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Expert Opinion on Biological Therapy Volume 7, 2007 - Issue 1
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Review

Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions

Michele Bombardieri Kings College London, Rheumatology Department, Guy’s Hospital, St Thomas Street, London, SE1 9RT, UK. [email protected]
,
Iain B McInnes Professor of Experimental Medicine and Rheumatology, University of Glasgow, Division of Immunology, Infection and Inflammation, Centre for Rheumatic Diseases, 10 Alexandra Parade, Glasgow, G31 2ER, Scotland, UK. [email protected]
&
Costantino Pitzalis Professor of Experimental Rheumatology, Kings College London, Rheumatology Department, Guy’s Hospital, St Thomas Street, London, SE1 9RT, UK. [email protected]
Pages 31-40 | Published online: 06 Dec 2006

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Serena Colafrancesco, Roberta Priori & Guido Valesini. (2015) Presentation and diagnosis of adult-onset Still’s disease: the implications of current and emerging markers in overcoming the diagnostic challenge. Expert Review of Clinical Immunology 11:6, pages 749-761.
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Michael D VanAuker & Elizabeth Hood. (2008) Delivery strategies to target therapies to inflammatory tissue. Expert Opinion on Drug Delivery 5:7, pages 767-774.
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Nicole Horwood. (2008) Lymphocyte-derived cytokines in inflammatory arthritis. Autoimmunity 41:3, pages 230-238.
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Alireza Rostamian, Azar Baradaran, Peyman Mottaghi, Mansour Salesi, Mansour Karimifar & Vahid Mansouri. (2022) Evaluation of diagnostic accuracy of alpha-fodrin antibody in Iranian patients with Sjogren's disease. Advanced Biomedical Research 11:1, pages 64.
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Sevim Barbasso Helmers, Mei Bruton, Ingela Loell, Ann-Kristin Ulfgren, Alastair J Gracie, Iain B McInnes & Ingrid E Lundberg. (2018) Expression of interleukin-18 in muscle tissue of patients with polymyositis or dermatomyositis and effects of conventional immunosuppressive treatment. Rheumatology 57:12, pages 2149-2157.
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Sherehan M. Ibrahim, Muhammad Y. Al-Shorbagy, Dalaal M. Abdallah & Hanan S. El-Abhar. (2018) Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice. Scientific Reports 8:1.
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Holly L. Hutton, Maliha A. Alikhan & A. Richard Kitching. 2018. Inflammasomes: Clinical and Therapeutic Implications. Inflammasomes: Clinical and Therapeutic Implications 177 210 .
Maryam Boshtam, Seddigheh Asgary, Shirin Kouhpayeh, Laleh Shariati & Hossein Khanahmad. (2016) Aptamers Against Pro- and Anti-Inflammatory Cytokines: A Review. Inflammation 40:1, pages 340-349.
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Mitrokhin VM, Shim AL, Aksyonov AA, Zotov AS, Konev AV, Ovchinnikov RS, Mladenov IM & Kamkin GA. (2016) Circulating interleukin-18: Association with IL-8, IL-10 and VEGF serum levels in patients with and without heart rhythm disorders. International Journal of Cardiology 215, pages 105-109.
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Robin Park & Jong Dae Ji. (2016) Unique gene expression profile in osteoarthritis synovium compared with cartilage: analysis of publicly accessible microarray datasets. Rheumatology International 36:6, pages 819-827.
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Marc A. Russo & Danielle M. Santarelli. (2015) Comment on “In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain” by Vasudeva et al., J. Neuroimmunol. 2015 June; 283:3–49. Journal of Neuroimmunology 286, pages 77-78.
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Xiang Li, Sheng Liu, Jingjing Luo, Anyuan Liu, Shuangyang Tang, Shuo Liu, Minjun Yu & Yan Zhang. (2015) Helicobacter pylori induces IL-1β and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway. Pathogens and Disease 73:4.
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Roberta Priori, Serena Colafrancesco, Cristiano Alessandri, Antonina Minniti, Carlo Perricone, Giancarlo Iaiani, Donatella Palazzo & Guido Valesini. (2014) Interleukin 18: A Biomarker for Differential Diagnosis Between Adult-onset Still’s Disease and Sepsis. The Journal of Rheumatology 41:6, pages 1118-1123.
