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Review

Glycoconjugate vaccines: an update

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Keep up to date with the latest research on this topic with citation updates for this article.

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Louis-Antoine Barel & Laurence A. Mulard. (2019) Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human. Human Vaccines & Immunotherapeutics 15:6, pages 1338-1356.
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Michael Bröker, Francesco Berti & Paolo Costantino. (2016) Factors contributing to the immunogenicity of meningococcal conjugate vaccines. Human Vaccines & Immunotherapeutics 12:7, pages 1808-1824.
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Wangxue Chen. (2015) Current advances and challenges in the development of Acinetobacter vaccines. Human Vaccines & Immunotherapeutics 11:10, pages 2495-2500.
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Articles from other publishers (54)

Linda Del Bino, Maria R. Romano & Roberto Adamo. 2023. Carbohydrate‐Based Therapeutics. Carbohydrate‐Based Therapeutics 57 72 .
Davide Oldrini, Roberta Di Benedetto, Martina Carducci, Daniele De Simone, Luisa Massai, Renzo Alfini, Barbara Galli, Brunella Brunelli, Amanda Przedpelski, Joseph T. Barbieri, Omar Rossi, Carlo Giannelli, Rino Rappuoli, Francesco Berti & Francesca Micoli. (2023) Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines. Vaccines 11:12, pages 1770.
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Sophia W. Hulbert, Primit Desai, Michael C. Jewett, Matthew P. DeLisa & Asher J. Williams. (2023) Glycovaccinology: The design and engineering of carbohydrate-based vaccine components. Biotechnology Advances 68, pages 108234.
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Guangzong Tian, Chunjun Qin, Jing Hu, Xiaopeng Zou & Jian Yin. (2023) Effect of Side-Chain Functional Groups in the Immunogenicity of Bacterial Surface Glycans. Molecules 28:20, pages 7112.
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A. Corrado, M. De Martino, V. Bordoni, S. Giannini, F. Rech, S. Cianetti, F. Berti, C. Magagnoli & R. De Ricco. (2023) A universal UHPLC-CAD platform for the quantification of polysaccharide antigens. Scientific Reports 13:1.
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Samim Sahaji, Pradip Shit & Anup Kumar Misra. (2023) Convergent Synthesis of the Octasaccharide Repeating Unit of the K55 Capsular Polysaccharide of Acinetobacter baumannii BAL_204 Strain. Synthesis.
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Riccardo De Ricco, Francesca Rech, Valeria Onnis, Salvatore Sanna Coccone, Giusy Scalia, Cristina Marcozzi, Massimiliano Gavini, Sara Beni, Sara Giannini, Luca Nompari, Chiara Parlati, Claudia Magagnoli, Simona Cianetti & Francesco Berti. (2022) Development of a New Solid-Phase Extraction Base Method for Free Saccharide Content Estimation of Meningococcal Conjugate Vaccines. ACS Omega 7:44, pages 39875-39883.
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Natalia Rudenko, Anna Karatovskaya, Anna Zamyatina, Anna Shepelyakovskaya, Svetlana Semushina, Fedor Brovko, Anna Shpirt, Vladimir Torgov, Natalia Kolotyrkina, Alexandr Zinin, Anastasiya Kasimova, Andrei Perepelov, Mikhail Shneider & Yuriy Knirel. (2022) Immune Response to Conjugates of Fragments of the Type K9 Capsular Polysaccharide of Acinetobacter baumannii with Carrier Proteins. Microbiology Spectrum 10:5.
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E.A. Khatuntseva & N.E. Nifantiev. (2022) Cross reacting material (CRM197) as a carrier protein for carbohydrate conjugate vaccines targeted at bacterial and fungal pathogens. International Journal of Biological Macromolecules 218, pages 775-798.
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Maria R Romano, Francesco Berti & Rino Rappuoli. (2022) Classical- and bioconjugate vaccines: comparison of the structural properties and immunological response. Current Opinion in Immunology 78, pages 102235.
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Arun Naini, Max Peter Bartetzko, Someswara Rao Sanapala, Felix Broecker, Victoria Wirtz, Marilda P. Lisboa, Sharavathi G. Parameswarappa, Daniel Knopp, Jessica Przygodda, Matthias Hakelberg, Rosalind Pan, Axay Patel, Laurent Chorro, Arthur Illenberger, Christopher Ponce, Srinivas Kodali, Jacqueline Lypowy, Annaliesa S. Anderson, Robert G. K. Donald, Arne von Bonin & Claney L. Pereira. (2022) Semisynthetic Glycoconjugate Vaccine Candidates against Escherichia coli O25B Induce Functional IgG Antibodies in Mice . JACS Au 2:9, pages 2135-2151.
