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Epigenetics in osteoarthritis and its implication for future therapeutics

, MD & , BS
Pages 713-721 | Published online: 15 Feb 2013

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Gun-Il Im & Kyung-Ju Shin. (2015) Epigenetic approaches to regeneration of bone and cartilage from stem cells. Expert Opinion on Biological Therapy 15:2, pages 181-193.
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Shirin Kadler, Özlem Vural, Jennifer Rosowski, Luzia Reiners-Schramm, Roland Lauster & Mark Rosowski. (2020) Effects of 5-aza-2´-deoxycytidine on primary human chondrocytes from osteoarthritic patients. PLOS ONE 15:6, pages e0234641.
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Wenting Liao, Jiadong Sun, Wenjing Liu, Wenyu Li, Jiaxin Jia, Farong Ou, Kai Su, Youhua Zheng, Zhiguang Zhang & Yangpeng Sun. (2018) HDAC10 upregulation contributes to interleukin 1β‐mediated inflammatory activation of synovium‐derived mesenchymal stem cells in temporomandibular joint. Journal of Cellular Physiology 234:8, pages 12646-12662.
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Guping Mao, Shu Hu, Ziji Zhang, Peihui Wu, Xiaoyi Zhao, Ruifu Lin, Weiming Liao & Yan Kang. (2018) Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8. Journal of Cellular and Molecular Medicine 22:11, pages 5354-5366.
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Ying-Jie Guan, Jing Li, Xu Yang, Shaohua Du, Jing Ding, Yun Gao, Ying Zhang, Kun Yang & Qian Chen. (2018) Evidence that miR-146a attenuates aging- and trauma-induced osteoarthritis by inhibiting Notch1, IL-6, and IL-1 mediated catabolism. Aging Cell 17:3, pages e12752.
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Swarna Raman, Una FitzGerald & J. Mary Murphy. (2018) Interplay of Inflammatory Mediators with Epigenetics and Cartilage Modifications in Osteoarthritis. Frontiers in Bioengineering and Biotechnology 6.
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Nazir M. Khan & Tariq M. Haqqi. (2018) Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics. Pharmacological Research 128, pages 73-79.
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Elke Kunisch, Raimund W. Kinne, Rayya J. Alsalameh & Saifeddin Alsalameh. (2016) Pro-inflammatory IL-1beta and/or TNF-alpha up-regulate matrix metalloproteases-1 and -3 mRNA in chondrocyte subpopulations potentially pathogenic in osteoarthritis: in situ hybridization studies on a single cell level . International Journal of Rheumatic Diseases 19:6, pages 557-566.
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Holger Jahr. (2015) HDACi and Nrf2: not from alpha to omega but from acetylation to OA. Arthritis Research & Therapy 17:1.
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E.L. Rogers, L.N. Reynard & J. Loughlin. (2015) The role of inflammation-related genes in osteoarthritis. Osteoarthritis and Cartilage 23:11, pages 1933-1938.
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Kenji Hata. (2015) Epigenetic regulation of chondrocyte differentiation. Japanese Dental Science Review 51:4, pages 105-113.
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TU MIN, LI YU SHENG, CHENG CHAO, TIAN JIAN, GAO SHU GUANG & LEI GUANG HUA. (2015) Correlation between osteopontin and caveolin-1 in the pathogenesis and progression of osteoarthritis. Experimental and Therapeutic Medicine 9:6, pages 2059-2064.
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Mikhail A. Selyanin, Petr Ya. Boykov, Vladimir N. Khabarov & Felix Polyak. 2015. Hyaluronic Acid. Hyaluronic Acid 143 192 .
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Jingting LiJames OhligerMing Pei. (2014) Significance of Epigenetic Landscape in Cartilage Regeneration from the Cartilage Development and Pathology Perspective. Stem Cells and Development 23:11, pages 1178-1194.
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Patrick du Souich. (2014) Absorption, distribution and mechanism of action of SYSADOAS. Pharmacology & Therapeutics 142:3, pages 362-374.
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