1,047
Views
56
CrossRef citations to date
0
Altmetric
Reviews

Amyloid-directed monoclonal antibodies for the treatment of Alzheimer’s disease: the point of no return?

, MD PhD, , MD PhD, , PhD & , MD PhD

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Justin L. Hoskin, Marwan Noel Sabbagh, Yazan Al-Hasan & Boris Decourt. (2019) Tau immunotherapies for Alzheimer’s disease. Expert Opinion on Investigational Drugs 28:6, pages 545-554.
Read now
Yuetiva Deming, Zeran Li, Bruno A. Benitez & Carlos Cruchaga. (2018) Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?. Expert Opinion on Therapeutic Targets 22:7, pages 587-598.
Read now
William M. Pardridge. (2016) Re-engineering therapeutic antibodies for Alzheimer’s disease as blood-brain barrier penetrating bi-specific antibodies. Expert Opinion on Biological Therapy 16:12, pages 1455-1468.
Read now
Francesco Panza, Davide Seripa, Vincenzo Solfrizzi, Bruno P. Imbimbo, Madia Lozupone, Antonio Leo, Rodolfo Sardone, Gaetano Gagliardi, Lucia Lofano, Bianca C. Creanza, Paola Bisceglia, Antonio Daniele, Antonello Bellomo, Antonio Greco & Giancarlo Logroscino. (2016) Emerging drugs to reduce abnormal β-amyloid protein in Alzheimer’s disease patients. Expert Opinion on Emerging Drugs 21:4, pages 377-391.
Read now
Davide Seripa, Vincenzo Solfrizzi, Bruno P. Imbimbo, Antonio Daniele, Andrea Santamato, Madia Lozupone, Giovanni Zuliani, Antonio Greco, Giancarlo Logroscino & Francesco Panza. (2016) Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium. Expert Review of Neurotherapeutics 16:3, pages 259-277.
Read now
Francesco Panza, Davide Seripa, Vincenzo Solfrizzi, Bruno P. Imbimbo, Andrea Santamato, Madia Lozupone, Rosa Capozzo, Camilla Prete, Alberto Pilotto, Antonio Greco & Giancarlo Logroscino. (2016) Tau aggregation inhibitors: the future of Alzheimer’s pharmacotherapy?. Expert Opinion on Pharmacotherapy 17:4, pages 457-461.
Read now
Francesco Panza, Vincenzo Solfrizzi, Davide Seripa, Bruno P Imbimbo, Andrea Santamato, Madia Lozupone, Camilla Prete, Antonio Greco, Alberto Pilotto & Giancarlo Logroscino. (2015) Progresses in treating agitation: a major clinical challenge in Alzheimer’s disease. Expert Opinion on Pharmacotherapy 16:17, pages 2581-2588.
Read now

Articles from other publishers (49)

Naif H. Ali, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Saud A. Alnaaim, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad & Gaber El-Saber Batiha. (2023) The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective. Acta Neurologica Belgica.
Crossref
Mona M. Marzouk, Mai M. Farid, Nesrine M. Hegazi & Shahira M. Ezzat. 2023. Phytochemical Drug Discovery for Central Nervous System Disorders. Phytochemical Drug Discovery for Central Nervous System Disorders 43 80 .
Anas Zakarya Nourelden, Ibrahim Kamal, Abdelrahman G. Tawfik, Abdulrahman Ibrahim Hagrass, Ahmed Hashem Fathallah & Mohamed Sayed Zaazouee. (2023) Safety and efficacy of sodium oligomannate in patients with Alzheimer’s disease: a systematic review and meta-analysis. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 59:1.
Crossref
Parth Sharma, Ritchu Babbar, Twinkle Sharma, Piyush Madaan, Sandeep Arora & Vishnu Nayak Badavath. (2023) Anti-Amyloid-β Immunotherapy: A Leading Novel Avenue for Alzheimer's Disease. Mini-Reviews in Medicinal Chemistry 23:1, pages 53-66.
