 23:3, pages 459-466.
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Sara Ghorashian & Persis Amrolia. 2017. Childhood Acute Lymphoblastic Leukemia. Childhood Acute Lymphoblastic Leukemia 239 254 .
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Melanie Bremm, Sabine Huenecke, Olga Zimmermann, Verena Pfirrmann, Andrea Quaiser, Halvard Bonig, Jan Soerensen, Thomas Klingebiel, Eva Rettinger, Peter Bader & Claudia Cappel. (2016) In-vitro influence of mycophenolate mofetil (MMF) and Ciclosporin A (CsA) on cytokine induced killer (CIK) cell immunotherapy. Journal of Translational Medicine 14:1.
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Sarah Oelsner, Juliane Wagner, Miriam E. Friede, Verena Pfirrmann, Sabrina Gen?ler, Eva Rettinger, Christian J. Buchholz, Heike Pfeifer, Ralf Schubert, Oliver G. Ottmann, Evelyn Ullrich, Peter Bader & Winfried S. Wels. (2016) Chimeric antigen receptor-engineered cytokine-induced killer cells overcome treatment resistance of pre-B-cell acute lymphoblastic leukemia and enhance survival. International Journal of Cancer 139:8, pages 1799-1809.
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RUNMEI LI, FANG YAN, LIANG LIU, HUI LI, BAOZHU REN, ZHENZHEN HUI & XIUBAO REN. (2016) Cytokine-induced killer cell therapy for the treatment of primary hepatocellular carcinoma subsequent to liver transplantation: A case report. Oncology Letters 11:3, pages 1885-1888.
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Xuequn Ren, Wanli Ma, Hong Lu, Lei Yuan, Lei An, Xicai Wang, Guanchang Cheng & Shuguang Zuo. (2015) Modification of cytokine-induced killer cells with chimeric antigen receptors (CARs) enhances antitumor immunity to epidermal growth factor receptor (EGFR)-positive malignancies. Cancer Immunology, Immunotherapy 64:12, pages 1517-1529.
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Verena Pfirrmann, Sarah Oelsner, Eva Rettinger, Sabine Huenecke, Halvard Bonig, Michael Merker, Winfried S. Wels, Jindrich Cinatl, Ralf Schubert, Thomas Klingebiel & Peter Bader. (2015) Cytomegalovirus-specific cytokine-induced killer cells: concurrent targeting of leukemia and cytomegalovirus. Cytotherapy 17:8, pages 1139-1151.
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Qiang Zhang, Xiao-yan Liu, Teng Zhang, Xin-feng Zhang, Lin Zhao, Fei Long, Zhuang-kai Liu & En-hua Wang. (2015) The dual-functional capability of cytokine-induced killer cells and application in tumor immunology. Human Immunology 76:5, pages 385-391.
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Angela R. EliaPaola CircostaDario SangioloChiara BoniniLoretta GammaitoniSara MastaglioPietro GenoveseMassimo GeunaFabio AvolioGiorgio InghiramiCorrado TarellaAlessandro Cignetti. (2015) Cytokine-Induced Killer Cells Engineered with Exogenous T-Cell Receptors Directed Against Melanoma Antigens: Enhanced Efficacy of Effector Cells Endowed with a Double Mechanism of Tumor Recognition. Human Gene Therapy 26:4, pages 220-231.
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XIN-YU YANG, HUI ZENG & FANG-PING CHEN. (2015) Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia. Oncology Letters 9:2, pages 535-541.
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Yu-Peng Hong. (2015) Immunotherapy for hepatocellular carcinoma: From basic research to clinical use. World Journal of Hepatology 7:7, pages 980.
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SHIYONG WANG, HUI ZHANG, CHANG LIU, XUE JIAO, DIJIE LIU, WEILI DU, YING HE, ZHE ZHANG, XIUYAN WU, JIALING WANG, CHUNYAN LIANG, LU ZHANG & SHU LIU. (2014) Human leukocyte antigen-haploidentical donor-derived cytokine-induced killer cells are safe and prolong the survival of patients with advanced non-small cell lung cancer. Oncology Letters 8:6, pages 2727-2733.
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Eva Rettinger, Andreas Glatthaar, Behnaz Ahangarian Abhari, Sarah Oelsner, Verena Pfirrmann, Sabine Huenecke, Selim Ku??i, Hermann Kreyenberg, Andre M. Willasch, Thomas Klingebiel, Simone Fulda & Peter Bader. (2014) SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy. Frontiers in Pediatrics 2.
