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Expert Opinion on Biological Therapy Volume 9, 2009 - Issue 8
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Reviews

Treating autoimmune disease by targeting CD8+ T suppressor cells

Christine Konya Emory University School of Medicine, Lowance Center for Human Immunology and Rheumatology, 101 Woodruff Circle #1003, Atlanta, GA 30322, USA +1 404 727 7310; +1 404 727 7371; [email protected]
,
Jőrg J Goronzy Emory University School of Medicine, Lowance Center for Human Immunology and Rheumatology, 101 Woodruff Circle #1003, Atlanta, GA 30322, USA +1 404 727 7310; +1 404 727 7371; [email protected]
&
Cornelia M Weyand Emory University School of Medicine, Lowance Center for Human Immunology and Rheumatology, 101 Woodruff Circle #1003, Atlanta, GA 30322, USA +1 404 727 7310; +1 404 727 7371; [email protected]
Pages 951-965 | Published online: 12 Jun 2009

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Isabel Gálvez, Silvia Torres-Piles & Eduardo Ortega. (2018) Innate/inflammatory bioregulation and clinical effectiveness of whole-body hyperthermia (balneotherapy) in elderly patients with osteoarthritis. International Journal of Hyperthermia 35:1, pages 340-347.
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M Orlovic, V Tomic, K Vukojevic, I Hudic, V Mandic, I Azinovic, D Soldo, M Kajic & V Soljic. (2017) Decreased expression of MMP-9 in CD8+ cells in placenta with severe preeclampsia. Biotechnic & Histochemistry 92:4, pages 288-296.
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Van Phi Luu, Monica I. Vazquez & Albert Zlotnik. (2014) B cells participate in tolerance and autoimmunity through cytokine production. Autoimmunity 47:1, pages 1-12.
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Gilberto Filaci, Daniela Fenoglio & Francesco Indiveri. (2011) CD8+ T regulatory/suppressor cells and their relationships with autoreactivity and autoimmunity. Autoimmunity 44:1, pages 51-57.
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Articles from other publishers (35)

Asma El‐Howati, Martin H. Thornhill, Helen E. Colley & Craig Murdoch. (2022) Immune mechanisms in oral lichen planus. Oral Diseases 29:4, pages 1400-1415.
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Anna Radziszewska, Zachary Moulder, Elizabeth C. Jury & Coziana Ciurtin. (2022) CD8+ T Cell Phenotype and Function in Childhood and Adult-Onset Connective Tissue Disease. International Journal of Molecular Sciences 23:19, pages 11431.
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Coziana Ciurtin, Ines Pineda-Torra, Elizabeth C. Jury & George A. Robinson. (2022) CD8+ T-Cells in Juvenile-Onset SLE: From Pathogenesis to Comorbidities. Frontiers in Medicine 9.
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Ramand Mohammed Haji, Nabaz Ali Ahmed & Shakhawan Azad Ahmed. (2022) Effect of COVID-19 on Severity of Signs and Symptoms of Autoimmune Diseases. Kurdistan Journal of Applied Research, pages 37-44.
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Arshi Khanam, Lydia S. Y. Tang & Shyam Kottilil. (2021) Programmed death 1 expressing CD8+CXCR5+ follicular T cells constitute effector rather than exhaustive phenotype in patients with chronic hepatitis B. Hepatology 75:3, pages 690-708.
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Sara Cheleschi, Sara Tenti, Iole Seccafico, Isabel Gálvez, Antonella Fioravanti & Eduardo Ortega. (2021) Balneotherapy year in review 2021: focus on the mechanisms of action of balneotherapy in rheumatic diseases. Environmental Science and Pollution Research 29:6, pages 8054-8073.
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Shuang Song, Nayang Shan, Geng Wang, Xiting Yan, Jun S Liu & Lin Hou. (2021) Openness weighted association studies: leveraging personal genome information to prioritize non-coding variants. Bioinformatics 37:24, pages 4737-4743.
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Shukkur M. Farooq & Hossam M. Ashour. (2021) Type II Collagen-Specific B Cells Induce Immune Tolerance in Th1-Skewed, Th2-Skewed, and Arthritis-Prone Strains of Mice. Cells 10:4, pages 870.
