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Drug Evaluation

The effect of parathyroid hormone and teriparatide on fracture healing

, Bsc Pharm (Medical Student) , , PhD & , MD FRCPC (Professor)

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Read on this site (2)

Magnus Bernhardsson & Per Aspenberg. (2018) Abaloparatide versus teriparatide: a head to head comparison of effects on fracture healing in mouse models. Acta Orthopaedica 89:6, pages 674-677.
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Letizia Vannucci & Maria Luisa Brandi. (2016) Healing of the bone with anti-fracture drugs. Expert Opinion on Pharmacotherapy 17:17, pages 2267-2272.
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Articles from other publishers (34)

István Gera & Nikolette Szücs. (2023) Humán rekombináns parathormon (teriparatid) mint alternatív megoldás a gyógyszer okozta állcsontnekrózis terápiájára. Orvosi Hetilap 164:36, pages 1406-1415.
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Zhiguo Bi, Xiaotong Shi, Shiyu Liao, Xiao Li, Chao Sun & Jianguo Liu. (2023) Strategies of immobilizing BMP-2 with 3D-printed scaffolds to improve osteogenesis. Regenerative Medicine 18:5, pages 425-441.
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Gabriele Gariffo, Vanna Bottai, Federico Falcinelli, Federico Di Sacco, Roberta Cifali, Elisa Troiano, Rodolfo Capanna, Nicola Mondanelli & Stefano Giannotti. (2023) Use of Teriparatide in preventing delayed bone healing and nonunion: a multicentric study on a series of 20 patients. BMC Musculoskeletal Disorders 24:1.
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Somayyeh Ebrahimi, Alireza Navabazam, Fateme Salemi, Fatemeh Khaleghi, Mohsen Barzegar, Fatemeh Saghafi & Hossien Fallahzadeh. (2023) The efficacy of teriparatide (Cinnopar®) on bone repair in mandibular fractures: A single blinded randomized clinical trial. Journal of Cranio-Maxillofacial Surgery.
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Yasin ÇAMILI, Sıddık MALKOÇ, Aslı TAŞLIDERE, Zehra İLERI & Ozge Celik GULER. (2022) Effects of teriparatide on bone formation in rats with experimentally induced premaxillary expansion. Dental Press Journal of Orthodontics 27:3.
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Alexander T. Carswell, Katharine G. Eastman, Anna Casey, Matthew Hammond, Lee Shepstone, Estelle Payerne, Andoni P. Toms, James W. MacKay, Ann Marie Swart, Julie P. Greeves & William D. Fraser. (2021) Teriparatide and stress fracture healing in young adults (RETURN – Research on Efficacy of Teriparatide Use in the Return of recruits to Normal duty): study protocol for a randomised controlled trial. Trials 22:1.
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Liza Osagie-Clouard, Richard Meeson, Anita Sanghani-Kerai, Mathias Bostrom, Timothy Briggs & Gorden Blunn. (2021) The role of intermittent PTH administration in conjunction with allogenic stem cell treatment to stimulate fracture healing. Bone & Joint Research 10:10, pages 659-667.
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Chenggui Zhang, Junxiong Zhu, Jialin Jia, Zhiyuan Guan, Tiantong Sun, Wang Zhang, Wanqiong Yuan, Hong Wang, Huijie Leng & Chunli Song. (2020) Once‐weekly parathyroid hormone combined with ongoing long‐term alendronate treatment promotes osteoporotic fracture healing in ovariectomized rats. Journal of Orthopaedic Research 39:10, pages 2103-2115.
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Cansu Gül Koca, Sanaz Sadry, Hasan Asker, Muhammet Fatih Çiçek, Meryem Kösehasanoğulları & Gürkan Kaya. (2021) Effects of the different administration frequencies of teriparatide (PTH [1‐34]) on new bone formation of expanded midpalatal sutures in rats: A histomorphometric and micro‐computed tomography analysis. Orthodontics & Craniofacial Research 24:3, pages 449-457.
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Shi-Kai Feng, Tuan-Hui Chen, Hong-Ming Li, Jia Cao, Dong-Biao Liu, Shan-Shan Rao, Jiang-Hua Liu, Yan Zhang, Zhen-Xing Wang, You-You Li, Yi-Juan Tan, Yi-Wei Liu, Chun-Gu Hong, Zi-Qi Yan, Meng-Lu Chen, Yi-Yi Wang, Hao Yin, Ling Jin, Hui Xie, Zheng-Guang Wang & Yong Zhou. (2021) Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31hiEmcnhi vessels. Molecular and Cellular Endocrinology 534, pages 111373.
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Jeffery J. Nielsen, Stewart A. Low, Neal T. Ramseier, Rahul V. Hadap, Nicholas A. Young, Mingding Wang & Philip S. Low. (2021) Analysis of the bone fracture targeting properties of osteotropic ligands. Journal of Controlled Release 329, pages 570-584.
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John C Becerra Sandoval, Lissette Ventura Huamán & Jhony A De La Cruz-Vargas. (2020) Factors associated with stress fracture: A case-control study in a Peruvian navy medical center. Medwave 20:05, pages e7936-e7936.
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Przemysław Jurczak, Julia Witkowska, Sylwia Rodziewicz-Motowidło & Sławomir Lach. (2020) Proteins, peptides and peptidomimetics as active agents in implant surface functionalization. Advances in Colloid and Interface Science 276, pages 102083.
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Marco Antonio Altamirano-Cruz, Diego Fernando Tovar-Cortés, Simon Quetzalcóatl Rodriguez-Lara & Leonardo Xicotencatl Gutierrez-Ramírez. (2020) Manejo quirúrgico de tumor pardo en metacarpo. Reporte de caso. Revista Colombiana de Ortopedia y Traumatología 34:1, pages 74-81.
