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Drug Evaluations

Adecatumumab: an anti-EpCAM monoclonal antibody, from the bench to the bedside

, MD PhD & , MD
Pages 951-958 | Published online: 29 Apr 2010

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Manuel Simon, Nikolas Stefan, Andreas Plückthun & Uwe Zangemeister-Wittke. (2013) Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy. Expert Opinion on Drug Delivery 10:4, pages 451-468.
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Zhao Liu, Chen Zhang, Beiming Cui, Yijie Wang, Kaisheng Lim, Kai Li, Jean Paul Thiery, Jun Chen & Chun Loong Ho. (2023) Targeted EpCAM-binding for the development of potent and effective anticancer proteins. Biomedicine & Pharmacotherapy 161, pages 114443.
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Teizo Asano, Tomohiro Tanaka, Hiroyuki Suzuki, Guanjie Li, Tomokazu Ohishi, Manabu Kawada, Takeo Yoshikawa, Mika K. Kaneko & Yukinari Kato. (2022) A Defucosylated Anti-EpCAM Monoclonal Antibody (EpMab-37-mG2a-f) Exerts Antitumor Activity in Xenograft Model. Antibodies 11:4, pages 74.
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Yanmei Qi, Fengqiang Zhou, Zhen Geng, Baozhong Ding & Lei Liu. (2022) EpCAM is critical for tumor proliferation and oxaliplatin chemoresistance in EpCAM high /CD44 + colorectal cancer stem cells . Turkish Journal of Biochemistry 47:5, pages 620-625.
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Seyed Muhammad Yahyazadeh Mashhadi, Monireh Kazemimanesh, Arash Arashkia, Kayhan Azadmanesh, Zahra Meshkat, Behrouz Golichenari & Amirhosein Sahebkar. (2019) Shedding light on the EpCAM: An overview. Journal of Cellular Physiology 234:8, pages 12569-12580.
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Seok Joo Lee, Kee Yang Chung, Ji Eun Kwon, Sun Och Yoon & Sang Kyum Kim. (2018) Expression of EpCAM in adenoid cystic carcinoma. Pathology 50:7, pages 737-741.
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Daria V. Zhernakova, Trang H. Le, Alexander Kurilshikov, Biljana Atanasovska, Marc Jan Bonder, Serena Sanna, Annique Claringbould, Urmo Võsa, Patrick Deelen, Lude Franke, Rudolf A. de Boer, Folkert Kuipers, Mihai G. Netea, Marten H. Hofker, Cisca Wijmenga, Alexandra Zhernakova & Jingyuan Fu. (2018) Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. Nature Genetics 50:11, pages 1524-1532.
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Lige Qiu, Hailiang Li, Sirui Fu, Xiaofang Chen & Ligong Lu. (2017) Surface markers of liver cancer stem cells and innovative targeted-therapy strategies for HCC (Review). Oncology Letters.
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Shingo Tayama, Takeshi Motohara, Dashdemberel Narantuya, Chenyan Li, Koichi Fujimoto, Isao Sakaguchi, Hironori Tashiro, Hideyuki Saya, Osamu Nagano & Hidetaka Katabuchi. (2017) The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer. Oncotarget 8:27, pages 44312-44325.
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Hongxia Wang, Nikolas H. Stoecklein, Peter P. Lin & Olivier Gires. (2016) Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion. Oncotarget 8:1, pages 1884-1912.
Crossref
Jing-Hui Sun, Qing Luo, Ling-Ling Liu & Guan-Bin Song. (2016) Liver cancer stem cell markers: Progression and therapeutic implications. World Journal of Gastroenterology 22:13, pages 3547.
Crossref
Mei-Ying Liao, Jun-Kai Lai, Mark Yen-Ping Kuo, Ruei-Min Lu, Cheng-Wei Lin, Ping-Chang Cheng, Kang-Hao Liang & Han-Chung Wu. (2015) An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer. Oncotarget 6:28, pages 24947-24968.
Crossref
Wei Shi, Yang Liao, Simon N Willis, Nadine Taubenheim, Michael Inouye, David M Tarlinton, Gordon K Smyth, Philip D Hodgkin, Stephen L Nutt & Lynn M Corcoran. (2015) Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells. Nature Immunology 16:6, pages 663-673.
Crossref
Sachiko Ogasawara, Jun Akiba, Masamichi Nakayama, Osamu Nakashima, Takuji Torimura & Hirohisa Yano. (2015) Epithelial cell adhesion molecule-positive human hepatic neoplastic cells: development of combined hepatocellular-cholangiocarcinoma in mice. Journal of Gastroenterology and Hepatology 30:2, pages 413-420.
