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Stem cells in clinical trials for treatment of retinal degeneration

, MD PhD (Associate Professor)

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Emin Ozmert, Sibel Demirel, Umut Arslan, Özlem Biçer, Ozan Ahlat & Figen Şermet. (2020) Effect of autologous growth factors on apoptosis and thickness of the outer nuclear layer in an experimental retinal degeneration model. Growth Factors 38:5-6, pages 247-258.
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Yuyao Wang, Dandan Zhang, Yi Zhang, Ni Ni, Zhimin Tang, Zhisha Bai, Bingqiao Shen, Hao Sun & Ping Gu. (2018) Insulin-like growth factor-1 regulation of retinal progenitor cell proliferation and differentiation. Cell Cycle 17:4, pages 515-526.
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Vibhuti Agrahari, Vivek Agrahari, Abhirup Mandal, Dhananjay Pal & Ashim K. Mitra. (2017) How are we improving the delivery to back of the eye? Advances and challenges of novel therapeutic approaches. Expert Opinion on Drug Delivery 14:10, pages 1145-1162.
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Articles from other publishers (53)

Paolo Giuseppe Limoli, Celeste Limoli, Enzo Maria Vingolo, Federica Franzone & Marcella Nebbioso. (2021) Mesenchymal stem and non-stem cell surgery, rescue, and regeneration in glaucomatous optic neuropathy. Stem Cell Research & Therapy 12:1.
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Allison L. Ludwig & David M. Gamm. (2021) Outer Retinal Cell Replacement: Putting the Pieces Together. Translational Vision Science & Technology 10:10, pages 15.
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Nurettin Sezer, İbrahim Arı, Yusuf Biçer & Muammer Koç. (2021) Superparamagnetic nanoarchitectures: Multimodal functionalities and applications. Journal of Magnetism and Magnetic Materials 538, pages 168300.
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Olga L German, Harmonie Vallese-Maurizi, Tamara B Soto, Nora P Rotstein & Luis Enrique Politi. (2021) Retina stem cells, hopes and obstacles. World Journal of Stem Cells 13:10, pages 1446-1479.
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Abdullah Al-Ani, Derek Toms, Saud Sunba, Kayla Giles, Yacine Touahri, Carol Schuurmans & Mark Ungrin. (2021) Scaffold-Free Retinal Pigment Epithelium Microtissues Exhibit Increased Release of PEDF. International Journal of Molecular Sciences 22:21, pages 11317.
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Anuradha Yadav, Brashket Seth & Rajnish Kumar Chaturvedi. (2020) Brain Organoids: Tiny Mirrors of Human Neurodevelopment and Neurological Disorders. The Neuroscientist 27:4, pages 388-426.
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Ishaq A. Viringipurampeer, Anat Yanai, Vahitha S. Nizamudheen, Cheryl Y. Gregory‐Evans & Kevin Gregory‐Evans. (2021) Photoreceptor precursor cell integration into rodent retina after treatment with novel glycopeptide PKX‐001. Journal of Tissue Engineering and Regenerative Medicine 15:6, pages 556-566.
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Peter-Paul Zwetsloot, Ana Antonic-Baker, Hendrik Gremmels, Kimberley Wever, Chris Sena, Sanne Jansen of Lorkeers, Steven Chamuleau, Joost Sluijter & David W Howells. (2021) Combined meta-analysis of preclinical cell therapy studies shows overlapping effect modifiers for multiple diseases. BMJ Open Science 5:1, pages e100061.
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Ratnesh K. SinghFrancois BinetteMagdalene SeilerSimon M. Petersen-JonesIgor O. Nasonkin. (2021) Pluripotent Stem Cell-Based Organoid Technologies for Developing Next-Generation Vision Restoration Therapies of Blindness. Journal of Ocular Pharmacology and Therapeutics 37:3, pages 147-156.
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Minfang Zhang, Wangbin Ouyang, Hao Wang, Xiaohong Meng, Shiying Li & Zheng Qin Yin. (2021) Quantitative assessment of visual pathway function in blind retinitis pigmentosa patients. Clinical Neurophysiology 132:2, pages 392-403.
