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Review

Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate?

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Pages 713-726 | Published online: 03 May 2007

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Vito Vetrugno, Maria Puopolo, Franco Cardone, Fiorentino Capozzoli, Anna Ladogana & Maurizio Pocchiari. (2015) The future for treating Creutzfeldt–Jakob disease. Expert Opinion on Orphan Drugs 3:1, pages 57-74.
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Brian S Appleby & Constantine G Lyketsos. (2011) Rapidly progressive dementias and the treatment of human prion diseases. Expert Opinion on Pharmacotherapy 12:1, pages 1-12.
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Suehiro Sakaguchi, Daisuke Ishibashi & Haruo Matsuda. (2009) Antibody-based immunotherapeutic attempts in experimental animal models of prion diseases. Expert Opinion on Therapeutic Patents 19:7, pages 907-917.
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Suehiro Sakaguchi. (2008) Recent developments in therapeutics for prion diseases. Expert Opinion on Therapeutic Patents 18:1, pages 35-59.
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Masahiro Shijo, Motoi Yoshimura, Tsuyoshi Omae, Go Hashimoto, Tadataka Mizoguchi, Takahiro Kuwashiro, Takashi Komori, Yoshio Tsuboi, Tomoko Saito, Masanori Nakagawa, Kyoko Itoh & Hiroyuki Honda. (2023) Altered properties of amyloidogenic prion protein in genetic Creutzfeldt–Jakob disease with PRNP V180I mutation in response to pentosan polysulfate . Brain Pathology.
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Kenta Teruya & Katsumi Doh-ura. (2022) Therapeutic development of polymers for prion disease. Cell and Tissue Research 392:1, pages 349-365.
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Ermias D. Belay & Brian S. Appleby. 2020. Viral Infections of Humans. Viral Infections of Humans 1 49 .
Nicolas Bizat, Valeria Parrales, Sofian Laoues, Sébastien Normant, Etienne Levavasseur, Julian Roussel, Nicolas Privat, Alexianne Gougerot, Philippe Ravassard, Patrice Beaudry, Jean-Philippe Brandel, Jean-Louis Laplanche & Stéphane Haïk. (2021) An in vivo Caenorhabditis elegans model for therapeutic research in human prion diseases . Brain 144:9, pages 2745-2758.
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Takao Ishikawa. (2021) Saccharomyces cerevisiae in neuroscience: how unicellular organism helps to better understand prion protein?. Neural Regeneration Research 16:3, pages 489.
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Barbara E. Stopschinski, Talitha L. Thomas, Sourena Nadji, Eric Darvish, Linfeng Fan, Brandon B. Holmes, Anuja R. Modi, Jordan G. Finnell, Omar M. Kashmer, Sandi Estill-Terpack, Hilda Mirbaha, Hung S. Luu & Marc I. Diamond. (2020) A synthetic heparinoid blocks Tau aggregate cell uptake and amplification. Journal of Biological Chemistry 295:10, pages 2974-2983.
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Kenta Teruya & Katsumi Doh-ura. (2017) Insights from Therapeutic Studies for PrP Prion Disease. Cold Spring Harbor Perspectives in Medicine 7:3, pages a024430.
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Annachiara Gandini & Maria Laura Bolognesi. 2017. Prion Protein. Prion Protein 433 453 .
Simon Mead, John Collinge & Sarah J. Tabrizi. 2017. Infectious Diseases. Infectious Diseases 214 220.e2 .
Jerson L. Silva & Yraima Cordeiro. (2016) The “Jekyll and Hyde” Actions of Nucleic Acids on the Prion-like Aggregation of Proteins. Journal of Biological Chemistry 291:30, pages 15482-15490.
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CLAUDIA P. FIGUEIREDO, NATALIA C. FERREIRA, GISELLE F. PASSOS, ROBSON DA COSTA, FERNANDA S. NEVES, CLARICE S.C. MACHADO, ALESSANDRA MASCARELLO, LOUISE D. CHIARADIA-DELATORRE, PATRÍCIA D. NEUENFELDT, RICARDO J. NUNES & YRAIMA CORDEIRO. (2015) Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles. Anais da Academia Brasileira de Ciências 87:2 suppl, pages 1421-1434.
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Kenta Teruya, Masahiro Wakao, Masaki Sato, Taichi Hamanaka, Keiko Nishizawa, Yukino Funayama, Yuji Sakasegawa, Yasuo Suda & Katsumi Doh-ura. (2015) Heparinase I-specific disaccharide unit of heparin is a key structure but insufficient for exerting anti-prion activity in prion-infected cells. Biochemical and Biophysical Research Communications 460:4, pages 989-995.
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Ermias D. Belay & Jason C. Bartz. 2014. Viral Infections of Humans. Viral Infections of Humans 1165 1186 .
Allen Herbst, Pamela Banser, Camilo Duque Velasquez, Charles E. Mays, Valerie L. Sim, David Westaway, Judd M. Aiken & Debbie McKenzie. (2013) Infectious Prions Accumulate to High Levels in Non Proliferative C2C12 Myotubes. PLoS Pathogens 9:11, pages e1003755.
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Magdalena Rowinska‐Zyrek, Daniela Valensin, Marek Luczkowski & Henryk Kozlowski. 2013. Mechanisms and Metal Involvement in Neurodegenerative Diseases. Mechanisms and Metal Involvement in Neurodegenerative Diseases 118 162 .