Crossref
Nastaran Karimi, Feyza Bayram Çatak, Ebru Arslan, Amene Saghazadeh & Nima Rezaei. (2022) Tau immunotherapy in Alzheimer’s disease and progressive supranuclear palsy. International Immunopharmacology 113, pages 109445.
Crossref
Afreen Hashmi, Vivek Srivastava, Syed Abul Kalam & Devesh Kumar Mishra. 2022. Alzheimer's Disease. Alzheimer's Disease.
Livia La Barbera, Emanuele Mauri, Marcello D’Amelio & Manuele Gori. (2022) Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer’s disease: Current trends and future perspectives. Frontiers in Neuroscience 16.
Crossref
Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper & Matthew G Holt. (2022) AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model. EMBO Molecular Medicine 14:4.
Crossref
Johan A. den Boer, Erik J.F. de Vries, Ronald J.H. Borra, Aren van Waarde, Adriaan A. Lammertsma & Rudi A. Dierckx. (2022) Role of Brain Imaging in Drug Development for Psychiatry. Current Reviews in Clinical and Experimental Pharmacology 17:1, pages 46-71.
Crossref
Valentina Tedeschi, Daniele La Russa, Cristina Franco, Antonio Vinciguerra, Diana Amantea & Agnese Secondo. (2021) Plasma Membrane and Organellar Targets of STIM1 for Intracellular Calcium Handling in Health and Neurodegenerative Diseases. Cells 10:10, pages 2518.
Crossref
Maria Calvo-Rodriguez, Elizabeth K. Kharitonova & Brian J. Bacskai. (2021) In vivo brain imaging of mitochondrial Ca2+ in neurodegenerative diseases with multiphoton microscopy. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:6, pages 118998.
Crossref
Maria Calvo-Rodriguez & Brian J. Bacskai. (2021) Mitochondria and Calcium in Alzheimer’s Disease: From Cell Signaling to Neuronal Cell Death. Trends in Neurosciences 44:2, pages 136-151.
Crossref
Son Tung Ngo. (2021) In silico Probing Ca2+ And Zn2+ Permeable Transmembrane 4Aβ1-42 Barrel. Communications in Physics 31:1, pages 57.
Crossref
Tao Wang, Weihong Kuang, Wei Chen, Wenwei Xu, Liming Zhang, Yingjie Li, Hailin Li, Ying Peng, Yangmei Chen, Baojun Wang, Jinsong Xiao, Honghua Li, Chuanzhu Yan, Yifeng Du, Mouni Tang, Zhiyi He, Haibo Chen, Wei Li, Hong Lin, Shugui Shi, Jianzhong Bi, Huadong Zhou, Yan Cheng, Xiaoping Gao, Yihui Guan, Qiu Huang, Kewei Chen, Xianliang Xin, Jian Ding, Meiyu Geng & Shifu Xiao. (2020) A phase II randomized trial of sodium oligomannate in Alzheimer’s dementia. Alzheimer's Research & Therapy 12:1.
Crossref
Chuan-cong Zhu, Si-yu Fu, Yu-xin Chen, Ling Li, Ruo-lin Mao, Jian-zhi Wang, Rong Liu, Yi Liu & Xiao-chuan Wang. (2021) Advances in Drug Therapy for Alzheimer’s Disease. Current Medical Science 40:6, pages 999-1008.
Crossref
Maria Calvo-Rodriguez, Elizabeth K. Kharitonova & Brian J. Bacskai. (2020) Therapeutic Strategies to Target Calcium Dysregulation in Alzheimer’s Disease. Cells 9:11, pages 2513.
Crossref
Jia Liu & Lu-ning Wang. (2020) Efficacy and safety of valproic acid in dementia: A systematic review with meta-analysis. Archives of Gerontology and Geriatrics 89, pages 104091.
Crossref
Ram Reddy Chandupatla, Andrew Flatley, Regina Feederle, Eva‐Maria Mandelkow & Senthilvelrajan Kaniyappan. (2020) Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes. Alzheimer's & Dementia: Translational Research & Clinical Interventions 6:1.