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Huimin Zhou, Jun Yang, Jie Tian & Shengjun Wang. (2021) CD8+ T Lymphocytes: Crucial Players in Sjögren’s Syndrome. Frontiers in Immunology 11.
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Maha Almanan, Claire Chougnet & David A. Hildeman. 2019. Handbook of Immunosenescence. Handbook of Immunosenescence 337 358 .
Maha Almanan, Claire Chougnet & David A. Hildeman. 2017. Handbook of Immunosenescence. Handbook of Immunosenescence 1 22 .
Yong-chao Qiao, Yan-hong Pan, Wei Ling, Fang Tian, Yin-ling Chen, Xiao-xi Zhang & Hai-lu Zhao. (2017) The Yin and Yang of regulatory T cell and therapy progress in autoimmune disease. Autoimmunity Reviews 16:10, pages 1058-1070.
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Lucie Barateau, Roland Liblau, Christelle Peyron & Yves Dauvilliers. (2017) Narcolepsy Type 1 as an Autoimmune Disorder: Evidence, and Implications for Pharmacological Treatment. CNS Drugs 31:10, pages 821-834.
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Caroline J. Voskens, Anika Fischer, Susanne Roessner, Carmen Lorenz, Simon Hirschmann, Raja Atreya, Clemens Neufert, Imke Atreya, Markus F. Neurath & Gerold Schuler. (2017) Characterization and Expansion of Autologous GMP-ready Regulatory T Cells for TREG-based Cell Therapy in Patients with Ulcerative Colitis. Inflammatory Bowel Diseases 23:8, pages 1348-1359.
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Zheng Xu, Sophey Ho, Chih-Chao Chang, Qing-Yin Zhang, Elena-Rodica Vasilescu, George Vlad & Nicole Suciu-Foca. (2016) Molecular and Cellular Characterization of Human CD8 T Suppressor Cells. Frontiers in Immunology 7.
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Nanette Mittereder, Ellen Kuta, Geetha Bhat, Karma Dacosta, Lily I. Cheng, Ronald Herbst & Gianluca Carlesso. (2016) Loss of Immune Tolerance Is Controlled by ICOS in Sle1 Mice. The Journal of Immunology 197:2, pages 491-503.
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Shukkur M. Farooq, Ashok Kumar & Hossam M. Ashour. (2014) Eye‐mediated immune tolerance to Type II collagen in arthritis‐prone strains of mice. Journal of Cellular and Molecular Medicine 18:12, pages 2512-2518.
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Shukkur M Farooq, Walid F Elkhatib & Hossam M Ashour. (2014) The in vivo and in vitro induction of anterior chamber associated immune deviation to myelin antigens in C57BL/6 mice. Brain, Behavior, and Immunity 42, pages 118-122.
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Khrishen Cunnusamy, Ethan J. Baughman, Jorge Franco, Sterling B. Ortega, Sushmita Sinha, Parul Chaudhary, Benjamin M. Greenberg, Elliot M. Frohman & Nitin J. Karandikar. (2014) Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells. Clinical Immunology 152:1-2, pages 115-126.
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X Zhang, C S Schaumburg, T G Coursey, K F Siemasko, E A Volpe, N B Gandhi, D-Q Li, J Y Niederkorn, M E Stern, S C Pflugfelder & C S de Paiva. (2014) CD8+ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome. Mucosal Immunology 7:2, pages 417-427.
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Thomas St?big, Anita Badbaran, Tim Luetkens, York Hildebrandt, Djordje Atanackovic, Thomas M. C. Binder, Boris Fehse & Nicolaus Kr?ger. (2014) 5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity. Mediators of Inflammation 2014, pages 1-12.
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David A. Horwitz, Stephanie Pan, Jing-Ni Ou, Julie Wang, Maogen Chen, J. Dixon Gray & Song Guo Zheng. (2013) Therapeutic polyclonal human CD8+ CD25+ Fox3+ TNFR2+ PD-L1+ regulatory cells induced ex-vivo. Clinical Immunology 149:3, pages 450-463.
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Anirban Banerjee, Jianming Wang, Sheetal Bodhankar, Arthur A. Vandenbark, Stephanie J. Murphy & Halina Offner. (2013) Phenotypic Changes in Immune Cell Subsets Reflect Increased Infarct Volume in Male vs. Female Mice. Translational Stroke Research 4:5, pages 554-563.