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Cristina Zanon, Matteo Stocchero, Elena Albiero, Silvia Castegnaro, Katia Chieregato, Domenico Madeo, Francesco Rodeghiero & Giuseppe Astori. (2014) Multivariate statistical data analysis as a tool to analyze ex vivo expansion dynamics of cytokine-induced killer cells. Cytometry Part B: Clinical Cytometry 86:4, pages 257-262.
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Eva Rettinger, Hermann Kreyenberg, Michael Merker, Selim Ku?i, Andre Willasch, Gesine Bug, Evelyn Ullrich, Winfried S. Wels, Halvard Bonig, Thomas Klingebiel & Peter Bader. (2014) Immunomagnetic selection or irradiation eliminates alloreactive cells but also reduces anti-tumor potential of cytokine-induced killer cells: implications for unmanipulated cytokine-induced killer cell infusion. Cytotherapy 16:6, pages 835-844.
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MIN ZHAO, HONGBING LI, LEI LI & YIJIE ZHANG. (2014) Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients. Experimental and Therapeutic Medicine 7:5, pages 1403-1407.
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Marco Ruella & Michael Kalos. (2014) Adoptive immunotherapy for cancer. Immunological Reviews 257:1, pages 14-38.
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Ke Pan, Yong-Qiang Li, Wei Wang, Li Xu, Yao-Jun Zhang, Hai-Xia Zheng, Jing-Jing Zhao, Hui-Juan Qiu, De-Sheng Weng, Jian-Jun Li, Qi-Jing Wang, Li-Xi Huang, Jia He, Shi-Ping Chen, Miao-La Ke, Pei-Hong Wu, Min-Shan Chen, Sheng-Ping Li, Jian-Chuan Xia & Yi-Xin Zeng. (2013) The Efficacy of Cytokine-Induced Killer Cell Infusion as an Adjuvant Therapy for Postoperative Hepatocellular Carcinoma Patients. Annals of Surgical Oncology 20:13, pages 4305-4311.
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Xiefu Zhang. (2013) Effects of cytokine‑induced killer cell treatment combined with FOLFOX4 on the recurrence and survival rates for gastric cancer following surgery. Experimental and Therapeutic Medicine.
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E Rettinger, H Bonig, S Wehner, G Lucchini, A Willasch, A Jarisch, J Soerensen, R Esser, C Rossig, T Klingebiel & P Bader. (2013) Feasibility of IL-15-activated cytokine-induced killer cell infusions after haploidentical stem cell transplantation. Bone Marrow Transplantation 48:8, pages 1141-1143.
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Simon F. Lacey & Michael Kalos. (2013) Biomarkers in T-cell therapy clinical trials. Cytotherapy 15:6, pages 632-640.
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Katia Chieregato, Elena Albiero, Silvia Castegnaro, Martina Bernardi, Emanuele S.G. d'Amore, Cristina Zanon, Domenico Madeo, Francesco Rodeghiero & Giuseppe Astori. (2012) A study on mutual interaction between cytokine induced killer cells and umbilical cord-derived mesenchymal cells: Implication for their in-vivo use. Blood Cells, Molecules, and Diseases 49:3-4, pages 159-165.
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M Dong, D Liang, Y Li, D Kong, P Kang, K Li, C Ping, Y Zhang, X Zhou, Y Zhang & L Hong. (2012) Autologous Dendritic Cells Combined with Cytokine-Induced Killer Cells Synergize Low-Dose Chemotherapy in Elderly Patients with Acute Myeloid Leukaemia. Journal of International Medical Research 40:4, pages 1265-1274.
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P Pedrazzoli, P Comoli, D Montagna, T Demirer & M Bregni. (2011) Is adoptive T-cell therapy for solid tumors coming of age?. Bone Marrow Transplantation 47:8, pages 1013-1019.
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Claudia Schlimper, Andreas A. Hombach, Hinrich Abken & Ingo G. H. Schmidt-Wolf. (2012) Improved Activation toward Primary Colorectal Cancer Cells by Antigen-Specific Targeting Autologous Cytokine-Induced Killer Cells. Clinical and Developmental Immunology 2012, pages 1-8.
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Tao Yang, Ying Xiang, Yucheng Li, Jianghe Shao, Qiying Li & Huiqing Yu. (2011) Clinical study of co-treatment with DC-CIK cells for advanced solid carcinomas. The Chinese-German Journal of Clinical Oncology 10:6, pages 354-359.
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Guang Tan, Xin Zhang, Hongbo Feng, Haifeng Luo & Zhongyu Wang. (2011) The Therapeutic Effect of Cytokine-Induced Killer Cells on Pancreatic Cancer Enhanced by Dendritic Cells Pulsed with K-Ras Mutant Peptide. Clinical and Developmental Immunology 2011, pages 1-9.
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