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Marko Anderluh, Francesco Berti, Anna Bzducha‐Wróbel, Fabrizio Chiodo, Cinzia Colombo, Federica Compostella, Katarzyna Durlik, Xhenti Ferhati, Rikard Holmdahl, Dragana Jovanovic, Wieslaw Kaca, Luigi Lay, Milena Marinovic‐Cincovic, Marco Marradi, Musa Ozil, Laura Polito, Josè Juan Reina, Celso A. Reis, Robert Sackstein, Alba Silipo, Urban Švajger, Ondřej Vaněk, Fumiichiro Yamamoto, Barbara Richichi & Sandra J. van Vliet. (2021) Recent advances on smart glycoconjugate vaccines in infections and cancer. The FEBS Journal 289:14, pages 4251-4303.
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William J. Smith, Patrick L. Ahl, Bei Wang, Melissa Hamm, Richard R. Rustandi, Michael A. Winters & Jeffrey T. Blue. (2022) Analytical technology development to monitor the stability of Polysaccharide-Protein conjugate vaccines. Vaccine 40:31, pages 4182-4189.
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Valeria Onnis, Alessio Moriconi, Marilena Paludi, Sara Giannini, Giusy Scalia, Silvia Martini, Stefania Berti, Marianna Aggravi, Chiara Parlati, Giovanna Campanella, Emanuele Tomba, Malte Meppen, Simona Cianetti, Simone Bufali & Francesco Berti. (2022) Clinically proven specification setting for a meningococcal serogroup a conjugate vaccine. Vaccine 40:24, pages 3366-3371.
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Francesca Rech, Riccardo De Ricco, Sara Giannini, Luca Nompari, Marilena Paludi, Stefania Berti, Chiara Parlati, Simona Cianetti & Francesco Berti. (2022) Glycoconjugate content quantification to assess vaccine potency: A simplified approach. Biologicals 76, pages 10-14.
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I-Fan Tu, Tzu-Lung Lin, Feng-Ling Yang, I-Ming Lee, Wei-Lin Tu, Jiahn-Haur Liao, Tzu-Ping Ko, Wen-Jin Wu, Jia-Tsrong Jan, Meng-Ru Ho, Ching-Yi Chou, Andrew H.-J. Wang, Chung-Yi Wu, Jin-Town Wang, Kai-Fa Huang & Shih-Hsiung Wu. (2022) Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use. Journal of Biomedical Science 29:1.
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Tanmoy Halder & Somnath Yadav. (2021) Total synthesis of the O-antigen repeating unit of Providencia stuartii O49 serotype through linear and one-pot assemblies . Beilstein Journal of Organic Chemistry 17, pages 2915-2921.
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Ruohan Wei, Xuemei Yang, Han Liu, Tongyao Wei, Sheng Chen & Xuechen Li. (2021) Synthetic Pseudaminic-Acid-Based Antibacterial Vaccine Confers Effective Protection against Acinetobacter baumannii Infection . ACS Central Science 7:9, pages 1535-1542.
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Michael Kowarik, Michael Wetter, Micha A. Haeuptle, Martin Braun, Michael Steffen, Stefan Kemmler, Neil Ravenscroft, Gianluigi De Benedetto, Matthias Zuppiger, Dominique Sirena, Paola Cescutti & Michael Wacker. (2021) The development and characterization of an E. coli O25B bioconjugate vaccine. Glycoconjugate Journal 38:4, pages 421-435.
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Jing Zhao, Gang Hu, Yi Huang, Yingchun Huang, Xin Wei & Jianyou Shi. (2021) Polysaccharide conjugate vaccine: A kind of vaccine with great development potential. Chinese Chemical Letters 32:4, pages 1331-1340.
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Farjana Khatun, Charles C. Dai, Tania Rivera-Hernandez, Waleed M. Hussein, Zeinab G. Khalil, Robert J. Capon, Istvan Toth & Rachel J. Stephenson. (2021) Immunogenicity Assessment of Cell Wall Carbohydrates of Group A Streptococcus via Self-Adjuvanted Glyco-lipopeptides . ACS Infectious Diseases 7:2, pages 390-405.
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Parinaz Emami, Fatemeh Fallahianbijan, Erica Dinse, Seyed Pouria Motevalian, Brenda Carrillo Conde, Kelvin Reilly & Andrew L. Zydney. (2021) Fouling Behavior during Sterile Filtration of Different Glycoconjugate Serotypes Used in Conjugate Vaccines. Pharmaceutical Research.
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Christa Litschko, Insa Budde, Monika Berger & Timm Fiebig. 2021. Vaccine Delivery Technology. Vaccine Delivery Technology 313 330 .
Ravinder Mettu, Chiang-Yun Chen & Chung-Yi Wu. (2020) Synthetic carbohydrate-based vaccines: challenges and opportunities. Journal of Biomedical Science 27:1.
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Linda Del Bino & Maria Rosaria Romano. (2020) Role of carbohydrate antigens in antifungal glycoconjugate vaccines and immunotherapy. Drug Discovery Today: Technologies 38, pages 45-55.
