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Review

Cell-penetrating TIR BB loop decoy peptides

a novel class of TLR signaling inhibitors and a tool to study topology of TIR–TIR interactions

&
Pages 1035-1050 | Published online: 31 Jul 2007

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U. Saqib & M. S. Baig. (2018) Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy. SAR and QSAR in Environmental Research 29:4, pages 295-318.
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Catherine M Greene, Peter Branagan & Noel G McElvaney. (2008) Toll-like receptors as therapeutic targets in cystic fibrosis. Expert Opinion on Therapeutic Targets 12:12, pages 1481-1495.
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Artur Javmen, Jun Zou, Shreeram C. Nallar, Henryk Szmacinski, Joseph R. Lakowicz, Andrew T. Gewirtz & Vladimir Y. Toshchakov. (2023) TLR5-Derived, TIR-Interacting Decoy Peptides to Inhibit TLR Signaling. The Journal of Immunology 210:9, pages 1419-1427.
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Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology 397 533 .
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Artur Javmen, Henryk Szmacinski, Joseph R Lakowicz & Vladimir Y Toshchakov. (2020) Frontline Science: Targeting the TLR7 signalosome assembly. Journal of Leukocyte Biology 108:6, pages 1697-1706.
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Kari Ann Shirey, Wendy Lai, Lindsey J Brown, Jorge C G Blanco, Robert Beadenkopf, Yajing Wang, Stefanie N Vogel & Greg A Snyder. (2020) Select targeting of intracellular Toll-interleukin-1 receptor resistance domains for protection against influenza-induced disease. Innate Immunity 26:1, pages 26-34.
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Artur Javmen, Henryk Szmacinski, Joseph R. Lakowicz & Vladimir Y. Toshchakov. (2018) Blocking TIR Domain Interactions in TLR9 Signaling. The Journal of Immunology 201:3, pages 995-1006.
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Wenji Piao, Kari Ann Shirey, Lisa W. Ru, Wendy Lai, Henryk Szmacinski, Greg A. Snyder, Eric J. Sundberg, Joseph R. Lakowicz, Stefanie N. Vogel & Vladimir Y. Toshchakov. (2015) A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza. Cell Reports 11:12, pages 1941-1952.
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Song Liu, Jianan Ren & Jieshou Li. (2015) IL-17RA in Intestinal Inflammation. Inflammatory Bowel Diseases 21:1, pages 154-166.
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M.J. Paul-Clark, P.M. George, T. Gatheral, K. Parzych, W.R. Wright, D. Crawford, L.K. Bailey, D.M. Reed & J.A. Mitchell. (2012) Pharmacology and therapeutic potential of pattern recognition receptors. Pharmacology & Therapeutics 135:2, pages 200-215.
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Leah A. Couture, Wenji Piao, Lisa W. Ru, Stefanie N. Vogel & Vladimir Y. Toshchakov. (2012) Targeting Toll-like Receptor (TLR) Signaling by Toll/Interleukin-1 Receptor (TIR) Domain-containing Adapter Protein/MyD88 Adapter-like (TIRAP/Mal)-derived Decoy Peptides. Journal of Biological Chemistry 287:29, pages 24641-24648.
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Caini LiuShadi SwaidaniWen QianZizhen KangPaige SunYue HanChenhui WangMuhammet Fatih GulenWeiguo YinChunjiang ZhangPaul L. FoxMark AronicaThomas A. HamiltonSaurav MisraJunpeng DengXiaoxia Li. (2011) A CC′ Loop Decoy Peptide Blocks the Interaction Between Act1 and IL-17RA to Attenuate IL-17– and IL-25–Induced Inflammation. Science Signaling 4:197.
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Georgina L. Hold & Clare E. Bryant. 2011. Bacterial Lipopolysaccharides. Bacterial Lipopolysaccharides 371 387 .
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