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Expert Opinion on Biological Therapy Volume 14, 2014 - Issue 7
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Phenotypic alterations, clinical impact and therapeutic potential of regulatory T cells in cancer

Belal ChaudharyUniversity of Salford, School of Environment & Life Sciences, Biomedical Research Centre, The Crescent, Peel Building, Manchester M5 4WT, UK
,
May Abd Al SamidUniversity of Salford, School of Environment & Life Sciences, Biomedical Research Centre, The Crescent, Peel Building, Manchester M5 4WT, UK
,
Basel K al-RamadiUnited Arab Emirates University, College of Medicine & Health Sciences, PO Box 17666, Al Ain, UAE+971 3 7137527; +971 3 7671966; [email protected], [email protected]
&
Eyad ElkordUniversity of Salford, School of Environment & Life Sciences, Biomedical Research Centre, The Crescent, Peel Building, Manchester M5 4WT, UK;United Arab Emirates University, College of Medicine & Health Sciences, PO Box 17666, Al Ain, UAE+971 3 7137527; +971 3 7671966; [email protected], [email protected];Institute of Cancer Sciences, University of Manchester, Manchester, UK
Pages 931-945 | Published online: 24 Mar 2014

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Maria Tsirogianni, Eirini Grigoriou, Violetta Kapsimalli, Kleopatra Dagla, Maria Stamouli, Konstantinos Gkirkas, Eve Konsta, Angeliki Karagiannidou, Konstantinos Gkodopoulos, Georgia Stavroulaki, Vassiliki Pappa, Maria Angelopoulou, Mark Lowdell & Panagiotis Tsirigotis. (2019) Natural killer cell cytotoxicity is a predictor of outcome for patients with high risk myelodysplastic syndrome and oligoblastic acute myeloid leukemia treated with azacytidine. Leukemia & Lymphoma 60:10, pages 2457-2463.
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Belal Chaudhary & Eyad Elkord. (2015) Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases. Expert Opinion on Therapeutic Targets 19:2, pages 147-161.
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Articles from other publishers (23)