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Emin Özmert & Umut Arslan. (2020) Management of retinitis pigmentosa by Wharton’s jelly-derived mesenchymal stem cells: prospective analysis of 1-year results. Stem Cell Research & Therapy 11:1.
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Paolo Giuseppe Limoli, Enzo Maria Vingolo, Celeste Limoli & Marcella Nebbioso. (2020) Antioxidant and Biological Properties of Mesenchymal Cells Used for Therapy in Retinitis Pigmentosa. Antioxidants 9:10, pages 983.
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Ye Shen, He Shen, Dongyu Guo, Xinghuai Sun, Yuan Sun, Nan Hong, Xiawei Wang, Chen Xie, Yuan Zhao, Qin He, Le Jin, Yingying Wen, Bo Jiang, Chenying Yu, Miaomiao Zhu, Feng Cai & Jianwu Dai. (2020) Recent developments in regenerative ophthalmology. Science China Life Sciences 63:10, pages 1450-1490.
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Abdullah Al-Ani, Saud Sunba, Bilal Hafeez, Derek Toms & Mark Ungrin. (2020) In Vitro Maturation of Retinal Pigment Epithelium Is Essential for Maintaining High Expression of Key Functional Genes. International Journal of Molecular Sciences 21:17, pages 6066.
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Paolo Giuseppe Limoli, Celeste Silvana Serena Limoli, Marco Ulises Morales & Enzo Maria Vingolo. (2020) Mesenchymal stem cell surgery, rescue and regeneration in retinitis pigmentosa: clinical and rehabilitative prognostic aspects. Restorative Neurology and Neuroscience 38:3, pages 223-237.
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Mandeep S. Singh, Susanna S. Park, Thomas A. Albini, M. Valeria Canto-Soler, Henry Klassen, Robert E. MacLaren, Masayo Takahashi, Aaron Nagiel, Steven D. Schwartz & Kapil Bharti. (2020) Retinal stem cell transplantation: Balancing safety and potential. Progress in Retinal and Eye Research 75, pages 100779.
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Gislin Dagnelie, H. Christiaan Stronks & Michael P. Barry. 2020. Principles of Tissue Engineering. Principles of Tissue Engineering 1163 1183 .
Paola Sasso, Valeria Silvestri, Marco Sulfaro, Andrea Scupola, Romina Fasciani & Filippo Amore. (2019) Perceptual learning in patients with Stargardt disease. Canadian Journal of Ophthalmology 54:6, pages 708-716.
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Paolo Giuseppe Limoli, Enzo Maria Vingolo, Celeste Limoli & Marcella Nebbioso. (2019) Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study after Literature Review. Biomedicines 7:4, pages 94.
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Xiao-Xia LiXiao-Jing YuanYue ZhaiShi YuRui-Xuan JiaLi-Ping YangZhi-Zhong MaYu-Ming ZhaoYi-Xiang WangLi-Hong Ge. (2019) Treatment with Stem Cells from Human Exfoliated Deciduous Teeth and Their Derived Conditioned Medium Improves Retinal Visual Function and Delays the Degeneration of Photoreceptors. Stem Cells and Development 28:22, pages 1514-1526.
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Nina Buus Sørensen. (2019) Subretinal surgery: functional and histological consequences of entry into the subretinal space. Acta Ophthalmologica 97:A114, pages 1-23.
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Yuan-Hsiang Chang, Kuniya Abe, Hideo Yokota, Kazuhiro Sudo, Yukio Nakamura, Slo-Li Chu, Chih-Yung Hsu & Ming-Dar Tsai. (2019) Human Induced Pluripotent Stem Cell Reprogramming Prediction in Microscopy Images using LSTM based RNN. Human Induced Pluripotent Stem Cell Reprogramming Prediction in Microscopy Images using LSTM based RNN.
Ting Zou, Lixiong Gao, Yuxiao Zeng, Qiyou Li, Yijian Li, Siyu Chen, Xisu Hu, Xi Chen, Caiyun Fu, Haiwei Xu & Zheng Qin Yin. (2019) Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents. Nature Communications 10:1.
