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Expert Opinion on Biological Therapy Volume 7, 2007 - Issue 12
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Review

Polycation-based nanoparticle delivery for improved RNA interference therapeutics

Kenneth A Howard University of Aarhus, Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology, 8000 Aarhus, Denmark +45 8942 3691; +45 8942 3690; [email protected]
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Jørgen Kjems University of Aarhus, Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology, 8000 Aarhus, Denmark +45 8942 3691; +45 8942 3690; [email protected]
Pages 1811-1822 | Published online: 22 Nov 2007

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Mohamad Alameh, Diogo DeJesus, Myriam Jean, Vincent Darras, Marc Thibault, Marc Lavertu, Michael D Buschmann & Abderrazzak Merzouki. (2012) Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery. International Journal of Nanomedicine 7, pages 1399-1414.
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Articles from other publishers (40)

Alexander D Josowitz, Ranjit S Bindra & W Mark Saltzman. (2022) Polymer nanocarriers for targeted local delivery of agents in treating brain tumors. Nanotechnology 34:7, pages 072001.
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Suk Ho Bhang, Kyuwon Kim, Won Jong Rhee & Min Suk Shim. (2018) Bioreducible Polyspermine-Based Gene Carriers for Efficient siRNA Delivery: Effects of PEG Conjugation on Gene Silencing Efficiency. Macromolecular Research 26:12, pages 1135-1142.
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Zohar Shatsberg, Xuejiao Zhang, Paula Ofek, Shashwat Malhotra, Adva Krivitsky, Anna Scomparin, Galia Tiram, Marcelo Calder?n, Rainer Haag & Ronit Satchi-Fainaro. (2016) Functionalized nanogels carrying an anticancer microRNA for glioblastoma therapy. Journal of Controlled Release 239, pages 159-168.
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A. Martirosyan, M. J. Olesen, R. A. Fenton, J. Kjems & K. A. Howard. (2016) Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours. Nanoscale 8:25, pages 12599-12607.
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NAYARA DELGADO ANDRÉ, VIVIANE ALINE OLIVEIRA SILVA, CAROLINA BATISTA ARIZA, MARIA ANGELICA EHARA WATANABE & FERNANDO LUIZ DE LUCCA. (2015) In vivo knockdown of CXCR4 using jetPEI/CXCR4 shRNA nanoparticles inhibits the pulmonary metastatic potential of B16-F10 melanoma cells. Molecular Medicine Reports 12:6, pages 8320-8326.
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Borja Ballarín-González, Morten Frendø Ebbesen & Kenneth Alan Howard. (2014) Polycation-based nanoparticles for RNAi-mediated cancer treatment. Cancer Letters 352:1, pages 66-80.
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Jong-Min Lim, Archana Swami, Laura M. Gilson, Sunandini Chopra, Sungyoung Choi, Jun Wu, Robert Langer, Rohit Karnik & Omid C. Farokhzad. (2014) Ultra-High Throughput Synthesis of Nanoparticles with Homogeneous Size Distribution Using a Coaxial Turbulent Jet Mixer. ACS Nano 8:6, pages 6056-6065.
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Loganathan Palanikumar, Sinna Nadar Ramasamy & Chandrasekaran Balachandran. (2014) Size‐dependent antimicrobial response of zinc oxide nanoparticles. IET Nanobiotechnology 8:2, pages 111-117.
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Morten Tobias Jarlstad Olesen, Borja Ballarín-González & Kenneth Alan Howard. (2013) The application of RNAi-based treatments for inflammatory bowel disease. Drug Delivery and Translational Research 4:1, pages 4-18.
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Troels B. Thomsen, Leon Li & Kenneth A. Howard. (2014) Mucus barrier-triggered disassembly of siRNA nanocarriers. Nanoscale 6:21, pages 12547-12554.
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Alina Martirosyan, Morten Jarlstad Olesen & Kenneth A. Howard. 2014. Nonviral Vectors for Gene Therapy - Lipid- and Polymer-based Gene Transfer. Nonviral Vectors for Gene Therapy - Lipid- and Polymer-based Gene Transfer 325 352 .
Kenneth Howard. 2013. Nanotechnology for the Delivery of Therapeutic Nucleic Acids. Nanotechnology for the Delivery of Therapeutic Nucleic Acids 129 151 .
Michael Wagner, Alexandra C. Rinkenauer, Anja Schallon & Ulrich S. Schubert. (2013) Opposites attract: influence of the molar mass of branched poly(ethylene imine) on biophysical characteristics of siRNA-based polyplexese. RSC Advances 3:31, pages 12774.
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Frederico Pittella & Kazunori Kataoka. 2013. RNA Interference from Biology to Therapeutics. RNA Interference from Biology to Therapeutics 161 184 .
