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Expert Opinion on Biological Therapy Volume 10, 2010 - Issue 2
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Original Research

Direct validation of NGcGM3 ganglioside as a new target for cancer immunotherapy

Mayrel Labrada Center of Molecular Immunology, Vaccine Department, 216 St and 15th Ave., Atabey, Playa, P. O. Box 16040, Havana, 11600, Cuba +53 7 271 6810; +53 7 272 0644; [email protected]
,
Marilyn Clavell Center of Molecular Immunology, Vaccine Department, 216 St and 15th Ave., Atabey, Playa, P. O. Box 16040, Havana, 11600, Cuba +53 7 271 6810; +53 7 272 0644; [email protected]
,
Yanín Bebelagua Center of Molecular Immunology, Vaccine Department, 216 St and 15th Ave., Atabey, Playa, P. O. Box 16040, Havana, 11600, Cuba +53 7 271 6810; +53 7 272 0644; [email protected]
,
Joel de León Center of Molecular Immunology, Vaccine Department, 216 St and 15th Ave., Atabey, Playa, P. O. Box 16040, Havana, 11600, Cuba +53 7 271 6810; +53 7 272 0644; [email protected]
,
Daniel F Alonso Quilmes National University, Department of Science and Technology, Laboratory of Molecular Oncology, R. Saenz Peña 180, Bernal B1876BXD, Buenos Aires, Argentina
,
Mariano R Gabri Quilmes National University, Department of Science and Technology, Laboratory of Molecular Oncology, R. Saenz Peña 180, Bernal B1876BXD, Buenos Aires, Argentina
,
Roberto C Veloso Center of Biomolecular Chemistry, Laboratory of Synthetic Antigens, 200 St, Atabey, Playa, Havana, 11600, Cuba
,
Vicente Vérez Center of Biomolecular Chemistry, Laboratory of Synthetic Antigens, 200 St, Atabey, Playa, Havana, 11600, Cuba
&
Luis E Fernández Center of Molecular Immunology, Vaccine Department, 216 St and 15th Ave., Atabey, Playa, P. O. Box 16040, Havana, 11600, Cuba +53 7 271 6810; +53 7 272 0644; [email protected]
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Pages 153-162 | Published online: 08 Dec 2009

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Zhongwu Guo. (2022) The structural diversity of natural glycosphingolipids (GSLs). Journal of Carbohydrate Chemistry 41:2-3, pages 63-154.
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Mariano R. Gabri, Walter Cacciavillano, Guillermo L. Chantada & Daniel F. Alonso. (2016) Racotumomab for treating lung cancer and pediatric refractory malignancies. Expert Opinion on Biological Therapy 16:4, pages 573-578.
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Kirenia Pérez, Marta Osorio, Julio Hernández, Adriana Carr & Luis Enrique Fernández. (2013) NGcGM3/VSSP vaccine as treatment for melanoma patients. Human Vaccines & Immunotherapeutics 9:6, pages 1237-1240.
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Marta Osorio, Elias Gracia, Edmundo Reigosa, Julio Hernandez, Ana de la Torre, Giselle Saurez, Kirenia Perez, Carmen Viada, Meylán Cepeda, Adriana Carr, Yisel Ávila, Migdalia Rodríguez & Luis E Fernandez. (2012) Effect of vaccination with N-glycolyl GM3/VSSP vaccine by subcutaneous injection in patients with advanced cutaneous melanoma. Cancer Management and Research 4, pages 341-345.
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Articles from other publishers (21)