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Michael A. B. Naafs. 2020. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 283 297 .
A. M. Zaydman, I. A. Shevchenko, E. L. Strokova, A. F. Gusev, N. Yu. Pakhomova, I. A. Kirilova, V. V. Rerikh & V. M. Subbotin. (2019) Histogenesis Stages of Osteogenic Grafts in Culture Medium and a Recipient Bed. Cell and Tissue Biology 13:5, pages 331-343.
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Diane R Wagner, Sonali Karnik, Zachary J Gunderson, Jeffery J Nielsen, Alanna Fennimore, Hunter J Promer, Jonathon W Lowery, M Terry Loghmani, Philip S Low, Todd O McKinley, Melissa A Kacena, Matthias Clauss & Jiliang Li. (2019) Dysfunctional stem and progenitor cells impair fracture healing with age. World Journal of Stem Cells 11:6, pages 281-296.
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Alecia Gende, Timothy W. Thomsen, Britt Marcussen & Carolyn Hettrich. (2019) Delayed-Union of Acetabular Stress Fracture in Female Gymnast. Clinical Journal of Sport Medicine Publish Ahead of Print.
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Hao Hong, Ting Song, Yang Liu, Jun Li, Qilong Jiang, Qizhi Song & Zhongliang Deng. (2019) The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis. Clinics 74, pages e800.
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Eric Kai-Chung Wong & Alexandra Papaioannou. (2018) Postmenopausal Osteoporosis Treatment Update. Current Treatment Options in Rheumatology 4:2, pages 142-157.
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Sébastien Baillieul, Michel Guinot, Caroline Dubois, André Prunier, Finn Mahler & Philippe Gaudin. (2018) Donner l’allure de la consolidation osseuse – Traitement d’une fracture de fatigue bilatérale du sacrum par tériparatide chez un coureur de fond. Revue du Rhumatisme 85:2, pages 212-214.
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Allan J. Williams, Faron Jordan, Gareth King, Andrew L. Lewis, Lisbeth Illum, Tahir Masud, Alan C. Perkins & Richard G. Pearson. (2018) In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1–34 for the treatment of osteoporosis. International Journal of Pharmaceutics 535:1-2, pages 113-119.
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Brendan F. Boyce, Michael J. Zuscik & Lianping Xing. 2018. Genetics of Bone Biology and Skeletal Disease. Genetics of Bone Biology and Skeletal Disease 173 195 .
S?bastien Baillieul, Michel Guinot, Caroline Dubois, Andr? Prunier, Finn Mahler & Philippe Gaudin. (2017) Set the pace of bone healing???Treatment of a bilateral sacral stress fracture using teriparatide in a long-distance runner. Joint Bone Spine 84:4, pages 499-500.
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Jean-Marc Feron & Adeline Cambon-Binder. (2017) Medication management after intramedullary nailing of atypical fractures. Injury 48, pages S15-S17.
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Enrico Pola, Virginia Pambianco, Debora Colangelo, Virginia M Formica, Giovanni Autore & Luigi A Nasto. (2017) Teriparatide anabolic therapy as potential treatment of type II dens non-union fractures. World Journal of Orthopedics 8:1, pages 82.
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Michael A. B. Naafs. 2017. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 1 14 .
Zhongju Shi, Hengxing Zhou, Bin Pan, Lu Lu, Jun Liu, Yi Kang, Xue Yao & Shiqing Feng. (2016) Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. PLOS ONE 11:12, pages e0168691.
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Maryam Ghodsi, Bagher larijani, Abbass Ali Keshtkar, Ensieh Nasli-Esfahani, Sudabeh Alatab & Mohammad Reza Mohajeri-Tehrani. (2016) Mechanisms involved in altered bone metabolism in diabetes: a narrative review. Journal of Diabetes & Metabolic Disorders 15:1.
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Ahmed E. Al‐Subaie, Marco Laurenti, Mohamed‐Nur Abdallah, Iskandar Tamimi, Farid Yaghoubi, Hazem Eimar, Nicholas Makhoul & Faleh Tamimi. (2016) Propranolol enhances bone healing and implant osseointegration in rats tibiae. Journal of Clinical Periodontology 43:12, pages 1160-1170.
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Per Aspenberg, Jorge Malouf, Umberto Tarantino, Pedro A. García-Hernández, Costantino Corradini, Søren Overgaard, Jan J. Stepan, Lars Borris, Eric Lespessailles, Frede Frihagen, Kyriakos Papavasiliou, Helmut Petto, José Ramón Caeiro & Fernando Marin. (2016) Effects of Teriparatide Compared with Risedronate on Recovery After Pertrochanteric Hip Fracture. Journal of Bone and Joint Surgery 98:22, pages 1868-1878.
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G.M. Campbell, S. Tiwari, A.-K. Picke, C. Hofbauer, M. Rauner, M.M. Morlock, L.C. Hofbauer & C.-C. Glüer. (2016) Effects of insulin therapy on porosity, non-enzymatic glycation and mechanical competence in the bone of rats with type 2 diabetes mellitus. Bone 91, pages 186-193.
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Jens Bay Vegger, Annemarie Br?el, Thomas Givskov S?rensen & Jesper Skovhus Thomsen. (2015) Systemic Treatment with Strontium Ranelate Does Not Influence the Healing of Femoral Mid-shaft Defects in Rats. Calcified Tissue International 98:2, pages 206-214.
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M. L. Gourlay, J. B. Renner, J. T. Spang & J. E. Rubin. (2015) Subchondral insufficiency fracture of the knee: a non-traumatic injury with prolonged recovery time. Case Reports 2015:jun08 1, pages bcr2015209399-bcr2015209399.
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