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Jacopo Enotarpi, Marta Tontini, Cristiana Balocchi, Daan van der Es, Ludovic Auberger, Evita Balducci, Filippo Carboni, Daniela Proietti, Daniele Casini, Dmitri V. Filippov, Hermen S. Overkleeft, Gijsbert A. van der Marel, Cinzia Colombo, Maria Rosaria Romano, Francesco Berti, Paolo Costantino, Jeroen D. C. Codeé, Luigi Lay & Roberto Adamo. (2020) A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A. Nature Communications 11:1.
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Alessio Moriconi, Valeria Onnis, Marianna Aggravi, Chiara Parlati, Simone Bufali, Simona Cianetti, William Egan, Amin Khan, Elena Fragapane, Malte Meppen, Marilena Paludi & Francesco Berti. (2020) A new strategy for preparing a tailored meningococcal ACWY conjugate vaccine for clinical testing. Vaccine 38:23, pages 3930-3933.
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Insa Budde, Christa Litschko, Jana I Führing, Rita Gerardy-Schahn, Mario Schubert & Timm Fiebig. (2020) An enzyme-based protocol for cell-free synthesis of nature-identical capsular oligosaccharides from Actinobacillus pleuropneumoniae serotype 1. Journal of Biological Chemistry 295:17, pages 5771-5784.
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Riyao Li, Hai Yu, Saddam M. Muthana, Darón I. Freedberg & Xi Chen. (2020) Size-Controlled Chemoenzymatic Synthesis of Homogeneous Oligosaccharides of Neisseria meningitidis W Capsular Polysaccharide . ACS Catalysis 10:4, pages 2791-2798.
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Dominique A. Caugant & Ola B. Brynildsrud. (2019) Neisseria meningitidis: using genomics to understand diversity, evolution and pathogenesis. Nature Reviews Microbiology 18:2, pages 84-96.
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Fikri Avci, Francesco Berti, Peter Dull, John Hennessey, Viliam Pavliak, A. Krishna Prasad, Willie Vann, Michael Wacker & Olivier Marcq. (2019) Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development. mSphere 4:5.
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Margarida Correia-Neves, Christopher Sundling, Andrea Cooper & Gunilla Källenius. (2019) Lipoarabinomannan in Active and Passive Protection Against Tuberculosis. Frontiers in Immunology 10.
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Neil Ravenscroft, Martin Braun, Joerg Schneider, Anita M Dreyer, Michael Wetter, Micha A Haeuptle, Stefan Kemmler, Michael Steffen, Dominique Sirena, Stefan Herwig, Paula Carranza, Claire Jones, Andrew J Pollard, Michael Wacker & Michael Kowarik. (2019) Characterization and immunogenicity of a Shigella flexneri 2a O-antigen bioconjugate vaccine candidate. Glycobiology 29:9, pages 669-680.
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Juned Dalal, Rakesh Rana, Kishore Harale, Sarmad Hanif, Nitin Kumar, Deepti Singh & Manoj Kumar Chhikara. (2019) Development and pre-clinical evaluation of a synthetic oligosaccharide-protein conjugate vaccine against Neisseria meningitidis serogroup C. Vaccine 37:36, pages 5297-5306.
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I-Ming Lee, Feng-Ling Yang, Te-Li Chen, Kuo-Shiang Liao, Chien-Tai Ren, Nien-Tsung Lin, Yu-Pei Chang, Chung-Yi Wu & Shih-Hsiung Wu. (2018) Pseudaminic Acid on Exopolysaccharide of Acinetobacter baumannii Plays a Critical Role in Phage-Assisted Preparation of Glycoconjugate Vaccine with High Antigenicity . Journal of the American Chemical Society 140:28, pages 8639-8643.
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Francesco Berti, Riccardo De Ricco & Rino Rappuoli. (2018) Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines. Molecules 23:6, pages 1340.
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María Victoria Humbert & Myron Christodoulides. (2018) Immunization with recombinant truncated Neisseria meningitidis -Macrophage Infectivity Potentiator (rT-Nm-MIP) protein induces murine antibodies that are cross-reactive and bactericidal for Neisseria gonorrhoeae. Vaccine 36:27, pages 3926-3936.
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Dapeng Zhou, Lan Xu, Wei Huang & Torsten Tonn. (2018) Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy. Molecules 23:6, pages 1326.
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Francesca Micoli, Paolo Costantino & Roberto Adamo. (2018) Potential targets for next generation antimicrobial glycoconjugate vaccines. FEMS Microbiology Reviews 42:3, pages 388-423.
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Kevin B Weyant, Dominic C Mills & Matthew P DeLisa. (2018) Engineering a new generation of carbohydrate-based vaccines. Current Opinion in Chemical Engineering 19, pages 77-85.
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I-Ming Lee, I-Fan Tu, Feng-Ling Yang, Tzu-Ping Ko, Jiahn-Haur Liao, Nien-Tsung Lin, Chung-Yi Wu, Chien-Tai Ren, Andrew H.-J. Wang, Ching-Ming Chang, Kai-Fa Huang & Shih-Hsiung Wu. (2017) Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein. Scientific Reports 7:1.
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