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Mahmoud Mona, Rehae Miller, Hui Li, Yun-Jong Park, Raafi Zaman, Li-Jun Yang & Seunghee Cha. (2019) MIST1, an Inductive Signal for Salivary Amylase in Mesenchymal Stem Cells. International Journal of Molecular Sciences 20:3, pages 767.
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Brian Fury, Henry Klassen & Gerhard Bauer. 2019. Cell-Based Therapy for Degenerative Retinal Disease. Cell-Based Therapy for Degenerative Retinal Disease 81 95 .
Kanza Aziz, Marco A. Zarbin & Mandeep S. Singh. 2019. Cell-Based Therapy for Degenerative Retinal Disease. Cell-Based Therapy for Degenerative Retinal Disease 245 265 .
Marco A. Zarbin. 2019. Cell-Based Therapy for Degenerative Retinal Disease. Cell-Based Therapy for Degenerative Retinal Disease 1 10 .
Marco Zarbin. 2019. Retinal Degeneration. Retinal Degeneration 367 381 .
Juan Pena, Nihan Dulger, Tanya Singh, Jing Zhou, Robert Majeska, Stephen Redenti & Maribel Vazquez. (2018) Controlled microenvironments to evaluate chemotactic properties of cultured Müller glia. Experimental Eye Research 173, pages 129-137.
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Jeffrey H. Stern, Yangzi Tian, James Funderburgh, Graziella Pellegrini, Kang Zhang, Jeffrey L. Goldberg, Robin R. Ali, Michael Young, Yubing Xie & Sally Temple. (2018) Regenerating Eye Tissues to Preserve and Restore Vision. Cell Stem Cell 22:6, pages 834-849.
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Valeria Chichagova, Dean Hallam, Joseph Collin, Darin Zerti, Birthe Dorgau, Majed Felemban, Majlinda Lako & David H. Steel. (2018) Cellular regeneration strategies for macular degeneration: past, present and future. Eye 32:5, pages 946-971.
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Samantha L. Ginn, Anais K. Amaya, Ian E. Alexander, Michael Edelstein & Mohammad R. Abedi. (2018) Gene therapy clinical trials worldwide to 2017: An update. The Journal of Gene Medicine 20:5.
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Yuyao Wang, Dandan Zhang, Zhimin Tang, Yi Zhang, Huiqin Gao, Ni Ni, Bingqiao Shen, Hao Sun & Ping Gu. (2018) REST, regulated by RA through miR-29a and the proteasome pathway, plays a crucial role in RPC proliferation and differentiation. Cell Death & Disease 9:5.
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Sehwon Koh, William J. Chen, Nadine S. Dejneka, Ian R. Harris, Bin Lu, Sergey Girman, Joshua Saylor, Shaomei Wang & Cagla Eroglu. (2018) Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity. The Journal of Neuroscience 38:12, pages 2923-2943.
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A Safwat, D Sabry, A Ragiae, E Amer, RH Mahmoud & RM Shamardan. (2018) Adipose mesenchymal stem cells–derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits. Journal of Circulating Biomarkers 7, pages 184945441880782.
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Dandan Zhang, Bingqiao Shen, Yi Zhang, Ni Ni, Yuyao Wang, Xianqun Fan, Hao Sun & Ping Gu. (2018) Betacellulin regulates the proliferation and differentiation of retinal progenitor cells in vitro . Journal of Cellular and Molecular Medicine 22:1, pages 330-345.
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Sílvia Llonch, Madalena Carido & Marius Ader. (2018) Organoid technology for retinal repair. Developmental Biology 433:2, pages 132-143.
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Marco A. Zarbin. 2018. Stem Cell Genetics for Biomedical Research. Stem Cell Genetics for Biomedical Research 73 85 .
Olivier Goureau, Christelle Monville, Antoine Chaffiol, Gregory Gauvain, Serge Picaud, Jens Duebel & José-Alain Sahel. 2018. Retinal Prosthesis. Retinal Prosthesis 105 125 .
