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Designing immunoconjugates for cancer therapy

, PhD & , ScD MD
Pages 873-890 | Published online: 11 Jun 2012

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Serengulam V. Govindan, Robert M. Sharkey & David M. Goldenberg. (2016) Prospects and progress of antibody-drug conjugates in solid tumor therapies. Expert Opinion on Biological Therapy 16:7, pages 883-893.
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Christine Sedlik, Adèle Heitzmann, Sophie Viel, Rafik Ait Sarkouh, Cornélie Batisse, Frédéric Schmidt, Philippe De La Rochere, Nathalie Amzallag, Eduardo Osinaga, Pablo Oppezzo, Otto Pritsch, Xavier Sastre-Garau, Pascale Hubert, Sebastian Amigorena & Eliane Piaggio. (2016) Effective antitumor therapy based on a novel antibody-drug conjugate targeting the Tn carbohydrate antigen. OncoImmunology 5:7.
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Erika Vacchelli, Fernando Aranda, Florine Obrist, Alexander Eggermont, Jérôme Galon, Isabelle Cremer, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2014) Trial watch. OncoImmunology 3:6.
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T Shantha Raju & William R Strohl. (2013) Potential therapeutic roles for antibody mixtures. Expert Opinion on Biological Therapy 13:10, pages 1347-1352.
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Articles from other publishers (34)