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Xu-Guang Guo & Yong Xia. (2013) The Interleukin-18 Promoter -607C>A Polymorphism Contributes to Nasopharyngeal Carcinoma Risk: Evidence from a Meta-analysis Including 1,886 Subjects. Asian Pacific Journal of Cancer Prevention 14:12, pages 7577-7581.
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Futoshi Matsui, Audrey Rhee, Karen L. Hile, Hongji Zhang & Kirstan K. Meldrum. (2013) IL-18 induces profibrotic renal tubular cell injury via STAT3 activation. American Journal of Physiology-Renal Physiology 305:7, pages F1014-F1021.
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S. Di Somma, V. Pittoni, S. Raffa, L. Magrini, G. Gagliano, R. Marino, V. Nobili & M. R. Torrisi. (2013) IL-18 stimulates B-type natriuretic peptide synthesis by cardiomyocytes in vitro and its plasma levels correlate with B-type natriuretic peptide in non-overloaded acute heart failure patients. European Heart Journal: Acute Cardiovascular Care.
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Serena Colafrancesco, Roberta Priori, Cristiano Alessandri, Carlo Perricone, Monica Pendolino, Giovanna Picarelli & Guido Valesini. (2012) IL-18 Serum Level in Adult Onset Still?s Disease: A Marker of Disease Activity. International Journal of Inflammation 2012, pages 1-6.
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Brian A. VanderBrink, Hiroshi Asanuma, Karen Hile, Honji Zhang, Richard C. Rink & Kirstan K. Meldrum. (2011) Interleukin-18 Stimulates a Positive Feedback Loop During Renal Obstruction via Interleukin-18 Receptor. The Journal of Urology 186:4, pages 1502-1508.
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R. Priori, F. Barone, C. Alessandri, S. Colafrancesco, I. B. McInnes, C. Pitzalis, G. Valesini & M. Bombardieri. (2010) Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis. Rheumatology 50:4, pages 776-780.
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Se-Ho Kim, Jung-Hee Kim, Su-Jin Yoon, Keun-Sik Kim, Moon-Young Yoon, Do-Young Yoon & Dong-Eun Kim. (2010) Generation of Antagonistic RNA Aptamers Specific to Proinflammatory Cytokine Interleukin-32. Bulletin of the Korean Chemical Society 31:12, pages 3561-3566.
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Marianne HartfordOlov WiklundLillemor Mattsson HulténAnita PerssonThomas KarlssonJohan HerlitzJohannes HultheKenneth Caidahl. (2010) Interleukin-18 as a Predictor of Future Events in Patients With Acute Coronary Syndromes. Arteriosclerosis, Thrombosis, and Vascular Biology 30:10, pages 2039-2046.
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Zhe Liu, Haining Wang, Wenhua Xiao, Chen Wang, Guoqiang Liu & Tianpei Hong. (2010) Thyrocyte interleukin-18 expression is up-regulated by interferon-γ and may contribute to thyroid destruction in Hashimoto’s thyroiditis. International Journal of Experimental Pathology 91:5, pages 420-425.
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Roberta Priori, Serena Colafrancesco, Angelica Gattamelata, Manuela Di Franco, Ugo Di Tondo & Guido Valesini. (2010) Adult-onset Still disease: a rare disorder with a potentially fatal outcome. Autoimmunity Highlights 1:1, pages 53-59.
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Jaewoo Hong, Suyoung Bae, Youngsun Kang, Doyoung Yoon, Xiyuan Bai, Edward D. Chan, Tania Azam, Charles A. Dinarello, Siyoung Lee, Erk Her, Gyujin Rho & Soohyun Kim. (2010) Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFα and IL-1β. Cytokine 49:2, pages 171-176.
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Gaetano Caramori, Kazuhiro Ito, Paolo Casolari, Marco Contoli, Alberto Papi & Ian M. Adcock. 2010. Allergy Frontiers: Future Perspectives. Allergy Frontiers: Future Perspectives 103 147 .
