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Drug Evaluations

Sclerostin monoclonal antibody therapy with AMG 785: a potential treatment for osteoporosis

, MD FACP FACE
Pages 117-127 | Published online: 29 Nov 2010

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Read on this site (4)

Katya Sapunarova, Vesselina Goranova-Marinova, Pencho Georgiev, Tanya Deneva, Silvia Tsvetkova & Zhanet Grudeva-Popova. (2020) Associations of serum sclerostin with bone mineral density, markers of bone metabolism and thalassaemia characteristics in adult patients with transfusion-dependent beta-thalassaemia. Annals of Medicine 52:3-4, pages 94-108.
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Aline G Costa, John P Bilezikian & E Michael Lewiecki. (2014) Update on romosozumab: a humanized monoclonal antibody to sclerostin. Expert Opinion on Biological Therapy 14:5, pages 697-707.
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Zakareya Gamie, Nectarios Korres, Andreas Leonidou, Andrew C Gray & Eleftherios Tsiridis. (2012) Sclerostin monoclonal antibodies on bone metabolism and fracture healing. Expert Opinion on Investigational Drugs 21:10, pages 1523-1534.
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Filippo Migliorini, Federico Cocconi, Gianluca Vecchio, Luise Schäefer, Julian Koettnitz & Nicola Maffulli. Pharmacological agents for bone fracture healing: talking points from recent clinical trials.. Expert Opinion on Investigational Drugs 0:0.
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Articles from other publishers (27)