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Avijit Kumar Bakshi, Tanweer Haider, Rahul Tiwari & Vandana Soni. (2022) Critical parameters for design and development of multivalent nanoconstructs: recent trends. Drug Delivery and Translational Research 12:10, pages 2335-2358.
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Md Abdus Subhan & Vladimir P. Torchilin. (2021) Advances with antibody-drug conjugates in breast cancer treatment. European Journal of Pharmaceutics and Biopharmaceutics 169, pages 241-255.
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Andrew P Mayer, Hermes Licea-Perez, Sharon Boram, Kristen E Pannullo, Jonathan Kehler & Christopher A Evans. (2021) Overcoming challenges associated with the bioanalysis of cysteine-conjugated metabolites in the presence of antibody–drug conjugates. Bioanalysis 13:18, pages 1427-1439.
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Amir-Hassan Zarnani, Davood Jafari, Mahmood Bozorgmehr, Mahdi Shabani, Leila Barzegar-Yarmohammadi, Fatemeh Ghaemimanesh & Mahmood Jeddi-Tehrani. 2021. Cancer Immunology. Cancer Immunology 273 312 .
M. Ángeles Rojo, Manuel Garrosa, Pilar Jiménez, Tomás Girbés, Verónica Garcia-Recio, Manuel Cordoba-Diaz & Damián Cordoba-Diaz. (2020) Unexpected Toxicity of Green Tea Polyphenols in Combination with the Sambucus RIL Ebulin. Toxins 12:9, pages 542.
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Jason J. Zoeller, Aleksandr Vagodny, Krishan Taneja, Benjamin Y. Tan, Neil O'Brien, Dennis J. Slamon, Deepak Sampath, Joel D. Leverson, Roderick T. Bronson, Deborah A. Dillon & Joan S. Brugge. (2019) Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo . Molecular Cancer Therapeutics 18:6, pages 1115-1126.
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Loganathan Rangasamy, Venkatesh Chelvam, Ananda Kumar Kanduluru, Madduri Srinivasarao, N. Achini Bandara, Fei You, Esteban A. Orellana, Andrea L. Kasinski & Philip S. Low. (2018) New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K + /H + Exchange . Bioconjugate Chemistry 29:4, pages 1047-1059.
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Nimish Gupta, Johny Kancharla, Shelly Kaushik, Aasif Ansari, Samad Hossain, Ravinder Goyal, Manoj Pandey, Jwala Sivaccumar, Sazid Hussain, Arindam Sarkar, Aniruddha Sengupta, Swadhin K. Mandal, Monideepa Roy & Shiladitya Sengupta. (2017) Development of a facile antibody–drug conjugate platform for increased stability and homogeneity. Chemical Science 8:3, pages 2387-2395.
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B. Vijayalakshmi Ayyar, Sushrut Arora & Richard O’Kennedy. (2016) Coming-of-Age of Antibodies in Cancer Therapeutics. Trends in Pharmacological Sciences 37:12, pages 1009-1028.
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Prince Awuah, Tapan K. Bera, Messan Folivi, Oleg Chertov & Ira Pastan. (2016) Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins. Molecular Cancer Therapeutics 15:7, pages 1648-1655.
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Noam Mamet & Ido Bachelet. 2016. Wireless Computing in Medicine. Wireless Computing in Medicine 359 375 .
Yosi Gilad, Michael Firer & Gary Gellerman. (2016) Recent Innovations in Peptide Based Targeted Drug Delivery to Cancer Cells. Biomedicines 4:2, pages 11.
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Robert M. Sharkey, William J. McBride, Thomas M. Cardillo, Serengulam V. Govindan, Yang Wang, Edmund A. Rossi, Chien-Hsing Chang & David M. Goldenberg. (2015) Enhanced Delivery of SN-38 to Human Tumor Xenografts with an Anti-Trop-2–SN-38 Antibody Conjugate (Sacituzumab Govitecan). Clinical Cancer Research 21:22, pages 5131-5138.
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Boris Redko, Elena Ragozin, Bazylevich Andreii, Tuchinsky Helena, Albeck Amnon, Shekhter Zahavi Talia, Oron-Herman Mor, Kostenich Genady & Gellerman Gary. (2015) Synthesis, drug release, and biological evaluation of new anticancer drug-bioconjugates containing somatostatin backbone cyclic analog as a targeting moiety. Biopolymers 104:6, pages 743-752.
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David M. Goldenberg, Thomas M. Cardillo, Serengulam V. Govindan, Edmund A. Rossi & Robert M. Sharkey. (2015) Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC)*. Oncotarget 6:26, pages 22496-22512.
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Hannes Brehm, Dmitrij Hristodorov, Alessa Pardo, Radoslav Mladenov, Judith Niesen, Rainer Fischer, Mehmet K. Tur & Stefan Barth. (2015) Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein. Cancer Letters 365:2, pages 149-155.
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Alison J. Smith. (2015) New Horizons in Therapeutic Antibody Discovery: Opportunities and Challenges versus Small-Molecule Therapeutics. SLAS Discovery 20:4, pages 437-453.
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Amir-Hassan Zarnani, Mahmood Bozorgmehr, Mahdi Shabani, Leila Barzegar-Yarmohammadi, Fatemeh Ghaemimanesh & Mahmood Jeddi-Tehrani. 2015. Cancer Immunology. Cancer Immunology 293 328 .
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Qichun Wei, Jing Xu, Li Shen, Xianhua Fu, Bicheng Zhang, Xiaofeng Zhou & Jorgen Carlsson. (2014) HER2 expression in primary gastric cancers and paired synchronous lymph node and liver metastases. A possible road to target HER2 with radionuclides. Tumor Biology 35:7, pages 6319-6326.
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Mojtaba Oraki Kohshour, Sako Mirzaie, Majid Zeinali, Mansour Amin, Mohammad Said Hakhamaneshi, Ali Jalaili, Nader Mosaveri & Mostafa Jamalan. (2014) Ablation of Breast Cancer Cells Using Trastuzumab-Functionalized Multi-Walled Carbon Nanotubes and Trastuzumab-Diphtheria Toxin Conjugate. Chemical Biology & Drug Design 83:3, pages 259-265.
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Serengulam V. Govindan, Thomas M. Cardillo, Robert M. Sharkey, Fatma Tat, David V. Gold & David M. Goldenberg. (2013) Milatuzumab–SN-38 Conjugates for the Treatment of CD74+ Cancers. Molecular Cancer Therapeutics 12:6, pages 968-978.
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Hendrik Fuchs, Christopher Bachran & David Flavell. (2013) Diving through Membranes: Molecular Cunning to Enforce the Endosomal Escape of Antibody-Targeted Anti-Tumor Toxins. Antibodies 2:4, pages 209-235.
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