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Review

B-cell depletion with rituximab in the treatment of autoimmune diseases

Graves' ophthalmopathy the latest addition to an expanding family

, , , &
Pages 1061-1078 | Published online: 31 Jul 2007

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Read on this site (3)

Shivani Gupta, César A Briceño & Raymond S Douglas. (2013) Customized minimally invasive orbital decompression for thyroid eye disease. Expert Review of Ophthalmology 8:3, pages 255-266.
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Sang-Rog Oh, Ayelet Priel, David B Granet, Leah Levi, Bobby S Korn & Don O Kikkawa. (2011) Thyroid-related orbitopathy: a multidisciplinary perspective. Expert Review of Ophthalmology 6:1, pages 43-53.
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Luigi Bartalena, Adriana Lai & Maria Laura Tanda. (2008) Perspectives in pharmacological management of Graves’ hyperthyroidism and orbitopathy. Expert Review of Clinical Immunology 4:3, pages 321-329.
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Articles from other publishers (37)

Rosa M. M. Gynthersen, Christen Rune Stensvold, Signe Ledou Nielsen, Holger Jon Møller, Henrik Vedel Nielsen, Anne‐Mette Lebech, Jeppe Romme Christensen, Helene Mens & Daniel El Fassi. (2023) Neoehrlichia mikurensis —An emerging opportunistic tick‐borne infection in immunosuppressed patients . Journal of Internal Medicine 293:6, pages 782-790.
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E. J. Neag & T. J. Smith. (2021) 2021 update on thyroid-associated ophthalmopathy. Journal of Endocrinological Investigation 45:2, pages 235-259.
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Claudio Marcocci & Terry J. Smith. 2018. Thyroid Diseases. Thyroid Diseases 451 488 .
Sofie Bliddal, Claus Henrik Nielsen & Ulla Feldt-Rasmussen. (2017) Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity. F1000Research 6, pages 1776.
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Geoffrey E. Rose & David H. Verity. 2017. Emergencies of the Orbit and Adnexa. Emergencies of the Orbit and Adnexa 171 178 .
Akira Kurozumi, Yosuke Okada, Tadashi Arao, Yusuke Miyazaki, Maiko Yoshikawa, Keiichi Torimoto, Satoshi Kubo, Shingo Nakayamada & Yoshiya Tanaka. (2016) Pancreas-protective effect of rituximab for acute-onset type 1 diabetes in the honeymoon period: a case report. Endocrinology, Diabetes & Metabolism Case Reports.
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Claudio Marcocci & Terry J. Smith. 2017. Thyroid Diseases. Thyroid Diseases 1 39 .
Syed Khalid Imam. 2016. Thyroid Disorders. Thyroid Disorders 147 168 .
Birte Kristensen, Laszlo Hegedüs, Steven K. Lundy, Marie K. Brimnes, Terry J. Smith & Claus H. Nielsen. (2015) Characterization of Regulatory B Cells in Graves’ Disease and Hashimoto’s Thyroiditis. PLOS ONE 10:5, pages e0127949.
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Akira Kurozumi, Yosuke Okada, Tadashi Arao, Manabu Narisawa, Keiichi Torimoto, Sunao Yamamoto & Yoshiya Tanaka. (2015) Induction of thyroid remission using rituximab in a patient with type 3 autoimmune polyglandular syndrome including Graves’ disease and type 1 diabetes mellitus: A case report. Endocrine Journal 62:1, pages 69-75.
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Marie Klinge Brimnes, Bjarke Endel Hansen, Leif Kofoed Nielsen, Morten Hanefeld Dziegiel & Claus Henrik Nielsen. (2014) Uptake and Presentation of Myelin Basic Protein by Normal Human B Cells. PLoS ONE 9:11, pages e113388.
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Tony Shang-Chuan Chen, Edwin Figueira, Oliver C. F. Lau, Penny A. McKelvie, Robert I. Smee, Laughlin C. Dawes, Ashish Agar, Geoff Wilcsek & Ian C. Francis. (2014) Successful “Medical” Orbital Decompression With Adjunctive Rituximab for Severe Visual Loss in IgG4-Related Orbital Inflammatory Disease With Orbital Myositis. Ophthalmic Plastic & Reconstructive Surgery 30:5, pages e122-e125.
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Sunny Shen, Anita Chan, Petros P. Sfikakis, Andrea Low Hsiu Ling, Efstathios T. Detorakis, Kostas G. Boboridis & Ioannis Mavrikakis. (2013) B-Cell Targeted Therapy With Rituximab for Thyroid Eye Disease: Closer to the Clinic. Survey of Ophthalmology 58:3, pages 252-265.
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D H Verity & G E Rose. (2013) Acute thyroid eye disease (TED): Principles of medical and surgical management. Eye 27:3, pages 308-319.
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Bingbing Zha, Luman Wang, Xiaoming Liu, Jun Liu, Zaoping Chen, Jiong Xu, Li Sheng, Yiming Li & Yiwei Chu. (2012) Decrease in Proportion of CD19+CD24hiCD27+ B Cells and Impairment of Their Suppressive Function in Graves’ Disease. PLoS ONE 7:11, pages e49835.
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Noriyasu Hashida, Nobuyuki Ohguro & Kohji Nishida. (2012) Efficacy and Complications of Intravitreal Rituximab Injection for Treating Primary Vitreoretinal Lymphoma. Translational Vision Science & Technology 1:3, pages 1.