Xingyu Zhao & Xia Cao. (2023) Dual-functional coating that inhibits bone resorption and promotes bone formation applied to the surface modification of titanium screws. Materials Letters 349, pages 134734.
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Abdulmajeed Fahad Alrefaei & Muhammad Abu-Elmagd. (2022) LRP6 Receptor Plays Essential Functions in Development and Human Diseases. Genes 13:1, pages 120.
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Yejing Jeong, Jinuk Kim, Hee-Jung Choi & Ka Young Chung. (2021) Conformational Dynamics of Sclerostin-LRP6 Complex Analyzed by HDX-MS. Biomolecules & Therapeutics 29:5, pages 527-535.
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Jinuk Kim, Wonhee Han, Taeyong Park, Eun Jin Kim, Injin Bang, Hyun Sik Lee, Yejin Jeong, Kyeonghwan Roh, Jeesoo Kim, Jong-Seo Kim, Chanhee Kang, Chaok Seok, Jin-Kwan Han & Hee-Jung Choi. (2020) Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains. Nature Communications 11:1.
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Mohit Bhandari, Emil H. Schemitsch, Theofilos Karachalios, Parag Sancheti, Rudolf W. Poolman, John Caminis, Nadia Daizadeh, Ricardo E. Dent-Acosta, Ogo Egbuna, Arkadi Chines & Theodore Miclau. (2020) Romosozumab in Skeletally Mature Adults with a Fresh Unilateral Tibial Diaphyseal Fracture. Journal of Bone and Joint Surgery 102:16, pages 1416-1426.
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Amit Singla, Jichuan Wang, Rui Yang, David S. Geller, David M. Loeb & Bang H. Hoang. 2020. Current Advances in the Science of Osteosarcoma. Current Advances in the Science of Osteosarcoma 125 139 .
Vincent Lemaire & David R. Cox. (2018) Dynamics of Bone Cell Interactions and Differential Responses to PTH and Antibody-Based Therapies. Bulletin of Mathematical Biology 81:9, pages 3575-3622.
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Hsiao-Hsuan Wang, Yu-Hsiang Hsu & Ming-Shi Chang. (2018) IL-20 bone diseases involvement and therapeutic target potential. Journal of Biomedical Science 25:1.
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Aline G. Costa, Serge Cremers & John P. Bilezikian. (2017) Sclerostin measurement in human disease: Validity and current limitations. Bone 96, pages 24-28.
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Hailin Yang, Jinbo Dong, Wei Xiong, Zhong Fang, Hanfeng Guan & Feng Li. (2016) N-cadherin restrains PTH repressive effects on sclerostin/SOST by regulating LRP6-PTH1R interaction. Annals of the New York Academy of Sciences 1385:1, pages 41-52.
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Yu-Hsiang Hsu, Yi-Shu Chiu, Wei-Yu Chen, Kuo-Yuan Huang, I-Ming Jou, Po-Tin Wu, Chih-Hsing Wu & Ming-Shi Chang. (2016) Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis. Scientific Reports 6:1.
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Claire MacNabb, D. Patton & J. S. Hayes. (2016) Sclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and Challenges. Journal of Osteoporosis 2016, pages 1-22.
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Changjun Li, Weishan Wang, Liang Xie, Xianghang Luo, Xu Cao & Mei Wan. (2016) Lipoprotein receptor-related protein 6 is required for parathyroid hormone-induced Sost suppression . Annals of the New York Academy of Sciences 1364:1, pages 62-73.
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Andrés Felipe Posada, Hernán Darío Aguirre, Julio Cesar García Casallas, Jhon Darío Lodoño Patiño & Rafael Valle Oñate. (2016) New therapies in osteoporosis. Revista Colombiana de Reumatología (English Edition) 23:1, pages 34-43.
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Andrés Felipe Posada, Hernán Darío Aguirre, Julio Cesar García Casallas, Jhon Darío Lodoño Patiño & Rafael Valle Oñate. (2016) Nuevas terapias en osteoporosis. Revista Colombiana de Reumatología 23:1, pages 34-43.
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M Invernizzi, S Carda, M Rizzi, E Grana, D F Squarzanti, C Cisari, C Molinari & F Renò. (2015) Evaluation of serum myostatin and sclerostin levels in chronic spinal cord injured patients. Spinal Cord 53:8, pages 615-620.
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Robert R. Recker, Charles T. Benson, Toshio Matsumoto, Michael A. Bolognese, Deborah A. Robins, Jahangir Alam, Alan Y Chiang, Leijun Hu, John H Krege, Hideaki Sowa, Bruce H. Mitlak & Stephen L. Myers. (2015) A Randomized, Double‐Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density. Journal of Bone and Mineral Research 30:2, pages 216-224.
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Qi Yao, Jie Ni, Yu Hou, Lixiang Ding, Licheng Zhang & Hua Jiang. (2013) Expression of Sclerostin scFv and the Effect of Sclerostin scFv on Healing of Osteoporotic Femur Fracture in Rats. Cell Biochemistry and Biophysics 69:2, pages 229-235.
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Yu-Hsiang Hsu & Ming-Shi Chang. (2014) The Therapeutic Potential of Anti-Interleukin-20 Monoclonal Antibody. Cell Transplantation 23:4-5, pages 631-639.
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Carol H. Lin, Tao Ji, Cheng-Fong Chen & Bang H. Hoang. 2014. Current Advances in Osteosarcoma. Current Advances in Osteosarcoma 33 45 .
Arjun Muralidharan & Maree T. Smith. (2013) Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments. Inflammopharmacology 21:5, pages 339-363.
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Jens Bollerslev, Kim Henriksen, Morten Frost Nielsen, Kim Brixen & Wim Van Hul. (2013) Genetics in Endocrinology: Autosomal dominant osteopetrosis revisited: lessons from recent studies. European Journal of Endocrinology 169:2, pages R39-R57.
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Tomoka HASEGAWA, Norio AMIZUKA, Tamaki YAMADA, Zhusheng LIU, Yukina MIYAMOTO, Tomomaya YAMAMOTO, Muneteru SASAKI, Hiromi HONGO, Reiko SUZUKI, Paulo Henrique Luiz DE FREITAS, Tsuneyuki YAMAMOTO, Kimimitsu ODA & Minqi LI. (2013) Sclerostin is differently immunolocalized in metaphyseal trabecules and cortical bones of mouse tibiae. Biomedical Research 34:3, pages 153-159.
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Ricardo A. Battaglino, Supreetha Sudhakar, Antonio A. Lazzari, Eric Garshick, Ross Zafonte & Leslie R. Morse. (2012) Circulating sclerostin is elevated in short-term and reduced in long-term SCI. Bone 51:3, pages 600-605.
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Aline G. Costa & John P. Bilezikian. (2012) Sclerostin: Therapeutic Horizons Based Upon Its Actions. Current Osteoporosis Reports 10:1, pages 64-72.
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Leslie R Morse, Supreetha Sudhakar, Valery Danilack, Carlos Tun, Antonio Lazzari, David R Gagnon, Eric Garshick & Ricardo A Battaglino. (2012) Association between sclerostin and bone density in chronic spinal cord injury. Journal of Bone and Mineral Research 27:2, pages 352-359.
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Antoon H van Lierop, Neveen AT Hamdy, Herman Hamersma, Rutger L van Bezooijen, Jon Power, Nigel Loveridge & Socrates E Papapoulos. (2011) Patients with sclerosteosis and disease carriers: Human models of the effect of sclerostin on bone turnover. Journal of Bone and Mineral Research 26:12, pages 2804-2811.
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