Yifu Liu, Shengqiang Fu, Zhicheng Zhang, Siyuan Wang, Xiaofeng Cheng, Zhilong Li, Yi Ding, Ting Sun & Ming Ma. (2022) GRAMD1A Is a Biomarker of Kidney Renal Clear Cell Carcinoma and Is Associated with Immune Infiltration in the Tumour Microenvironment. Disease Markers 2022, pages 1-25.
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Alhasan Alsalman, Mohammad A. Al-Mterin, Khaled Murshed, Ferial Alloush, Samia T. Al-Shouli, Salman M. Toor & Eyad Elkord. (2022) Circulating and Tumor-Infiltrating Immune Checkpoint-Expressing CD8+ Treg/T Cell Subsets and Their Associations with Disease-Free Survival in Colorectal Cancer Patients. Cancers 14:13, pages 3194.
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Jessica Waibl Polania, Emily C. Lerner, Daniel S. Wilkinson, Alexandra Hoyt-Miggelbrink & Peter E. Fecci. (2021) Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies. Frontiers in Immunology 12.
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Katarina Kalavska, Zuzana Sestakova, Andrea Mlcakova, Katarína Kozics, Paulina Gronesova, Lenka Hurbanova, Viera Miskovska, Katarina Rejlekova, Daniela Svetlovska, Zuzana Sycova-Mila, Jana Obertova, Patrik Palacka, Jozef Mardiak, Michal Chovanec, Miroslav Chovanec & Michal Mego. (2021) Are Changes in the Percentage of Specific Leukocyte Subpopulations Associated with Endogenous DNA Damage Levels in Testicular Cancer Patients?. International Journal of Molecular Sciences 22:15, pages 8281.
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Jinhui Liu, Sipei Nie, Zhipeng Wu, Yi Jiang, Yicong Wan, Siyue Li, Huangyang Meng, Shulin Zhou & Wenjun Cheng. (2020) Exploration of a novel prognostic risk signatures and immune checkpoint molecules in endometrial carcinoma microenvironment. Genomics 112:5, pages 3117-3134.
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Weikan Wang, Rachel Thomas, Olga Sizova & Dong-Ming Su. (2020) Thymic Function Associated With Cancer Development, Relapse, and Antitumor Immunity – A Mini-Review. Frontiers in Immunology 11.
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Shamir Cassim & Jacques Pouyssegur. (2019) Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response. International Journal of Molecular Sciences 21:1, pages 157.
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Farouk Abou HassanMirna Bou HamdanNada M. Melhem. (2019) The Role of Natural Killer Cells and Regulatory T Cells While Aging with Human Immunodeficiency Virus. AIDS Research and Human Retroviruses 35:11-12, pages 1123-1135.
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Zhilin Hu, Qiang Zou & Bing Su. (2018) Regulation of T cell immunity by cellular metabolism. Frontiers of Medicine 12:4, pages 463-472.
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Katarzyna Donskow-Łysoniewska, Katarzyna Krawczak, Katarzyna Bocian & Maria Doligalska. (2017) The Effects of Intestinal Nematode L4 Stage on Mouse Experimental Autoimmune Encephalomyelitis. Archivum Immunologiae et Therapiae Experimentalis 66:3, pages 231-243.
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Elena Lo Presti, Roberto Di Mitri, Gabriele Pizzolato, Filippo Mocciaro, Francesco Dieli & Serena Meraviglia. (2018) γδ cells and tumor microenvironment: A helpful or a dangerous liason?. Journal of Leukocyte Biology 103:3, pages 485-492.
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Julen Tomás-Cortázar, Itziar Martín-Ruiz, Diego Barriales, Miguel Ángel Pascual-Itoiz, Virginia Gutiérrez de Juan, Alfredo Caro-Maldonado, Nekane Merino, Alberto Marina, Francisco J. Blanco, Juana María Flores, James D. Sutherland, Rosa Barrio, Adriana Rojas, María Luz Martínez-Chantar, Arkaitz Carracedo, Carolina Simó, Virginia García-Cañas, Leticia Abecia, José Luis Lavín, Ana M. Aransay, Héctor Rodríguez & Juan Anguita. (2017) The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant. Scientific Reports 7:1.
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Salman M. Toor, Azharuddin Sajid Syed Khaja, Haytham El Salhat, Issam Faour, Jihad Kanbar, Asif A. Quadri, Mohamed Albashir & Eyad Elkord. (2017) Myeloid cells in circulation and tumor microenvironment of breast cancer patients. Cancer Immunology, Immunotherapy 66:6, pages 753-764.
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Soumaya Kouidhi, Amel Benammar Elgaaied & Salem Chouaib. (2017) Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment. Frontiers in Immunology 8.
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Salman M. Toor, Azharuddin Sajid Syed Khaja, Haytham El Salhat, Omar Bekdache, Jihad Kanbar, Mohammed Jaloudi & Eyad Elkord. (2016) Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients. Frontiers in Immunology 7.
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Belal Chaudhary & Eyad Elkord. (2016) Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting. Vaccines 4:3, pages 28.
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Eyad Elkord. (2016) Helios Should Not Be Cited as a Marker of Human Thymus-Derived Tregs. Commentary: Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans. Frontiers in Immunology 7.
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May Abd Al Samid, Belal Chaudhary, Yazan S. Khaled, Basil J. Ammori & Eyad Elkord. (2016) Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients. Oncotarget 7:12, pages 14083-14094.
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I Sawazaki-Calone, ALCA Rangel, AG Bueno, CF Morais, HM Nagai, RP Kunz, RL Souza, L Rutkauskis, T Salo, A Almangush & RD Coletta. (2015) The prognostic value of histopathological grading systems in oral squamous cell carcinomas. Oral Diseases 21:6, pages 755-761.
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Rhiannon Koirala & David Gyorki. (2015) Targeting the Immune System for Cancer Therapy: Lessons for Perioperative Management?. Current Anesthesiology Reports 5:3, pages 257-267.
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Eyad Elkord, May Abd Al Samid & Belal Chaudhary. (2015) Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP. Oncotarget 6:24, pages 20026-20036.
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Belal Chaudhary & Eyad Elkord. (2015) Downregulation of Immunosuppressive Environment in Patients with Chronic HBV Hepatitis on Maintained Remission. Frontiers in Immunology 6.
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Elizabeth C. Halvorsen, Sahar M. Mahmoud & Kevin L. Bennewith. (2014) Emerging roles of regulatory T cells in tumour progression and metastasis. Cancer and Metastasis Reviews 33:4, pages 1025-1041.
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