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Anina Langkjær, Birte Kristensen, Bjarke E. Hansen, Heidi Schultz, Laszlo Hegedüs & Claus H. Nielsen. (2012) B-cell exposure to self-antigen induces IL-10 producing B cells as well as IL-6- and TNF-α-producing B-cell subsets in healthy humans. Clinical Immunology 145:1, pages 1-10.
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Michael Gonzales, Carmel Fratianni, Chaitanya Mamillapali & Romesh Khardori. (2012) Immunotherapy in Miscellaneous Medical Disorders Graves Ophthalmopathy, Asthma, and Regional Painful Syndrome. Medical Clinics of North America 96:3, pages 635-654.
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Byung-Chun ParkKyung-In WooYoon-Duck Kim. (2012) Three Cases of Rituximab Treatment for Orbital Inflammatory Disease. Journal of the Korean Ophthalmological Society 53:5, pages 721.
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Claus H. Nielsen & Klaus Bendtzen. 2012. Naturally Occurring Antibodies (NAbs). Naturally Occurring Antibodies (NAbs) 116 132 .
Anders E. Pedersen, Mette B Jungersen & Charlotte D. Pedersen. (2011) Monocytes mediate shaving of B-cell-bound anti-CD20 antibodies. Immunology 133:2, pages 239-245.
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Luigi Bartalena. (2011) The Dilemma of How to Manage Graves' Hyperthyroidism in Patients with Associated Orbitopathy. The Journal of Clinical Endocrinology & Metabolism 96:3, pages 592-599.
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Laszlo Hegedüs, Terry J. Smith, Raymond S. Douglas & Claus H. Nielsen. (2010) Targeted biological therapies for Graves’ disease and thyroid‐associated ophthalmopathy. Focus on B‐cell depletion with Rituximab. Clinical Endocrinology 74:1, pages 1-8.
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Vibhavari M. Naik, Milind N. Naik, Robert A. Goldberg, Terry J. Smith & Raymond S. Douglas. (2010) Immunopathogenesis of Thyroid Eye Disease: Emerging Paradigms. Survey of Ophthalmology 55:3, pages 215-226.
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Dinesh Khanna, Kelvin K.L. Chong, Nikoo F. Afifiyan, Catherine J. Hwang, Diana K. Lee, Helene Chokron Garneau, Robert A. Goldberg, Christine H. Darwin, Terry J. Smith & Raymond S. Douglas. (2010) Rituximab Treatment of Patients with Severe, Corticosteroid-Resistant Thyroid-Associated Ophthalmopathy. Ophthalmology 117:1, pages 133-139.e2.
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Laszlo Hegedüs. (2009) Treatment of Graves' Hyperthyroidism: Evidence-Based and Emerging Modalities. Endocrinology and Metabolism Clinics of North America 38:2, pages 355-371.
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Petros Perros & Gerasimos E. Krassas. (2009) Graves orbitopathy: a perspective. Nature Reviews Endocrinology 5:6, pages 312-318.
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Daniel El Fassi, J. Paul Banga, Jacqueline A. Gilbert, Carolyn Padoa, Laszlo Hegedüs & Claus H. Nielsen. (2009) Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies. Clinical Immunology 130:3, pages 252-258.
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. (2008) Current World Literature. Current Opinion in Ophthalmology 19:6, pages 541-548.
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Raymond S. Douglas, Vibharavi Naik, Catherine J. Hwang, Nikoo F. Afifiyan, Andrew G. Gianoukakis, Daniel Sand, Shweta Kamat & Terry J. Smith. (2008) B Cells from Patients with Graves’ Disease Aberrantly Express the IGF-1 Receptor: Implications for Disease Pathogenesis. The Journal of Immunology 181:8, pages 5768-5774.
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. (2008) Current World Literature. Current Opinion in Endocrinology, Diabetes & Obesity 15:5, pages 470-479.
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Luigi Bartalena, Adriana Lai, Emanuele Compri, Claudio Marcocci & Maria Laura Tanda. (2008) Novel Immunomodulating Agents for Graves Orbitopathy. Ophthalmic Plastic & Reconstructive Surgery 24:4, pages 251-256.
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Basil RapoportSandra M. McLachlan. (2008) Whither TSH Receptor Blocking Antibodies in the Treatment of Graves' Disease?. Thyroid 18:7, pages 695-696.
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Shiguang Yu, Robert Dunn, Marilyn R. Kehry & Helen Braley-Mullen. (2008) B Cell Depletion Inhibits Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice. The Journal of Immunology 180:11, pages 7706-7713.
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George S. Eisenbarth & Joy Jeffrey. (2008) The natural history of type 1A diabetes. Arquivos Brasileiros de Endocrinologia & Metabologia 52:2, pages 146-155.
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Clara-Dina Cokonis, Carrie W. Cobb, Warren R. Heymann & Chad M. Hivnor. 2008. Thyroid Disorders with Cutaneous Manifestations. Thyroid Disorders with Cutaneous Manifestations 73 87 .
Daniel El Fassi, Ole Clemmensen, Claus H. Nielsen, Rona Z. Silkiss & Laszlo Hegedüs. (2007) Evidence of Intrathyroidal B-Lymphocyte Depletion after rituximab Therapy in a Patient with Graves’ Disease. The Journal of Clinical Endocrinology & Metabolism 92:10, pages 3762-3763.
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