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Review

mRNA stability and cancer: an emerging link?

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Pages 1515-1529 | Published online: 05 Oct 2007

Keep up to date with the latest research on this topic with citation updates for this article.

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Guoqing Fan, Danni Li, Jingjing Liu, Ningning Tao, Chao Meng, Ju Cui, Jianping Cai & Tieying Sun. (2023) HNRNPD is a prognostic biomarker in non-small cell lung cancer and affects tumor growth and metastasis via the PI3K-AKT pathway. Biotechnology and Genetic Engineering Reviews 0:0, pages 1-20.
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Mohammad Jamshidi, Somayeh Mohammadi Pour & Mohammad-Reza Mahmoudian-Sani. (2020) Single Nucleotide Variants Associated with Colorectal Cancer Among Iranian Patients: A Narrative Review. Pharmacogenomics and Personalized Medicine 13, pages 167-180.
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Piyush Joshi, Tatsuya Seki, Shinobu Kitamura, Andrea Bergano, Bongyong Lee & Ranjan J. Perera. (2019) Transcriptome stability profiling using 5’-bromouridine IP chase (BRIC-seq) identifies novel and functional microRNA targets in human melanoma cells. RNA Biology 16:10, pages 1355-1363.
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Fernando F. Blanco, Sandhya Sanduja, Natasha G. Deane, Perry J. Blackshear & Dan A. Dixon. (2014) Transforming Growth Factor β Regulates P-Body Formation through Induction of the mRNA Decay Factor Tristetraprolin. Molecular and Cellular Biology 34:2, pages 180-195.
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Aparna Kishor, Bishal Tandukar, Yann V. Ly, Eric A. Toth, Yvelisse Suarez, Gary Brewer & Gerald M. Wilson. (2013) Hsp70 Is a Novel Posttranscriptional Regulator of Gene Expression That Binds and Stabilizes Selected mRNAs Containing AU-Rich Elements. Molecular and Cellular Biology 33:1, pages 71-84.
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Sheng Zhou, Lubing Gu, Jing He, Hailong Zhang & Muxiang Zhou. (2011) MDM2 Regulates Vascular Endothelial Growth Factor mRNA Stabilization in Hypoxia. Molecular and Cellular Biology 31:24, pages 4928-4937.
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Wei Li, Xiaolan Deng & Jianjun Chen. (2022) RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer. Seminars in Cancer Biology 86, pages 664-677.
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Chen Chen, Yuying Guo, Yaxin Guo, Xiaoke Wu, Chaohua Si, Yanxin Xu, Qiaozhen Kang & Zhenqiang Sun. (2021) m6A Modification in Non-Coding RNA: The Role in Cancer Drug Resistance. Frontiers in Oncology 11.
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Maria C. Rezcallah, Trisha Al-mazi & Alaina J. Ammit. (2021) Cataloguing the phosphorylation sites of tristetraprolin (TTP): Functional implications for inflammatory diseases. Cellular Signalling 78, pages 109868.
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Nina Ripin, Julien BoudetMalgorzata M. DuszczykAlexandra HinnigerMichael FallerMiroslav Krepl, Abhilash Gadi, Robert J. Schneider, Jiří ŠponerNicole C. Meisner-KoberFrédéric H.-T. Allain. (2019) Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM. Proceedings of the National Academy of Sciences 116:8, pages 2935-2944.
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Shannon L. Nowotarski, Sofia Origanti, Suzanne Sass-Kuhn & Lisa M. Shantz. (2016) Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin. Amino Acids 48:10, pages 2303-2311.
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Eonyoung Park & Lynne E. Maquat. (2013) Staufen-mediated mRNA decay. Wiley Interdisciplinary Reviews: RNA 4:4, pages 423-435.
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Seth A. Brooks & Perry J. Blackshear. (2013) Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:6-7, pages 666-679.
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Jingjie Zhang, Weiming Ouyang, Jingxia Li, Dongyun Zhang, Yonghui Yu, York Wang, Xuejun Li & Chuanshu Huang. (2012) Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability. Toxicology and Applied Pharmacology 263:2, pages 218-224.
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Lisa E. Young, Ashleigh E. Moore, Lena Sokol, Nicole Meisner-Kober & Dan A. Dixon. (2012) The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of COX-2. Molecular Cancer Research 10:1, pages 167-180.
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K S Chae, M J Kang, J H Lee, B K Ryu, M G Lee, N G Her, T K Ha, J Han, Y K Kim & S G Chi. (2010) Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions. Oncogene 30:10, pages 1213-1228.
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Sandhya Sanduja, Fernando F. Blanco & Dan A. Dixon. (2011) The roles of TTP and BRF proteins in regulated mRNA decay. Wiley Interdisciplinary Reviews: RNA 2:1, pages 42-57.
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S Planel, A Salomon, P Jalinot, J-J Feige & N Cherradi. (2010) A novel concept in antiangiogenic and antitumoral therapy: multitarget destabilization of short-lived mRNAs by the zinc finger protein ZFP36L1. Oncogene 29:45, pages 5989-6003.
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L. V. Sharova, A. A. Sharov, T. Nedorezov, Y. Piao, N. Shaik & M. S.H. Ko. (2009) Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells. DNA Research 16:1, pages 45-58.
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