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Drug Evaluations

Carfilzomib in multiple myeloma

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Xavier Leleu, Ajai Chari, Shambavi Richard, Monica Khurana, Akeem Yusuf & Saad Z. Usmani. (2021) A combination of carfilzomib, dexamethasone, and daratumumab for treatment of adult patients with relapsed/refractory multiple myeloma in two dosing regimens: once-weekly and twice-weekly. Expert Review of Hematology 14:12, pages 1049-1058.
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Jumpei Teramachi, Hirokazu Miki, Shingen Nakamura, Masahiro Hiasa, Takeshi Harada & Masahiro Abe. (2023) Myeloma bone disease: pathogenesis and management in the era of new anti-myeloma agents. Journal of Bone and Mineral Metabolism 41:3, pages 388-403.
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Evert Njomen, Allison Vanecek, Theresa A. Lansdell, Ya-Ting Yang, Peter Z. Schall, Christi M. Harris, Matthew P. Bernard, Daniel Isaac, Omar Alkharabsheh, Anas Al-Janadi, Matthew B. Giletto, Edmund Ellsworth, Catherine Taylor, Terence Tang, Sarah Lau, Marc Bailie, Jamie J. Bernard, Vilma Yuzbasiyan-Gurkan & Jetze J. Tepe. (2022) Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma. Biomedicines 10:5, pages 938.
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Tanya R. Porras-Yakushi, Justin M. Reitsma, Michael J. Sweredoski, Raymond J. Deshaies & Sonja Hess. (2021) In-depth proteomic analysis of proteasome inhibitors bortezomib, carfilzomib and MG132 reveals that mortality factor 4-like 1 (MORF4L1) protein ubiquitylation is negatively impacted. Journal of Proteomics 241, pages 104197.
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Aida Varela-Moreira, Demian van Straten, Heleen F. van Leur, Ruud W.J. Ruiter, Anil K. Deshantri, Wim E. Hennink, Marcel H.A.M. Fens, Richard W.J. Groen & Raymond M. Schiffelers. (2020) Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model. International Journal of Pharmaceutics: X, pages 100049.
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Matthew B. Giletto, Pawel A. Osmulski, Corey L. Jones, Maria E. Gaczynska & Jetze J. Tepe. (2019) Pipecolic esters as minimized templates for proteasome inhibition. Organic & Biomolecular Chemistry 17:10, pages 2734-2746.
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Joshua Richter, Noa Biran, Narjust Duma, David H. Vesole & David Siegel. (2017) Safety and tolerability of pomalidomide-based regimens (pomalidomide-carfilzomib-dexamethasone with or without cyclophosphamide) in relapsed/refractory multiple myeloma and severe renal dysfunction: a case series. Hematological Oncology 35:2, pages 246-251.
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Jonghoon Park, Eok Park, Cheol-Kyu Jung, Seung-Wan Kang, Byung Gyu Kim, Youngjoo Jung, Tae Hun Kim, Ji-Young Lim, Sung-Eun Lee, Chang-Ki Min & Kwang-Ai Won. (2016) Oral proteasome inhibitor with strong preclinical efficacy in myeloma models. BMC Cancer 16:1.
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C O'Connor, F Lohan, J Campos, E Ohlsson, M Salomè, C Forde, R Artschwager, R M Liskamp, M R Cahill, P A Kiely, B Porse & K Keeshan. (2016) The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia. Oncogene 35:40, pages 5272-5281.
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A Keith Stewart. (2015) Carfilzomib for the treatment of patients with relapsed and/or refractory multiple myeloma. Future Oncology 11:15, pages 2121-2136.
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Lixia Wang, Jinfang Zhang, Lixin Wan, Xiuxia Zhou, Zhiwei Wang & Wenyi Wei. (2015) Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacology & Therapeutics 151, pages 141-151.
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Jia Liu, Shavali Shaik, Xiangpeng Dai, Qiong Wu, Xiuxia Zhou, Zhiwei Wang & Wenyi Wei. (2015) Targeting the ubiquitin pathway for cancer treatment. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1855:1, pages 50-60.
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