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Expert Opinion on Biological Therapy Volume 7, 2007 - Issue 2
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Gene therapy for disc degeneration

Gianluca Vadalà Campus Bio-Medico University, Department of Orthopaedic and Trauma Surgery, Via E. Longoni 69, 00155 Rome, Italy; University of Pittsburgh School of Medicine, Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, 200 Lothrop Street, E1641 BST, Pittsburgh, PA 15261, USA
,
Gwendolyn A Sowa Campus Bio-Medico University, Department of Orthopaedic and Trauma Surgery, Via E. Longoni 69, 00155 Rome, Italy; University of Pittsburgh School of Medicine, Department of Physical Medicine and Rehabilitation, 3471 Fifth Avenue, KAU 202, Pittsburgh, PA 15213, USA
&
James D Kang Associate Professor, Director of the Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, 200 Lothrop Street, E1641 BST, Pittsburgh, PA 15261, USA. [email protected]
Pages 185-196 | Published online: 24 Jan 2007

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J. Niinimäki, J. Ruohonen, M. Silfverhuth, A. Lappalainen, E. Kääpä & O. Tervonen. (2007) Quantitative Magnetic Resonance Imaging of Experimentally Injured Porcine Intervertebral Disc. Acta Radiologica 48:6, pages 643-649.
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Articles from other publishers (27)