Crossref
Guan‐Jun Yang, Hao Liu, Dik-Lung Ma & Chung-Hang Leung. (2019) Rebalancing metal dyshomeostasis for Alzheimer’s disease therapy. JBIC Journal of Biological Inorganic Chemistry 24:8, pages 1159-1170.
Crossref
Gabor G Kovacs. (2019) Molecular pathology of neurodegenerative diseases: principles and practice. Journal of Clinical Pathology 72:11, pages 725-735.
Crossref
Elisa Greotti, Paola Capitanio, Andrea Wong, Tullio Pozzan, Paola Pizzo & Diana Pendin. (2019) Familial Alzheimer’s disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis. Cell Calcium 79, pages 44-56.
Crossref
Son Tung Ngo, Philippe Derreumaux & Van V. Vu. (2019) Probable Transmembrane Amyloid α-Helix Bundles Capable of Conducting Ca 2+ Ions . The Journal of Physical Chemistry B 123:12, pages 2645-2653.
Crossref
Lei Zhao, Xiaoqin Cheng & Chunjiu Zhong. (2018) Implications of Successful Symptomatic Treatment in Parkinson’s Disease for Therapeutic Strategies of Alzheimer’s Disease. ACS Chemical Neuroscience 10:2, pages 922-930.
Crossref
A. J. LarnerA. J. Larner. 2019. Diagnostic Test Accuracy Studies in Dementia. Diagnostic Test Accuracy Studies in Dementia 163 179 .
Niyanta N. Kumar, Michelle E. Pizzo, Geetika Nehra, Brynna Wilken-Resman, Sam Boroumand & Robert G. Thorne. (2018) Passive Immunotherapies for Central Nervous System Disorders: Current Delivery Challenges and New Approaches. Bioconjugate Chemistry 29:12, pages 3937-3966.
Crossref
Jiqing Cao, Jianwei Hou, Jing Ping & Dongming Cai. (2018) Advances in developing novel therapeutic strategies for Alzheimer’s disease. Molecular Neurodegeneration 13:1.
Crossref
Erin E. Congdon & Einar M. Sigurdsson. (2018) Tau-targeting therapies for Alzheimer disease. Nature Reviews Neurology 14:7, pages 399-415.
Crossref
Nguyen Minh Tam, Khanh B. Vu, Van V. Vu & Son Tung Ngo. (2018) Influence of various force fields in estimating the binding affinity of acetylcholinesterase inhibitors using fast pulling of ligand scheme. Chemical Physics Letters 701, pages 65-71.
Crossref
Yangmei Huang, Baihong Guo, Bihua Shi, Qingtao Gao & Qiang Zhou. (2018) Chinese Herbal Medicine Xueshuantong Enhances Cerebral Blood Flow and Improves Neural Functions in Alzheimer’s Disease Mice. Journal of Alzheimer's Disease 63:3, pages 1089-1107.
Crossref
Kayla M. Pate, Brandon J. Kim, Eric V. Shusta & Regina M. Murphy. (2018) Transthyretin Mimetics as Anti‐β‐Amyloid Agents: A Comparison of Peptide and Protein Approaches. ChemMedChem 13:9, pages 968-979.
Crossref
Dongtak Lee, Gyudo Lee & Dae Sung Yoon. (2018) Anti-Aβ drug candidates in clinical trials and plasmonic nanoparticle-based drug-screen for Alzheimer's disease. The Analyst 143:10, pages 2204-2212.
Crossref
J. Folch, M. Ettcheto, D. Petrov, S. Abad, I. Pedrós, M. Marin, J. Olloquequi & A. Camins. (2018) Review of the advances in treatment for Alzheimer disease: strategies for combating β-amyloid protein. Neurología (English Edition) 33:1, pages 47-58.
Crossref
J. Folch, M. Ettcheto, D. Petrov, S. Abad, I. Pedrós, M. Marin, J. Olloquequi & A. Camins. (2018) Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide. Neurología 33:1, pages 47-58.