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Shukkur M. Farooq & Hossam M. Ashour. (2013) Eye‐Mediated Induction of Specific Immune Tolerance to Encephalitogenic Antigens. CNS Neuroscience & Therapeutics 19:7, pages 503-510.
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Shukkur M. Farooq & Hossam M. Ashour. (2012) Type II Collagen Induces Peripheral Tolerance in BALB/c Mice via the Generation of CD8+ T Regulatory Cells. PLoS ONE 7:11, pages e48635.
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Maryam Gol-Ara, Farhad Jadidi-Niaragh, Reza Sadria, Gholamreza Azizi & Abbas Mirshafiey. (2012) The Role of Different Subsets of Regulatory T Cells in Immunopathogenesis of Rheumatoid Arthritis. Arthritis 2012, pages 1-16.
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Masakatsu Suzuki, Ann L. Jagger, Christine Konya, Yasuhiro Shimojima, Sergey Pryshchep, Jörg J. Goronzy & Cornelia M. Weyand. (2012) CD8+CD45RA+CCR7+FOXP3+ T Cells with Immunosuppressive Properties: A Novel Subset of Inducible Human Regulatory T Cells. The Journal of Immunology 189:5, pages 2118-2130.
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Bon-A Cho, Ji Hyun Sim, Ji Ah Park, Hye Won Kim, Wan-Hee Yoo, Seung-Hyun Lee, Dong-Sup Lee, Jae Seung Kang, Young-Il Hwang, Wang Jae Lee, Insoo Kang, Eun Bong Lee & Hang-Rae Kim. (2012) Characterization of Effector Memory CD8+ T Cells in the Synovial Fluid of Rheumatoid Arthritis. Journal of Clinical Immunology 32:4, pages 709-720.
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Zachary S. Buchwald, Jennifer R. Kiesel, Richard DiPaolo, Meghana S. Pagadala & Rajeev Aurora. (2012) Osteoclast Activated FoxP3+ CD8+ T-Cells Suppress Bone Resorption in vitro. PLoS ONE 7:6, pages e38199.
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Yuming Yu, Jennifer R. Zitzner, Josetta Houlihan, Nancy Herrera, Luting Xu, Joshua Miller, James M. Mathew, Anat R. Tambur & Xunrong Luo. (2011) Common Gamma Chain Cytokines Promote Rapid In Vitro Expansion of Allo-Specific Human CD8+ Suppressor T Cells. PLoS ONE 6:12, pages e28948.
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Basset El Essawy, Prabhakar Putheti, Wenda Gao & Terry B. Strom. (2011) Rapamycin Generates Graft-Homing Murine Suppressor CD8 + T Cells That Confer Donor-Specific Graft Protection . Cell Transplantation 20:11-12, pages 1759-1769.
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Daniel S Smyk, Eirini I Rigopoulou, Ana Lleo, Robin D Abeles, Athanasios Mavropoulos, Charalambos Billinis, Pietro Invernizzi & Dimitrios P Bogdanos. (2011) Immunopathogenesis of primary biliary cirrhosis: an old wives' tale. Immunity & Ageing 8:1.
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Caroline G. McPhee, Thomas J. Sproule, Dong-Mi Shin, Jason A. Bubier, William H. Schott, Martin P. Steinbuck, Lia Avenesyan, Herbert C. MorseIIIIII & Derry C. Roopenian. (2011) MHC Class I Family Proteins Retard Systemic Lupus Erythematosus Autoimmunity and B Cell Lymphomagenesis. The Journal of Immunology 187:9, pages 4695-4704.
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Francesca Bernuzzi, Daniela Fenoglio, Florinda Battaglia, Marco Fravega, M. Eric Gershwin, Francesco Indiveri, Aftab A. Ansari, Mauro Podda, Pietro Invernizzi & Gilberto Filaci. (2010) Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis. Journal of Autoimmunity 35:3, pages 176-180.
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Keisuke TOBITA, Hiroyuki YANAKA & Hajime OTANI. (2010) Lactobacillus crispatus KT-11 Enhances Intestinal Immune Functions in C3H/HeN Mice. Journal of Nutritional Science and Vitaminology 56:6, pages 441-445.
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