Yoshio Tsuboi. (2013) Treatment for prion disease: recent progress. Rinsho Shinkeigaku 53:11, pages 1255-1257.
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Valerie L. Sim. 2013. Viral Infections of the Human Nervous System. Viral Infections of the Human Nervous System 371 401 .
Hiroyuki Honda, Kensuke Sasaki, Haruhiko Minaki, Kenta Masui, Satoshi O. Suzuki, Katsumi Doh-ura & Toru Iwaki. (2012) Protease-resistant PrP and PrP oligomers in the brain in human prion diseases after intraventricular pentosan polysulfate infusion. Neuropathology 32:2, pages 124-132.
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Markus Geissen, Fabienne Leidel, Martin Eiden, Thomas Hirschberger, Christine Fast, Uwe Bertsch, Paul Tavan, Armin Giese, Hans Kretzschmar, Hermann M. Schatzl & Martin H. Groschup. (2011) From High-Throughput Cell Culture Screening to Mouse Model: Identification of New Inhibitor Classes against Prion Disease. ChemMedChem 6:10, pages 1928-1937.
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Valerie L. Sim & Byron Caughey. 2010. Protein Misfolding Diseases. Protein Misfolding Diseases 259 303 .
Nobuyuki Okamura, Yusei Shiga, Shozo Furumoto, Manabu Tashiro, Yoshio Tsuboi, Katsutoshi Furukawa, Kazuhiko Yanai, Ren Iwata, Hiroyuki Arai, Yukitsuka Kudo, Yasuhito Itoyama & Katsumi Doh-ura. (2009) In vivo detection of prion amyloid plaques using [11C]BF-227 PET. European Journal of Nuclear Medicine and Molecular Imaging 37:5, pages 934-941.
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T. Terada, Y. Tsuboi, T. Obi, K. Doh-ura, S. Murayama, T. Kitamoto, T. Yamada & K. Mizoguchi. (2010) Less protease-resistant PrP in a patient with sporadic CJD treated with intraventricular pentosan polysulphate. Acta Neurologica Scandinavica 121:2, pages 127-130.
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Torger Stølsmark & Ole-Bjørn Tysnes. (2010) Ny kunnskap om Creutzfeldt-Jakobs sykdom kan gi terapeutiske muligheter. Tidsskrift for Den norske legeforening 130:6, pages 601-604.
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Mark J. ThompsonVinciane BorsenbergerJennifer C. LouthKatie E. JuddBeining Chen. (2009) Design, Synthesis, and Structure−Activity Relationship of Indole-3-glyoxylamide Libraries Possessing Highly Potent Activity in a Cell Line Model of Prion Disease. Journal of Medicinal Chemistry 52:23, pages 7503-7511.
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Yoshio Tsuboi, Katsumi Doh-ura & Tatsuo Yamada. (2009) Continuous intraventricular infusion of pentosan polysulfate: Clinical trial against prion diseases. Neuropathology 29:5, pages 632-636.
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Chang-Hyun Song, Osamu Honmou, Natsuo Ohsawa, Kiminori Nakamura, Hirofumi Hamada, Hidefumi Furuoka, Rie Hasebe & Motohiro Horiuchi. (2009) Effect of Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells on Mice Infected with Prions. Journal of Virology 83:11, pages 5918-5927.
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Katsumi Doh-ura. (2009) Innovation of therapeutics and prophylaxis for prion diseases. Rinsho Shinkeigaku 49:11, pages 946-948.
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Takehiro Nagatsuka, Hirotaka Uzawa & Yoshihiro Nishida. (2009) Library assembly of mono-, di- and tri-O-sulfated β-d-xylopyranosides; effect of O-sulfation on pyranose ring conformation. Chemical Communications:27, pages 4109.
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Chang-Hyun Song, Hidefumi Furuoka, Chan-Lan Kim, Michiko Ogino, Akio Suzuki, Rie Hasebe & Motohiro Horiuchi. (2008) Effect of intraventricular infusion of anti-prion protein monoclonal antibodies on disease progression in prion-infected mice. Journal of General Virology 89:6, pages 1533-1544.
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M. Pocchiari, A. Ladogana, S. Graziano & M. Puopolo. (2008) Creutzfeldt-Jakob disease: hopes for therapy. European Journal of Neurology 15:5, pages 435-436.
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Ada De Luigi, Laura Colombo, Luisa Diomede, Raffaella Capobianco, Michela Mangieri, Claudia Miccolo, Lucia Limido, Gianluigi Forloni, Fabrizio Tagliavini & Mario Salmona. (2008) The Efficacy of Tetracyclines in Peripheral and Intracerebral Prion Infection. PLoS ONE 3:3, pages e1888.
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Sabrina Cronier, Vincent Beringue, Anne Bellon, Jean-Michel Peyrin & Hubert Laude. (2007) Prion Strain- and Species-Dependent Effects of Antiprion Molecules in Primary Neuronal Cultures. Journal of Virology 81:24, pages 13794-13800.
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Yuri Kawasaki, Keiichi Kawagoe, Chun-jen Chen, Kenta Teruya, Yuji Sakasegawa & Katsumi Doh-ura. (2007) Orally Administered Amyloidophilic Compound Is Effective in Prolonging the Incubation Periods of Animals Cerebrally Infected with Prion Diseases in a Prion Strain-Dependent Manner. Journal of Virology 81:23, pages 12889-12898.
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