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Joachim Allouche. 2013. Nanomaterials: A Danger or a Promise?. Nanomaterials: A Danger or a Promise? 27 74 .
Borja Ballarín-González & Kenneth Alan Howard. (2012) Polycation-based nanoparticle delivery of RNAi therapeutics: Adverse effects and solutions. Advanced Drug Delivery Reviews 64:15, pages 1717-1729.
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Ian S. BlagbroughAbdelkader A. MetwallyHassan M. Ghonaim. (2012) Asymmetrical N 4 , N 9 -Diacyl Spermines: SAR Studies of Nonviral Lipopolyamine Vectors for Efficient siRNA Delivery with Silencing of EGFP Reporter Gene . Molecular Pharmaceutics 9:7, pages 1853-1861.
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Jørgen Kjems & Kenneth A Howard. (2012) Oligonucleotide Delivery to the Lung: Waiting to Inhale. Molecular Therapy - Nucleic Acids 1, pages e1.
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AHMED A. TAYEL, WAEL F. EL-TRAS, SHAABAN MOUSSA, ASHRAF F. EL-BAZ, HODA MAHROUS, MOHAMMED F. SALEM & LEON BRIMER. (2011) ANTIBACTERIAL ACTION OF ZINC OXIDE NANOPARTICLES AGAINST FOODBORNE PATHOGENS. Journal of Food Safety 31:2, pages 211-218.
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Haijun Yu, Chao Deng, Huayu Tian, Tiancheng Lu, Xuesi Chen & Xiabin Jing. (2011) Chemo-Physical and Biological Evaluation of Poly( L -lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery . Macromolecular Bioscience 11:3, pages 352-361.
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Ebbe J. B. Nielsen, Jan M. Nielsen, Daniel Becker, Alexander Karlas, Hridayesh Prakash, Sys Z. Glud, Jonathan Merrison, Flemming Besenbacher, Thomas F. Meyer, Jørgen Kjems & Kenneth A. Howard. (2010) Pulmonary Gene Silencing in Transgenic EGFP Mice Using Aerosolised Chitosan/siRNA Nanoparticles. Pharmaceutical Research 27:12, pages 2520-2527.
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Ge Shan. (2010) RNA interference as a gene knockdown technique. The International Journal of Biochemistry & Cell Biology 42:8, pages 1243-1251.
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Lijun Jia, Jie Yang, Xinbao Hao, Min Zheng, Hongbin He, Xiufang Xiong, Liang Xu & Yi Sun. (2010) Validation of SAG/RBX2/ROC2 E3 Ubiquitin Ligase as an Anticancer and Radiosensitizing Target. Clinical Cancer Research 16:3, pages 814-824.
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Hassan M. Ghonaim, Shi Li & Ian S. Blagbrough. (2009) N 1,N 12 -Diacyl Spermines: SAR Studies on Non-viral Lipopolyamine Vectors for Plasmid DNA and siRNA Formulation. Pharmaceutical Research 27:1, pages 17-29.
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Shan Gao, Frederik Dagnaes-Hansen, Ebbe Juel Bech Nielsen, Jesper Wengel, Flemming Besenbacher, Kenneth Alan Howard & Jørgen Kjems. (2009) The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice. Molecular Therapy 17:7, pages 1225-1233.
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Kenneth Alan Howard. (2009) Delivery of RNA interference therapeutics using polycation-based nanoparticles. Advanced Drug Delivery Reviews 61:9, pages 710-720.
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Christine Vauthier & Kawthar Bouchemal. (2008) Methods for the Preparation and Manufacture of Polymeric Nanoparticles. Pharmaceutical Research 26:5, pages 1025-1058.
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Hassan M. Ghonaim, Shi Li & Ian S. Blagbrough. (2008) Very Long Chain N 4 ,N 9 -Diacyl Spermines: Non-Viral Lipopolyamine Vectors for Efficient Plasmid DNA and siRNA Delivery. Pharmaceutical Research 26:1, pages 19-31.
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Koen Raemdonck, Roosmarijn E. Vandenbroucke, Joseph Demeester, Niek N. Sanders & Stefaan C. De Smedt. (2008) Maintaining the silence: reflections on long-term RNAi. Drug Discovery Today 13:21-22, pages 917-931.
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Yoram RudyMichael J. AckermanDonald M. BersColleen E. ClancySteven R. HouserBarry LondonAndrew D. McCullochDennis A. PrzywaraRandall L. RasmussonR. John SolaroNatalia A. TrayanovaDavid R. Van WagonerAndrás VarróJames N. WeissDavid A. Lathrop. (2008) Systems Approach to Understanding Electromechanical Activity in the Human Heart. Circulation 118:11, pages 1202-1211.
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Takehiko Shiraishi, Ramin Hamzavi & Peter E. Nielsen. (2008) Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells. Nucleic Acids Research 36:13, pages 4424-4432.
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