Maria A. Argiriadi, Tao Xiang, Chengbin Wu, Tariq Ghayur & David W. Borhani. (2009) Unusual Water-mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18. Journal of Biological Chemistry 284:36, pages 24478-24489.
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Ji-Da Choi, Su-Young Bae, Jae-Woo Hong, Tania Azam, Charles A. Dinarello, Erk Her, Whan-Soo Choi, Bo-Kyung Kim, Chang-Kwon Lee, Do-Young Yoon, Sun-Jong Kim & Soo-Hyun Kim. (2009) Identification of the most active interleukin-32 isoform. Immunology 126:4, pages 535-542.
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Ahmad H. Bani-Hani, Matthew T. Campbell, Daniel R. Meldrum & Kirstan K. Meldrum. (2008) Cytokines in Epithelial-Mesenchymal Transition: A New Insight Into Obstructive Nephropathy. Journal of Urology 180:2, pages 461-468.
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Daniel A. Cohen, David E. Hornung, Lawrence Mays, Rodney Douglas, Henry Kennedy, Kenneth Knoblauch, Kevan Martin, Valery V. Abramov, Irina A. Gontova, Tatjana Ya. Abramova, Vladimir A. Kozlov, Alexander Kusnecov, Karim Benchenane, Michaël Zugaro, Sidney Wiener, Martin Witt, Adonis Moschovakis, Anna Katharina Braun, Shigeru Kuratani, Fujio Murakami, Angela Starkweather, Yannis Dalezios, Kazuyuki Aihara, Masato Okada, Masaharu Adachi, Masataka Watanabe, Uri Rokni, Peter G. Smith, Diethelm W. Richter, Michael Müller, M. Griffiths, J. W Neal, P. Gasque, Rommy von Bernhardi, Gilles J. Guillemin, Ruud M. Buijs, Andries Kalsbeek, Cynthia L. Darlington, Dick F. Swaab, Paul J. Lucassen, Inge Huitinga, Ai-Min Bao, Bernd Ladwig, Frank W. Ohl, Hans-Ulrich Schnitzler, Annette Denzinger, Terry Takahashi, Anne-Kathrin Warzecha, Roland Kern, Koji Oishi, Kazunori Nakajima, Liliana Bernardino, Fabienne Agasse, João O. Malva, Thomas D. Bird, Mariana Alonso, David Dubayle, D. Menetrey, John J. Haddad, Anna Lobell, Philip F. Stahel, Ursula Felderhoff-Mueser, Scott R. Barnum, Mehrnaz Jafarian-Tehrani, Tetsuya Mizuno, W. Dalton Dietrich, Robert W. Keane, Jung-Soo Han, Hassan R. Dhaini, William J. Spain, Nathalie Mandairon, Anne Didier, Mark M. Rich, Yoshihisa Kudo, Araya Ruangkittisakul, Klaus Ballanyi, Naweed I. Syed, Axel Petzold, Jeffrey A. Rumbaugh, Avindra Nath, Håkan Aldskogius, José M. Delgado-García, Mineko Kengaku, Joanne SM Kim, Mei Zhen, Alistair Mathie, Emma L. Veale, Maike Stengel, Ralf Baron, Willis K. Samson, Melissa J. S. Chee, William F. Colmers, Paul F. Smith, Michael Pauen, Stacy L. Elliott, Georg Northoff, René J. Jorna, Kazuhide Inoue, Hiroshi Kawabe, Frederique Varoqueaux, Nils Brose, Kohichi Tanaka, Patrick J. Whelan, Ronald S. Petralia, Robert J. Wenthold, Matt S. Ramer, Lowell T. McPhail, Ian Mullaney, Darius Widera, Christian Kaltschmidt, Barbara Kaltschmidt, Keith R. Pennypacker, Glen Pollock, Samuel Saporta, H. Richard Koerber, Herrmann O. Handwerker, Laura Smale, Antonio A. Nunez, Nahum Shimkin, Frederick W. Tse, Nan Wang, Lei Yan, Amy Tse, Ellen Covey & R. Alberto Travagli. 2009. Encyclopedia of Neuroscience. Encyclopedia of Neuroscience 2527 2912 .

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