Mirela Sarbu, David E. Clemmer & Alina D. Zamfir. (2020) Ion mobility mass spectrometry of human melanoma gangliosides. Biochimie 177, pages 226-237.
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Anoopjit Singh Kooner, Hai Yu & Xi Chen. (2019) Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. Frontiers in Immunology 10.
Crossref
Chirag Dhar, Aniruddha Sasmal & Ajit Varki. (2019) From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc. Frontiers in Immunology 10.
Crossref
Addys González Palomo, Armando López Medinilla, Valeria Segatori, María del Carmen Barroso, Rances Blanco, Mariano R. Gabri, Adriana Carr Pérez & Kalet León Monzón. (2018) Synergistic potentiation of the anti-metastatic effect of anti EGFR mAb by its combination with immunotherapies targeting the ganglioside NGcGM3. Oncotarget 9:35, pages 24069-24080.
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Mayrel Labrada, Denise Dorvignit, Giselle Hevia, Nely Rodríguez-Zhurbenko, Ana M. Hernández, Ana M. Vázquez & Luis E. Fernández. (2018) GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy. Seminars in Oncology 45:1-2, pages 41-51.
Crossref
Anet Valdes-Zayas, Zuyen Gonzalez, Vladimir Mulens, Aliz M. Vega, Kirenia Perez, Patricia Lorenzo-Luaces, Maria C. Rubio, Anabely Estevez, Idelmis Curbelo, Luis E. Fernandez, Tania Crombet & Zaima Mazorra. (2017) Immunologic Response Elicited in Breast Cancer Patients Receiving a NeuGcGM3-based Vaccine as Adjuvant Therapy. Journal of Immunotherapy 40:8, pages 289-301.
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Rady J. Laborde, Oraly Sanchez-Ferras, María C. Luzardo, Yoelys Cruz-Leal, Audry Fernández, Circe Mesa, Liliana Oliver, Liem Canet, Liane Abreu-Butin, Catarina V. Nogueira, Mayra Tejuca, Fabiola Pazos, Carlos Álvarez, María E. Alonso, Ieda M. Longo-Maugéri, Michael N. Starnbach, Darren E. Higgins, Luis E. Fernández & María E. Lanio. (2017) Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune Response. The Journal of Immunology 198:7, pages 2772-2784.
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Giselle Hevia, Isabel Pablos, Marilyn Clavell, Judith Raymond, Mayrel Labrada & Luis E. Fernández. (2017) Cyclooxygenase Inhibition in Cancer Immunotherapy: Combination of Indomethacin with Cancer Vaccines Is Not Always Beneficial. Journal of Cancer Therapy 08:02, pages 188-209.
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Addys González Palomo, Rancés Blanco Santana, Xiomara Escobar Pérez, Damián Blanco Santana, Mariano Rolando Gabri, Kalet León Monzon & Adriana Carr Pérez. (2016) Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications. Clinical & Experimental Metastasis 33:7, pages 717-725.
Crossref
Elmira Safaie Qamsari, Alireza Nourazarian, Salman Bagheri & Morteza Motallebnezhad. (2016) Ganglioside as a Therapy Target in Various Types of Cancer. Asian Pacific Journal of Cancer Prevention 17:4, pages 1643-1647.
Crossref
Ana de la TorreKirenia PérezAliz M. VegaEduardo SantiestebanRaiza RuizLeonardo HernándezDayamí DurrutíCarmen E. ViadaLiset SánchezMabel álvarezYunier DuránYoisbel G. MorenoMaylén ArencibiaMeylán CepedaMilagros DomecqLeticia CabreraJorge L. SánchezJosé J. HernándezAna R. VallsLuis E. Fernández. (2016) Superior Efficacy and Safety of a Nonemulsive Variant of the NGcGM3/VSSP Vaccine in Advanced Breast Cancer Patients. Breast Cancer: Basic and Clinical Research 10, pages BCBCR.S32785.
Crossref
Kayluz Frias Boligan, Circe Mesa, Luis Enrique Fernandez & Stephan von Gunten. (2014) Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense. Cellular and Molecular Life Sciences 72:7, pages 1231-1248.
Crossref
Vered Padler-Karavani. (2014) Aiming at the sweet side of cancer: Aberrant glycosylation as possible target for personalized-medicine. Cancer Letters 352:1, pages 102-112.
Crossref
Ron Amon, Eliran Moshe Reuven, Shani Leviatan Ben-Arye & Vered Padler-Karavani. (2014) Glycans in immune recognition and response. Carbohydrate Research 389, pages 115-122.
Crossref
Pradeep Chopra, Paul D. Madge, Robin J. Thomson, I. Darren Grice & Mark von Itzstein. (2013) Microwave-assisted synthesis of N-glycolylneuraminic acid derivatives. Tetrahedron Letters 54:41, pages 5558-5561.
Crossref
Ana Victoria Casadesús, Yuniel Fernández-Marrero, Marilyn Clavell, José Alberto Gómez, Tays Hernández, Ernesto Moreno & Alejandro López-Requena. (2013) A shift from N-glycolyl- to N-acetyl-sialic acid in the GM3 ganglioside impairs tumor development in mouse lymphocytic leukemia cells. Glycoconjugate Journal 30:7, pages 687-699.
Crossref
Y Zhong, Y Wu, C Li, J Tang, X Wang, G Ren, A Carr, R Pérez & W Guo. (2012) N ‐Glycolyl GM3 ganglioside immunoexpression in oral mucosal melanomas of Chinese . Oral Diseases 18:8, pages 741-747.
Crossref
Rancés Blanco, Enrique Rengifo, Mercedes Cedeño, Charles E. Rengifo, Daniel F. Alonso & Adriana Carr. (2011) Immunoreactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Epithelial Malignant Tumors from Digestive System. ISRN Gastroenterology 2011, pages 1-8.
Crossref
Jamie Heimburg-Molinaro, Michelle Lum, Geraldine Vijay, Miten Jain, Adel Almogren & Kate Rittenhouse-Olson. (2011) Cancer vaccines and carbohydrate epitopes. Vaccine 29:48, pages 8802-8826.
Crossref
Raine Garrido Arteaga, Roberto Carlos Veloso Pita, Miguel Antonio López López, José Antonio González Labaut, María del Carmen Rodríguez Montero, Hermán Vélez Castro & José Alberto Cremata Alvarez. (2011) Evaluation and evidence of natural gangliosides with two unsaturated bonds in the ceramide structure obtained by a combination of MALDI-MS and NMR spectroscopy. Analytical and Bioanalytical Chemistry 400:10, pages 3675-3680.
Crossref
Luis E. Fernandez, Mariano R. Gabri, Marcelo D. Guthmann, Roberto E. Gomez, Silvia Gold, Leonardo Fainboim, Daniel E. Gomez & Daniel F. Alonso. (2010) NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines. Clinical and Developmental Immunology 2010, pages 1-8.
Crossref

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