Mundackal S. Divya, Vazhanthodi A. Rasheed, Tiffany Schmidt, Soundararajan Lalitha, Samer Hattar & Jackson James. (2017) Intraocular Injection of ES Cell-Derived Neural Progenitors Improve Visual Function in Retinal Ganglion Cell-Depleted Mouse Models. Frontiers in Cellular Neuroscience 11.
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George M. Ghobrial, Kim D. Anderson, Marine Dididze, Jasmine Martinez-Barrizonte, Gabriel H. Sunn, Katie L. Gant & Allan D. Levi. (2017) Human Neural Stem Cell Transplantation in Chronic Cervical Spinal Cord Injury. Neurosurgery 64:CN_suppl_1, pages 87-91.
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Anat Yanai, Ishaq A. Viringipurampeer, Emran Bashar & Kevin Gregory-Evans. (2017) Anti-ageing glycoprotein promotes long-term survival of transplanted neurosensory precursor cells. Journal of Tissue Engineering and Regenerative Medicine 11:9, pages 2658-2662.
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Elizabeth D. Au, Rosario Fernandez-Godino, Tadeusz J. Kaczynksi, Maria E. Sousa & Michael H. Farkas. (2017) Characterization of lincRNA expression in the human retinal pigment epithelium and differentiated induced pluripotent stem cells. PLOS ONE 12:8, pages e0183939.
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Suet Ding, Suresh Kumar & Pooi Mok. (2017) Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases. International Journal of Molecular Sciences 18:8, pages 1406.
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Yuan-Hsiang Chang, Kuniya Abe, Hideo Yokota, Kazuhiro Sudo, Yukio Nakamura, Cheng-Yu Lin & Ming-Dar Tsai. (2017) Human induced pluripotent stem cell region recognition in microscopy images using Convolutional Neural Networks. Human induced pluripotent stem cell region recognition in microscopy images using Convolutional Neural Networks.
Paola Sasso, Andrea Scupola, Valeria Silvestri, Filippo M. Amore, Edoardo Abed, Luigi Calandriello, Gabriela Grimaldi & Aldo Caporossi. (2017) Morpho-functional analysis of Stargardt Disease for reading. Canadian Journal of Ophthalmology 52:3, pages 287-294.
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Yi Zhang, Bingqiao Shen, Dandan Zhang, Yuyao Wang, Zhimin Tang, Ni Ni, Xiaoliang Jin, Min Luo, Hao Sun & Ping Gu. (2017) miR-29a regulates the proliferation and differentiation of retinal progenitors by targeting Rbm8a. Oncotarget 8:19, pages 31993-32008.
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Michael J. Gilhooley & James Acheson. (2017) Artificial vision: principles and prospects. Current Opinion in Neurology 30:1, pages 55-60.
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Krista M. Beach, Jianbo Wang & Deborah C. Otteson. (2017) Regulation of Stem Cell Properties of Müller Glia by JAK/STAT and MAPK Signaling in the Mammalian Retina. Stem Cells International 2017, pages 1-15.
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Lijie Huang, Jianjing Yang, Mark Nyanzu, Felix Siaw-Debrah & Qichuan Zhuge. 2017. Bone marrow stem cell therapy for stroke. Bone marrow stem cell therapy for stroke 261 271 .
Mark Fields, Hui Cai, Jie Gong & Lucian Del Priore. (2016) Potential of Induced Pluripotent Stem Cells (iPSCs) for Treating Age-Related Macular Degeneration (AMD). Cells 5:4, pages 44.
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Tanzina Mollick, Camilla Mohlin & Kjell Johansson. (2016) Human neural progenitor cells decrease photoreceptor degeneration, normalize opsin distribution and support synapse structure in cultured porcine retina. Brain Research 1646, pages 522-534.
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Ann E. CooperJang-Hyeon ChoSteven MengesSahar MasoodJun XieJing YangHenry Klassen. (2016) Immunosuppressive Treatment Can Alter Visual Performance in the Royal College of Surgeons Rat. Journal of Ocular Pharmacology and Therapeutics 32:5, pages 296-303.
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