Crossref
Andrea GrignolioAndrea Grignolio. 2018. Vaccines: Are they Worth a Shot?. Vaccines: Are they Worth a Shot? 111 135 .
Aseel Eid, Shannon E. May, Nasser Zawia & Jodi L. Camberg. 2018.
Shih-Ya Hung & Wen-Mei Fu. (2017) Drug candidates in clinical trials for Alzheimer’s disease. Journal of Biomedical Science 24:1.
Crossref
B. Mehrazma, M. Robinson, S.K.A. Opare, A. Petoyan, J. Lou, F.T. Hane, A. Rauk & Z. Leonenko. (2017) Pseudo-peptide amyloid-β blocking inhibitors: molecular dynamics and single molecule force spectroscopy study. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1865:11, pages 1707-1718.
Crossref
Janine Gronewold, Olga Todica, Hans-Wolfgang Klafki, Ulla K. Seidel, Britta Kaltwasser, Jens Wiltfang, Andreas Kribben, Heike Bruck & Dirk M. Hermann. (2016) Association of Plasma β-Amyloid with Cognitive Performance and Decline in Chronic Kidney Disease. Molecular Neurobiology 54:9, pages 7194-7203.
Crossref
Valentin K. Gribkoff & Leonard K. Kaczmarek. (2017) The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes. Neuropharmacology 120, pages 11-19.
Crossref
Kayla M. Pate & Regina M. Murphy. (2017) Cerebrospinal Fluid Proteins as Regulators of Beta‐amyloid Aggregation and Toxicity. Israel Journal of Chemistry 57:7-8, pages 602-612.
Crossref
Francis T. Hane, Morgan Robinson, Brenda Y. Lee, Owen Bai, Zoya Leonenko & Mitchell S. Albert. (2017) Recent Progress in Alzheimer’s Disease Research, Part 3: Diagnosis and Treatment. Journal of Alzheimer's Disease 57:3, pages 645-665.
Crossref
Tsuneya Ikezu. 2017. Neuroimmune Pharmacology. Neuroimmune Pharmacology 753 766 .
Xiaomeng Lu, Claire R. Brickson & Regina M. Murphy. (2016) TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides. ACS Chemical Neuroscience 7:9, pages 1264-1274.
Crossref
Francesco Panza, Vincenzo Solfrizzi, Davide Seripa, Bruno P Imbimbo, Madia Lozupone, Andrea Santamato, Rosanna Tortelli, Ilaria Galizia, Camilla Prete, Antonio Daniele, Alberto Pilotto, Antonio Greco & Giancarlo Logroscino. (2016) Tau-based therapeutics for Alzheimer’s disease: active and passive immunotherapy. Immunotherapy 8:9, pages 1119-1134.
Crossref
Jun Wang, Lan Tan & Jin-tai Yu. (2016) Prevention Trials in Alzheimer’s Disease: Current Status and Future Perspectives. Journal of Alzheimer's Disease 50:4, pages 927-945.
Crossref
Peter Panegyres, Renee Berry & Jennifer Burchell. (2016) Early Dementia Screening. Diagnostics 6:1, pages 6.
Crossref
Jaume Folch, Dmitry Petrov, Miren Ettcheto, Sonia Abad, Elena Sánchez-López, M. Luisa García, Jordi Olloquequi, Carlos Beas-Zarate, Carme Auladell & Antoni Camins. (2016) Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment. Neural Plasticity 2016, pages 1-15.
Crossref
Francesco Panza, Vincenzo Solfrizzi, Davide Seripa, Bruno P. Imbimbo, Madia Lozupone, Andrea Santamato, Chiara Zecca, Maria Rosaria Barulli, Antonello Bellomo, Alberto Pilotto, Antonio Daniele, Antonio Greco & Giancarlo Logroscino. (2016) Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease. BioMed Research International 2016, pages 1-15.
Crossref
A.J. LarnerA. J. Larner. 2015. Diagnostic Test Accuracy Studies in Dementia. Diagnostic Test Accuracy Studies in Dementia 127 142 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.