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Xin Chen, Wei-Yuan Ma, Shang-Chen Xu, Yu Liang, Yi-Bing Fu, Bo Pang, Tao Xin, Hai-Tao Fan, Rui Zhang, Jian-Gang Luo, Wen-Qing Kang, Min Wang & Qi Pang. (2014) The overexpression of Epithelial cell adhesion molecule (EpCAM) in glioma. Journal of Neuro-Oncology 119:1, pages 39-47.
Crossref
H. Zhang, W.J. Chang, X.Y. Li, N. Zhang, J.J. Kong & Y.F. Wang. (2014) Liver cancer stem cells are selectively enriched by low-dose cisplatin. Brazilian Journal of Medical and Biological Research 47:6, pages 478-482.
Crossref
Marius Ciurea, Ada Georgescu, Stefana Purcaru, Stefan-Alexandru Artene, Ghazaleh Emami, Mihai Boldeanu, Daniela Tache & Anica Dricu. (2014) Cancer Stem Cells: Biological Functions and Therapeutically Targeting. International Journal of Molecular Sciences 15:5, pages 8169-8185.
Crossref
Nadia M Penrod, Casey S Greene & Jason H Moore. (2014) Predicting targeted drug combinations based on Pareto optimal patterns of coexpression network connectivity. Genome Medicine 6:4, pages 33.
Crossref
Nai-Kong V. Cheung. 2014. Abeloff's Clinical Oncology. Abeloff's Clinical Oncology 508 518.e7 .
Juan Carlos Mellídez Barroso & Maria C. Santos. 2014. Stem Cells in Cancer: Should We Believe or Not?. Stem Cells in Cancer: Should We Believe or Not? 263 290 .
John Maher & Antonella A. Adami. (2013) Antitumor Immunity: Easy as 1, 2, 3 with Monoclonal Bispecific Trifunctional Antibodies?. Cancer Research 73:18, pages 5613-5617.
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Haiyang Chen, Zaili Luo, Wen Sun, Cunzhen Zhang, Huanlin Sun, Nanjie Zhao, Jin Ding, Mengchao Wu, Zhong Li & Hongyang Wang. (2013) Low glucose promotes CD133mAb-elicited cell death via inhibition of autophagy in hepatocarcinoma cells. Cancer Letters 336:1, pages 204-212.
Crossref
Nuzhat Ahmed, Khalid Abubaker, Jock Findlay & Michael Quinn. (2012) Cancerous ovarian stem cells: Obscure targets for therapy but relevant to chemoresistance. Journal of Cellular Biochemistry 114:1, pages 21-34.
Crossref
Sheng-Ta Tsai, Chih-Chiang Tsou, Wan-Yu Mao, Wei-Chao Chang, Hsin-Ying Han, Wen-Lian Hsu, Chung-Leung Li, Chia-Ning Shen & Chung-Hsuan Chen. (2012) Label-free quantitative proteomics of CD133-positive liver cancer stem cells. Proteome Science 10:1.
Crossref
Jie Ni, Paul J. Cozzi, Wei Duan, Sarah Shigdar, Peter H. Graham, Kearsley H. John & Yong Li. (2012) Role of the EpCAM (CD326) in prostate cancer metastasis and progression. Cancer and Metastasis Reviews 31:3-4, pages 779-791.
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Tianqing Liu & Benjamin Thierry. (2012) A Solution to the PEG Dilemma: Efficient Bioconjugation of Large Gold Nanoparticles for Biodiagnostic Applications using Mixed Layers. Langmuir 28:44, pages 15634-15642.
Crossref
Rona Ortenberg, Yair Sapir, Lee Raz, Liat Hershkovitz, Ayelet Ben Arav, Sivan Sapoznik, Iris Barshack, Camila Avivi, Yackov Berkun, Michal J. Besser, Tehila Ben-Moshe, Jacob Schachter & Gal Markel. (2012) Novel Immunotherapy for Malignant Melanoma with a Monoclonal Antibody That Blocks CEACAM1 Homophilic Interactions. Molecular Cancer Therapeutics 11:6, pages 1300-1310.
Crossref
Roberto Ronca, Patrizia Benzoni, Angela De Luca, Elisabetta Crescini & Patrizia Dell’Era. (2012) Phage Displayed Peptides/Antibodies Recognizing Growth Factors and Their Tyrosine Kinase Receptors as Tools for Anti-Cancer Therapeutics. International Journal of Molecular Sciences 13:4, pages 5254-5277.
Crossref
Changyong Guo, Haibo Liu, Bao-Hui Zhang, Radu M. Cadaneanu, Aqila M. Mayle & Isla P. Garraway. (2012) Epcam, CD44, and CD49f Distinguish Sphere-Forming Human Prostate Basal Cells from a Subpopulation with Predominant Tubule Initiation Capability. PLoS ONE 7:4, pages e34219.
Crossref
Mohid S. Khan, Theodora Tsigani, Mohammed Rashid, Jeremy S. Rabouhans, Dominic Yu, Tu Vinh Luong, Martyn Caplin & Tim Meyer. (2011) Circulating Tumor Cells and EpCAM Expression in Neuroendocrine Tumors. Clinical Cancer Research 17:2, pages 337-345.
Crossref
Michael A Ströhlein & Markus M Heiss. (2010) The trifunctional antibody catumaxomab in treatment of malignant ascites and peritoneal carcinomatosis. Future Oncology 6:9, pages 1387-1394.
Crossref

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