Wensen Jiang, Juliane D. Glaeser, Giselle Kaneda, Julia SheynJacob T. Wechsler, Stephen StephanKhosrowdad Salehi, Julie L. Chan, Wafa Tawackoli, Pablo Avalos, Christopher JohnsonChloe Castaneda, Linda E.A. Kanim, Teerachat TanasansomboonJoshua E. Burda, Oksana Shelest, Haneen YameenTiffany G. Perry, Michael KropfJason M. CuellarDror SeliktarHyun W. Bae, Laura S. Stone & Dmitriy Sheyn. (2023) Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats. Science Translational Medicine 15:725.
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Claudia Cicione, Gianluca Vadalà, Giuseppina Di Giacomo, Veronica Tilotta, Luca Ambrosio, Fabrizio Russo, Biagio Zampogna, Francesca Cannata, Rocco Papalia & Vincenzo Denaro. (2023) Micro-fragmented and nanofat adipose tissue derivatives: In vitro qualitative and quantitative analysis. Frontiers in Bioengineering and Biotechnology 11.
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Manuele Gori, Sara Maria Giannitelli, Gianluca Vadalà, Rocco Papalia, Loredana Zollo, Massimo Sanchez, Marcella Trombetta, Alberto Rainer, Giovanni Di Pino & Vincenzo Denaro. (2022) A Soft Zwitterionic Hydrogel as Potential Coating on a Polyimide Surface to Reduce Foreign Body Reaction to Intraneural Electrodes. Molecules 27:10, pages 3126.
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Joo Han Kim, Chang Hwa Ham & Woo-Keun Kwon. (2022) Current Knowledge and Future Therapeutic Prospects in Symptomatic Intervertebral Disc Degeneration. Yonsei Medical Journal 63:3, pages 199.
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Veronica Tilotta, Gianluca Vadalà, Luca Ambrosio, Fabrizio Russo, Claudia Cicione, Giuseppina Di Giacomo, Rocco Papalia & Vincenzo Denaro. (2021) Mesenchymal Stem Cell-Derived Exosomes: The New Frontier for the Treatment of Intervertebral Disc Degeneration. Applied Sciences 11:23, pages 11222.
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Sajjad Ashraf, Kenny Chatoor, Jasmine Chong, Robert Pilliar, Paul Santerre & Rita Kandel. (2019) Transforming Growth Factor β Enhances Tissue Formation by Passaged Nucleus Pulposus Cells In Vitro. Journal of Orthopaedic Research 38:2, pages 438-449.
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O. Togao, A. Hiwatashi, T. Wada, K. Yamashita, K. Kikuchi, C. Tokunaga, J. Keupp, M. Yoneyama & H. Honda. (2018) A Qualitative and Quantitative Correlation Study of Lumbar Intervertebral Disc Degeneration Using Glycosaminoglycan Chemical Exchange Saturation Transfer, Pfirrmann Grade, and T1-ρ. American Journal of Neuroradiology 39:7, pages 1369-1375.
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Xiexing Wu, Yu Liu, Xiaobin Guo, Wei Zhou, Liangliang Wang, Jiawei Shi, Yunxia Tao, Mo Zhu, Dechun Geng, Huilin Yang & Haiqing Mao. (2018) Prolactin inhibits the progression of intervertebral disc degeneration through inactivation of the NF-κB pathway in rats. Cell Death & Disease 9:2.
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J. Rigal, A. Léglise, T. Barnetche, A. Cogniet, S. Aunoble & J. C. Le Huec. (2017) Meta-analysis of the effects of genetic polymorphisms on intervertebral disc degeneration. European Spine Journal 26:8, pages 2045-2052.
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V. A. Byvaltsev, I. A. Stepanov, L. A. Bardonova & E. G. Belykh. (2016) The Use of Stem Cells in the Treatment of Intervertebral Disc Degeneration. Annals of the Russian academy of medical sciences 71:5, pages 359-366.
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Greta S.P. Mok, Duo Zhang, Shu-Zhong Chen, Jing Yuan, James F. Griffith & Yi Xiang J. Wang. (2016) Comparison of three approaches for defining nucleus pulposus and annulus fibrosus on sagittal magnetic resonance images of the lumbar spine. Journal of Orthopaedic Translation 6, pages 34-41.
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Gianluca Vadalà, Fabrizio Russo, Luca Ambrosio, Mattia Loppini & Vincenzo Denaro. (2016) Stem cells sources for intervertebral disc regeneration. World Journal of Stem Cells 8:5, pages 185.
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Roman Tsaryk, Antonio Gloria, Teresa Russo, Laura Anspach, Roberto De Santis, Shahram Ghanaati, Ronald E. Unger, Luigi Ambrosio & C. James Kirkpatrick. (2015) Collagen-low molecular weight hyaluronic acid semi-interpenetrating network loaded with gelatin microspheres for cell and growth factor delivery for nucleus pulposus regeneration. Acta Biomaterialia 20, pages 10-21.
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Gianluca Vadal?, Fabrizio Russo, Alberto Di Martino & Vincenzo Denaro. (2015) Intervertebral disc regeneration: from the degenerative cascade to molecular therapy and tissue engineering. Journal of Tissue Engineering and Regenerative Medicine 9:6, pages 679-690.
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Gianluca Fontana, Eugene See & Abhay Pandit. (2015) Current trends in biologics delivery to restore intervertebral disc anabolism. Advanced Drug Delivery Reviews 84, pages 146-158.
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Maria Molinos, Catarina R. Almeida, Joana Caldeira, Carla Cunha, Raquel M. Gonçalves & Mário A. Barbosa. (2015) Inflammation in intervertebral disc degeneration and regeneration. Journal of The Royal Society Interface 12:104, pages 20141191.
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Gianluca Vadalà, Fabrizio Russo, Sofia Battisti, Luigi Stellato, Francesca Martina, Riccardo Del Vescovo, Antonino Giacalone, Arijitt Borthakur, Bruno Beomonte Zobel & Vincenzo Denaro. (2014) Early Intervertebral Disc Degeneration Changes in Asymptomatic Weightlifters Assessed by T1ρ-Magnetic Resonance Imaging. Spine 39:22, pages 1881-1886.
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Frances C Bach, Nicole Willems, Louis C Penning, Keita Ito, Björn P Meij & Marianna A Tryfonidou. (2014) Potential regenerative treatment strategies for intervertebral disc degeneration in dogs. BMC Veterinary Research 10:1, pages 3.
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Jason M. Cuellar, S. Raymond Golish, Eric J. Leroux, Merrill W. Reuter, Eugene J. Carragee, Lewis S. Hanna & Gaetano J. Scuderi. (2013) Does a Fibronectin and Aggrecan Complex Play a Role in Painful Vertebral Disks?. PM&R 5:4, pages 297-302.
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Stefano Negrini & Fabio Zaina. (2013) The Chimera of Low Back Pain Etiology. American Journal of Physical Medicine & Rehabilitation 92:1, pages 93-97.
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Yi-Xiang J. Wang, Feng Zhao, James F. Griffith, Greta S. P. Mok, Jason C. S. Leung, Anil T. Ahuja & Jing Yuan. (2012) T1rho and T2 relaxation times for lumbar disc degeneration: an in vivo comparative study at 3.0-Tesla MRI. European Radiology 23:1, pages 228-234.
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S. V. Anisimov. (2012) Cell therapy for age-related intervertebral disc pathologies. Advances in Gerontology 2:4, pages 300-305.
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Bruno Beomonte Zobel, Gianluca Vadalà, Riccardo Del Vescovo, Sofia Battisti, Francesca Maria Martina, Luigi Stellato, Emanuele Leoncini, Arijitt Borthakur & Vincenzo Denaro. (2012) T1ρ Magnetic Resonance Imaging Quantification of Early Lumbar Intervertebral Disc Degeneration in Healthy Young Adults. Spine 37:14, pages 1224-1230.
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S. Raymond Golish, Lewis S. Hanna, Robert P. Bowser, Pasquale X. Montesano, Eugene J. Carragee & Gaetano J. Scuderi. (2011) Outcome of Lumbar Epidural Steroid Injection Is Predicted by Assay of a Complex of Fibronectin and Aggrecan From Epidural Lavage. Spine 36:18, pages 1464-1469.
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Frank L. Acosta & Christopher P. Ames. 2011. Youmans Neurological Surgery. Youmans Neurological Surgery 2789 2795 .
Gwendolyn Sowa, Gianluca Vadalà, Rebecca Studer, John Kompel, Christina Iucu, Helga Georgescu, Lars Gilbertson & James Kang. (2008) Characterization of Intervertebral Disc Aging. Spine 33:17, pages 1821-1828.
Crossref
Seong-Hwan Moon. (2007) Biochemical Factors of Intervertebral Disc Degeneration: Implications for Disc Regeneration. Journal of Korean Society of Spine Surgery 14:2, pages 120.
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